Closes #34 function for growth parameters for height/length

NAMESPACE

@@ -1,14 +1,18 @@
 # Generated by roxygen2: do not edit by hand
 
+export(derive_params_growth_height)
 importFrom(admiral,derive_vars_dy)
 importFrom(admiraldev,assert_character_scalar)
 importFrom(admiraldev,assert_character_vector)
 importFrom(admiraldev,assert_data_frame)
+importFrom(admiraldev,assert_expr)
 importFrom(admiraldev,assert_filter_cond)
 importFrom(admiraldev,assert_logical_scalar)
 importFrom(admiraldev,assert_numeric_vector)
 importFrom(admiraldev,assert_symbol)
 importFrom(admiraldev,assert_vars)
+importFrom(admiraldev,assert_varval_list)
+importFrom(admiraldev,expr_c)
 importFrom(dplyr,arrange)
 importFrom(dplyr,bind_cols)
 importFrom(dplyr,bind_rows)
@@ -21,6 +25,8 @@ importFrom(dplyr,filter)
 importFrom(dplyr,full_join)
 importFrom(dplyr,group_by)
 importFrom(dplyr,if_else)
+importFrom(dplyr,lead)
+importFrom(dplyr,left_join)
 importFrom(dplyr,mutate)
 importFrom(dplyr,mutate_at)
 importFrom(dplyr,mutate_if)
@@ -93,12 +99,14 @@ importFrom(rlang,eval_tidy)
 importFrom(rlang,expr)
 importFrom(rlang,expr_interp)
 importFrom(rlang,expr_label)
+importFrom(rlang,exprs)
 importFrom(rlang,f_lhs)
 importFrom(rlang,f_rhs)
 importFrom(rlang,inform)
 importFrom(rlang,is_bare_formula)
 importFrom(rlang,is_call)
 importFrom(rlang,is_character)
+importFrom(rlang,is_empty)
 importFrom(rlang,is_formula)
 importFrom(rlang,is_integerish)
 importFrom(rlang,is_logical)
@@ -124,6 +132,8 @@ importFrom(rlang,sym)
 importFrom(rlang,syms)
 importFrom(rlang,type_of)
 importFrom(rlang,warn)
+importFrom(stats,pnorm)
+importFrom(stats,qnorm)
 importFrom(stringr,str_c)
 importFrom(stringr,str_detect)
 importFrom(stringr,str_extract)

R/admiralpeds-package.R

@@ -1,14 +1,14 @@
 #' @keywords internal
 #' @family internal
 #' @importFrom dplyr arrange bind_rows case_when desc ends_with filter full_join group_by
-#'             if_else mutate mutate_at mutate_if n pull rename rename_at row_number select slice
-#'             starts_with transmute ungroup vars n_distinct union distinct
+#'             if_else lead left_join mutate mutate_at mutate_if n pull rename rename_at row_number
+#'             select slice starts_with transmute ungroup vars n_distinct union distinct
 #'             summarise_at summarise coalesce bind_cols na_if tibble
 #' @importFrom magrittr %>%
 #' @importFrom rlang := abort arg_match as_function as_string call2 caller_env
-#'             call_name current_env .data enexpr enquo eval_bare eval_tidy expr
+#'             call_name current_env .data enexpr enquo eval_bare eval_tidy expr exprs
 #'             expr_interp expr_label f_lhs f_rhs inform
-#'             is_bare_formula is_call is_character is_formula is_integerish
+#'             is_bare_formula is_call is_character is_formula is_empty is_integerish
 #'             is_logical is_quosure is_quosures is_symbol new_formula
 #'             parse_expr parse_exprs quo quo_get_expr quo_is_call
 #'             quo_is_missing quo_is_null quo_is_symbol quos quo_squash quo_text
@@ -27,5 +27,6 @@
 #' @importFrom admiral derive_vars_dy
 #' @importFrom admiraldev assert_logical_scalar assert_character_vector assert_vars
 #'             assert_data_frame assert_character_scalar assert_numeric_vector assert_filter_cond
-#'             assert_symbol
+#'             assert_symbol assert_expr assert_varval_list expr_c
+#' @importFrom stats pnorm qnorm
 "_PACKAGE"

