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danielwitte authored Jun 4, 2024
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DP-Next is a project in development aimed at developing a sustainably effective strategy for prevention of Type 2 Diabetes in Denmark, Greenland and the Faroe Islands. The project is currently in development and seeking funding. The full name of the project is: Sustainable Type 2 Diabetes Prevention for the 21st Century. We call it DP-Next because we intend to develop the next generation of Diabetes Prevention strategies.

## Why is a new strategy for diabetes prevention necessary?
We have known for over two decades that it is possible *italics*-in principle- to prevent Type 2 Diabetes in people at very high risk by encouraging them to participate in a very intensive lifestyle modification programme.
We have known for over two decades that it is possible *-in principle-* to prevent Type 2 Diabetes in people at very high risk by encouraging them to participate in a very intensive lifestyle modification programme.

<details>
<summary>The original Diabetes Prevention Studies were conducted around the turn of the century.</summary>
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![There are 5 Steno Diabetes Centers in Denmark, one in Greenland and one on the Faroe Islands.](./images/DK_map_SDC.jpg)

WP1 (Management and Collaboration) will manage the project and foster deep collaboration between all partners.

WP2 (Risk Prediction) will develop an exclusively register-based diabetes risk prediction model for the entire Danish, Greenlandic and Faroese populations, applying advanced statistical and machine learning approaches on a wide set of risk indicators. It will map out meaningful subgroups and validate internally and in external populations.
WP3 (Heterogeneity) will map out heterogeneity in T2D risk in a subgroup of ~1000 participants with HbA1c-based pre-diabetes with a special focus on regional fat distribution, hepatic steatosis and insulin resistance.
WP4 (Intervention Development) will develop an intervention for sustainable primary diabetes prevention based on co-creation, a systems approach and the “Complex Interventions” framework and evaluate the pragmatic feasibility of intervention components in two risk subgroups in real life practical settings.

See the WP tabs for more details about each Work Packages

## Who are we?
DP-Next will be carried out by a cross disciplinary team of epidemiologists, clinicians, health scientists and data scientists across all seven Steno Diabetes Centres.


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