Release 304
If you use pip: pip install pywin32 --upgrade
A number of things don't work via pip, so you may choose to install binaries - but you must choose both the correct Python version and "bittedness". Note that due to changes in Python there are no binary installers for version 3.10 32bit and later, so pypi is your only option there.
Even if you have a 64bit computer, if you installed a 32bit version of Python you must install the 32bit version of pywin32.
There is one binary per-version, per-bittedness. To determine what version of Python you have, start Python and look at the first line of the banner. Compare these 2:
Python 2.7.2+ ... [MSC v.1500 32 bit (Intel)] on win32
Python 2.7.2+ ... [MSC v.1500 64 bit (AMD64)] on win32
^^^^^^^^^^^^^^
If the installation process informs you that Python is not found in the registry, it almost certainly means you have downloaded the wrong version - either for the wrong version of Python, or the wrong "bittedness".