feat: add drugAdministration characteristic

input/fsh/eligibility-criteria/ext-dosage.fsh

@@ -0,0 +1,12 @@
+Extension: CharacteristicDosage
+Id: ext-characteristic-dosage
+Title: "Characteristic Dosage"
+Description: "Adds Dosage type to characteristic"
+* value[x] 1..1
+* value[x] only Dosage
+* valueDosage
+  * extension contains DosageCondition named condition 0..1 MS
+  * route MS
+  * route from $vs-route-codes (required)
+  * timing 1..1
+  * doseAndRate 1..*

input/fsh/eligibility-criteria/p-eligibility-criteria.fsh

@@ -37,7 +37,8 @@ RuleSet: characteristic-definition
   procedure 0..* and
   assessmentScale 0..* and
   device 0..* and
-  observation 0..*
+  observation 0..* and
+  drugAdministration 0..*
 * characteristic.definitionByTypeAndValue
   * value[x] only Quantity or Range or CodeableConcept // 22-11-02 @glichtner: required, otherwise "* valueCodeableConcept.coding 1..1 MS" leads to FHIR validator error
 * characteristic[condition].definitionByTypeAndValue
@@ -75,4 +76,8 @@ RuleSet: characteristic-definition
   * valueCodeableConcept from $vs-devices (required)
 * characteristic[observation].definitionByTypeAndValue
   * type from vs-observations (required)
-  //* value[x] only Range or Quantity // 22-07-22 @glichtner: removed due to sushi error
+  //* value[x] only Range or Quantity // 22-07-22 @glichtner: removed due to sushi error
+* characteristic[drugAdministration].definitionByTypeAndValue
+  * type = $sct#432102000 "Administration of substance (procedure)"
+  * valueCodeableConcept from vs-drugs (required)
+  * extension contains CharacteristicDosage named dosage 0..*

input/fsh/eligibility-criteria/p-recommendation-eligibility-criteria.fsh

@@ -37,4 +37,35 @@ Description: "Example of a population element of a PICO construct that evidence
       * characteristic[+].definitionByCombination
         * code = #all-of
         * characteristic[condition][+].definitionByTypeAndValue
-          * valueCodeableConcept = $sct#840539006 "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"  
+          * valueCodeableConcept = $sct#840539006 "Disease caused by Severe acute respiratory syndrome coronavirus 2 (disorder)"
+
+Instance: ExampleRecommendationEligibilityCriteriaDrugs
+InstanceOf: recommendation-eligibility-criteria
+Usage: #example
+Title: "Example Recommendation Eligibility Criteria"
+Description: "Example of a population element of a PICO construct that evidence is about."
+* insert canonical-url(example/recommendation-eligibility-criteria)
+* status = #active
+* name = "PopulationExample"
+* characteristic[+].definitionByCombination
+  * code = #all-of
+  * characteristic[+].definitionByCombination
+    * code = #all-of
+    * characteristic[drugAdministration].definitionByTypeAndValue
+      * valueCodeableConcept = $sct#372877000 "Heparin (substance)"
+      * extension[dosage].valueDosage
+        * extension[condition]
+          * extension[type].valueCodeableConcept = $loinc#29463-7 "Body weight"
+          * extension[value].valueRange.high = 70 'kg' "kg"
+        * route = $sct#26643006 "Oral route"
+        * timing
+          * repeat
+            * count = 10
+            * duration = 10
+            * durationUnit = $ucum#d "d"
+            * frequency = 1
+            * period = 1
+            * periodUnit = $ucum#d "d"
+        * doseAndRate
+          * doseQuantity = 6 'mg' "mg"
+          * rateQuantity = 1 '/d' "/d"

input/fsh/eligibility-criteria/vs-drugs.fsh

@@ -0,0 +1,9 @@
+// Author: Gregor Lichtner, @glichtner
+ValueSet: Drugs
+Id: vs-drugs
+Title: "Drugs"
+Description: "Drugs"
+* include codes from system $sct where concept is-a $sct#105590001 "Substance (substance)"
+* include codes from system $sct where concept is-a $sct#763158003 "Medicinal product (product)"
+* include codes from system $atc
+* include codes from system $atcde