TwoSampleMR 0.5.10

• Added local options for clump_data
• Fixed bugs with mv_extract_exposures_local

TwoSampleMR 0.5.9

• Fixed a minor issue in dat_to_RadialMR()
• Minor improvements to make_dat() default arguments and helpfile
• Minor improvements to package tests
• Amendments to GitHub Actions workflows
• Updated several URLs which had changed

TwoSampleMR 0.5.8

• Improved speed of harmonisation using data.table functions (thanks @nicksunderland)
• Updated URL to R-CMD-check README badge
• Updates to GitHub Actions workflows

And some other minor updates to the documentation and pkgdown site.

TwoSampleMR 0.5.7

• Move car package to Suggests to allow TwoSampleMR to install on R between versions 4.0.0 and 4.1.0
• In DESCRIPTION use pkgdepends syntax for MRPRESSO package due its repository name being different to the package name so that installing TwoSampleMR under pak continues to work
• Various minor code tweaks to fix 2 R CMD check notes
• Add Cairo package to Suggests list (thanks @hdraisma)
• Fix error in outcome data vignette (thanks @hdraisma)
• Some p-values that should have been ~0 were being stored as 1 in the elasticsearch database. This has now been fixed and those datasets have been clumped again to re-define the tophits. A full list of affected GWAS is available here: https://github.com/MRCIEU/opengwas-infpval-fix
• Updated steiger filtering to use effective sample size for case control studies (thanks to @niekverw)
• Fixed issue with tri-allelic SNPs in harmonisation. Credit to Clare Horscroft (@chorscroft) for spotting the error and fixing
• Fixed an issue with experimental version of local multivariable MR method. Credit to Mischa Lundberg (@MischaLundberg).
• Catching edge cases for retrieving sample size meta data
• Updating default rsq estimation function to use beta and standard error instead of p-value, should improve numerical stability
• Allow chr and pos to be read in from local summary data files
• When reading in local data without p-values, editing the inferred p-value method to be two-sided
• All images in the vignettes (and hence also in the rendered pkgdown website) now have accompanying alt text descriptions
• The accompanying website for the package now uses Bootstrap 5, which means a search facility is enabled
• The NAMESPACE has been simplified, hence the package load time is very slightly improved

Various minor updates

v0.5.6

bumping version

WellcomeOpen

Release to create a DOI for Wellcome Open publication