Repository Structure--------------------------------------

This repository contains folders corresponding to the simulation figures in the main text of our paper with the title: "Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proo-of-Concet Model Development for Remdesivir"
Paper's link: https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2686

Description of Folders------------------------------------

The Fig2 folder includes the code and data for generating Figure 2 in the main maniscript.

 Figure 2. "Disease model calibration."
 

The Fig4a folder includes the code and data for generating Figure 4a in the main maniscript.

 Figure 4a. "Calibrating of the PK model."
 

The Fig4b folder includes the code and data for generating Figure 4b in the main maniscript.

 Figure 4b. "Intracellular nucleoside triphosphate (TP) concentration following in vitro incubation with the parent drug remdesivir"
 

The Fig5 folder includes the code and data for generating Figure 5 in the main maniscript.

 Figure 5. "Calibrating (a,b) and validating (c,d) the model for the primary endpoint (time to recovery) used in the remdesivir trial"
 

------------------------------------------------------------------------------

The "readme" file and codes are written by:
Mohammadreza Samieegohar