diff --git a/UefiCpuPkg/Library/MtrrLib/MtrrLib.c b/UefiCpuPkg/Library/MtrrLib/MtrrLib.c
index 4d4b52a4c3b2..61af77d9de43 100644
--- a/UefiCpuPkg/Library/MtrrLib/MtrrLib.c
+++ b/UefiCpuPkg/Library/MtrrLib/MtrrLib.c
@@ -161,6 +161,13 @@ MtrrLibIsMtrrSupported (
   CPUID_VERSION_INFO_EDX     Edx;
   MSR_IA32_MTRRCAP_REGISTER  MtrrCap;
 
+  //
+  // MTRR is not supported in TD-Guest.
+  //
+  if (TdIsEnabled ()) {
+    return FALSE;
+  }
+
   //
   // Check CPUID(1).EDX[12] for MTRR capability
   //