-
Notifications
You must be signed in to change notification settings - Fork 0
/
Copy path目录.html
930 lines (786 loc) · 32.5 KB
/
目录.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
<!DOCTYPE html>
<html lang="en">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<meta charset="utf-8">
<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
<title>目录 | 纵向与事件时间数据的联合模型及其在 R 中的应用</title>
<meta name="author" content="Wang Zhen">
<meta name="description" content="介绍 1.1 目标 1.2 激励性研究 1.2.1 原发性胆汁性肝硬化 (PBC) 数据 1.2.2 艾滋病数据 1.2.3 肝硬化数据 1.2.4 主动脉瓣数据 1.2.5 其他应用 1.3 纵向研究中的推断目标 1.3.1 协变量对单一结果的效应 1.3.2 结果之间的关联 1.3.3 复杂的假设检验 1.3.4 预测 1.3.5 隐式结果的统计分析 1.4 概述 纵向数据分析...">
<meta name="generator" content="bookdown 0.38 with bs4_book()">
<meta property="og:title" content="目录 | 纵向与事件时间数据的联合模型及其在 R 中的应用">
<meta property="og:type" content="book">
<meta property="og:description" content="介绍 1.1 目标 1.2 激励性研究 1.2.1 原发性胆汁性肝硬化 (PBC) 数据 1.2.2 艾滋病数据 1.2.3 肝硬化数据 1.2.4 主动脉瓣数据 1.2.5 其他应用 1.3 纵向研究中的推断目标 1.3.1 协变量对单一结果的效应 1.3.2 结果之间的关联 1.3.3 复杂的假设检验 1.3.4 预测 1.3.5 隐式结果的统计分析 1.4 概述 纵向数据分析...">
<meta name="twitter:card" content="summary">
<meta name="twitter:title" content="目录 | 纵向与事件时间数据的联合模型及其在 R 中的应用">
<meta name="twitter:description" content="介绍 1.1 目标 1.2 激励性研究 1.2.1 原发性胆汁性肝硬化 (PBC) 数据 1.2.2 艾滋病数据 1.2.3 肝硬化数据 1.2.4 主动脉瓣数据 1.2.5 其他应用 1.3 纵向研究中的推断目标 1.3.1 协变量对单一结果的效应 1.3.2 结果之间的关联 1.3.3 复杂的假设检验 1.3.4 预测 1.3.5 隐式结果的统计分析 1.4 概述 纵向数据分析...">
<!-- JS --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://kit.fontawesome.com/6ecbd6c532.js" crossorigin="anonymous"></script><script src="libs/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
<link href="libs/bootstrap-4.6.0/bootstrap.min.css" rel="stylesheet">
<script src="libs/bootstrap-4.6.0/bootstrap.bundle.min.js"></script><script src="libs/bs3compat-0.7.0/transition.js"></script><script src="libs/bs3compat-0.7.0/tabs.js"></script><script src="libs/bs3compat-0.7.0/bs3compat.js"></script><link href="libs/bs4_book-1.0.0/bs4_book.css" rel="stylesheet">
<script src="libs/bs4_book-1.0.0/bs4_book.js"></script><script>
/* ========================================================================
* Bootstrap: transition.js v3.3.7
* http://getbootstrap.com/javascript/#transitions
* ========================================================================
* Copyright 2011-2016 Twitter, Inc.
* Licensed under MIT (https://github.com/twbs/bootstrap/blob/master/LICENSE)
* ======================================================================== */
+function ($) {
'use strict';
// CSS TRANSITION SUPPORT (Shoutout: http://www.modernizr.com/)
// ============================================================
function transitionEnd() {
var el = document.createElement('bootstrap')
var transEndEventNames = {
WebkitTransition : 'webkitTransitionEnd',
MozTransition : 'transitionend',
OTransition : 'oTransitionEnd otransitionend',
transition : 'transitionend'
}
for (var name in transEndEventNames) {
if (el.style[name] !== undefined) {
return { end: transEndEventNames[name] }
}
}
return false // explicit for ie8 ( ._.)
