Shen2015

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.

• Shen, J. P. et al. Oncotarget 6, 35755–35769

The authors screened 112 known tumor suppressor genes for synthetic lethal interactions with inhibitors of the CHEK1 and CHEK2 checkpoint kinases. They identified eight interactions, including the Replication Factor C (RFC)-related protein RAD17.