You can now set a base_url when creating a Zencoder client. This will allow you to use the Zencoder client in conjunction with a service like Runscope.
For example:
from zencoder import Zencoder
client = Zencoder(base_url='https://app-zencoder-com-<runscope-bucket-key>.runscope.net/api/v2/')
client.job.list()