}
// http://blog.alexmaccaw.com/css-transitions
$.fn.emulateTransitionEnd = function (duration) {
var called = false
var $el = this
$(this).one('bsTransitionEnd', function () { called = true })
var callback = function () { if (!called) $($el).trigger($.support.transition.end) }
setTimeout(callback, duration)
return this
}
$(function () {
$.support.transition = transitionEnd()
if (!$.support.transition) return
$.event.special.bsTransitionEnd = {
bindType: $.support.transition.end,
delegateType: $.support.transition.end,
handle: function (e) {
if ($(e.target).is(this)) return e.handleObj.handler.apply(this, arguments)
}
}
})
}(jQuery);
</script><script>
/* ========================================================================
* Bootstrap: collapse.js v3.3.7
* http://getbootstrap.com/javascript/#collapse
* ========================================================================
* Copyright 2011-2016 Twitter, Inc.
* Licensed under MIT (https://github.com/twbs/bootstrap/blob/master/LICENSE)
* ======================================================================== */
/* jshint latedef: false */
+function ($) {
'use strict';
// COLLAPSE PUBLIC CLASS DEFINITION
// ================================
var Collapse = function (element, options) {
this.$element = $(element)
this.options = $.extend({}, Collapse.DEFAULTS, options)
this.$trigger = $('[data-toggle="collapse"][href="#' + element.id + '"],' +
'[data-toggle="collapse"][data-target="#' + element.id + '"]')
this.transitioning = null
if (this.options.parent) {
this.$parent = this.getParent()
} else {
this.addAriaAndCollapsedClass(this.$element, this.$trigger)
}
if (this.options.toggle) this.toggle()
}
Collapse.VERSION = '3.3.7'
Collapse.TRANSITION_DURATION = 350
Collapse.DEFAULTS = {
toggle: true
}
Collapse.prototype.dimension = function () {
var hasWidth = this.$element.hasClass('width')
return hasWidth ? 'width' : 'height'
}
Collapse.prototype.show = function () {
if (this.transitioning || this.$element.hasClass('in')) return
var activesData
var actives = this.$parent && this.$parent.children('.panel').children('.in, .collapsing')
if (actives && actives.length) {
activesData = actives.data('bs.collapse')
if (activesData && activesData.transitioning) return
}
var startEvent = $.Event('show.bs.collapse')
this.$element.trigger(startEvent)
if (startEvent.isDefaultPrevented()) return
if (actives && actives.length) {
Plugin.call(actives, 'hide')
activesData || actives.data('bs.collapse', null)
}
var dimension = this.dimension()
this.$element
.removeClass('collapse')
.addClass('collapsing')[dimension](0)
.attr('aria-expanded', true)
this.$trigger
.removeClass('collapsed')
.attr('aria-expanded', true)
this.transitioning = 1
var complete = function () {
this.$element
.removeClass('collapsing')
.addClass('collapse in')[dimension]('')
this.transitioning = 0
this.$element
.trigger('shown.bs.collapse')
}
if (!$.support.transition) return complete.call(this)
var scrollSize = $.camelCase(['scroll', dimension].join('-'))
this.$element
.one('bsTransitionEnd', $.proxy(complete, this))
.emulateTransitionEnd(Collapse.TRANSITION_DURATION)[dimension](this.$element[0][scrollSize])
}
Collapse.prototype.hide = function () {
if (this.transitioning || !this.$element.hasClass('in')) return
var startEvent = $.Event('hide.bs.collapse')
this.$element.trigger(startEvent)
if (startEvent.isDefaultPrevented()) return
var dimension = this.dimension()
this.$element[dimension](this.$element[dimension]())[0].offsetHeight
this.$element
.addClass('collapsing')
.removeClass('collapse in')
.attr('aria-expanded', false)
this.$trigger
.addClass('collapsed')
.attr('aria-expanded', false)
this.transitioning = 1
var complete = function () {
this.transitioning = 0
this.$element
.removeClass('collapsing')
.addClass('collapse')
.trigger('hidden.bs.collapse')
}
if (!$.support.transition) return complete.call(this)
this.$element
