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@@ -3,23 +3,27 @@ Type: Package | |
Title: High Performance Li & Stephens Local Ancestry Inference | ||
Version: 2.0.0 | ||
Authors@R: c(person("Louis", "Aslett", role = c("aut", "cre"), | ||
email = "[email protected]"), | ||
email = "[email protected]", | ||
comment = c(ORCID = "0000-0003-2211-233X")), | ||
person("Ryan", "Christ", role = "aut", | ||
email = "[email protected]")) | ||
email = "[email protected]", | ||
comment = c(ORCID = "0000-0002-2049-3389"))) | ||
Author: Louis Aslett [aut, cre], | ||
Ryan Christ [aut] | ||
Maintainer: Louis Aslett <[email protected]> | ||
Description: kalis provides a high performance implementation of the Li & | ||
Stephens model <https://www.ncbi.nlm.nih.gov/pubmed/14704198> for local | ||
ancestry inference (local referring to a region of the genome). For a set of N | ||
phased haplotypes, kalis computes the posterior marginal probability of each | ||
haplotype copying every other haplotype by running N hidden Markov models in | ||
parallel. This yields an N x N distance matrix that summarizes the recent | ||
local ancestry at each variant of interest. The package provides functionality | ||
for specifying a recombination map, site-specific mutation rates, and | ||
differing prior copying probabilities for each recipient haplotype. Extensive | ||
use is made of low level threading and CPU vector instructions. | ||
Description: kalis <doi:10.1186/s12859-024-05688-8> provides a high performance | ||
implementation of the Li & Stephens model <doi:10.1093/genetics/165.4.2213> | ||
for local ancestry inference (local referring to a region of the genome). For | ||
a set of N phased haplotypes, kalis computes the posterior marginal | ||
probability of each haplotype copying every other haplotype by running N | ||
hidden Markov models in parallel. This yields an N x N distance matrix that | ||
summarizes the recent local ancestry at each variant of interest. The package | ||
provides functionality for specifying a recombination map, site-specific | ||
mutation rates, and differing prior copying probabilities for each recipient | ||
haplotype. Extensive use is made of low level threading and CPU vector | ||
instructions. | ||
License: GPL (>= 3) | ||
BugReports: https://github.com/louisaslett/kalis/issues | ||
URL: https://kalis.louisaslett.com/, https://github.com/louisaslett/kalis | ||
LazyData: TRUE | ||
Depends: R (>= 3.5.0) | ||
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