Skip to content

Commit

Permalink
Built site for gh-pages
Browse files Browse the repository at this point in the history
  • Loading branch information
Quarto GHA Workflow Runner committed Jul 3, 2024
1 parent 92755be commit b6a7eb6
Show file tree
Hide file tree
Showing 13 changed files with 37 additions and 36 deletions.
2 changes: 1 addition & 1 deletion .nojekyll
Original file line number Diff line number Diff line change
@@ -1 +1 @@
ed7fdccc
617dd326
4 changes: 2 additions & 2 deletions index.html
Original file line number Diff line number Diff line change
Expand Up @@ -2,7 +2,7 @@
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>

<meta charset="utf-8">
<meta name="generator" content="quarto-1.5.52">
<meta name="generator" content="quarto-1.5.53">

<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">

Expand Down Expand Up @@ -136,7 +136,7 @@
<span class="menu-text">WP4</span></a>
</li>
<li class="nav-item">
<a class="nav-link" href="./whoweare.html">
<a class="nav-link" href="./who-we-are.html">
<span class="menu-text">Who We Are</span></a>
</li>
</ul>
Expand Down
6 changes: 3 additions & 3 deletions search.json
Original file line number Diff line number Diff line change
Expand Up @@ -95,11 +95,11 @@
"text": "WP 3.2 Deep Phenotyping of HbA1c defined pre-diabetes\n\nHypothesis:\nAmong individuals with routinely identified prediabetes based on HbA1c, deep phenotyping with non-invasive methods will identify subgroups at the highest risk of progression to T2D and subgroups likely to maintain prediabetes or achieve remission; beyond the predictive ability of age, sex, HbA1c and BMI.\n\n\nBackground:\nAlthough elevated blood glucose precedes T2D onset by over a decade14, many people with slightly elevated HbA1c do not progress to diabetes15. Depending on the criteria for prediabetes, 10-40% develop T2D within 1-5 years16–18 and 17-45% revert to normoglycaemia15, pointing to significant heterogeneity in diabetes risk among individuals with prediabetes19–21. A relatively recent cluster-driven diabetes subclassification delineated two subgroups with relatively young age of diabetes onset and absence of marked obesity and low insulin secretion22, which map to genetic, metabolic and phenotypic characteristics already present in pre-diabetes. Notably, a recent study identified elevated liver fat and diminished beta-cell function as the most predictive factors for progressing to T2D in people with pre-diabetes23, highlighting the need to extend precision approaches for diabetes prevention beyond genetic predisposition and insulin resistance. The current vision for precision prevention integrates data from genetic, biological (multi-omic), health behavioural and psycho-social components; however, few cohorts have these data in a contemporary population defined in a clinical context.\n\n\nStrategic Vision:\nWP3 establishes such a cohort across Steno Centers with long-term academic and strategic visions. The strategic vision is to establish the facilities, expertise and capacity across all Steno Centers to carry out multi-center clinical studies with a standardised protocol and management/data infrastructure. We also want to prepare the centers for the standardised application of deep phenotyping close to clinical practice by applying a high degree of standardisation, openness and reproducibility (WP1).\n\n\nAcademic Objectives:\nAcademically, we describe a core protocol, which will be carried out within the DP-Next budget and timeframe, and an extended protocol, which describes our ambitions for deeper phenotyping and longer follow-up. Funding for the extended protocol will be sought separately on a project basis and will build on the capacity established in the core protocol. Connection and coordination will be sought with new Danish phenotyping initiatives currently underway or in the planning process (e.g. PRECiSE).\n\n\nWho will be included:\nIn the core protocol we will identify a cohort of 1000 individuals aged 40 to 55 years who have recently (within the past 12 months) had a routine HbA1c measurement in the pre-diabetic range (42-47 mmol/mol) and are not using any glucose lowering medication. This age range was chosen to maximise life-long impact on diabetes risk. Sample size calculations use our recent analysis of HbA1c defined (pre)diabetes in Denmark1, showing that 25 to 40% of Danish residents aged 40-55 had at least 1 HbA1c measurement in 2018. In our target age range pre-diabetes incidence was 9/1000 person years, and the subsequent incidence of diabetes was 7/1000, and hence an expected cumulative T2D incidence of 22% in a median of 3.5 years of follow-up. Logistic regression based power calculations show that a cohort of 1050 individuals gives us 0.9 power at a 0.05 significance level to detect an odds ratio of at least 1.28 per standard deviation in a continuous exposure variable.\n\n\nRecruitment:\nParticipants will be recruited in Odense (350), Aarhus (350), Aalborg (150), Greenland (50) and the Faroe Islands (50). We intend to include 100 individuals of Greenlandic ancestry, 50 living in Denmark and 50 living in Greenland. Participants will be recruited based on data from routine HbA1c checks, accessed through the LABKA registers. Consequently the clinical decisions prompting a HbA1c measurement will form part of the selection process, reflecting current clinical practice.