[dimension](0)
.one('bsTransitionEnd', $.proxy(complete, this))
.emulateTransitionEnd(Collapse.TRANSITION_DURATION)
}
Collapse.prototype.toggle = function () {
this[this.$element.hasClass('in') ? 'hide' : 'show']()
}
Collapse.prototype.getParent = function () {
return $(this.options.parent)
.find('[data-toggle="collapse"][data-parent="' + this.options.parent + '"]')
.each($.proxy(function (i, element) {
var $element = $(element)
this.addAriaAndCollapsedClass(getTargetFromTrigger($element), $element)
}, this))
.end()
}
Collapse.prototype.addAriaAndCollapsedClass = function ($element, $trigger) {
var isOpen = $element.hasClass('in')
$element.attr('aria-expanded', isOpen)
$trigger
.toggleClass('collapsed', !isOpen)
.attr('aria-expanded', isOpen)
}
function getTargetFromTrigger($trigger) {
var href
var target = $trigger.attr('data-target')
|| (href = $trigger.attr('href')) && href.replace(/.*(?=#[^\s]+$)/, '') // strip for ie7
return $(target)
}
// COLLAPSE PLUGIN DEFINITION
// ==========================
function Plugin(option) {
return this.each(function () {
var $this = $(this)
var data = $this.data('bs.collapse')
var options = $.extend({}, Collapse.DEFAULTS, $this.data(), typeof option == 'object' && option)
if (!data && options.toggle && /show|hide/.test(option)) options.toggle = false
if (!data) $this.data('bs.collapse', (data = new Collapse(this, options)))
if (typeof option == 'string') data[option]()
})
}
var old = $.fn.collapse
$.fn.collapse = Plugin
$.fn.collapse.Constructor = Collapse
// COLLAPSE NO CONFLICT
// ====================
$.fn.collapse.noConflict = function () {
$.fn.collapse = old
return this
}
// COLLAPSE DATA-API
// =================
$(document).on('click.bs.collapse.data-api', '[data-toggle="collapse"]', function (e) {
var $this = $(this)
if (!$this.attr('data-target')) e.preventDefault()
var $target = getTargetFromTrigger($this)
var data = $target.data('bs.collapse')
var option = data ? 'toggle' : $this.data()
Plugin.call($target, option)
})
}(jQuery);
</script><script>
window.initializeCodeFolding = function(show) {
// handlers for show-all and hide all
$("#rmd-show-all-code").click(function() {
$('div.r-code-collapse').each(function() {
$(this).collapse('show');
});
});
$("#rmd-hide-all-code").click(function() {
$('div.r-code-collapse').each(function() {
$(this).collapse('hide');
});
});
// index for unique code element ids
var currentIndex = 1;
// select all R code blocks
var rCodeBlocks = $('pre.sourceCode, pre.r, pre.python, pre.bash, pre.sql, pre.cpp, pre.stan, pre.js');
rCodeBlocks.each(function() {
// create a collapsable div to wrap the code in
var div = $('<div class="collapse r-code-collapse"></div>');
if (show)
div.addClass('in');
var id = 'rcode-643E0F36' + currentIndex++;
div.attr('id', id);
$(this).before(div);
$(this).detach().appendTo(div);
// add a show code button right above
var showCodeText = $('<span>' + (show ? 'Hide' : 'Code') + '</span>');
var showCodeButton = $('<button type="button" class="btn btn-default btn-xs code-folding-btn pull-right"></button>');
showCodeButton.append(showCodeText);
showCodeButton
.attr('data-toggle', 'collapse')
.attr('data-target', '#' + id)
.attr('aria-expanded', show)
.attr('aria-controls', id);
var buttonRow = $('<div class="row"></div>');
var buttonCol = $('<div class="col-md-12"></div>');
buttonCol.append(showCodeButton);
buttonRow.append(buttonCol);
div.before(buttonRow);
// update state of button on show/hide
div.on('hidden.bs.collapse', function () {
showCodeText.text('Code');
});
div.on('show.bs.collapse', function () {
showCodeText.text('Hide');
});
});
}
</script><script>
/* ========================================================================
* Bootstrap: dropdown.js v3.3.7
* http://getbootstrap.com/javascript/#dropdowns
* ========================================================================
* Copyright 2011-2016 Twitter, Inc.
