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arokem committed Jun 11, 2024
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52 changes: 31 additions & 21 deletions poster.Rmd
Original file line number Diff line number Diff line change
Expand Up @@ -96,10 +96,12 @@ img[src*='#logo'] {
knitr::opts_chunk$set(echo = FALSE)
```

![](./images/university-of-washington-501924867.gif){height=200 style="position: absolute; top: 4000px; left: 700px;"}
![](./images/Block_S_2_color_red.png){height=200 style="position: absolute; top: 4000px; left: 950px;"}
![](./images/biu_logo.png){height=200 style="position: absolute; top: 4000px; left: 1100px;"}
![](./images/qr.png){height=200 style="position: absolute; top: 4000px; left: 1300px;"}
![](./images/W-Logo_White.png){height=200 style="position: absolute; top: 50px; left: 50px;"}
![](./images/Block_S_2_color_red.png){height=150 style="position: absolute; top: 150px; left: 2920px;"}
![](./images/Bar_Ilan_seal.svg.png){height=150 style="position: absolute; top: -50px; left: 2900px;"}


![](./images/qr_poster.png){height=200 style="position: absolute; top: 3800px; left: 2900px;"}


# Background
Expand Down Expand Up @@ -139,20 +141,15 @@ knitr::opts_chunk$set(echo = FALSE)
- Data quality confounds were mitigated by matching each SZ/ADHD/BD to a HC with similar age, sex and data quality (neighbor correlations, NDC).
- Generalized additive models (GAMs) for FA and MD in each SCP as [@Muncy2022GAMs]:
<p style="font-family:'Lucida Console', monospace">
FA/MD ~ group + s(nodeID, k) + age + sex + QC
FA/MD ~ group + s(nodeID, k, by=group) + \n age + sex + QC + s(subjectID, bs="re")
</p>
with k chosen to minimize AIC and neighbor correlations for QC.

<!--
![](./images/cubic-spline-example.png)
-->
with k chosen to minimize AIC and neighbor correlations [@Yeh2019NDC] for QC.

# Acknowledgements
<div style="font-size:32px">
<div style="font-size:36px">
NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfallidis)
</div>


# Results{.mybreak}

![](images/SCP_right.png){width=24% height=24%}
Expand All @@ -161,25 +158,38 @@ NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfall
![](images/SCP_top.png){width=24% height=24%}
<div style="font-size:32px; font-family:'Palatino'; text-align:center">The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal, coronal and axial anatomical views of the T1-weighted scan of this individual.</div>

<center>
![](./images/tract-profile_by-Group_dti-md.png){width=49% height=49%}
![](./images/tract-profile_by-Group_dti-fa.png){width=49% height=49%}
</center>
<div style="font-size:32px; font-family:'Palatino'; text-align:center">Tract profiles of MD (left) and FA (right) $\pm$ bootstrapped 95% confidence interval</div>

![](./images/model-SCP_L.png){width=49% height=49%}
![](./images/model-SCP_R.png){width=49% height=49%}
<div style="font-size:32px; font-family:'Palatino'; text-align:center">GAM model fits of MD with model-estimated confidence intervals</div>

- MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and HC groups (p<0.05), but not between the ADHD and HC groups or BD and HC groups.
- Individuals with SZ had lower MD in this tract than the matched controls (as indicated).
- This finding held after adding medication as a covariate (haloperidol equivalent dosage).

# Conclusions

<div style="font-size:48px">
- We found decreased MD in the left SCP, a component of the CTC.
- These results appear in line with previous fMRI results that found increased functional connectivity in the CTC in individuals with SZ. [@Cao2018]
- This provides additional support for the cognitive dysmetria theory of SZ.
</div>
- We found decreased MD in SZ in the left SCP, a component of the CTC.
- In line with fMRI results that found increased functional connectivity in CTC in SZ. [@Cao2018]
- Provides additional support for the cognitive dysmetria theory of SZ.


