diff --git a/.meta.toml b/.meta.toml
index d01daeef97..45294331e3 100644
--- a/.meta.toml
+++ b/.meta.toml
@@ -35,6 +35,7 @@ testenv-deps = [
     "# universal2 mode instead of architecture-specific. These dependencies",
     "# must be installed separately, zc.buildout is incompatible with the",
     "# universal2 mode and cannot install them itself.",
+    "universal2: -c {toxinidir}/constraints.txt",
     "universal2: zope.interface",
     "universal2: zope.security",
     "universal2: zope.container",
diff --git a/constraints.txt b/constraints.txt
index 51ed120c5a..8b182d23f1 100644
--- a/constraints.txt
+++ b/constraints.txt
@@ -1,7 +1,7 @@
-AccessControl==6.3
-Acquisition==5.2
+AccessControl==7.0
+Acquisition==6.0
 AuthEncoding==5.0
-BTrees==5.2
+BTrees==6.0
 Chameleon==4.4.4; python_version == '3.8'
 Chameleon==4.4.4; python_version > '3.8'
 DateTime==5.5
@@ -10,7 +10,7 @@ ExtensionClass==5.1
 MultiMapping==5.0
 Paste==3.10.1
 PasteDeploy==3.1.0
-Persistence==4.1
+Persistence==5.0
 RestrictedPython==7.1
 WSGIProxy2==0.5.1
 WebOb==1.8.7
@@ -21,7 +21,7 @@ Zope2==4.0
 beautifulsoup4==4.12.3
 cffi==1.16.0
 multipart==0.2.4
-persistent==5.2
+persistent==6.0
 pycparser==2.22
 python-gettext==5.0
 pytz==2024.1
@@ -34,7 +34,7 @@ z3c.pt==4.3
 zExceptions==5.0
 zc.lockfile==3.0.post1
 zc.recipe.egg==2.0.7
-zodbpickle==3.3
+zodbpickle==4.0
 zope.annotation==5.0
 zope.browser==3.0
 zope.browsermenu==5.0
@@ -66,7 +66,7 @@ zope.proxy==5.2
 zope.ptresource==5.0
 zope.publisher==7.0
 zope.schema==7.0.1
-zope.security==6.2
+zope.security==7.0
 zope.sequencesort==5.0
 zope.site==5.0
 zope.size==5.0
diff --git a/requirements-full.txt b/requirements-full.txt
index df051186e5..05daad6d43 100644
--- a/requirements-full.txt
+++ b/requirements-full.txt
@@ -1,8 +1,8 @@
 -e git+https://github.com/zopefoundation/Zope.git@master#egg=Zope
-AccessControl==6.3
-Acquisition==5.2
+AccessControl==7.0
+Acquisition==6.0
 AuthEncoding==5.0
-BTrees==5.2
+BTrees==6.0
 Chameleon==4.4.4; python_version == '3.8'
 Chameleon==4.4.4; python_version > '3.8'
 DateTime==5.5
@@ -11,7 +11,7 @@ ExtensionClass==5.1
 MultiMapping==5.0
 Paste==3.10.1
 PasteDeploy==3.1.0
-Persistence==4.1
+Persistence==5.0
 RestrictedPython==7.1
 WSGIProxy2==0.5.1
 WebOb==1.8.7
@@ -22,7 +22,7 @@ Zope2==4.0
 beautifulsoup4==4.12.3
 cffi==1.16.0
 multipart==0.2.4
-persistent==5.2
+persistent==6.0
 pycparser==2.22
 python-gettext==5.0
 pytz==2024.1
@@ -35,7 +35,7 @@ z3c.pt==4.3
 zExceptions==5.0
 zc.lockfile==3.0.post1
 zc.recipe.egg==2.0.7
-zodbpickle==3.3
+zodbpickle==4.0
 zope.annotation==5.0
 zope.browser==3.0
 zope.browsermenu==5.0
@@ -67,7 +67,7 @@ zope.proxy==5.2
 zope.ptresource==5.0
 zope.publisher==7.0
 zope.schema==7.0.1
-zope.security==6.2
+zope.security==7.0
 zope.sequencesort==5.0
 zope.site==5.0
 zope.size==5.0
diff --git a/tox.ini b/tox.ini
index 67a5283340..27ff40a780 100644
--- a/tox.ini
+++ b/tox.ini
@@ -25,6 +25,7 @@ deps =
     # universal2 mode instead of architecture-specific. These dependencies
     # must be installed separately, zc.buildout is incompatible with the
     # universal2 mode and cannot install them itself.
+    universal2: -c {toxinidir}/constraints.txt
     universal2: zope.interface
     universal2: zope.security
     universal2: zope.container
diff --git a/versions-prod.cfg b/versions-prod.cfg
index 56edc8103c..f630e925b7 100644
--- a/versions-prod.cfg
+++ b/versions-prod.cfg
@@ -4,10 +4,10 @@
 [versions]
 Zope =
 Zope2 = 4.0
-AccessControl = 6.3
-Acquisition = 5.2
+AccessControl = 7.0
+Acquisition = 6.0
 AuthEncoding = 5.0
-BTrees = 5.2
+BTrees = 6.0
 Chameleon = 4.4.4
 DateTime = 5.5
 DocumentTemplate = 4.6
@@ -15,7 +15,7 @@ ExtensionClass = 5.1
 MultiMapping = 5.0
 Paste = 3.10.1
 PasteDeploy = 3.1.0
-Persistence = 4.1
+Persistence = 5.0
 RestrictedPython = 7.1
 WebTest = 3.0.0
 WSGIProxy2 = 0.5.1
@@ -25,7 +25,7 @@ ZODB = 6.0
 beautifulsoup4 = 4.12.3
 cffi = 1.16.0
 multipart = 0.2.4
-persistent = 5.2
+persistent = 6.0
 pycparser = 2.22
 python-gettext = 5.0
 pytz = 2024.1
@@ -38,7 +38,7 @@ z3c.pt = 4.3
 zExceptions = 5.0
 zc.lockfile = 3.0.post1
 zc.recipe.egg = 2.0.7
-zodbpickle = 3.3
+zodbpickle = 4.0
 zope.annotation = 5.0
 zope.browser = 3.0
 zope.browsermenu = 5.0
@@ -70,7 +70,7 @@ zope.proxy = 5.2
 zope.ptresource = 5.0
 zope.publisher = 7.0
 zope.schema = 7.0.1
-zope.security = 6.2
+zope.security = 7.0
 zope.sequencesort = 5.0
 zope.site = 5.0
 zope.size = 5.0