* Licensed under MIT (https://github.com/twbs/bootstrap/blob/master/LICENSE)
* ======================================================================== */
+function ($) {
'use strict';
// DROPDOWN CLASS DEFINITION
// =========================
var backdrop = '.dropdown-backdrop'
var toggle = '[data-toggle="dropdown"]'
var Dropdown = function (element) {
$(element).on('click.bs.dropdown', this.toggle)
}
Dropdown.VERSION = '3.3.7'
function getParent($this) {
var selector = $this.attr('data-target')
if (!selector) {
selector = $this.attr('href')
selector = selector && /#[A-Za-z]/.test(selector) && selector.replace(/.*(?=#[^\s]*$)/, '') // strip for ie7
}
var $parent = selector && $(selector)
return $parent && $parent.length ? $parent : $this.parent()
}
function clearMenus(e) {
if (e && e.which === 3) return
$(backdrop).remove()
$(toggle).each(function () {
var $this = $(this)
var $parent = getParent($this)
var relatedTarget = { relatedTarget: this }
if (!$parent.hasClass('open')) return
if (e && e.type == 'click' && /input|textarea/i.test(e.target.tagName) && $.contains($parent[0], e.target)) return
$parent.trigger(e = $.Event('hide.bs.dropdown', relatedTarget))
if (e.isDefaultPrevented()) return
$this.attr('aria-expanded', 'false')
$parent.removeClass('open').trigger($.Event('hidden.bs.dropdown', relatedTarget))
})
}
Dropdown.prototype.toggle = function (e) {
var $this = $(this)
if ($this.is('.disabled, :disabled')) return
var $parent = getParent($this)
var isActive = $parent.hasClass('open')
clearMenus()
if (!isActive) {
if ('ontouchstart' in document.documentElement && !$parent.closest('.navbar-nav').length) {
// if mobile we use a backdrop because click events don't delegate
$(document.createElement('div'))
.addClass('dropdown-backdrop')
.insertAfter($(this))
.on('click', clearMenus)
}
var relatedTarget = { relatedTarget: this }
$parent.trigger(e = $.Event('show.bs.dropdown', relatedTarget))
if (e.isDefaultPrevented()) return
$this
.trigger('focus')
.attr('aria-expanded', 'true')
$parent
.toggleClass('open')
.trigger($.Event('shown.bs.dropdown', relatedTarget))
}
return false
}
Dropdown.prototype.keydown = function (e) {
if (!/(38|40|27|32)/.test(e.which) || /input|textarea/i.test(e.target.tagName)) return
var $this = $(this)
e.preventDefault()
e.stopPropagation()
if ($this.is('.disabled, :disabled')) return
var $parent = getParent($this)
var isActive = $parent.hasClass('open')
if (!isActive && e.which != 27 || isActive && e.which == 27) {
if (e.which == 27) $parent.find(toggle).trigger('focus')
return $this.trigger('click')
}
var desc = ' li:not(.disabled):visible a'
var $items = $parent.find('.dropdown-menu' + desc)
if (!$items.length) return
var index = $items.index(e.target)
if (e.which == 38 && index > 0) index-- // up
if (e.which == 40 && index < $items.length - 1) index++ // down
if (!~index) index = 0
$items.eq(index).trigger('focus')
}
// DROPDOWN PLUGIN DEFINITION
// ==========================
function Plugin(option) {
return this.each(function () {
var $this = $(this)
var data = $this.data('bs.dropdown')
if (!data) $this.data('bs.dropdown', (data = new Dropdown(this)))
