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Compound file updated to V11 and evaluation plan #3

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686b525
Compound file updated to V11 and evaluation plan
mgsc1020 Nov 15, 2024
b71a9cf
Updated observed data and Formulation name
mgsc1020 Dec 18, 2024
29d63b7
Updated read me file and evaluation plan text
mgsc1020 Dec 18, 2024
e2c4aac
Removed Metformin-Model-renal impairment (not re-evaluated) and metfo…
mgsc1020 Dec 18, 2024
b6edc9c
Model File minor updates
mgsc1020 Dec 19, 2024
725c3b4
Updated model file name and observed data mappings
mgsc1020 Jan 3, 2025
fb39c12
Updated author name in report text
mgsc1020 Jan 3, 2025
849e392
Author name updated
mgsc1020 Jan 3, 2025
e6f7d1a
Updated evaluation plan for new file name
mgsc1020 Jan 3, 2025
9d961df
Delete Evaluation/report directory
mgsc1020 Jan 3, 2025
8f9f133
Updated reference anchors
mgsc1020 Jan 3, 2025
65d742b
reviewed anchors and references based on feedback
mgsc1020 Jan 6, 2025
7ae7ed9
Update Evaluation/Input/Content/Section1_Introduction.md
mgsc1020 Jan 30, 2025
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Update Evaluation/Input/Content/Section1_Introduction.md
mgsc1020 Jan 30, 2025
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Update Evaluation/Input/Content/Section1_Introduction.md
mgsc1020 Jan 30, 2025
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Update Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assum…
mgsc1020 Jan 30, 2025
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Update Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assum…
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Update Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assum…
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Update Evaluation/Input/Content/Section2.3_Model_Parameters_and_Assum…
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Update Evaluation/Input/Content/Section2.1_Modeling_Strategy.md
mgsc1020 Jan 30, 2025
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Update of Evaluation/Input/Content sections
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Update of Evaluation/Input/Content/Section2.3_Model_Parameters_and_As…
mgsc1020 Jan 30, 2025
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Update of Evaluation/Input/Content/Section2.3_Model_Parameters_and_As…
mgsc1020 Jan 30, 2025
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updated section2.2_data.md
mgsc1020 Mar 6, 2025
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Updated read me.md
mgsc1020 Mar 6, 2025
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Updated read me file and evaluation plan text
mgsc1020 committed Dec 18, 2024
commit 29d63b7a7f6e0d83ea9b3def80274c14c33903cc
2 changes: 2 additions & 0 deletions Evaluation/Input/Content/References.md
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@@ -29,6 +29,8 @@ of substrates, inhibitors and inducers. https://www.fda.gov/drugs/drug-interacti

**Gusler 2001** Gusler G, Gorsline J, Levy G, et al (2001) Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers. J Clin Pharmacol 41:655–661. https://doi.org/10.1177/00912700122010546

**Hanke 2020** Hanke N, Türk D, Selzer D, et al (2020) A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals. Clin Pharmacokinet. 59:1419-1431. doi: 10.1007/s40262-020-00896-w.

**Hibma 2016** Hibma JE, Zur AA, Castro RA, et al (2016) The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet 55:711–721. https://doi.org/10.1007/s40262-015-0346-3

**Jang 2016** Jang K, Chung H, Yoon J-S, et al (2016) Pharmacokinetics, Safety, and Tolerability of Metformin in Healthy Elderly Subjects. J Clin Pharmacol 56:1104–1110. https://doi.org/10.1002/jcph.699
2 changes: 2 additions & 0 deletions Evaluation/Input/Content/Section1_Introduction.md
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The presented model building and evaluation report evaluates the performance of a PBPK model for metformin in healthy adults.

The herein presented model was developed and published by Hanke et al. [Hanke 2020](#5-references) and adjusted later on to PK-Sim V11 by re-optimizing OCT2.

Metformin is widely used as first-line treatment of type 2 diabetes. It is a highly hydrophilic compound, positively
charged at physiological pH and depends on active transport for its absorption, distribution and
excretion. The absorption of metformin is saturable and reported to be restricted to the upper
2 changes: 1 addition & 1 deletion README.md
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@@ -7,7 +7,7 @@ Within this repository, we share a whole-body PBPK model of metformin that has b
The PK-Sim project file contains simulation examples and the observed data of all clinical studies used for model development and evaluation. For further details, quantitative model evaluation, sensitivity analysis and extensive documentation please refer to [[1](#reference)].

### Version information
PK-Sim Version 8.0.
PK-Sim Version 11.

### License
The model is distributed under the [GPLv2 License](https://github.com/Open-Systems-Pharmacology/Suite/blob/develop/LICENSE).