# Software

![](./images/qr_pyafq.png){height=260 style="position: absolute; top: 2875px; left: 1800px;"}
![](./images/qr_tractable.png){height=260 style="position: absolute; top: 3200px; left: 1800px;"}

<p style="margin-bottom:8cm">
**pyAFQ**: Automated Fiber Quantification / tractometry
</p>

![](./images/pyAFQ.png){height=300 style="position: absolute; top: 2875px; left: 2750px;"}

<p style="margin-bottom:8cm">
**Tractable**: Statistical analysis tract profiles in R
</p>
![](./images/cubic-spline-single.png){height=320 style="position: absolute; top: 3200px; left: 2700px;"}

# References

46 changes: 27 additions & 19 deletions poster.html
Original file line number Diff line number Diff line change
Expand Up @@ -336,10 +336,10 @@ <h5 id="affiliation"><sup>1</sup> Department of Psychology and eScience Institut
}

</style>
<p><img src="images/university-of-washington-501924867.gif" style="position: absolute; top: 4000px; left: 700px;" height="200" />
<img src="images/Block_S_2_color_red.png" style="position: absolute; top: 4000px; left: 950px;" height="200" />
<img src="images/biu_logo.png" style="position: absolute; top: 4000px; left: 1100px;" height="200" />
<img src="images/qr.png" style="position: absolute; top: 4000px; left: 1300px;" height="200" /></p>
<p><img src="images/W-Logo_White.png" style="position: absolute; top: 50px; left: 50px;" height="200" />
<img src="images/Block_S_2_color_red.png" style="position: absolute; top: 150px; left: 2920px;" height="150" />
<img src="images/Bar_Ilan_seal.svg.png" style="position: absolute; top: -50px; left: 2900px;" height="150" /></p>
<p><img src="images/qr_poster.png" style="position: absolute; top: 3800px; left: 2900px;" height="200" /></p>
<div id="background" class="section level1">
<h1>Background</h1>
<ul>
Expand Down Expand Up @@ -378,17 +378,14 @@ <h1>Methods</h1>
<li>Data quality confounds were mitigated by matching each SZ/ADHD/BD to a HC with similar age, sex and data quality (neighbor correlations, NDC).</li>
<li>Generalized additive models (GAMs) for FA and MD in each SCP as <span class="citation">(<em>7</em>)</span>:
<p style="font-family:&#39;Lucida Console&#39;, monospace">
FA/MD ~ group + s(nodeID, k) + age + sex + QC
FA/MD ~ group + s(nodeID, k, by=group) + age + sex + QC + s(subjectID, bs=“re”)
</p>
with k chosen to minimize AIC and neighbor correlations for QC.</li>
with k chosen to minimize AIC and neighbor correlations <span class="citation">(<em>8</em>)</span> for QC.</li>
</ul>
<!--
![](./images/cubic-spline-example.png)
-->
</div>
<div id="acknowledgements" class="section level1">
<h1>Acknowledgements</h1>
<div style="font-size:32px">
<div style="font-size:36px">
<p>NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfallidis)</p>
</div>
</div>
Expand All @@ -401,16 +398,13 @@ <h1>Results</h1>
<div style="font-size:32px; font-family:&#39;Palatino&#39;; text-align:center">
The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal, coronal and axial anatomical views of the T1-weighted scan of this individual.
