v0.11.0

• Improved counting of N and n for subjects for summaries
• lin-log integration method is now available
• PKNCA has begun the process of deprecating dots in favor of underscores in function and parameter names.

And, may other improvements and bug fixes (see the NEWS.md file for full details).

v0.10.2

The main purpose of this release is to work with new versions of testthat and waldo.

What's Changed

• Allow duplicated PPSTRESU by @billdenney in #191
• Generalize message checks to be independent of dplyr version by @billdenney in #199
• Update continuous integration and testing infrastructure code by @billdenney in #200
• Add aucabove by @billdenney in #196
• Simplify column handling by @billdenney in #201
• Add more detail to error messages by @billdenney in #204
• Clean up imports; bump version; update docs by @billdenney in #206
• Fix for development version of waldo by @billdenney in #209
• Work with development version of testthat by @billdenney in #214
• Fix for dev testthat by @hadley in #213
• Fix #207 by @billdenney in #215
• AUC warning given as exclusion reason by @billdenney in #216
• Give reason for NA result with ae calculations by @billdenney in #217
• "PKNCA_impute_method_start_predose" and "start_predose" are equivalent by @billdenney in #219
• Prepare for CRAN submission by @billdenney in #220

New Contributors

• @hadley made their first contribution in #213

Full Changelog: v0.10.0...v0.10.2

CRAN release version 0.10.0

PKNCA 0.10.0

Bugs Fixed

• When calculating AUC with only a single concentration measurement, NA is now
  returned instead of 0. (fix #176)

New Features

• Initial support for unit assignment and conversion has been added. See the
  units argument to the PKNCAdata() function and the function
  pknca_units_table().
• Initial support for imputation has been added. See the impute argument to
  the PKNCAdata() function and the Data Imputation vignette.
• With the addition of units, several outputs now will differ, if units are
  used:
  • summary() on a PKNCAresults object shows the units in the column
    heading.
  • When running as.data.frame() on a PKNCAresults object with the argument
    out.format="wide", if standardized units values are available, they will
    be used. And if any unit are available, they will be in the column names.
• Summary tables with units use the "pretty_name" for a parameter which is
  intended for clearer representation in reports. "pretty_name" use can be
  controlled with the "pretty_names" argument to summary().
  • Note that the pretty names themselves may be modified to help clarify and/or
    shorten the names to make the table heading more useful. If you intend to
    modify column headers programmatically, set pretty_names=FALSE when
    calling the summary() function.
• New, IV AUC calculation methods have been added.
• pk.calc.time_above() now uses the default AUC calculation method for
  interpolation of time above. And, it can use 'lin up/log down' interpolation.
• PKNCA can now calculate parameters that require extra information by adding
  the extra information to the intervals data.frame. For example, add
  conc_above as a column to the intervals to allow calculation of
  time_above. With this change, the "conc_above" PKNCA.options() value has
  been removed.
• Added dplyr joins, filter, mutate, group_by, and ungroup to allow modification
  of PKNCA objects after creation. (Note that these functions will make the
  provenance no longer match for PKNCAresults objects.)

Breaking Changes

• Some functions that were intended to be internal were removed:
  • All getData() functions were removed.
  • The getDataName() function for PKNCAdata objects was removed.
• interpolate.conc() and interp.extrap.conc() now give more errors with
  missing (NA) input. This should not affect typical NCA (where NA values are
  dropped), but it may affect direct calls to the functions themselves.

Internal Breaking Changes (these should not affect PKNCA users)

• print.parseFormula() was removed from the package.

0.9.5

On CRAN

0.9.4

Ignore extraneous CRAN files

Version 0.9.1

Version 0.9.1 as submitted to CRAN

Release 0.8.4 on CRAN

Version 0.8.4 as submitted to CRAN

Version 0.8.1 as released on CRAN

Version 0.8.1 as accepted on CRAN