Update positions.md

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@@ -16,7 +16,6 @@ Ph.D. Fellowship in Bioengineering and Robotics, Curriculum Bionanotechnologies
 Optical microscopy is among the least invasive techniques for visualizing biological structures and functions at near-molecular scales in living cells and organisms. However, many fundamental biological processes relevant to health and disease remain beyond the reach of conventional optical microscopy. Our mission is to design and develop state-of-the- art microscopes and analytical tools that enable biologists to explore living systems with unprecedented spatiotemporal resolutions, reduced invasiveness, and enhanced information content. To achieve this, our projects integrate novel photonics technologies, labelling protocols, optical architectures, spectroscopy techniques, and machine learning approaches. While our primary focus is on technology development, we also collaborate with biologists to test and refine our tools, ensuring they yield new biological insights. The PhD student will be fully integrated into this mission working on a dedicated project involving fluorescence lifetime imaging microscopy (FLIM). FLIM is an advanced imaging technique that combines conventional fluorescence intensity measurements with nanosecond-scale temporal dynamics. This dual capability provides detailed structural and functional information about specimens, allowing for the mapping of protein-protein interactions and biochemical reactions in living cells. In recent years, our group has focused on developing FLIM for laser-scanning microscopy, introducing a novel single-photon detector array composed of a few elements (e.g., 5x5) capable of correlating super-resolved microscopy with fluorescence lifetime imaging [1-3]. However, laser-scanning microscopy suffers from lower temporal resolution (e.g., frame rate) compared to wide-field optical architectures, which require large detector arrays (megapixel).
 The aim of this PhD project is to implement a wide-field fluorescence lifetime imaging system with high temporal resolution. This will be achieved by combining innovative optical light-sheet optical architecture with novel large pixellated detector featuring the time-resolved capability.
 
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 [1] M. Castello et al., “A robust and versatile platform for image scanning microscopy enabling super-resolution FLIM,” Nat Methods 16(2), 175-178 (2019).
 
 [2] A. Rossetta, et al., “The BrightEyes-TTM as an open-source time-tagging module for democratising single-photon microscopy,” Nat Comm 13, 7406 (2022).