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/cardinal /posts/2023-07-09_cardinal
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<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-06-27__hackathon_app/index.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
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<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-06-28_welcome/index.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
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<meta name="author" content="Vincent Shen">
<meta name="dcterms.date" content="2023-07-09">
<meta name="description" content="The {falcon} initiative is an industry collaborative effort under pharmaversewith the aspiration of building and open-sourcing a comprehensive catalog of harmonized TLGs for clinical study reporting.">
<meta name="description" content="The {cardinal} initiative is an industry collaborative effort under pharmaversewith the aspiration of building and open-sourcing a comprehensive catalog of harmonized TLGs for clinical study reporting.">

<title>falcon – pharmaverse blog</title>
<title>cardinal – pharmaverse blog</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
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<link rel="stylesheet" href="../../styles.css">
<meta property="og:title" content="falcon – pharmaverse blog">
<meta property="og:description" content="The {falcon} initiative is an industry collaborative effort under pharmaversewith the aspiration of building and open-sourcing a comprehensive catalog of harmonized TLGs for clinical study reporting.">
<meta property="og:image" content="https://pharmaverse.github.io/blog/posts/2023-07-09_falcon/falcon.png">
<meta property="og:title" content="cardinal – pharmaverse blog">
<meta property="og:description" content="The {cardinal} initiative is an industry collaborative effort under pharmaversewith the aspiration of building and open-sourcing a comprehensive catalog of harmonized TLGs for clinical study reporting.">
<meta property="og:image" content="https://pharmaverse.github.io/blog/posts/2023-07-09_cardinal/cardinal.png">
<meta property="og:site_name" content="pharmaverse blog">
<meta property="og:image:height" content="599">
<meta property="og:image:width" content="1280">
<meta property="og:image:height" content="1182">
<meta property="og:image:width" content="1181">
</head>

<body class="floating nav-fixed">
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<header id="title-block-header" class="quarto-title-block default toc-left page-columns page-full">
<div class="quarto-title-banner page-columns page-full">
<div class="quarto-title column-body">
<h1 class="title">falcon</h1>
<h1 class="title">cardinal</h1>
<div>
<div class="description">
The <a href="https://pharmaverse.github.io/cardinal/">{falcon} initiative</a> is an industry collaborative effort under <a href="https://pharmaverse.org/">pharmaverse</a>with the aspiration of building and open-sourcing a comprehensive catalog of harmonized TLGs for clinical study reporting.
The <a href="https://pharmaverse.github.io/cardinal/">{cardinal} initiative</a> is an industry collaborative effort under <a href="https://pharmaverse.org/">pharmaverse</a>with the aspiration of building and open-sourcing a comprehensive catalog of harmonized TLGs for clinical study reporting.
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<h2 id="toc-title">Table of contents</h2>

