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Jim Balhoff edited this page Sep 28, 2017 · 19 revisions

Main ontology

The NCIt OBO Library edition is available from its ontology IRI:

http://purl.obolibrary.org/obo/ncit.owl

http://purl.obolibrary.org/obo/ncit.obo

This ontology is basically a direct transformation of the standard NCIt content using OBO-style term IRIs and annotation properties. The OBO transformation pipeline is under active development, so the ontology content may be in flux for the time being.

NCIt Plus

This version replaces NCIt terms with direct references to terms from other domain-specific OBO Library ontologies (e.g. cell types, cellular components, anatomy). The current release incorporates CL (cell types) and Uberon (anatomy).

http://purl.obolibrary.org/obo/ncit/ncit-plus.owl

A report is available which provides a classification diff between the neoplasm hierarchy in NCIt OBO Edition and NCIt Plus.

Neoplasm Core

This is a subset extracted from NCIt Plus using the Syntactic Locality Module Extractor BOT algorithm, with the NCIt Neoplasm Core value set as a starting point. This includes about 1400 neoplasm concepts along with other terms and axioms related to those concepts via SLME.

http://purl.obolibrary.org/obo/ncit/neoplasm-core.owl

Subsets

OncoTree slim

A simple hierarchy extract for NCIt terms used within OncoTree. The ontology hierarchy does not exactly parallel the tree structure used in OncoTree.

http://purl.obolibrary.org/obo/ncit/ncit-oncotree.ttl

http://purl.obolibrary.org/obo/ncit/ncit-oncotree.obo

Bridge axioms

Bridging ontologies consist of OWL axioms that connect NCIt to another ontology (typically through equivalence axioms).

http://purl.obolibrary.org/obo/ncit/ncit-bridge-to-cl.owl

http://purl.obolibrary.org/obo/ncit/ncit-bridge-to-uberon.owl

Logical tests

Ontologies built to demonstrate consequences of certain axiom types within NCIt.

NCIt OBO Edition with property negations

Converts excludes properties to logical negations; currently results in some unsatisfiable classes.

http://purl.obolibrary.org/obo/ncit/ncit-negations.owl

NCIt Plus with property negations

Converts excludes properties to logical negations; currently results in some unsatisfiable classes.

http://purl.obolibrary.org/obo/ncit/ncit-plus-negations.owl

NCIt Benign vs. Malignant classification

Converts Neoplastic Status annotation values to logical axioms, and enforces disjointness between benign and malignant neoplasms; currently results in some unsatisfiable classes. owl:import this into NCIt to test.

http://purl.obolibrary.org/obo/ncit/ncit-benign-malignant.ttl

SPARQL endpoint

The ontology as well as some accessory RDF graphs are queryable via this SPARQL endpoint: https://stars-app.renci.org/ncitgraph/sparql

More information about the SPARQL endpoint is available on its wiki page.