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 What if I told you we don't need alignments to find variants?

kevlar

Daniel Standage, 2016-2019
https://kevlar.readthedocs.io

Welcome to kevlar, software for predicting de novo genetic variants without mapping reads to a reference genome! kevlar's k-mer abundance based method calls single nucleotide variants (SNVs), multinucleotide variants (MNVs), insertion/deletion variants (indels), and structural variants (SVs) simultaneously with a single simple model. This software is free for use under the MIT license.

Where can I find kevlar online?

If you have questions or need help with kevlar, the GitHub issue tracker should be your first point of contact.

How do I install kevlar?

See the kevlar documentation for complete instructions, but the impatient can try the following.

pip3 install git+https://github.com/dib-lab/khmer.git
pip3 install biokevlar
How do I use kevlar?
How do I cite kevlar?

Standage DS, Brown CT, Hormozdiari F (2019) Kevlar: a mapping-free framework for accurate discovery of de novo variants. bioRxiv, doi:10.1101/549154.

How can I contribute?

We welcome contributions to the kevlar project from the community! If you're interested in modifying kevlar or contributing to its ongoing development, feel free to send us a message or submit a pull request!

The kevlar software is a project of the Lab for Data Intensive Biology and the Computational Genomics Lab at UC Davis.