This repository contains the DYRK-1A homology model (./homology_model) as well the structures (./lead_structures) of the top 3 selective DYRK-1B lead compounds from the optimization procedure that we have reported in our paper V. Alexandrov et al, "Novel Efficient Multistage Lead Optimization Pipeline Experimentally Validated for DYRK1B Selective Inhibitors", J.Med.Chem. (2022).