\n\n\nCore Protocol:\nParticipants will be invited to answer an online questionnaire (medical and family history, sociodemographic data, health literacy, food habits and cravings , personality traits such as willingness to take risks, quality of life, self-perceived mental stress, depression, anxiety, sleep apnea scores) followed by a 4-hour clinical examination at one of the Steno Diabetes Centers. The programme includes: anthropometric measures (height, weight, waist-hip ratio, and DEXA-scan for body composition), a 5-point oral glucose tolerance test to estimate insulin sensitivity and beta-cell function, liver elastography to estimate liver fat and liver stiffness, blood pressure, heart rate variability and pulse-wave velocity for arterial stiffness estimation. Participants will measure physical activity with a combined heart rate monitor / accelerometer during 7 days following the visit. Blood samples will be analysed for lipids and HbA1c and processed for biobanking of plasma, serum and DNA. The biobank will further include urine, saliva and faeces samples. All further measurements will be in biobank samples as part of the extended protocol.\nThe primary outcome for the core protocol is incident Type 2 Diabetes. The LABKA register will identify incident T2D (based on routine HbA1c) supplemented with a study HbA1c measurement at the end of the DP-Next project. The primary statistical analysis will use unsupervised Latent Class Analysis28 to map the heterogeneity across all measured variables. LCA will be carried out at two levels: a full model including all available data and a minimal model using as few data as possible with limited loss of strength. Modelling studies show that our sample of 1000 is sufficient to identify patterns and clusters in most data sets.\n\n\nExtended Protocol:\nOur ambition is to extend the WP3 protocol beyond the budget and time of DP-Next. Additional funding will be sought to expand the depth of the cardiometabolic phenotyping under real life settings, including a 24-hour ambulatory blood pressure, cardiorespiratory monitoring, and continuous glucose monitoring, with simultaneous app-based diet diaries. We further have the ambition to invite a subset of ~300 participants for a second examination with optical coherence tomography to detect early retinal changes, a single breath-hold MR scan of the liver, and an OGTT during short-term oral steroid treatment. We intend to expand the project carrying out a comprehensive set of omics analyses in biobank materials, including genotyping, proteomics, metabolomics and metagenomic characterisation of faeces and saliva as well as a set of targeted biomarkers covering mechanisms such as endothelial function, liver function and auto-immunity (GAD and islet cell antibodies). Our ambition is to extend the follow-up beyond the DP-Next project period, extending the accrual not only of diabetes cases but also of secondary endpoints such as cardiovascular events."
},
{
"objectID": "whoweare.html",
"href": "whoweare.html",
"objectID": "who-we-are.html",
"href": "who-we-are.html",
"title": "Who We Are",
"section": "",
"text": "DP-Next will be carried out by a cross-disciplinary team of epidemiologists, clinicians, health scientists and data scientists across all seven Steno Diabetes Centres:\nDaniel Witte is professor of Diabetes Epidemiology at Aarhus University and has worked across various themes in prevention and prediction of diabetes and its complications in (inter)national cohorts and register-based studies. He will be the Principal Investigator of the DP-Next project.\nStine Byberg is an epidemiologist and Senior researcher at Steno Diabetes Center Copenhagen, and currently also Head of Research at Steno Diabetes Center Greenland. Stine has extensive experience in both conducting and supervising students in prediction models using register-based data. Stine will be the work package leader for Work Package 2.\nClaus Bogh Juhl is clinical professor at University Hospital of Southern Denmark, Esbjerg and program leader of Clinical Interventions at Steno Diabetes Center Odense. The has extensive experience in clinical research within type 2 diabetes, obesity and type 1 diabetes. He will be the work package leader for Work Package 3.\nInger Katrine Dahl-Petersen is a researcher/special consultant at Steno Diabetes Center Copenhagen. She is experienced in co-creating complex interventions and evaluation in the field of GDM and prevention of type 2 diabetes and has substantial experience in coordination of research projects. She will be the work package leader for WP4.\nGunnar Toft is senior researcher at SDCA, with broad epidemiological experience and experience in coordination of international research projects. He will act as general coordinator of the DP-Next project.\nKaroline Kragelund Nielsen is a senior researcher and heads the reproductive & family health group at Steno Diabetes Center Copenhagen. She has vast experience with research related to GDM, prevention of type 2 diabetes and health systems research, including intervention, epidemiological and qualitative research. She will contribute to the project with her expertise within GDM, epidemiology and intervention research.\nMaria Skaalum Petersen, professor in health science, is Head of Research at SDCF together with Dr. Johannesen, endocrinologist. She is also head of the Department of Research at the National Hospital of the Faroe Islands. She has a broad epidemiological experience and experience in conducting research projects in the Faroe Islands. She will contribute to the project with her expertise within epidemiology and registry data in the Faroe Islands."
