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Fluvastatin_terbinafine Combo Analysis

Introduction

This is a project to analyze combo data in this manuscript:

Genome-wide CRISPR Screen Identifies Squalene Epoxidase as a Fluvastatin Sensitizer to Effectively Target the Mevalonate Pathway in Breast Cancer, 2024, Leeuwen et. al..

The script for the analysis is written in R.


Dependencies:

These R packages need to be installed in order to run the analysis script:

  • PharmacoGx
  • magicaxis
  • abind
  • robustbase
  • Biobase
  • synergyfinder (1.8.0)
  • ComplexHeatmap
  • circlize
  • ggplot2
  • ggpubr
  • reshape
  • snowfall
  • GSA
  • piano
  • scales
  • ggrepel
  • dplyr
  • tidyr
  • BoutrosLab.plotting.general
  • UpSetR

Reproducibility of the Analysis:

  • Inside the main directory, there is an R script file named "combo_analysis.R". Running this script will regenerate the combo data and analyses in the manuscript linked above.

Important Note: the user needs to set the working directory inside the script file before running it, i.e. setting the working directory to "combo_analysis"

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