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chore(client): make FAQ dataset-generic
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davidlougheed committed Jan 17, 2024
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28 changes: 8 additions & 20 deletions client/src/components/pages/FAQPage.js
Original file line number Diff line number Diff line change
Expand Up @@ -8,43 +8,31 @@ const FAQPage = () => {
<details open={true}>
<summary>How are the QTL plots generated?</summary>
<p>
To generate plots, we use the UCSC <em>bigWigSummary</em> tool to calculate average signal across a feature
for each sample upon request. These values are combined with genotype information extracted from a{" "}
To generate plots, we either use pre-computed, batch-corrected and normalized sample-wise signal matrices,
or use the UCSC <em>bigWigSummary</em> tool to calculate average signal across a feature for each sample
upon request. These values are combined with genotype information extracted from a{" "}
<a href="https://gemini.readthedocs.io/en/latest/"
target="_blank"
rel="noreferrer">Gemini database</a> into a box plot on a server, which is
then sent to the user’s browser if they have signed in and agreed to the terms of use. Plots are generated
as needed, rather than in advance, and are derived directly from the count matrix or track and genotype
data.
as needed, rather than in advance, and are derived directly from the matrix or track and genotype data.
</p>
</details>
<details open={true}>
<summary>How were the genomic tracks grouped by genotype generated?</summary>
<p>
Genome browser tracks were created with the HOMER <em>makeUCSCfile</em> command and{" "}
<em>bedGraphToBigWig</em> utility from UCSC. Tracks were normalized so that each value represents the read
count per base pair per 10 million reads. We generate{" "}
We generate{" "}
<a href="https://genome.ucsc.edu/"
target="_blank"
rel="noreferrer">UCSC Genome Browser</a> track hubs upon
request to visualize averaged track segments for a given genomic feature. These tracks are created on the
fly by averaging bigWig regions of samples sharing an experimental treatment and genotype, using our
command-line tool:
request to visualize averaged normalized track segments for a given genomic feature. These averaged tracks
are created on the fly by averaging bigWig regions of samples sharing an experimental treatment and
genotype, using our command-line tool:
<a href="https://github.com/c3g/bw-merge-window"
target="_blank"
rel="noreferrer"><code>bw-merge-window</code></a>.
</p>
</details>
<details open={true}>
<summary>How were the global tracks per ancestry group generated?</summary>
<p>
The dark shaded area denotes the distribution of the average RPM values and the light shaded area denotes
the standard deviation. Signals of various epigenetic marks are shown in blue color for non-infected samples
and red color for infected samples. For RNA-seq, forward and reverse transcripts are shown in blue and green
color separately for non-infected samples; while forward and reverse transcripts are shown in red and brown
color separately for infected samples.
</p>
</details>
</Col>
</Row>
</Container>;
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