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Add CHANGELOG entries
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DriesSchaumont committed Oct 16, 2023
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# openpipelines 0.12.0

## BREAKING CHANGES

The detection of mitochondrial genes has been revisited in order to remove the interdependency with the count filtering and the QC metric calculation.
Implementing this changes involved breaking some existing functionality:

* `filter/filter_with_counts`: removed `--var_gene_names`, `--mitochondrial_gene_regex`, `--var_name_mitochondrial_genes`, `--min_fraction_mito` and `--max_fraction_mito` (PR #585).

* `workflows/prot_singlesample`: removed `--min_fraction_mito` and `--max_fraction_mito` because regex-based detection detection of mitochondrial genes is not possible (PR #585).

* The fraction of counts that originated from mitochondrial genes used to be written to an .obs column with a name that was derived from `pct_` suffixed by the name of the mitochondrial gene column. The `--obs_name_mitochondrial_fraction` argument is introduced to change the destination column and the default prefix has changed from `pct_` to `fraction_` (PR #585).

## NEW FUNCTIONALITY

* `workflows/qc`: A pipeline to add basic qc statistics to a MuData object (PR #585).

* `workflows/rna_singlesample`: added `--obs_name_mitochondrial_fraction` and make sure that the values from `--max_fraction_mito` and `--min_fraction_mito` are bound between 0 and 1 (PR #585).

* Added `filter/delimit_fraction`: Turns an annotation column containing values between 0 and 1 into a boolean column based on thresholds (PR #585).

* Added `metadata/grep_annotation_column`: Perform a regex lookup on a column from the annotation matrices .obs or .var (PR #585).

* `workflows/full_pipelines`: added `--obs_name_mitochondrial_fraction` argument (PR #585).

* `workflows/prot_multisample`: added `--var_qc_metrics` and `--top_n_vars` arguments (PR #585).

## MINOR CHANGES

* Refactored `prot_multisample` and `prot_singlesample` pipelines to use `fromState` and `toState` functionality (PR #585).

# openpipelines 0.11.0

## BREAKING CHANGES
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