<ul>
<li><a href="#what-is-falcon" id="toc-what-is-falcon" class="nav-link active" data-scroll-target="#what-is-falcon">What is {falcon}?</a></li>
<li><a href="#what-is-cardinal" id="toc-what-is-cardinal" class="nav-link active" data-scroll-target="#what-is-cardinal">What is {cardinal}?</a></li>
<li><a href="#why-do-we-build-it" id="toc-why-do-we-build-it" class="nav-link" data-scroll-target="#why-do-we-build-it">Why do we build it?</a></li>
<li><a href="#what-has-been-done-so-far" id="toc-what-has-been-done-so-far" class="nav-link" data-scroll-target="#what-has-been-done-so-far">What has been done so far?</a></li>
<li><a href="#next-steps-vision" id="toc-next-steps-vision" class="nav-link" data-scroll-target="#next-steps-vision">Next steps &amp; vision</a></li>
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<!--------------- typical setup ----------------->
<!--------------- post begins here ----------------->
<section id="what-is-falcon" class="level2">
<h2 class="anchored" data-anchor-id="what-is-falcon">What is {falcon}?</h2>
<p>The <a href="https://pharmaverse.github.io/cardinal/">{falcon} initiative</a> is an industry collaborative effort under <a href="https://pharmaverse.org/">pharmaverse</a> that unites Boehringer Ingelheim, Moderna, Roche, and Sanofi with the aspiration of building and open-sourcing a comprehensive catalog of harmonized tables, listings, and graphs (TLGs) for clinical study reporting. By leveraging existing open-source R packages, {falcon} aims to simplify the process of output review, comparison, and meta-analyses, while fostering efficient communication among stakeholders in the pharmaceutical industry.</p>
<section id="what-is-cardinal" class="level2">
<h2 class="anchored" data-anchor-id="what-is-cardinal">What is {cardinal}?</h2>
<p>The <a href="https://pharmaverse.github.io/cardinal/">{cardinal} initiative</a> is an industry collaborative effort under <a href="https://pharmaverse.org/">pharmaverse</a> that unites Boehringer Ingelheim, Moderna, Roche, and Sanofi with the aspiration of building and open-sourcing a comprehensive catalog of harmonized tables, listings, and graphs (TLGs) for clinical study reporting. By leveraging existing open-source R packages, {cardinal} aims to simplify the process of output review, comparison, and meta-analyses, while fostering efficient communication among stakeholders in the pharmaceutical industry.</p>
</section>
<section id="why-do-we-build-it" class="level2">
<h2 class="anchored" data-anchor-id="why-do-we-build-it">Why do we build it?</h2>
<p>The collaborative effort focuses on improving the clarity, consistency, and accessibility of TLGs by addressing variations and redundancies in their creation and use. This harmonized approach allows for streamlined reporting processes and facilitates effective communication of study results within the industry and to regulatory authorities.</p>
</section>
<section id="what-has-been-done-so-far" class="level2">
<h2 class="anchored" data-anchor-id="what-has-been-done-so-far">What has been done so far?</h2>
<p>Drawing inspiration from the FDA Standard Safety Tables and Figures Integrated Guide, the {falcon} initiative has successfully developed and open-sourced 11 templates to date. 4 product owners and 11 developers from 4 companies have collaborated to make these templates available and also published them on the official <a href="https://pharmaverse.github.io/cardinal/">{falcon} website</a>.</p>
<p>Drawing inspiration from the FDA Standard Safety Tables and Figures Integrated Guide, the {cardinal} initiative has successfully developed and open-sourced 11 templates to date. 4 product owners and 11 developers from 4 companies have collaborated to make these templates available and also published them on the official <a href="https://pharmaverse.github.io/cardinal/">{cardinal} website</a>.</p>
</section>
<section id="next-steps-vision" class="level2">
<h2 class="anchored" data-anchor-id="next-steps-vision">Next steps &amp; vision</h2>
<p>Future plans for {falcon} involve expanding the catalog through continuous collaboration from participating companies and inviting wider industry engagement. The ultimate goal is to promote harmonization of TLGs for clinical reporting across the pharmaceutical industry, leading to greater efficiency, collaboration, and innovation. Even though templates currently come from a published FDA guide, the collaborating companies are open to share and discuss similarities and differences on analysis concepts and output layouts of their own implementations in clinical reporting, for both safety and efficacy analyses.</p>
<p>Future plans for {cardinal} involve expanding the catalog through continuous collaboration from participating companies and inviting wider industry engagement. The ultimate goal is to promote harmonization of TLGs for clinical reporting across the pharmaceutical industry, leading to greater efficiency, collaboration, and innovation. Even though templates currently come from a published FDA guide, the collaborating companies are open to share and discuss similarities and differences on analysis concepts and output layouts of their own implementations in clinical reporting, for both safety and efficacy analyses.</p>
<p>In addition, while currently all templates were built using {rtables}, {tern}, {rlistings} and drew inspiration from the open-sourced <a href="https://insightsengineering.github.io/tlg-catalog/">TLG-Catalog</a>, moving forward, we plan to support creating the same templates using alternative table engines such as {gt}.</p>
<p>{falcon} will be presented at the upcoming PHUSE EU (Standards Implementation stream), where we will share the collaboration journey of {falcon} so far, providing more details on the current progress, long-term vision, and strategies for this initiative. Attendees will gain insights into the challenges and opportunities of harmonizing clinical reporting through open-source collaboration and learn about the potential benefits and future direction of {falcon}.</p>
<p>{cardinal} will be presented at the upcoming PHUSE EU (Standards Implementation stream), where we will share the collaboration journey of {cardinal} so far, providing more details on the current progress, long-term vision, and strategies for this initiative. Attendees will gain insights into the challenges and opportunities of harmonizing clinical reporting through open-source collaboration and learn about the potential benefits and future direction of {cardinal}.</p>
<!--------------- appendices go here ----------------->
</section>
<div class="cell">
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<div id="quarto-appendix" class="default"><section id="last-updated" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Last updated</h2><div class="quarto-appendix-contents">