if (typeof option == 'string') data[option].call($this)
})
}
var old = $.fn.dropdown
$.fn.dropdown = Plugin
$.fn.dropdown.Constructor = Dropdown
// DROPDOWN NO CONFLICT
// ====================
$.fn.dropdown.noConflict = function () {
$.fn.dropdown = old
return this
}
// APPLY TO STANDARD DROPDOWN ELEMENTS
// ===================================
$(document)
.on('click.bs.dropdown.data-api', clearMenus)
.on('click.bs.dropdown.data-api', '.dropdown form', function (e) { e.stopPropagation() })
.on('click.bs.dropdown.data-api', toggle, Dropdown.prototype.toggle)
.on('keydown.bs.dropdown.data-api', toggle, Dropdown.prototype.keydown)
.on('keydown.bs.dropdown.data-api', '.dropdown-menu', Dropdown.prototype.keydown)
}(jQuery);
</script><style type="text/css">
.code-folding-btn { margin-bottom: 4px; }
.row { display: flex; }
.collapse { display: none; }
.in { display:block }
.pull-right > .dropdown-menu {
right: 0;
left: auto;
}
.open > .dropdown-menu {
display: block;
}
.dropdown-menu {
position: absolute;
top: 100%;
left: 0;
z-index: 1000;
display: none;
float: left;
min-width: 160px;
padding: 5px 0;
margin: 2px 0 0;
font-size: 14px;
text-align: left;
list-style: none;
background-color: #fff;
-webkit-background-clip: padding-box;
background-clip: padding-box;
border: 1px solid #ccc;
border: 1px solid rgba(0,0,0,.15);
border-radius: 4px;
-webkit-box-shadow: 0 6px 12px rgba(0,0,0,.175);
box-shadow: 0 6px 12px rgba(0,0,0,.175);
}
</style>
<script>
$(document).ready(function () {
window.initializeCodeFolding("show" === "show");
});
</script><script>
document.write('<div class="btn-group pull-right" style="position: absolute; top: 20%; right: 2%; z-index: 200"><button type="button" class="btn btn-default btn-xs dropdown-toggle" data-toggle="dropdown" aria-haspopup="true" aria-expanded="true" data-_extension-text-contrast=""><span>Code</span> <span class="caret"></span></button><ul class="dropdown-menu" style="min-width: 50px;"><li><a id="rmd-show-all-code" href="#">Show All Code</a></li><li><a id="rmd-hide-all-code" href="#">Hide All Code</a></li></ul></div>')
</script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- CSS --><style type="text/css">
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
</style>
<link rel="stylesheet" href="style.css">
</head>
<body data-spy="scroll" data-target="#toc">
<div class="container-fluid">
<div class="row">
<header class="col-sm-12 col-lg-3 sidebar sidebar-book"><a class="sr-only sr-only-focusable" href="#content">Skip to main content</a>
<div class="d-flex align-items-start justify-content-between">
<h1>
<a href="index.html" title="">纵向与事件时间数据的联合模型及其在 R 中的应用</a>
</h1>
<button class="btn btn-outline-primary d-lg-none ml-2 mt-1" type="button" data-toggle="collapse" data-target="#main-nav" aria-expanded="true" aria-controls="main-nav"><i class="fas fa-bars"></i><span class="sr-only">Show table of contents</span></button>
</div>
<div id="main-nav" class="collapse-lg">
<form role="search">
<input id="search" class="form-control" type="search" placeholder="Search" aria-label="Search">
</form>
<nav aria-label="Table of contents"><h2>Table of contents</h2>