R/derive_params_growth_height.R

@@ -0,0 +1,282 @@
+#' Derive Anthropometric indicators (Z-Scores/Percentiles-for-Height/Length)
+#' based on Standard Growth Charts
+#'
+#' Derive Anthropometric indicators (Z-Scores/Percentiles-for-Height/Lenght)
+#' based on Standard Growth Charts for Weight by Height/Length
+#'
+#' @param dataset Input dataset
+#'
+#'   The variables specified in `sex`, `height`, `height_unit`, `parameter`, `analysis_var`
+#'   are expected to be in the dataset.
+#'
+#' @param sex Sex
+#'
+#'   A character vector is expected.
+#'
+#'   Expected Values: `M`, `F`
+#'
+#' @param height Current Height/length
+#'
+#'   A numeric vector is expected. Note that this is the actual height at the current visit.
+#'
+#' @param height_unit Height/Length Unit
+#
+#'   A character vector is expected.
+#'
+#'   Expected values: 'cm'
+#'
+#' @param meta_criteria Metadata dataset
+#'
+#'   A metadata dataset with the following expected variables:
+#'   `HEIGHT_LENGTH`, `HEIGHT_LENGTHU`, `SEX`, `L`, `M`, `S`
+#'
+#'   The dataset can be derived from WHO or user-defined datasets.
+#'   The WHO growth chart metadata datasets are available in the package and will
+#'   require small modifications.
+#'   * `HEIGHT_LENGTH` - Height/Length
+#'   * `HEIGHT_LENGTHU` - Height/Length Unit
+#'   * `SEX` - Sex
+#'   * `L` - Power in the Box-Cox transformation to normality
+#'   * `M` - Median
+#'   * `S` - Coefficient of variation
+#'
+#' @param parameter Anthropometric measurement parameter to calculate z-score or percentile
+#'
+#'   A condition is expected with the input dataset `VSTESTCD`/`PARAMCD`
+#'   for which we want growth derivations:
+#'
+#'   e.g. `parameter = VSTESTCD == "WEIGHT"`.
+#'
+#'   There is WHO metadata available for Weight available in the `admiralpeds` package.
+#'
+#' @param analysis_var Variable containing anthropometric measurement
+#'
+#' A numeric vector is expected, e.g. `AVAL`, `VSSTRESN`
+#'
+#' @param set_values_to_sds Variables to be set for Z-Scores
+#'
+#'  The specified variables are set to the specified values for the new
+#'  observations. For example,
+#'   `set_values_to_sds(exprs(PARAMCD = “WTASDS”, PARAM = “Weight-for-height z-score”))`
+#'  defines the parameter code and parameter.
+#'
+#' *Permitted Values*: List of variable-value pairs
+#'
+#'  If left as default value, `NULL`, then parameter not derived in output dataset
+#'
+#' @param set_values_to_pctl Variables to be set for Percentile
+#'
+#'  The specified variables are set to the specified values for the new
+#'  observations. For example,
+#'   `set_values_to_pctl(exprs(PARAMCD = “WTHPCTL”, PARAM = “Weight-for-height percentile”))`
+#'  defines the parameter code and parameter.
+#'
+#' *Permitted Values*: List of variable-value pair
+#'
+#'  If left as default value, `NULL`, then parameter not derived in output dataset
+#'
+#' @return The input dataset additional records with the new parameter added.
+#'
+#'
+#' @family der_prm_bds_vs
+#'
+#' @keywords der_prm_bds_vs
+#'
+#' @export
+#'
