-
Notifications
You must be signed in to change notification settings - Fork 13
Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
May2024 - new files for the IQB workshop (#32)
* eliminated one variable in the final cell * added an exercise for the workshop and homework * starting a notebook on small molecules * first draft of the search for trypsin ligands * second image for the EC_class_ligands_search notebook * first image for the EC_class_ligands_search notebook * latest update with Jessica's suggested changes * a ligand file for the EC_Class notebook * images for the new notebooks * first attempt at ligand modification * optimize in 3D and print 3D sdf files * ligand 13U and 3 modified ligands in 3D * Exploring AllChem MMFF * changed the ligand to be used in the rdkit notebook * fully functional notebook with glucose and ATP test cases * restarted notebooks and cleared all outputs * restarted and cleared all output * Adds notebook to TOC, adds missing image --------- Co-authored-by: Jessica Nash <[email protected]>
- Loading branch information
Showing
15 changed files
with
2,876 additions
and
0 deletions.
There are no files selected for viewing
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
357 changes: 357 additions & 0 deletions
357
biochemist-python/chapters/EC_class_ligands_search.ipynb
Large diffs are not rendered by default.
Oops, something went wrong.
1,663 changes: 1,663 additions & 0 deletions
1,663
biochemist-python/chapters/Modifying_Ligands_with_rdkit.ipynb
Large diffs are not rendered by default.
Oops, something went wrong.
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,70 @@ | ||
{ | ||
"cells": [ | ||
{ | ||
"cell_type": "markdown", | ||
"id": "739f4a0d-a082-417a-a983-225798383b06", | ||
"metadata": {}, | ||
"source": [ | ||
"# Viewing Small Molecules in iCN3D\n", | ||
"\n", | ||
"While most people use iCN3D to view proteins and other macromolecular structures, it can also be used to explore small molecules of interest. The simplest way to do this is to find the small molecule on [PubChem](https://pubchem.ncbi.nlm.nih.gov/), capture its unique identifier and modify the iCN3D code we have used so far, replacing `mmdbid` or `pdbid` with `cid`.\n", | ||
"\n", | ||
"Here is the [PubChem Search Page for ATP](https://pubchem.ncbi.nlm.nih.gov/) page which contains 231 compounds. \n", | ||
"![ATP Search Results](images/PubChem_ATP_231.png \"ATP Search Results\")\n", | ||
"\n", | ||
"Explore the page to find the line that says, **Compound CID: 644208**. The number **644208** is the critical piece of information. If PubChem contains a 3D version of this molecule, you can view it in iCN3D.\n" | ||
] | ||
}, | ||
{ | ||
"cell_type": "code", | ||
"execution_count": 1, | ||
"id": "ef33b2c7-1613-430f-8b75-b954186115c6", | ||
"metadata": {}, | ||
"outputs": [ | ||
{ | ||
"data": { | ||
"text/plain": [ | ||
"'/Users/pac8612/Desktop/python-scripting-biochemistry/biochemist-python/chapters'" | ||
] | ||
}, | ||
"execution_count": 1, | ||
"metadata": {}, | ||
"output_type": "execute_result" | ||
} | ||
], | ||
"source": [ | ||
"import os\n", | ||
"os.getcwd()" | ||
] | ||
}, | ||
{ | ||
"cell_type": "code", | ||
"execution_count": null, | ||
"id": "0f72f8f2-d478-4c46-a3cc-0a1508d310f1", | ||
"metadata": {}, | ||
"outputs": [], | ||
"source": [] | ||
} | ||
], | ||
"metadata": { | ||
"kernelspec": { | ||
"display_name": "Python 3", | ||
"language": "python", | ||
"name": "python3" | ||
}, | ||
"language_info": { | ||
"codemirror_mode": { | ||
"name": "ipython", | ||
"version": 3 | ||
}, | ||
"file_extension": ".py", | ||
"mimetype": "text/x-python", | ||
"name": "python", | ||
"nbconvert_exporter": "python", | ||
"pygments_lexer": "ipython3", | ||
"version": "3.8.8" | ||
} | ||
}, | ||
"nbformat": 4, | ||
"nbformat_minor": 5 | ||
} |
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,138 @@ | ||
|
||
RDKit 3D | ||
|
||
65 67 0 0 0 0 0 0 0 0999 V2000 | ||
6.9596 1.4301 1.2036 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
6.4999 -0.0268 1.1959 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
6.1183 -0.5709 -0.1846 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.6568 -0.3674 -0.5905 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.3589 0.9126 -1.3992 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.7820 2.2540 -0.7672 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.5762 2.3749 0.7433 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.8777 2.4575 1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
2.9599 0.8866 -1.8622 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1.9383 1.1995 -0.8522 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.5528 1.0066 -1.4871 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.0857 1.8523 -2.2550 O 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.1239 -0.1567 -1.1819 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.4718 -1.3715 -0.6557 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.3511 -2.4843 -1.2853 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-1.7402 -1.8688 -1.3802 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-1.4596 -0.4001 -1.7207 C 0 0 1 0 0 0 0 0 0 0 0 0 | ||
