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Bumped version to 1.0.0 and updated ChangeLog.
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2016-02-24 Peter Briggs <[email protected]> | ||
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* Version 1.0.0 | ||
- Complete reimplementation of RnaChipIntegrator to unify internal | ||
algorithms, simplify usage and substantially update the | ||
documentation. | ||
- Installs using 'pip'; can be obtained directly from PyPI using | ||
'pip install RnaChipIntegrator'. | ||
- Executable now installs as 'RnaChipIntegrator' (i.e. no '.py' | ||
extension) | ||
- Documentation now available via ReadTheDocs: | ||
http://rnachipintegrator.readthedocs.org/en/latest/ | ||
- No distinction is now made between 'summits' and 'peaks'; the | ||
same algorithm is applied in each case. | ||
- The program always finds the nearest genes to each peak, and | ||
vice versa. The same distance cutoff and maximum number of hits | ||
are applied to both and can be specified using the --cutoff and | ||
--number options. | ||
- By default all pairs within the cut-off distance are reported | ||
unless the user explicitly restricts this to a subset by | ||
specifying the --number option (i.e. --number now turned off | ||
by default). | ||
- By default nearest distances between peaks and gene are | ||
calculated from the TSS of the feature to whichever of the peak | ||
edges are closer; alternatively distances can be calculated | ||
between the nearest pair of peak/gene edges by specifying the | ||
--edge=both option. | ||
- Any differential expression flags in the input genes file | ||
are ignored unless the --only-DE option is specified, in which | ||
case only the differentially expressed genes are considered | ||
in the analyses. | ||
- By default each peak/gene pair is reported on a separate | ||
line; the --compact option reports all nearest gene/peaks | ||
on a single line of output. | ||
- New 'direction' field in output indicates whether hits are | ||
up- or downstream from reference. | ||
- Specify arbitrary columns from input peaks file using new | ||
--peak_cols options to set chromosome, start and end. | ||
- Output file names now end with 'gene-centric' and 'peak-centric'. | ||
- Excel output is only produced if the --xlsx option is specified; | ||
spreadsheets are now output in XLSX format (instead of XLS). | ||
- Summary output is only produced if --summary is specified. | ||
- The 'rearrange_columns.py' utility has been dropped. | ||
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2016-02-18 Peter Briggs <[email protected]> | ||
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* Version 0.5.0-alpha.8 | ||
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