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--- | ||
figid: PMC11353926__foods-13-02573-g003 | ||
pmcid: PMC11353926 | ||
image_filename: foods-13-02573-g003.jpg | ||
figure_link: /pmc/articles/PMC11353926/figure/F3/ | ||
number: Figure 3 | ||
figure_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
caption: Enrichment analysis bubble diagrams of KEGG metabolic pathway in samples | ||
from inhibition group and reduction group | ||
article_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
citation: Yinxue Liu, et al. Foods. 2024 Aug;13(16). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-17 | ||
doi: 10.3390/foods13162573 | ||
journal_title: Foods | ||
journal_nlm_ta: Foods | ||
publisher_name: MDPI | ||
keywords: | ||
- plantaricin Q7 | ||
- Listeria monocytogenes biofilm | ||
- metabolomics | ||
- inhibition | ||
- reduction | ||
--- |
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figid: PMC11353926__foods-13-02573-g004 | ||
pmcid: PMC11353926 | ||
image_filename: foods-13-02573-g004.jpg | ||
figure_link: /pmc/articles/PMC11353926/figure/F4/ | ||
number: Figure 4 | ||
figure_title: Venn diagram of enrichment pathway. | ||
caption: Venn diagram of enrichment pathway. The yellow circle represents the Inhibition_TR | ||
vs. Inhibition_Control group, and the blue circle represents the Reduction_TR vs. | ||
Reduction_Control | ||
article_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
citation: Yinxue Liu, et al. Foods. 2024 Aug;13(16). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-17 | ||
doi: 10.3390/foods13162573 | ||
journal_title: Foods | ||
journal_nlm_ta: Foods | ||
publisher_name: MDPI | ||
keywords: | ||
- plantaricin Q7 | ||
- Listeria monocytogenes biofilm | ||
- metabolomics | ||
- inhibition | ||
- reduction | ||
--- |
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--- | ||
figid: PMC11353926__foods-13-02573-g005 | ||
pmcid: PMC11353926 | ||
image_filename: foods-13-02573-g005.jpg | ||
figure_link: /pmc/articles/PMC11353926/figure/F5/ | ||
number: Figure 5 | ||
figure_title: Purine metabolic pathway and major metabolites. | ||
caption: Purine metabolic pathway and major metabolites. (A) Purine metabolic pathway; | ||
(B) metabolites in purine metabolic pathway. Blue words indicate the metabolites | ||
with significant differences between the inhibition group and the reduction group, | ||
green words indicate the metabolites with significant differences only in the inhibition | ||
group, and red words indicate the metabolites with significant differences only | ||
in the reduction group. ↑ indicates up-regulation and ↓ indicates down-regulation. | ||
* p < 0.05, ** p < 0.01, *** p < 0.001, ns, not significant | ||
article_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
citation: Yinxue Liu, et al. Foods. 2024 Aug;13(16). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-17 | ||
doi: 10.3390/foods13162573 | ||
journal_title: Foods | ||
journal_nlm_ta: Foods | ||
publisher_name: MDPI | ||
keywords: | ||
- plantaricin Q7 | ||
- Listeria monocytogenes biofilm | ||
- metabolomics | ||
- inhibition | ||
- reduction | ||
--- |
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--- | ||
figid: PMC11353926__foods-13-02573-g007 | ||
pmcid: PMC11353926 | ||
image_filename: foods-13-02573-g007.jpg | ||
figure_link: /pmc/articles/PMC11353926/figure/F7/ | ||
number: Figure 7 | ||
figure_title: Glycerol phospholipid metabolic pathway and major metabolites. | ||
caption: Glycerol phospholipid metabolic pathway and major metabolites. (A) Glycerol | ||
phospholipid metabolic pathway; (B) effect of plantaricin Q7 on metabolites of glycerol | ||
phospholipid metabolic pathway in the inhibition group. The black words in Figure | ||