<ul class="book-toc list-unstyled">
<li><a class="" href="index.html">前言</a></li>
<li><a class="active" href="%E7%9B%AE%E5%BD%95.html">目录</a></li>
<li class="book-part">正文</li>
<li><a class="" href="chap1.html"><span class="header-section-number">1</span> 介绍</a></li>
<li><a class="" href="chap2.html"><span class="header-section-number">2</span> 纵向数据分析</a></li>
<li><a class="" href="chap3.html"><span class="header-section-number">3</span> 事件时间数据分析</a></li>
<li><a class="" href="chap4.html"><span class="header-section-number">4</span> 纵向与事件时间数据的联合模型</a></li>
<li><a class="" href="chap5.html"><span class="header-section-number">5</span> 标准联合模型的扩展</a></li>
<li><a class="" href="chap6.html"><span class="header-section-number">6</span> 联合模型诊断</a></li>
<li><a class="" href="chap7.html"><span class="header-section-number">7</span> 联合模型的预测和准确性</a></li>
<li class="book-part">附录</li>
<li><a class="" href="A.html"><span class="header-section-number">A</span> R 的简要介绍</a></li>
<li class="book-part">—</li>
<li><a class="" href="bib.html">参考文献</a></li>
</ul>
<div class="book-extra">
</div>
</nav>
</div>
</header><main class="col-sm-12 col-md-9 col-lg-7" id="content"><div id="目录" class="section level1 unnumbered">
<h1>目录<a class="anchor" aria-label="anchor" href="#%E7%9B%AE%E5%BD%95"><i class="fas fa-link"></i></a>
</h1>
<ol style="list-style-type: decimal">
<li>
<a href="chap1.html#chap1">介绍</a>
<ul>
<li>1.1 <a href="chap1.html#sec1-1">目标</a>
</li>
<li>1.2 <a href="chap1.html#sec1-2">激励性研究</a>
<ul>
<li>1.2.1 <a href="chap1.html#sec1-2-1">原发性胆汁性肝硬化 (PBC) 数据</a>
</li>
<li>1.2.2 <a href="chap1.html#sec1-2-2">艾滋病数据</a>
</li>
<li>1.2.3 <a href="chap1.html#sec1-2-3">肝硬化数据</a>
</li>
<li>1.2.4 <a href="chap1.html#sec1-2-4">主动脉瓣数据</a>
</li>
<li>1.2.5 <a href="chap1.html#sec1-2-5">其他应用</a>
</li>
</ul>
</li>
<li>1.3 <a href="chap1.html#sec1-3">纵向研究中的推断目标</a>
<ul>
<li>1.3.1 <a href="chap1.html#sec1-3-1">协变量对单一结果的效应</a>
</li>
<li>1.3.2 <a href="chap1.html#sec1-3-2">结果之间的关联</a>
</li>
<li>1.3.3 <a href="chap1.html#sec1-3-3">复杂的假设检验</a>
</li>
<li>1.3.4 <a href="chap1.html#sec1-3-4">预测</a>
</li>
<li>1.3.5 <a href="chap1.html#sec1-3-5">隐式结果的统计分析</a>
</li>
</ul>
</li>
<li>1.4 <a href="chap1.html#sec1-4">概述</a>
</li>
</ul>
</li>
<li>
<a href="chap2.html#chap2">纵向数据分析</a>
<ul>
<li>2.1 <a href="chap2.html#sec2-1">纵向数据的特征</a>
</li>
<li>2.2 <a href="chap2.html#sec2-2">线性混合效应模型</a>
<ul>
<li>2.2.1 <a href="chap2.html#sec2-2-1">估计</a>
</li>
<li>2.2.2 <a href="chap2.html#sec2-2-2">在 R 中的实现</a><br>
</li>
</ul>
</li>
<li>2.3 <a href="chap2.html#sec2-3">纵向研究中的缺失数据</a>
<ul>
<li>2.3.1 <a href="chap2.html#sec2-3-1">缺失数据机制</a>
</li>
<li>2.3.2 <a href="chap2.html#sec2-3-2">非随机缺失模型族</a>
</li>
</ul>
</li>
<li>2.4 <a href="chap2.html#sec2-4">延伸阅读</a>
</li>
</ul>
</li>
<li>
<a href="chap3.html#chap3">事件时间数据分析</a>
<ul>
<li>3.1 <a href="chap3.html#sec3-1">事件时间数据的特征</a>
</li>
<li>3.2 <a href="chap3.html#sec3-2">生存分析的基本函数</a>
<ul>
<li>3.2.1 <a href="chap3.html#sec3-2-1">删失数据的似然构造</a>
</li>
</ul>
</li>
<li>3.3 <a href="chap3.html#sec3-3">相对风险回归模型</a>
<ul>
<li>3.3.1 <a href="#sec3-3-1">在 R 中的实现</a>
</li>
</ul>
