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niklases committed Sep 29, 2024
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- [Model Hyperparameter Grids for Training](#model-hyperparameter-grids-for-training)
- [Setting Up the Scripts Yourself](#setting-up-the-scripts-yourself)
- [Preprocessing for DCA-based Sequence Encoding](#preprocessing-for-dca-based-sequence-encoding)
- [Unsupervised/zero-shot prediction](#unsupervisedzero-shot-prediction)
- [Unsupervised/zero-shot prediction vs. supervised few-shot prediction](#unsupervisedzero-shot-prediction-vs-supervised-few-shot-prediction)
- [API Usage for Sequence Encoding](#api-usage-for-sequence-encoding)
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<a name="zero-shot-prediction"></a>
## Unsupervised/zero-shot prediction
## Unsupervised/zero-shot prediction vs. supervised few-shot prediction
Several developed methods allow unsupervised prediction of a proteins fitness based on its sequence (and/or structure).
These methods have the advantage that no initial knowledge about a proteins fitness is required for prediction, while a correlation of the predicted score and a protein's natural fitness is assumed.
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