+#' @examples
+#' library(dplyr)
+#' library(lubridate)
+#' library(rlang)
+#' library(admiral)
+#'
+#' advs <- dm_peds %>%
+#'   select(USUBJID, BRTHDTC, SEX) %>%
+#'   right_join(., vs_peds, by = "USUBJID") %>%
+#'   mutate(
+#'     VSDT = ymd(VSDTC),
+#'     BRTHDT = ymd(BRTHDTC)
+#'   ) %>%
+#'   derive_vars_duration(
+#'     new_var = AAGECUR,
+#'     new_var_unit = AAGECURU,
+#'     start_date = BRTHDT,
+#'     end_date = VSDT,
+#'     out_unit = "months"
+#'   )
+#'
+#' heights <- vs_peds %>%
+#'   filter(VSTESTCD == "HEIGHT") %>%
+#'   select(USUBJID, VSSTRESN, VSSTRESU, VSDTC) %>%
+#'   rename(
+#'     HGTTMP = VSSTRESN,
+#'     HGTTMPU = VSSTRESU
+#'   )
+#'
+#' advs <- advs %>%
+#'   right_join(., heights, by = c("USUBJID", "VSDTC"))
+#'
+#' advs_under2 <- advs %>%
+#'   filter(AAGECUR <= 24)
+#'
+#' advs_over2 <- advs %>%
+#'   filter(AAGECUR > 24)
+#'
+#' who_under2 <- bind_rows(
+#'   (admiralpeds::who_wt_for_lgth_boys %>%
+#'     mutate(
+#'       SEX = "M",
+#'       height_unit = "cm"
+#'     )
+#'   ),
+#'   (admiralpeds::who_wt_for_lgth_girls %>%
+#'     mutate(
+#'       SEX = "F",
+#'       height_unit = "cm"
+#'     )
+#'   )
+#' ) %>%
+#'   rename(
+#'     HEIGHT_LENGTH = Length,
+#'     HEIGHT_LENGTHU = height_unit
+#'   )
+#'
+#' who_over2 <- bind_rows(
+#'   (admiralpeds::who_wt_for_ht_boys %>%
+#'     mutate(
+#'       SEX = "M",
+#'       height_unit = "cm"
+#'     )
+#'   ),
+#'   (admiralpeds::who_wt_for_ht_girls %>%
+#'     mutate(
+#'       SEX = "F",
+#'       height_unit = "cm"
+#'     )
+#'   )
+#' ) %>%
+#'   rename(
+#'     HEIGHT_LENGTH = Height,
+#'     HEIGHT_LENGTHU = height_unit
+#'   )
+#'
+#'
+#' derive_params_growth_height(
+#'   advs_under2,
+#'   sex = SEX,
+#'   height = HGTTMP,
+#'   height_unit = HGTTMPU,
+#'   meta_criteria = who_under2,
+#'   parameter = VSTESTCD == "WEIGHT",
+#'   analysis_var = VSSTRESN,
+#'   set_values_to_sds = exprs(
+#'     PARAMCD = "WTHSDS",
+#'     PARAM = "Weight-for-height z-score"
+#'   ),
+#'   set_values_to_pctl = exprs(
+#'     PARAMCD = "WTHPCTL",
+#'     PARAM = "Weight-for-height percentile"
+#'   )
+#' )
+#'
+#' derive_params_growth_height(
+#'   advs_over2,
+#'   sex = SEX,
+#'   height = HGTTMP,
+#'   height_unit = HGTTMPU,
+#'   meta_criteria = who_over2,
+#'   parameter = VSTESTCD == "WEIGHT",
+#'   analysis_var = VSSTRESN,
+#'   set_values_to_sds = exprs(
+#'     PARAMCD = "WTHSDS",
+#'     PARAM = "Weight-for-height z-score"
+#'   ),
+#'   set_values_to_pctl = exprs(
+#'     PARAMCD = "WTHPCTL",
+#'     PARAM = "Weight-for-height percentile"
+#'   )
+#' )
+derive_params_growth_height <- function(dataset,
+                                        sex,
+                                        height,
+                                        height_unit,
+                                        meta_criteria,
+                                        parameter,
+                                        analysis_var,
+                                        set_values_to_sds = NULL,
