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Hi @lh3, and thanks for another brilliant tool.
I recently found myself needing to calculate something like a mash distance from a bunch of kmer profiles I'd made with Yak, and so implemented a simple profile distance calculator into yak.
Currently it's not as efficient as it could be, but if this is something you would like to see implemented then I'd be happy to tidy it up and fix some of the more egregiously inefficient parts and then make a PR.
If not, and anyone needs this functionality, it will live in its current state in my fork, just be aware it was made as a one-off and has not been reviewed, so if it breaks you get to keep both pieces. My coding is far from what you're used to from @lh3
Best,
Kevin