diff --git a/pkg/core/region.go b/pkg/core/region.go
index 57ba5cb3db06..53fd14f56528 100644
--- a/pkg/core/region.go
+++ b/pkg/core/region.go
@@ -18,11 +18,13 @@ import (
 	"bytes"
 	"encoding/hex"
 	"fmt"
+	"github.com/pingcap/failpoint"
 	"math"
 	"reflect"
 	"sort"
 	"strings"
 	"sync/atomic"
+	"time"
 	"unsafe"
 
 	"github.com/docker/go-units"
@@ -968,6 +970,11 @@ func (r *RegionsInfo) setRegionLocked(region *RegionInfo, withOverlaps bool, ol
 
 // UpdateSubTree updates the subtree.
 func (r *RegionsInfo) UpdateSubTree(region, origin *RegionInfo, overlaps []*RegionInfo, rangeChanged bool) {
+	failpoint.Inject("UpdateSubTree", func() {
+		if origin == nil {
+			time.Sleep(time.Second)
+		}
+	})
 	r.st.Lock()
 	defer r.st.Unlock()
 	if origin != nil {
@@ -976,8 +983,17 @@ func (r *RegionsInfo) UpdateSubTree(region, origin *RegionInfo, overlaps []*Regi
 			// TODO: Improve performance by deleting only the different peers.
 			r.removeRegionFromSubTreeLocked(origin)
 		} else {
-			r.updateSubTreeStat(origin, region)
-			r.subRegions[region.GetID()].RegionInfo = region
+			// The region tree and the subtree update is not atomic and the region tree is updated first.
+			// If there are two thread needs to update region tree,
+			// t1: thread-A  update region tree
+			// 										t2: thread-B: update region three again
+			//										t3: thread-B: update subtree
+			// t4: thread-A: update region subtree
+			// to keep region tree consistent with subtree, we need to drop this update.
+			if tree, ok := r.subRegions[region.GetID()]; ok {
+				r.updateSubTreeStat(origin, region)
+				tree.RegionInfo = region
+			}
 			return
 		}
 	}
diff --git a/pkg/core/region_test.go b/pkg/core/region_test.go
index 1e6b43fbf964..179a738bffdc 100644
--- a/pkg/core/region_test.go
+++ b/pkg/core/region_test.go
@@ -21,6 +21,7 @@ import (
 	"strconv"
 	"testing"
 
+	"github.com/pingcap/failpoint"
 	"github.com/pingcap/kvproto/pkg/metapb"
 	"github.com/pingcap/kvproto/pkg/pdpb"
 	"github.com/stretchr/testify/require"
@@ -423,6 +424,17 @@ func TestRegionKey(t *testing.T) {
 	}
 }
 
+func TestSetRegionConcurrence(t *testing.T) {
+	re := require.New(t)
+	re.NoError(failpoint.Enable("github.com/tikv/pd/pkg/core/UpdateSubTree", `return()`))
+	regions := NewRegionsInfo()
+	region := NewTestRegionInfo(1, 1, []byte("a"), []byte("b"))
+	go func() {
+		regions.AtomicCheckAndPutRegion(region)
+	}()
+	regions.AtomicCheckAndPutRegion(region)
+}
+
 func TestSetRegion(t *testing.T) {
 	re := require.New(t)
 	regions := NewRegionsInfo()