Integrative Multi-Omics Analysis of IFNγ-induced Macrophages and Atherosclerotic Plaques

This repository contains the scripts and motifs used in the article Integrative Multi-Omics Analysis of IFNγ-induced Macrophages and Atherosclerotic Plaques Reveals Macrophage-dependent STAT1-Driven Transcription in Atherosclerosis

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Repository Files

Scripts: This folder holds the scripts for analyzing and generating the figures used in the article.

• DE_analysis_MQ.R The script for bulk RNA-seq data analysis
• MQ_Meta_Analysis_Bulk_Figures_2_3.Rmd The script for bulk data analysis used in figures 2&3
• 1_* The scripts for single-cell data analysis in a mouse model
• 2_* The scripts for single-cell data analysis in human samples

PU1_GAS_ISRE_motifs.txt PU1, GAS & ISRE motifs used for the analysis.

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Citation

Eskandarian Boroujeni, M., Lopacinska, N., Antonczyk, A., Kluzek, K., Wesoly, J., & AR Bluyssen, H. (2024). Integrative Multi-Omics Analysis of IFNγ-induced Macrophages and Atherosclerotic Plaques Reveals Macrophage-dependent STAT1-Driven Transcription in Atherosclerosis. bioRxiv, 2024-09.