7A represent metabolites with no significant changes, while the green words represent | ||
metabolites with significant changes. Green ↑ indicates up-regulation and green | ||
↓ indicates down-regulation. * p < 0.05, *** p < 0.001 | ||
article_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
citation: Yinxue Liu, et al. Foods. 2024 Aug;13(16). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-17 | ||
doi: 10.3390/foods13162573 | ||
journal_title: Foods | ||
journal_nlm_ta: Foods | ||
publisher_name: MDPI | ||
keywords: | ||
- plantaricin Q7 | ||
- Listeria monocytogenes biofilm | ||
- metabolomics | ||
- inhibition | ||
- reduction | ||
--- |
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--- | ||
figid: PMC11353926__foods-13-02573-g008 | ||
pmcid: PMC11353926 | ||
image_filename: foods-13-02573-g008.jpg | ||
figure_link: /pmc/articles/PMC11353926/figure/F8/ | ||
number: Figure 8 | ||
figure_title: Arginine biosynthesis pathway and major metabolites. | ||
caption: Arginine biosynthesis pathway and major metabolites. (A) Arginine biosynthesis | ||
pathway; (B) effect of plantaricin Q7 on metabolites of arginine biosynthesis pathway | ||
in the reduction group. Red indicates metabolites with significant differences. | ||
Red ↑ indicates up-regulation and red ↓ indicates down-regulation. * p < 0.05, ** | ||
p < 0.01, *** p < 0.001 | ||
article_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
citation: Yinxue Liu, et al. Foods. 2024 Aug;13(16). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-17 | ||
doi: 10.3390/foods13162573 | ||
journal_title: Foods | ||
journal_nlm_ta: Foods | ||
publisher_name: MDPI | ||
keywords: | ||
- plantaricin Q7 | ||
- Listeria monocytogenes biofilm | ||
- metabolomics | ||
- inhibition | ||
- reduction | ||
--- |
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--- | ||
figid: PMC11353926__foods-13-02573-g009 | ||
pmcid: PMC11353926 | ||
image_filename: foods-13-02573-g009.jpg | ||
figure_link: /pmc/articles/PMC11353926/figure/F9/ | ||
number: Figure 9 | ||
figure_title: Metabolic pathways related to the inhibition and reduction in L. | ||
caption: Metabolic pathways related to the inhibition and reduction in L. monocytogenes | ||
biofilm by plantaricin Q7. The red text boxes indicate up-regulation and the blue | ||
text boxes indicate down-regulation. The orange dashed circles represent the two | ||
metabolites with the largest difference in fold in the inhibition groups, and the | ||
green dashed circles represent the two metabolites with the largest difference in | ||
fold in the reduction groups. The remaining dashed lines indicate direct or indirect | ||
connections between metabolic pathways. The green background indicates purine metabolism, | ||
the gray background indicates arginine biosynthesis, the pink background indicates | ||
glycerol phospholipid metabolism, and the light orange background indicates plantaricin | ||
Q7 acting on the L. monocytogenes biofilm | ||
article_title: Metabolomic Approaches to Study the Potential Inhibitory Effects of | ||
Plantaricin Q7 against Listeria monocytogenes Biofilm | ||
citation: Yinxue Liu, et al. Foods. 2024 Aug;13(16). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-17 | ||
doi: 10.3390/foods13162573 | ||
journal_title: Foods | ||
journal_nlm_ta: Foods | ||
publisher_name: MDPI | ||
keywords: | ||
- plantaricin Q7 | ||
- Listeria monocytogenes biofilm | ||
- metabolomics | ||
- inhibition | ||
- reduction | ||
--- |
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--- | ||
figid: PMC11357534__pharmaceuticals-17-01094-g004 | ||
pmcid: PMC11357534 | ||
image_filename: pharmaceuticals-17-01094-g004.jpg | ||
figure_link: /pmc/articles/PMC11357534/figure/F4/ | ||
number: Figure 4 | ||
figure_title: Effects of 5-fluorouracil with or without thymol on the p-AKT/p-GSK3α,3β | ||
