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GO:0052735 tRNA (cytosine-3-)-methyltransferase activity - add RHEA xref #25722

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sjm41 opened this issue Jul 11, 2023 · 2 comments
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GO:0052735 tRNA (cytosine-3-)-methyltransferase activity - add RHEA xref #25722

sjm41 opened this issue Jul 11, 2023 · 2 comments

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@sjm41
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sjm41 commented Jul 11, 2023

I think RHEA:60908 (https://www.rhea-db.org/rhea/60908) can be added as a exact xref to GO:0052735.
Could also tweak the def to match RHEA.

id: GO:0052735
name: tRNA (cytosine-3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine." [PMID:21518804, PMID:21518805]
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity" EXACT []
synonym: "transfer ribonucleate cytosine 3-methyltransferase activity" EXACT []
synonym: "tRNA (cytosine 3)-methyltransferase activity" EXACT []
synonym: "tRNA cytosine 3-methyltransferase activity" EXACT []
synonym: "tRNA cytosine-3-methyltransferase activity" EXACT []
is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity

@ValWood
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ValWood commented Jul 14, 2023

Just to check

cytidine in tRNA + S-adenosyl-L-methionine = N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine

?

@sjm41
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sjm41 commented Jul 14, 2023

Yes, thanks.
I guess the full def should read:
"Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = an N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine." [RHEA:60908]

@ValWood ValWood added the ready label Jul 14, 2023
ValWood added a commit that referenced this issue Jul 14, 2023
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