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Apply @lbergelson's wording tweak; add "1-based"
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jmarshall committed Aug 19, 2019
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4 changes: 2 additions & 2 deletions VCFv4.3.tex
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Expand Up @@ -372,8 +372,8 @@ \subsubsection{Fixed fields}

\begin{itemize}
\renewcommand{\labelitemii}{$\circ$}
\item END: End reference position, indicating that the variant spans positions POS--END on reference/contig CHROM.
Normally this is the position of the last base in the REF allele, so can be derived from POS and the length of REF, and no END INFO field is needed.
\item END: End reference position (1-based), indicating the variant spans positions POS--END on reference/contig CHROM.
Normally this is the position of the last base in the REF allele, so it can be derived from POS and the length of REF, and no END INFO field is needed.
However when symbolic alleles are used, e.g.\ in gVCF or structural variants, an explicit END INFO field provides variant span information that is otherwise unknown.

This field is used to compute BCF's {\tt rlen} field (see~\ref{BcfSiteEncoding}) and is important when indexing VCF/BCF files to enable random access and querying by position.
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