"text": "DP-Next will be carried out by a cross-disciplinary team of epidemiologists, clinicians, health scientists and data scientists across all seven Steno Diabetes Centres:\nDaniel Witte is professor of Diabetes Epidemiology at Aarhus University and has worked across various themes in prevention and prediction of diabetes and its complications in (inter)national cohorts and register-based studies. He will be the Principal Investigator of the DP-Next project.\nStine Byberg is an epidemiologist and Senior researcher at Steno Diabetes Center Copenhagen, and currently also Head of Research at Steno Diabetes Center Greenland. Stine has extensive experience in both conducting and supervising students in prediction models using register-based data. Stine will be the work package leader for Work Package 2.\nClaus Bogh Juhl is clinical professor at University Hospital of Southern Denmark, Esbjerg and program leader of Clinical Interventions at Steno Diabetes Center Odense. The has extensive experience in clinical research within type 2 diabetes, obesity and type 1 diabetes. He will be the work package leader for Work Package 3.\nInger Katrine Dahl-Petersen is a researcher/special consultant at Steno Diabetes Center Copenhagen. She is experienced in co-creating complex interventions and evaluation in the field of GDM and prevention of type 2 diabetes and has substantial experience in coordination of research projects. She will be the work package leader for WP4.\nGunnar Toft is senior researcher at SDCA, with broad epidemiological experience and experience in coordination of international research projects. He will act as general coordinator of the DP-Next project.\nKaroline Kragelund Nielsen is a senior researcher and heads the reproductive & family health group at Steno Diabetes Center Copenhagen. She has vast experience with research related to GDM, prevention of type 2 diabetes and health systems research, including intervention, epidemiological and qualitative research. She will contribute to the project with her expertise within GDM, epidemiology and intervention research.\nMaria Skaalum Petersen, professor in health science, is Head of Research at SDCF together with Dr. Johannesen, endocrinologist. She is also head of the Department of Research at the National Hospital of the Faroe Islands. She has a broad epidemiological experience and experience in conducting research projects in the Faroe Islands. She will contribute to the project with her expertise within epidemiology and registry data in the Faroe Islands.\nLuke Johnston is a team leader at SDCA on the Seedcase Project, a NNF-funded software and training-based project that aims at improving research data engineering and management practices and knowledge. While he now largely develops software and training material, he has a PhD in Nutritional Sciences doing diabetes epidemiology, is a strong advocate for more openness and reproducibility in science, and works to improve operational and organizational practices on several larger projects across SDCA. He will be the work package leader for Work Package 1."
},
{
"objectID": "index.html",
Expand Down
22 changes: 11 additions & 11 deletions sitemap.xml
Original file line number Diff line number Diff line change
Expand Up @@ -2,42 +2,42 @@
<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9">
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp4.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp1/application.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.978Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp1/roadmap.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp3.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/whoweare.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<loc>https://steno-aarhus.github.io/dp-next/who-we-are.html</loc>
<lastmod>2024-07-03T09:53:54.978Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/index.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.978Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp2.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp1/strategy.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp1/index.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
<url>
<loc>https://steno-aarhus.github.io/dp-next/wp1/introduction.html</loc>
<lastmod>2024-07-02T13:29:21.051Z</lastmod>
<lastmod>2024-07-03T09:53:54.982Z</lastmod>
</url>
</urlset>
7 changes: 4 additions & 3 deletions whoweare.html → who-we-are.html
Original file line number Diff line number Diff line change
Expand Up @@ -2,7 +2,7 @@
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>