</div>
<center>
<img src="images/tract-profile_by-Group_dti-md.png" style="width:49.0%;height:49.0%" />
<img src="images/tract-profile_by-Group_dti-fa.png" style="width:49.0%;height:49.0%" />
</center>
<div style="font-size:32px; font-family:&#39;Palatino&#39;; text-align:center">
Tract profiles of MD (left) and FA (right) <span class="math inline">\(\pm\)</span> bootstrapped 95% confidence interval
</div>
<img src="images/model-SCP_L.png" style="width:49.0%;height:49.0%" />
<img src="images/model-SCP_R.png" style="width:49.0%;height:49.0%" />
<div style="font-size:32px; font-family:&#39;Palatino&#39;; text-align:center">
GAM model fits of MD with model-estimated confidence intervals
</div>
<ul>
<li>MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and HC groups (p&lt;0.05), but not between the ADHD and HC groups or BD and HC groups.</li>
<li>Individuals with SZ had lower MD in this tract than the matched controls (as indicated).</li>
Expand All @@ -419,13 +413,24 @@ <h1>Results</h1>
</div>
<div id="conclusions" class="section level1">
<h1>Conclusions</h1>
<div style="font-size:48px">
<ul>
<li>We found decreased MD in the left SCP, a component of the CTC.</li>
<li>These results appear in line with previous fMRI results that found increased functional connectivity in the CTC in individuals with SZ. <span class="citation">(<em>2</em>)</span></li>
<li>This provides additional support for the cognitive dysmetria theory of SZ.</li>
<li>We found decreased MD in SZ in the left SCP, a component of the CTC.</li>
<li>In line with fMRI results that found increased functional connectivity in CTC in SZ. <span class="citation">(<em>2</em>)</span></li>
<li>Provides additional support for the cognitive dysmetria theory of SZ.</li>
</ul>
</div>
<div id="software" class="section level1">
<h1>Software</h1>
<p><img src="images/qr_pyafq.png" style="position: absolute; top: 2875px; left: 1800px;" height="260" />
<img src="images/qr_tractable.png" style="position: absolute; top: 3200px; left: 1800px;" height="260" /></p>
<p style="margin-bottom:8cm">
<strong>pyAFQ</strong>: Automated Fiber Quantification / tractometry
</p>
<p><img src="images/pyAFQ.png" style="position: absolute; top: 2875px; left: 2750px;" height="300" /></p>
<p style="margin-bottom:8cm">
<strong>Tractable</strong>: Statistical analysis tract profiles in R
</p>
<p><img src="images/cubic-spline-single.png" style="position: absolute; top: 3200px; left: 2700px;" height="320" /></p>
</div>
<div id="references" class="section level1 unnumbered">
<h1>References</h1>
Expand All @@ -451,6 +456,9 @@ <h1>References</h1>
<div id="ref-Muncy2022GAMs" class="csl-entry">
7. N. M. Muncy <em>et al.</em>, <em>Neuroimage Clin</em>. <strong>33</strong>, 102937 (2022).
</div>
<div id="ref-Yeh2019NDC" class="csl-entry">
8. F.-C. Yeh <em>et al.</em>, <em>Neuroimage</em>. <strong>202</strong>, 116131 (2019).
</div>
</div>
</div>
</div>
Expand Down
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35 changes: 35 additions & 0 deletions references.bib
Original file line number Diff line number Diff line change
@@ -1,4 +1,39 @@

@ARTICLE{Yeh2019NDC,
title = "Differential tractography as a track-based biomarker for neuronal
injury",
author = "Yeh, Fang-Cheng and Zaydan, Islam M and Suski, Valerie R and
Lacomis, David and Richardson, R Mark and Maroon, Joseph C and
Barrios-Martinez, Jessica",
abstract = "Diffusion MRI tractography has been used to map the axonal
structure of the human brain, but its ability to detect neuronal
injury is yet to be explored. Here we report differential
tractography, a new type of tractography that utilizes repeat MRI
scans and a novel tracking strategy to map the exact segment of
fiber pathways with a neuronal injury. We examined differential
tractography on multiple sclerosis, Huntington's disease,
amyotrophic lateral sclerosis, and epileptic patients. The
results showed that the affected pathways shown by differential
tractography matched well with the unique clinical symptoms of
the patients, and the false discovery rate of the findings could
be estimated using a sham setting to provide a reliability
measurement. This novel approach enables a quantitative and
objective method to monitor neuronal injury in individuals,
allowing for diagnostic and prognostic evaluation of brain
diseases.",
journal = "Neuroimage",
volume = 202,
pages = "116131",
month = nov,
year = 2019,
keywords = "Amyotrophic lateral sclerosis; Differential tractography;
Diffusion MRI; Epilepsy; Fiber tracking; Huntington's disease;
Imaging biomarker; Multiple sclerosis; Neuronal injury",
language = "en"
}



@ARTICLE{Muncy2022GAMs,
title = "General additive models address statistical issues in diffusion
{MRI}: An example with clinically anxious adolescents",
Expand Down

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