signaling pathway in liver tissue of rats. | ||
caption: 'Effects of 5-fluorouracil with or without thymol on the p-AKT/p-GSK3α,3β | ||
signaling pathway in liver tissue of rats. (I) Representative immunoblot of protein | ||
levels of AKT, p-AKT, GSK3α,3β, and p-GSK3α,3β (the upper band for α and the lower | ||
band for β) in liver tissues. Proteins were immunoblotted with Akt antibody in “the | ||
first upper panel,” p-Akt antibody in “the second panel,” GSK3α,3β antibody in “the | ||
third panel,” p-GSK3α,3β antibody in “the fourth panel,” and after stripping with | ||
GAPDH antibody as a loading control in the “lower panel.” (II) Quantitative results | ||
for the immunoblot, showing (a) the ratio of p-Akt/Akt and (b) the ratio of p-GSK3α,3β/GSK3α,3β | ||
protein levels expressed, and the relative quantities were normalized to the control | ||
and expressed as a fold of induction. The densities of immunoblots were quantified | ||
using analysis software. Values are mean ± SEM (n = 3). x, y, or z: The 5-fluorouracil | ||
and Fu+ thymol (60 mg/kg) groups are significantly different at p < 0.05. p ≤ 0.05 | ||
was evaluated using ANOVA followed by Tukey–Kramer as a post-hoc test. 5-FU: 5-fluorouracil; | ||
Akt: protein Kinase B; p-Akt: phosphorylated Akt, GSK3α,3β: glycogen synthase kinase | ||
3 α and 3β; p-GSK3α,3β: phosphorylated glycogen synthase kinase 3 α and 3β' | ||
article_title: Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the | ||
Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models | ||
citation: Yasmen F. Mahran, et al. Pharmaceuticals (Basel). 2024 Aug;17(8). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-21 | ||
doi: 10.3390/ph17081094 | ||
journal_title: Pharmaceuticals | ||
journal_nlm_ta: Pharmaceuticals (Basel) | ||
publisher_name: MDPI | ||
keywords: | ||
- thymol | ||
- 5-flourouracil | ||
- hepatotoxicity | ||
- apoptosis | ||
- GSK-3β signaling | ||
- p44/42 MAPK(ERK1/2) signaling | ||
--- |
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--- | ||
figid: PMC11359896__toxics-12-00609-g005 | ||
pmcid: PMC11359896 | ||
image_filename: toxics-12-00609-g005.jpg | ||
figure_link: /pmc/articles/PMC11359896/figure/F5/ | ||
number: Figure 5 | ||
figure_title: KEGG analysis of DEGs. | ||
caption: KEGG analysis of DEGs. (A) Bar chart of KEGG classification statistics. The | ||
horizontal coordinate indicates the names of the KEGG metabolic pathway; the vertical | ||
coordinate is the number of genes or transcripts annotated to the pathway. (B) Top | ||
20 enriched KEGG signaling pathways. The size of the dots indicates the number of | ||
genes in this KEGG term, and the color of the dots corresponds to different Padjust | ||
ranges | ||
article_title: Toxicity Evaluation and Transcriptome Analysis of Yellowstripe Goby | ||
(Mugilogobius chulae) in Response to 2,7-Dibromocarbazole Exposure during Early | ||
Development | ||
citation: Caixia Gao, et al. Toxics. 2024 Aug;12(8). | ||
year: '2024' | ||
pub_date: 2024-8- | ||
epub_date: 2024-8-20 | ||
doi: 10.3390/toxics12080609 | ||
journal_title: Toxics | ||
journal_nlm_ta: Toxics | ||
publisher_name: MDPI | ||
keywords: | ||
- Mugilogobius chulae | ||
- 2,7-DBCZ | ||
- fish embryo acute toxicity (FET) | ||
- concentration–effect curves | ||
- differentially expressed genes (DEGs) | ||
--- |
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--- | ||
figid: PMC11364484__nihms-2018135-f0001 | ||
pmcid: PMC11364484 | ||
image_filename: nihms-2018135-f0001.jpg | ||
figure_link: /pmc/articles/PMC11364484/figure/F1/ | ||
number: Fig. 1. | ||
figure_title: Pathogenesis of pulmonary fibrosis | ||
caption: Alveolar inflammation and injury induce fibroblast activation and differentiation | ||