-2.5551 0.4934 -1.1063 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-2.3764 1.2550 -0.1614 O 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-3.7940 0.3245 -1.7045 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-4.9755 0.9762 -1.1877 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.5746 0.1875 -0.0503 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.3690 0.6025 1.2748 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.8718 -0.1457 2.3397 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.5689 -1.3300 2.0861 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.7847 -1.7537 0.7723 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.2888 -0.9970 -0.2925 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.0621 -2.1418 3.2266 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.9770 -3.4349 3.2443 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.6178 -1.5325 4.3102 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.7419 1.5356 1.9677 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.4485 1.6834 0.2574 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.7042 -0.2001 1.9277 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.3532 -0.6264 1.5399 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
6.2757 -1.6574 -0.1357 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
6.8033 -0.2075 -0.9601 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.0107 -0.4568 0.2903 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.3868 -1.2210 -1.2297 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.9463 0.8266 -2.3238 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.2270 3.0639 -1.2597 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.8237 2.4578 -1.0340 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
3.9570 1.5651 1.1397 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.0080 3.2923 0.9469 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
6.3078 3.4583 1.4052 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.6323 2.3774 2.6061 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
2.8420 1.5539 -2.6294 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1.9974 2.2415 -0.5218 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
2.0337 0.5671 0.0310 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1.5313 -1.4596 -0.9140 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.3583 -1.3580 0.4355 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.0233 -2.7036 -2.2942 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.3312 -3.4117 -0.7042 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-2.3583 -2.3591 -2.1396 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-2.2528 -1.9676 -0.4127 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-1.4273 -0.2442 -2.8039 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-3.9176 -0.4046 -2.3909 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-4.7246 1.9951 -0.8705 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.6975 1.0564 -2.0075 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-4.7947 1.5059 1.4823 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.6789 0.1740 3.3599 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.3480 -2.6602 0.5694 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.4601 -1.3370 -1.3114 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.5006 -3.7787 2.4057 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-8.0695 -2.2082 4.9205 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-8.1987 -0.7238 4.1176 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1 2 1 0 | ||
2 3 1 0 | ||
3 4 1 0 | ||
4 5 1 0 | ||
5 6 1 0 | ||
6 7 1 0 | ||
7 8 1 0 | ||
5 9 1 0 | ||
9 10 1 0 | ||
10 11 1 0 | ||
11 12 2 0 | ||
11 13 1 0 | ||
13 14 1 0 | ||
14 15 1 0 | ||
15 16 1 0 | ||
16 17 1 0 | ||
17 18 1 0 | ||
18 19 2 0 | ||
18 20 1 0 | ||
20 21 1 0 | ||
21 22 1 0 | ||
22 23 2 0 | ||
23 24 1 0 | ||
24 25 2 0 | ||
25 26 1 0 | ||
26 27 2 0 | ||
25 28 1 0 | ||
28 29 2 3 | ||
28 30 1 0 | ||
8 1 1 0 | ||
17 13 1 0 | ||
27 22 1 0 | ||
1 31 1 0 | ||
1 32 1 0 | ||
2 33 1 0 | ||
2 34 1 0 | ||
3 35 1 0 | ||
3 36 1 0 | ||
4 37 1 0 | ||
4 38 1 0 | ||
5 39 1 0 | ||
6 40 1 0 | ||
6 41 1 0 | ||
7 42 1 0 | ||
7 43 1 0 | ||
8 44 1 0 | ||
8 45 1 0 | ||
9 46 1 0 | ||
10 47 1 0 | ||
10 48 1 0 | ||
14 49 1 0 | ||
14 50 1 0 | ||
15 51 1 0 | ||
15 52 1 0 | ||
16 53 1 0 | ||
16 54 1 0 | ||
17 55 1 6 | ||
20 56 1 0 | ||
21 57 1 0 | ||
21 58 1 0 | ||
23 59 1 0 | ||
24 60 1 0 | ||
26 61 1 0 | ||
27 62 1 0 | ||
29 63 1 0 | ||
30 64 1 0 | ||
30 65 1 0 | ||
M END | ||
|
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,156 @@ | ||
|
||
RDKit 3D | ||
|
||
74 76 0 0 0 0 0 0 0 0999 V2000 | ||
7.9438 -1.7628 1.6641 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.3325 -2.7439 0.6656 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.8011 -2.6913 0.5581 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.2581 -1.7295 -0.5007 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.8616 -0.3278 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.9450 0.3826 0.8431 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.3496 0.3418 0.2390 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
8.3675 -0.4053 1.0977 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.4792 0.4496 -1.1805 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
3.5540 1.5610 -0.9066 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
2.1463 1.0966 -0.4792 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1.7323 -0.0570 -0.6156 O 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1.3355 2.0690 0.0745 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1.6741 3.4526 0.3566 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.3634 4.0919 0.7959 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.4240 2.9198 1.3806 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.0305 1.7560 0.4701 C 0 0 1 0 0 0 0 0 0 0 0 0 | ||
