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Merge pull request #49 from bedroesb/wittigue-patch-1
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Update proteomics.md
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bedroesb authored Jul 25, 2023
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Expand Up @@ -36,11 +36,11 @@ For different proteomics experiments and different steps of the respective data
### Solutions
The Human Proteome Organisation (HUPO) Proteomics Standards Initiative ({% tool "proteomics-standards-initiative" %}), a proteomics community-driven organization, provides several different controlled vocabularies, standard data formats, converter and validator software tools. The most important include:
- Controlled vocabularies: PSI-MS, PSI-MI, XLMOD and sepCV, which are provided as OBO files.
- The Minimum Information About a Proteomics Experiment (MIAPE) guidelines document.
- mzML - a standard format for encoding raw mass spectrometer output.
- mzIdentML - a standard exchange format for peptides and proteins identified from mass spectra.
- mzQuantML - a standard format that is intended to store the systematic description of workflows quantifying molecules (principally peptides and proteins) by mass spectrometry.
- mzTab - a tab delimited text file format to report proteomics and metabolomics results.
- The Minimum Information About a Proteomics Experiment ([MIAPE](https://psidev.info/miape)) guidelines document.
- [mzML](https://www.psidev.info/mzML) - a standard format for encoding raw mass spectrometer output.
- [mzIdentML](https://www.psidev.info/mzidentml) - a standard exchange format for peptides and proteins identified from mass spectra.
- [mzQuantML](https://psidev.info/mzquantml) - a standard format that is intended to store the systematic description of workflows quantifying molecules (principally peptides and proteins) by mass spectrometry.
- [mzTab](https://www.psidev.info/mztab) - a tab delimited text file format to report proteomics and metabolomics results.


## Processing and analysis of proteomics data
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- Can your proteomics raw data recorded by a mass spectrometer be stored as an mzML file?
- Is it possible to convert your raw data to mzML?
- Does your search engine support mzML and/or mzIdentML?
- Does your quantification software support mzQuantML or mzTAB?
- Does your quantification software support mzQuantML or mzTab?


### Solutions
- Within the proteomics community various converter software tools such as {% tool "msconvert" %} were implemented, which support the conversion of mass spectrometer output formats to the mzML standard data format as well as other conversions to standard data formats.
- Information on software tools that support HUPO-PSI data formats can be found on the standard format-specific web pages of the HUPO-PSI (e.g., [mzML](https://www.psidev.info/mzML) , [mzIdentML](https://www.psidev.info/mzidentml) and [MZTAB](https://www.psidev.info/mztab) ). The following list shows just a few tools using standard data formats as input and/or output:
- Information on software tools that support HUPO-PSI data formats can be found on the standard format-specific web pages of the HUPO-PSI (e.g., [mzML](https://www.psidev.info/mzML) , [mzIdentML](https://www.psidev.info/mzidentml) and [mzTab](https://www.psidev.info/mztab) ). The following list shows just a few tools using standard data formats as input and/or output:
* {% tool "comet" %}
* {% tool "mascot" %}
* {% tool "openms" %}
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