<meta charset="utf-8">
<meta name="generator" content="quarto-1.5.52">
<meta name="generator" content="quarto-1.5.53">

<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">

Expand Down Expand Up @@ -136,7 +136,7 @@
<span class="menu-text">WP4</span></a>
</li>
<li class="nav-item">
<a class="nav-link active" href="./whoweare.html" aria-current="page">
<a class="nav-link active" href="./who-we-are.html" aria-current="page">
<span class="menu-text">Who We Are</span></a>
</li>
</ul>
Expand Down Expand Up @@ -186,6 +186,7 @@ <h1 class="title">Who We Are</h1>
<p><a href="https://orcid.org/0000-0002-7542-6853">Gunnar Toft</a> is senior researcher at SDCA, with broad epidemiological experience and experience in coordination of international research projects. He will act as general coordinator of the DP-Next project.</p>
<p><a href="https://orcid.org/0000-0002-4058-0615">Karoline Kragelund Nielsen</a> is a senior researcher and heads the reproductive &amp; family health group at Steno Diabetes Center Copenhagen. She has vast experience with research related to GDM, prevention of type 2 diabetes and health systems research, including intervention, epidemiological and qualitative research. She will contribute to the project with her expertise within GDM, epidemiology and intervention research.</p>
<p><a href="https://orcid.org/0000-0001-9404-8440">Maria Skaalum Petersen</a>, professor in health science, is Head of Research at SDCF together with Dr.&nbsp;Johannesen, endocrinologist. She is also head of the Department of Research at the National Hospital of the Faroe Islands. She has a broad epidemiological experience and experience in conducting research projects in the Faroe Islands. She will contribute to the project with her expertise within epidemiology and registry data in the Faroe Islands.</p>
<p><a href="https://orcid.org/0000-0003-4169-2616">Luke Johnston</a> is a team leader at SDCA on the <a href="https://seedcase-project.org/">Seedcase Project</a>, a NNF-funded software and training-based project that aims at improving research data engineering and management practices and knowledge. While he now largely develops software and training material, he has a PhD in Nutritional Sciences doing diabetes epidemiology, is a strong advocate for more openness and reproducibility in science, and works to improve operational and organizational practices on several larger projects across SDCA. He will be the work package leader for Work Package 1.</p>



Expand Down Expand Up @@ -634,7 +635,7 @@ <h1 class="title">Who We Are</h1>
</a>
</li>
</ul>
<div class="toc-actions"><ul><li><a href="https://github.com/steno-aarhus/dp-next/edit/main/whoweare.qmd" class="toc-action"><i class="bi bi-github"></i>Edit this page</a></li><li><a href="https://github.com/steno-aarhus/dp-next/issues/new" class="toc-action"><i class="bi empty"></i>Report an issue</a></li><li><a href="https://github.com/steno-aarhus/dp-next/blob/main/whoweare.qmd" class="toc-action"><i class="bi empty"></i>View source</a></li></ul></div></div>
<div class="toc-actions"><ul><li><a href="https://github.com/steno-aarhus/dp-next/edit/main/who-we-are.qmd" class="toc-action"><i class="bi bi-github"></i>Edit this page</a></li><li><a href="https://github.com/steno-aarhus/dp-next/issues/new" class="toc-action"><i class="bi empty"></i>Report an issue</a></li><li><a href="https://github.com/steno-aarhus/dp-next/blob/main/who-we-are.qmd" class="toc-action"><i class="bi empty"></i>View source</a></li></ul></div></div>
<div class="nav-footer-right">
&nbsp;
</div>
Expand Down
4 changes: 2 additions & 2 deletions wp1/application.html
Original file line number Diff line number Diff line change
Expand Up @@ -2,7 +2,7 @@
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>

<meta charset="utf-8">
<meta name="generator" content="quarto-1.5.52">
<meta name="generator" content="quarto-1.5.53">

<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">

Expand Down Expand Up @@ -159,7 +159,7 @@
<span class="menu-text">WP4</span></a>
</li>
<li class="nav-item">
<a class="nav-link" href="../whoweare.html">
<a class="nav-link" href="../who-we-are.html">
<span class="menu-text">Who We Are</span></a>
</li>
</ul>
Expand Down
Loading

0 comments on commit b6a7eb6

Please sign in to comment.