-0.9700 1.6927 -0.7555 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.7540 2.2972 -1.8036 O 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-2.1294 0.9788 -0.5294 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-3.0680 0.7418 -1.6007 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-4.4525 0.5247 -1.0492 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.0154 -0.7610 -0.9895 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.3138 -0.9792 -0.4817 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.8703 -2.3939 -0.3975 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.0923 -3.2303 0.6251 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.8984 -3.0870 -1.7629 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.0287 0.1417 -0.0209 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.4658 1.4236 -0.0503 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.1862 1.6136 -0.5641 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-8.4151 0.0540 0.4989 C 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-9.4003 -0.3270 -0.2474 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-8.6723 0.3980 1.7894 N 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.2745 -1.6298 2.5204 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
8.8504 -2.2249 2.0782 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.5801 -3.7491 1.0306 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.8101 -2.6565 -0.3164 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.3385 -2.5097 1.5354 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.4799 -3.6983 0.2581 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
4.3488 -2.1858 -0.9188 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.9576 -1.6702 -1.3426 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
3.9889 -0.4635 0.6597 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.6675 1.4341 0.9894 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.9365 -0.0299 1.8571 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.3501 -0.0790 -0.7719 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
7.7092 1.3734 0.1163 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
9.2807 -0.5364 0.5050 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
8.6518 0.2347 1.9422 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
5.3111 0.8034 -1.6477 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
3.4252 2.1300 -1.8354 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
3.9783 2.2340 -0.1573 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
2.4064 3.4592 1.1710 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
2.1093 3.9359 -0.5213 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.1649 4.4999 -0.0730 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
0.5119 4.9041 1.5122 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.0788 2.7260 2.4040 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-1.4993 3.1187 1.4108 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-0.0600 0.7966 0.9988 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-2.1606 0.3435 0.2580 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-3.0731 1.5809 -2.3055 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-2.7204 -0.1384 -2.1534 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-4.4301 -1.6042 -1.3516 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.9053 -2.3696 -0.0448 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.5570 -4.2161 0.7472 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.0485 -3.3843 0.3273 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-6.0929 -2.7403 1.6066 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.4420 -2.4821 -2.4967 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-5.8911 -3.2681 -2.1536 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.4016 -4.0575 -1.6905 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.0335 2.2770 0.3107 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-4.7627 2.6167 -0.5956 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-9.0692 -0.5246 -1.1986 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-7.9433 0.1931 2.4597 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
-9.5898 0.0660 2.0767 H 0 0 0 0 0 0 0 0 0 0 0 0 | ||
1 2 1 0 | ||
2 3 1 0 | ||
3 4 1 0 | ||
4 5 1 0 | ||
5 6 1 0 | ||
6 7 1 0 | ||
7 8 1 0 | ||
5 9 1 0 | ||
9 10 1 0 | ||
10 11 1 0 | ||
11 12 2 0 | ||
11 13 1 0 | ||
13 14 1 0 | ||
14 15 1 0 | ||
15 16 1 0 | ||
16 17 1 0 | ||
17 18 1 0 | ||
18 19 2 0 | ||
18 20 1 0 | ||
20 21 1 0 | ||
21 22 1 0 | ||
22 23 2 0 | ||
23 24 1 0 | ||
24 25 1 0 | ||
25 26 1 0 | ||
25 27 1 0 | ||
24 28 2 0 | ||
28 29 1 0 | ||
29 30 2 0 | ||
28 31 1 0 | ||
31 32 2 3 | ||
31 33 1 0 | ||
8 1 1 0 | ||
17 13 1 0 | ||
30 22 1 0 | ||
1 34 1 0 | ||
1 35 1 0 | ||
2 36 1 0 | ||
2 37 1 0 | ||
3 38 1 0 | ||
3 39 1 0 | ||
4 40 1 0 | ||
4 41 1 0 | ||
5 42 1 0 | ||
6 43 1 0 | ||
6 44 1 0 | ||
7 45 1 0 | ||
7 46 1 0 | ||
8 47 1 0 | ||
8 48 1 0 | ||
9 49 1 0 | ||
10 50 1 0 | ||
10 51 1 0 | ||
14 52 1 0 | ||
14 53 1 0 | ||
15 54 1 0 | ||
15 55 1 0 | ||
16 56 1 0 | ||
16 57 1 0 | ||
17 58 1 1 | ||
20 59 1 0 | ||
21 60 1 0 | ||
21 61 1 0 | ||
23 62 1 0 | ||
25 63 1 0 | ||
26 64 1 0 | ||
26 65 1 0 | ||
26 66 1 0 | ||
27 67 1 0 | ||
27 68 1 0 | ||
27 69 1 0 | ||
29 70 1 0 | ||
30 71 1 0 | ||
32 72 1 0 | ||
33 73 1 0 | ||
33 74 1 0 | ||
M END | ||
|
Oops, something went wrong.