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Compound file updated to V11 and evaluation plan #3

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686b525
Compound file updated to V11 and evaluation plan
mgsc1020 Nov 15, 2024
b71a9cf
Updated observed data and Formulation name
mgsc1020 Dec 18, 2024
29d63b7
Updated read me file and evaluation plan text
mgsc1020 Dec 18, 2024
e2c4aac
Removed Metformin-Model-renal impairment (not re-evaluated) and metfo…
mgsc1020 Dec 18, 2024
b6edc9c
Model File minor updates
mgsc1020 Dec 19, 2024
725c3b4
Updated model file name and observed data mappings
mgsc1020 Jan 3, 2025
fb39c12
Updated author name in report text
mgsc1020 Jan 3, 2025
849e392
Author name updated
mgsc1020 Jan 3, 2025
e6f7d1a
Updated evaluation plan for new file name
mgsc1020 Jan 3, 2025
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Delete Evaluation/report directory
mgsc1020 Jan 3, 2025
8f9f133
Updated reference anchors
mgsc1020 Jan 3, 2025
65d742b
reviewed anchors and references based on feedback
mgsc1020 Jan 6, 2025
7ae7ed9
Update Evaluation/Input/Content/Section1_Introduction.md
mgsc1020 Jan 30, 2025
3c64263
Update Evaluation/Input/Content/Section1_Introduction.md
mgsc1020 Jan 30, 2025
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Update Evaluation/Input/Content/Section1_Introduction.md
mgsc1020 Jan 30, 2025
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Update Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assum…
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Update Evaluation/Input/Content/Section2.1_Modeling_Strategy.md
mgsc1020 Jan 30, 2025
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Update of Evaluation/Input/Content/Section2.3_Model_Parameters_and_As…
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updated section2.2_data.md
mgsc1020 Mar 6, 2025
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Updated read me.md
mgsc1020 Mar 6, 2025
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Update Evaluation/Input/Content/Section1_Introduction.md
Co-authored-by: Pavel Balazki <[email protected]>
mgsc1020 and PavelBal authored Jan 30, 2025
commit 9dca4dfa705074dadfcc45fe4590f2791f38428c
2 changes: 1 addition & 1 deletion Evaluation/Input/Content/Section1_Introduction.md
Original file line number Diff line number Diff line change
@@ -8,7 +8,7 @@ excretion. The absorption of metformin is saturable and reported to be restricte
intestine ([Vidon 1988](#5-references)). The excretion of metformin is mainly mediated via the sequential action of OCT2 and
MATE in the kidney, with a moderate contribution of renal glomerular filtration (approximately
20 %). Metformin is recommended by the FDA as OCT2/MATE victim drug for the use in clinical
DDI studies and drug labeling [FDA 2017](#5-references).
DDI studies and drug labeling ([FDA 2017](#5-references)).

The herein presented PBPK model of metformin PBPK model has been developed using 39 clinical studies. The model was evaluated by comparing simulations to observed data of both intravenously and orally administered metformin covering a dosing range from 0.001 to 2550 mg.