to myofibroblast and ECM accumulation. Activation of TGF-β pathway and reduced BMP | ||
pathway contribute to the pathogenesis of PF | ||
article_title: Emerging role of BMPs/BMPR2 signaling pathway in treatment for pulmonary | ||
fibrosis | ||
citation: Qinmao Ye, et al. Biomed Pharmacother. 2024 Aug 23;178(NA). | ||
year: '2024' | ||
pub_date: 2024-8-23 | ||
epub_date: 2024-8-13 | ||
doi: 10.1016/j.biopha.2024.117178 | ||
journal_title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | ||
journal_nlm_ta: Biomed Pharmacother | ||
publisher_name: .na.character | ||
keywords: | ||
- Pulmonary fibrosis | ||
- TGF-β pathway | ||
- BMP ligands | ||
- BMP receptors | ||
- Myofibroblast differentiation | ||
- Pro-fibrotic responses | ||
- Anti-fibrosis | ||
--- |
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--- | ||
figid: PMC11364484__nihms-2018135-f0002 | ||
pmcid: PMC11364484 | ||
image_filename: nihms-2018135-f0002.jpg | ||
figure_link: /pmc/articles/PMC11364484/figure/F2/ | ||
number: Fig. 2. | ||
figure_title: TGF-β and BMP receptors and their signaling pathways | ||
caption: BMP type I receptors have 4 subtypes including ALK1 (ACVRL1), ALK2 (ACVR1), | ||
ALK3 (BMPR1A) and ALK6 (BMPR1B); type II receptors consist of ACVR2A (ActRIIA), | ||
ACVR2B (ActRIIB) and BMPR2B (BMPR2). TGF-β signaling pathway plays a pro-fibrotic | ||
role to promote the α-smooth muscle actin (SMA), fibronectin (FN), and collagen | ||
expression; while BMP signaling pathway indicates the anti-fibrotic function | ||
article_title: Emerging role of BMPs/BMPR2 signaling pathway in treatment for pulmonary | ||
fibrosis | ||
citation: Qinmao Ye, et al. Biomed Pharmacother. 2024 Aug 23;178(NA). | ||
year: '2024' | ||
pub_date: 2024-8-23 | ||
epub_date: 2024-8-13 | ||
doi: 10.1016/j.biopha.2024.117178 | ||
journal_title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | ||
journal_nlm_ta: Biomed Pharmacother | ||
publisher_name: .na.character | ||
keywords: | ||
- Pulmonary fibrosis | ||
- TGF-β pathway | ||
- BMP ligands | ||
- BMP receptors | ||
- Myofibroblast differentiation | ||
- Pro-fibrotic responses | ||
- Anti-fibrosis | ||
--- |
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--- | ||
figid: PMC11370353__nihpp-2024.08.15.608164v2-f0004 | ||
pmcid: PMC11370353 | ||
image_filename: nihpp-2024.08.15.608164v2-f0004.jpg | ||
figure_link: /pmc/articles/PMC11370353/figure/F4/ | ||
number: Figure 4. | ||
figure_title: Gene expression in the core dauer pathway is robust | ||
caption: 'A. Density plot of the Coefficient of Variation (CV) of genes in the core | ||
dauer pathway. Labels of the pathway on top. X-axis: CVs of all genes in the pathway | ||
computed by dividing the standard deviation (SD) of its expression across all dauers | ||
by its mean expression across all dauers. Dotted lines demarcating CVs: low, (CV | ||
< 30), moderate (30 < CV < 50), high (CV > 50). Y-axis (left) density.B. Dumbbell | ||
Plot showing Spearman’s correlation coefficient (rho) between pairs of dauers in | ||
‘core’ dauer pathways. TOP labels: the pair of dauers compared. Y-axis: pathway. | ||
X-axis: rho value and confidence interval (CI): blue dot represents lower CI, yellow | ||
dot represents rho value, and red dot represents high CI. p-values, Bonferroni corrected. | ||
*p-value <0.05; ns, not-significant' | ||
article_title: Robustness and variability in Caenorhabditis elegans dauer gene expression | ||
citation: Johnny Cruz Corchado, et al. bioRxiv. 2024 Aug 26;NA(NA). | ||
year: '2024' | ||
pub_date: 2024-8-26 | ||
epub_date: 2024-8-26 | ||
doi: 10.1101/2024.08.15.608164 | ||
journal_title: bioRxiv | ||
journal_nlm_ta: bioRxiv | ||
publisher_name: Cold Spring Harbor Laboratory | ||
keywords: [] | ||
--- |
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