WGPAN v0.1-beta
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bradfordcondon
released this
07 Mar 20:16
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WGPAN (Whole-Genome Pairwise Alignment Noising) is an R package designed to deal with neighbor-joining trees built from whole-genome pairwise alignment. Traditional bootstrapping methods are invalid, because there is not a single alignment of all genomes to sample with replacement from.
As such, a new method for assigning confidence to nodes in a tree was required. WGPAN allows you to assign confidence values to nodes that are relevant for within clade confidence only. You can therefore test hypotheses regarding user-defined clades, not the relationship among those clades.