iCCA_Diversity

Exploring analysis and final results

iCCA classification: cell differentiation-based: Morphology and/or phenotype;

SBD: small bile duct (interlobular to steptal duct);

CLC: Bile ductules/CoH;

DPM: Ductal plate malformation

HCC-like, iCCA with morphological features resembing classical HCC.

Evaluate in 5% increasements Group classifcation:

1. SBD (>95%) = pure SBD
2. cSBD-CLC (5% < CLC <= 80%] without DPM
3. CLC, CLC >80% (consensus paper, WHO)
4. iCCA with DPM, >5% DPM
5. HCC-like (>95% Hepatoid/HCC-like pattern In addition: All iCCA with > 5% CLC => iCCA with CLC pattern

Note CLC = bile ductular (BD) in some codes

https://pubmed.ncbi.nlm.nih.gov/34018212/