diff --git a/samples/sensor/bme280/boards/lp_em_cc2340r5.overlay b/samples/sensor/bme280/boards/lp_em_cc2340r5.overlay
new file mode 100644
index 000000000000..1a18dcbcfa7a
--- /dev/null
+++ b/samples/sensor/bme280/boards/lp_em_cc2340r5.overlay
@@ -0,0 +1,13 @@
+/*
+ * Copyright (c) 2024 Baylibre, SAS
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+&i2c0 {
+	bme280@76 {
+		compatible = "bosch,bme280";
+		reg = <0x76>;
+		status = "okay";
+	};
+};