</li>
<li>3.4 <a href="chap3.html#sec3-4">时依协变量</a>
</li>
<li>3.5 <a href="chap3.html#sec3-5">扩展的 Cox 模型</a>
</li>
<li>3.6 <a href="chap3.html#sec3-6">延伸阅读</a>
</li>
</ul>
</li>
<li>
<a href="chap4.html#chap4">纵向与事件时间数据的联合模型</a>
<ul>
<li>4.1 <a href="chap4.html#sec4-1">基本联合模型</a>
<ul>
<li>4.1.1 <a href="chap4.html#sec4-1-1">生存子模型</a>
</li>
<li>4.1.2 <a href="chap4.html#sec4-1-2">纵向子模型</a>
</li>
</ul>
</li>
<li>4.2 <a href="chap4.html#sec4-2">R 中的联合建模：与扩展的 Cox 模型比较</a>
</li>
<li>4.3 <a href="chap4.html#sec4-3">联合模型的估计</a>
<ul>
<li>4.3.1 <a href="chap4.html#sec4-3-1">两阶段法</a>
</li>
<li>4.3.2 <a href="chap4.html#sec4-3-2">联合似然公式</a>
</li>
<li>4.3.3 <a href="chap4.html#sec4-3-3">具有未指定基线风险函数的标准误</a>
</li>
<li>4.3.4 <a href="chap4.html#sec4-3-4"><code>JM</code> 中的优化控制</a>
</li>
<li>4.3.5 <a href="chap4.html#sec4-3-5">数值积分</a>
</li>
<li>4.3.6 <a href="chap4.html#sec4-3-6"><code>JM</code> 中的数值积分控制</a>
</li>
<li>4.3.7 <a href="chap4.html#sec4-3-7">收敛问题</a>
</li>
</ul>
</li>
<li>4.4 <a href="chap4.html#sec4-4">联合模型的渐近推断</a>
<ul>
<li>4.4.1 <a href="chap4.html#sec4-4-1">假设检验</a>
</li>
<li>4.4.2 <a href="chap4.html#sec4-4-2">置信区间</a>
</li>
<li>4.4.3 <a href="chap4.html#sec4-4-3">设计考虑</a>
</li>
</ul>
</li>
<li>4.5 <a href="chap4.html#sec4-5">随机效应的估计</a>
</li>
<li>4.6 <a href="chap4.html#sec4-6">与缺失数据框架的连接</a>
</li>
<li>4.7 <a href="chap4.html#sec4-7">联合模型的敏感性分析</a>
</li>
</ul>
</li>
<li>
<a href="chap5.html#chap5">标准联合模型的扩展</a>
<ul>
<li>5.1 <a href="chap5.html#sec5-1">参数化</a>
<ul>
<li>5.1.1 <a href="chap5.html#sec5-1-1">交互效应</a>
</li>
<li>5.1.2 <a href="chap5.html#sec5-1-2">滞后效应</a>
</li>
<li>5.1.3 <a href="chap5.html#sec5-1-3">滞后效应</a>
</li>
<li>5.1.4 <a href="chap5.html#sec5-1-4">时依斜率参数化</a>
</li>
<li>5.1.5 <a href="chap5.html#sec5-1-5">累积效应参数化</a>
</li>
<li>5.1.6 <a href="#sec5-1-6">随机效应参数化</a>
</li>
</ul>
</li>
<li>5.2 <a href="chap5.html#sec5-2">处理外源时依协变量</a>
</li>
<li>5.3 <a href="chap5.html#sec5-3">分层相对风险模型</a>
</li>
<li>5.4 <a href="chap5.html#sec5-4">潜类别联合模型</a>
</li>
<li>5.5 <a href="chap5.html#sec5-5">多个事件</a>
<ul>
<li>5.5.1 <a href="chap5.html#sec5-5-1">竞争风险</a>
</li>
<li>5.5.2 <a href="chap5.html#sec5-5-2">复发事件</a>
</li>
</ul>
</li>
<li>5.6 <a href="chap5.html#sec5-6">加速失效时间模型</a>
</li>
<li>5.7 <a href="chap5.html#sec5-7">分类纵向结果的联合模型</a>
<ul>
<li>5.7.1 <a href="chap5.html#sec5-7-1">广义线性混合模型 (GLMM)</a>
</li>
<li>5.7.2 <a href="chap5.html#sec5-7-2">将离散重复测量与生存结合</a>
</li>
</ul>
</li>
<li>5.8 <a href="chap5.html#sec5-8">多个纵向结果的联合模型</a>
</li>
</ul>
</li>
<li>
<a href="chap6.html#chap6">标准联合模型的扩展</a>
<ul>
<li>6.1 <a href="chap6.html#sec6-1">联合模型的残差</a>
<ul>
<li>6.1.1 <a href="chap6.html#sec6-1-1">纵向部分的残差</a>
</li>
<li>6.1.2 <a href="chap6.html#sec6-1-2">生存部分的残差</a>
</li>
</ul>
</li>
<li>6.2 <a href="chap6.html#sec6-2">脱落和残差</a>
</li>
<li>6.3 <a href="chap6.html#sec6-3">多重插补残差</a>
<ul>
<li>6.3.1 <a href="chap6.html#sec6-3-1">固定就诊时间</a>
</li>
<li>6.3.2 <a href="chap6.html#sec6-3-2">随机就诊时间</a>
</li>
</ul>
</li>
<li>6.4 <a href="chap6.html#sec6-4">随机效应分布</a>
</li>
</ul>
</li>
<li>
<a href="chap7.html#chap7">联合模型的预测和准确性</a>
<ul>
<li>7.1 <a href="chap7.html#sec7-1">生存概率的动态预测</a>
<ul>
