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Determine best default values for jump_score_* parameters #57

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jdidion opened this issue Sep 19, 2023 · 0 comments
Open

Determine best default values for jump_score_* parameters #57

jdidion opened this issue Sep 19, 2023 · 0 comments

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@jdidion
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jdidion commented Sep 19, 2023

In #48 we see an example where a single read is aligned to multiple contiguous regions of the same contig (i.e., it is split into primary and supplementary alignments). Modifying the jump penalty (--jump-score-* options) to the following fixes the issue for that specific case. This is a tracking issue to evaluate the parameter settings on multiple examples to see which default values are best (i.e., produce reasonable results for the most cases).

--jump-score-same-contig-and-strand -40 \
--jump-score-same-contig-opposite-strand -80 \
--jump-score-inter-contig -160
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