Add figure PMC9949038_3

figure_fetch.log

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+2024-09-09 22:27:04 - Starting NCBI PMC Single Figure Fetcher for PMC9949038 Figure 3
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+2024-09-09 22:27:05 - Successfully downloaded image to figures/PMC9949038__nihpp-2023.02.15.528365v2-f0003.jpg
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+2024-09-09 22:27:05 - Successfully wrote YAML file to figures/PMC9949038__nihpp-2023.02.15.528365v2-f0003.yml
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+2024-09-09 22:27:05 - NCBI PMC Single Figure Fetcher completed
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figures/PMC9949038__nihpp-2023.02.15.528365v2-f0003.yml

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+---
+figid: PMC9949038__nihpp-2023.02.15.528365v2-f0003
+pmcid: PMC9949038
+image_filename: PMC9949038__nihpp-2023.02.15.528365v2-f0003.jpg
+figure_link: /pmc/articles/PMC9949038/figure/nihpp-2023.02.15.528365v2-f0003/
+number: Figure 3.
+figure_title: Increased intratumoral heterogeneity in Cracd KO SCLC tumors
+caption: 'A, UMAPs of the scRNA-seq datasets of RPR2 and CRPR2 SCLC tumors.B, UMAPs
+  of subsets of cells from the global level (left) to SCLC tumor epithelial cells
+  (right). Each dot represents a single cell, colored by cell type. Tumor epithelial
+  cells (RPR2 and CRPR2) were replotted into another UMAP (right).C, UMAPs of cell
+  types within RPR2 (left) and CRPR2 cell subsets (right). The top two genes that
+  were highly expressed in each cluster were used for cell cluster annotation of the
+  UMAPs.D, Comparison of proportions of different cell types between the RPR2 and
+  CRPR2 datasets.E, CytoTRACE scores of RPR2 and CRPR2 datasets were analyzed and
+  plotted.F, Boxplots of the cell differentiation potential of each cell cluster based
+  on the CytoTRACE score analysis; diff.: cell differentiation; **: P < 0.01; ***:
+  P < 0.001.G, GSEA of gene sets associated with the epithelial-mesenchymal transition
+  pathway and hypoxia pathway in cluster 4 in CRPR2 datasets compared to in RPR2 scRNA-seq
+  datasets; NES, normalized enrichment score.H, Feature plots displaying the expression
+  of epithelial-mesenchymal transition marker Vim and Fn1, hypoxia marker Hif1a.I,
+  Violin (left) and feature (right) plots visualizing Ascl1 and Calca expression between
+  RPR2 and CRPR2 datasets'
+article_title: CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated
+  immune evasion
+citation: Shengzhe Zhang, et al. bioRxiv. 2023 May 17;121(5).
+year: '2023'
+pub_date: 2023-5-17
+epub_date: 2023-5-17
+doi: 10.1101/2023.02.15.528365
+journal_title: bioRxiv
+journal_nlm_ta: bioRxiv
+publisher_name: Cold Spring Harbor Laboratory
+keywords:
+- CRACD
+- CRAD
+- KIAA1211
+- small cell lung cancer
+- immune evasion
+- EZH2
+- PRC2
+- immunotherapy
+---