<li>7.1.1 <a href="chap7.html#sec7-1-1">定义</a>
</li>
<li>7.1.2 <a href="chap7.html#sec7-1-2">估计</a>
</li>
<li>7.1.3 <a href="chap7.html#sec7-1-3">在 R 中的实现</a>
</li>
</ul>
</li>
<li>7.2 <a href="chap7.html#sec7-2">纵向结果的动态预测</a>
</li>
<li>7.3 <a href="chap7.html#sec7-3">参数化对预测的影响</a>
</li>
<li>7.4 <a href="chap7.html#sec7-4">联合模型的前瞻准确性</a>
<ul>
<li>7.4.1 <a href="chap7.html#sec7-4-1">二项结果的判别度量</a>
</li>
<li>7.4.2 <a href="chap7.html#sec7-4-2">生存结果的判别度量</a>
</li>
<li>7.4.3 <a href="chap7.html#sec7-4-3">纵向标志物的预测规则</a>
</li>
<li>7.4.4 <a href="chap7.html#sec7-4-4">判别指数</a>
</li>
<li>7.4.5 <a href="chap7.html#sec7-4-5">联合建模框架下的估计</a>
</li>
<li>7.4.6 <a href="chap7.html#sec7-4-6">在 R 中的实现</a>
</li>
</ul>
</li>
</ul>
</li>
</ol>
<ul>
<li>附录 A <a href="A.html#A">R 的简要介绍</a>
<ul>
<li>A.1 <a href="#secA-1">获取并安装 R 和 R 包</a>
</li>
</ul>
</li>
<li>附录 B <a href="#B">联合模型的 EM 算法</a>
</li>
<li>附录 C <a href="#C">JM 包的结构</a>
</li>
<li><a href="bib.html#bib">参考书目</a></li>
</ul>
</div>
<div class="chapter-nav">
<div class="prev"><a href="index.html">前言</a></div>
<div class="next"><a href="chap1.html"><span class="header-section-number">1</span> 介绍</a></div>
</div></main><div class="col-md-3 col-lg-2 d-none d-md-block sidebar sidebar-chapter">
<nav id="toc" data-toggle="toc" aria-label="On this page"><h2>On this page</h2>
<ul class="nav navbar-nav"><li><a class="nav-link" href="#%E7%9B%AE%E5%BD%95">目录</a></li></ul>
<div class="book-extra">
<ul class="list-unstyled">
</ul>
</div>
</nav>
</div>
</div>
</div> <!-- .container -->
<footer class="bg-primary text-light mt-5"><div class="container"><div class="row">
<div class="col-12 col-md-6 mt-3">
<p>"<strong>纵向与事件时间数据的联合模型及其在 R 中的应用</strong>" was written by Wang Zhen. It was last built on 2024-04-19.</p>
</div>
<div class="col-12 col-md-6 mt-3">
<p>This book was built by the <a class="text-light" href="https://bookdown.org">bookdown</a> R package.</p>
</div>
</div></div>
</footer><!-- dynamically load mathjax for compatibility with self-contained --><script>
(function () {
var script = document.createElement("script");
script.type = "text/javascript";
var src = "true";
if (src === "" || src === "true") src = "https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.9/latest.js?config=TeX-MML-AM_CHTML";
if (location.protocol !== "file:")
if (/^https?:/.test(src))
src = src.replace(/^https?:/, '');
script.src = src;
document.getElementsByTagName("head")[0].appendChild(script);
})();
</script><script type="text/x-mathjax-config">const popovers = document.querySelectorAll('a.footnote-ref[data-toggle="popover"]');
for (let popover of popovers) {
const div = document.createElement('div');
div.setAttribute('style', 'position: absolute; top: 0, left:0; width:0, height:0, overflow: hidden; visibility: hidden;');
div.innerHTML = popover.getAttribute('data-content');
var has_math = div.querySelector("span.math");
if (has_math) {
document.body.appendChild(div);
MathJax.Hub.Queue(["Typeset", MathJax.Hub, div]);
MathJax.Hub.Queue(function() {
popover.setAttribute('data-content', div.innerHTML);
document.body.removeChild(div);
})
}
}
</script>
</body>
</html>