<p>2024-10-24 08:04:21.918623</p>
<p>2024-10-24 11:18:07.11905</p>
</div></section><section id="details" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Details</h2><div class="quarto-appendix-contents">

<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-07-09_falcon/falcon.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-07-09_cardinal/falcon.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
</div></section><section class="quarto-appendix-contents" id="quarto-reuse"><h2 class="anchored quarto-appendix-heading">Reuse</h2><div class="quarto-appendix-contents"><div><a rel="license" href="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0</a></div></div></section><section class="quarto-appendix-contents" id="quarto-citation"><h2 class="anchored quarto-appendix-heading">Citation</h2><div><div class="quarto-appendix-secondary-label">BibTeX citation:</div><pre class="sourceCode code-with-copy quarto-appendix-bibtex"><code class="sourceCode bibtex">@online{shen2023,
author = {Shen, Vincent},
title = {Falcon},
title = {Cardinal},
date = {2023-07-09},
url = {https://pharmaverse.github.io/blog/posts/2023-07-09_falcon/falcon.html},
url = {https://pharmaverse.github.io/blog/posts/2023-07-09_cardinal/falcon.html},
langid = {en}
}
</code><button title="Copy to Clipboard" class="code-copy-button"><i class="bi"></i></button></pre><div class="quarto-appendix-secondary-label">For attribution, please cite this work as:</div><div id="ref-shen2023" class="csl-entry quarto-appendix-citeas" role="listitem">
Shen, Vincent. 2023. <span>Falcon.”</span> July 9, 2023. <a href="https://pharmaverse.github.io/blog/posts/2023-07-09_falcon/falcon.html">https://pharmaverse.github.io/blog/posts/2023-07-09_falcon/falcon.html</a>.
Shen, Vincent. 2023. <span>Cardinal.”</span> July 9, 2023. <a href="https://pharmaverse.github.io/blog/posts/2023-07-09_cardinal/falcon.html">https://pharmaverse.github.io/blog/posts/2023-07-09_cardinal/falcon.html</a>.
</div></div></section></div></main> <!-- /main -->
<script id="quarto-html-after-body" type="application/javascript">
window.document.addEventListener("DOMContentLoaded", function (event) {
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<p>2024-10-24 08:05:25.813361</p>
<p>2024-10-24 11:17:52.937506</p>
</div></section><section id="details" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Details</h2><div class="quarto-appendix-contents">

<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-07-10_blanks_and_nas/blanks_and_nas.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
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<div id="quarto-appendix" class="default"><section id="last-updated" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Last updated</h2><div class="quarto-appendix-contents">

<p>2024-10-24 08:05:00.103349</p>
<p>2024-10-24 11:17:24.534685</p>
</div></section><section id="details" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Details</h2><div class="quarto-appendix-contents">

<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-07-14_code_sections/code_sections.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
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<div id="quarto-appendix" class="default"><section id="last-updated" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Last updated</h2><div class="quarto-appendix-contents">

<p>2024-10-24 08:05:04.906538</p>
<p>2024-10-24 11:17:29.30698</p>
</div></section><section id="details" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Details</h2><div class="quarto-appendix-contents">

<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-07-20_cross_company_dev/cross_industry_dev.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
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<div id="quarto-appendix" class="default"><section id="last-updated" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Last updated</h2><div class="quarto-appendix-contents">

<p>2024-10-24 08:04:23.691897</p>
<p>2024-10-24 11:16:51.690405</p>
</div></section><section id="details" class="level2 appendix"><h2 class="anchored quarto-appendix-heading">Details</h2><div class="quarto-appendix-contents">

<p><a href="https://github.com/pharmaverse/blog/tree/main/posts/2023-07-24_rounding/rounding.qmd">Source</a>, <a href="https://pharmaverse.github.io/blog/session_info.html">Session info</a></p>
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