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Update ci_for_prop.qmd #370

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Jan 6, 2025
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Update ci_for_prop.qmd #370

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5 changes: 2 additions & 3 deletions R/ci_for_prop.qmd
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Expand Up @@ -88,7 +88,7 @@ Code example for Blaker's exact method:\
Code example for Clopper-pearson:\
`binconf(x=<count of successes> , n=<Total>,method="exact",alpha=0.05)`

**The {RBesT} package** produces CIs using the Clopper-Pearson method. In this example (x=36 and n=154), the results match the cardx package. However, as described below, there are 2 cases where the results using RBesT package do not match cardx or Hmisc.
**The {RBesT} package (Prior to Version 1.8-0)** produces CIs using the Clopper-Pearson method. In this example (x=36 and n=154), the results match the cardx package. However, as described below, there are 2 cases where the results using RBesT package do not match cardx or Hmisc.

1) x = 0 (0% responders), in which case the lower limit does not match.
2) x = n (100% responders), in which case the upper limit does not match.
Expand All @@ -101,13 +101,12 @@ RBesT equations are:\
pLow \<- qbeta(Low, r + (r == 0), n - r + 1)\
pHigh \<- qbeta(High, r + 1, n - r + ((n - r) == 0))

If the equations were updated as follows then it would match Hmisc intervals:\
In Version 1.8-0 onwards the equations were updated as follows, which then match the Hmisc intervals:\
pLow \<- qbeta(Low, r, n - r + 1)\
pHigh \<- qbeta(High, r + 1, n - r)

`BinaryExactCI(x=<count of successes> , n=<Total>,alpha=0.05)`

It is currently unclear why the RBesT script has the logical conditions (r==0) and ((n-r)==0. Therefore, we currently do not recommend using this package and suggest cardx or Hmisc is used instead. For updates about this, see the [issue](https://github.com/Novartis/RBesT/issues/21)

**The {ExactCIdiff} package** produces CIs for two dependent proportions (matched pairs) and two independent proportions (unmatched pairs).

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