+                                        set_values_to_pctl = NULL) {
+  # Apply assertions to each argument to ensure each object is appropriate class
+  sex <- assert_symbol(enexpr(sex))
+  height <- assert_symbol(enexpr(height))
+  height_unit <- assert_symbol(enexpr(height_unit))
+  analysis_var <- assert_symbol(enexpr(analysis_var))
+  assert_data_frame(dataset, required_vars = expr_c(sex, height, height_unit, analysis_var))
+  assert_data_frame(meta_criteria, required_vars = exprs(SEX, HEIGHT_LENGTH, HEIGHT_LENGTHU, L, M, S)) # nolint
+
+  assert_expr(enexpr(parameter))
+  assert_varval_list(set_values_to_sds, optional = TRUE)
+  assert_varval_list(set_values_to_pctl, optional = TRUE)
+
+  if (is.null(set_values_to_sds) && is.null(set_values_to_pctl)) {
+    abort("One of `set_values_to_sds`/`set_values_to_pctl` has to be specified.")
+  }
+
+  # create a unified join naming convention, hard to figure out in by argument
+  dataset <- dataset %>%
+    mutate(
+      sex_join := {{ sex }},
+      heightu_join := {{ height_unit }}
+    )
+
+  # Process metadata
+  # Metadata should contain SEX, HEIGHT_LENGTH, HEIGHT_LENGTHU, L, M, S
+  # Processing the data to be compatible with the dataset object
+  processed_md <- meta_criteria %>%
+    arrange(SEX, HEIGHT_LENGTHU, HEIGHT_LENGTH) %>%
+    group_by(SEX, HEIGHT_LENGTHU) %>%
+    mutate(next_height = lead(HEIGHT_LENGTH)) %>%
+    rename(
+      sex_join = SEX,
+      prev_height = HEIGHT_LENGTH,
+      heightu_join = HEIGHT_LENGTHU
+    )
+
+  # Merge the dataset that contains the vs records and filter the L/M/S that match height
+  # To parse out the appropriate age, create [x, y) using prev_height <= height < next_height
+  added_records <- dataset %>%
+    filter(!!enexpr(parameter)) %>%
+    left_join(.,
+      processed_md,
+      by = c("sex_join", "heightu_join"),
+      relationship = "many-to-many"
+    ) %>%
+    filter(prev_height <= {{ height }} & {{ height }} < next_height)
+
+  dataset_final <- dataset
+
+  # create separate records objects as appropriate depending if user specific sds and/or pctl
+  if (!is_empty(set_values_to_sds)) {
+    add_sds <- added_records %>%
+      mutate(
+        AVAL := (({{ analysis_var }} / M)^L - 1) / (L * S), # nolint
+        !!!set_values_to_sds
+      )
+
+    dataset_final <- bind_rows(dataset, add_sds) %>%
+      select(-c(L, M, S, sex_join, heightu_join, prev_height, next_height))
+  }
+
+  if (!is_empty(set_values_to_pctl)) {
+    add_pctl <- added_records %>%
+      mutate(
+        AVAL := (({{ analysis_var }} / M)^L - 1) / (L * S), # nolint
+        AVAL = pnorm(AVAL) * 100,
+        !!!set_values_to_pctl
+      )
+
+    dataset_final <- bind_rows(dataset_final, add_pctl) %>%
+      select(-c(L, M, S, sex_join, heightu_join, prev_height, next_height))
+  }
+
+  return(dataset_final)
+}

inst/WORDLIST

@@ -1,15 +1,15 @@
+ADSL
 ADaM
 ADaMs
-ADSL
+Anthropometric
 BMI
 Biologics
 CDISC
 DM
+Lenght
 SDTM
 anthropometric
+bds
+der
 pharmaverse
-renv
-repo
-roxygen
-Template
-bmi
+prm