diff --git a/README.rst b/README.rst
index 7468f9b2..fd793e6d 100644
--- a/README.rst
+++ b/README.rst
@@ -152,7 +152,7 @@ It's all written in C++ with a handful of ugly optimizations for performance and
 
 The code should support Windows, thanks to `Qiang Kou <https://github.com/thirdwing>`__ and `Timothy Riley <https://github.com/tjrileywisc>`__.
 
-To run the tests, execute `python setup.py nosetests`. The test suite includes a big real world dataset that is downloaded from the internet, so it will take a few minutes to execute.
+To run the tests, execute `python -m unittest`. The test suite includes a big real world dataset that is downloaded from the internet, so it will take a few minutes to execute.
 
 Discuss
 -------
diff --git a/appveyor.yml b/appveyor.yml
index cb0c2a15..e47798df 100644
--- a/appveyor.yml
+++ b/appveyor.yml
@@ -18,4 +18,4 @@ build_script:
   - "python setup.py build"
 
 test_script:
-  - "python setup.py nosetests"
+  - "python -m unittest -v"
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 8bbe8b72..00000000
--- a/setup.cfg
+++ /dev/null
@@ -1,4 +0,0 @@
-[nosetests]
-attr=!slow
-nocapture=1
-
diff --git a/setup.py b/setup.py
index f29e9f29..5c5213e2 100644
--- a/setup.py
+++ b/setup.py
@@ -100,6 +100,5 @@
           'Programming Language :: Python :: 3.6',
       ],
       keywords='nns, approximate nearest neighbor search',
-      setup_requires=['nose>=1.0'],
       tests_require=['numpy', 'h5py']
       )
diff --git a/test/accuracy_test.py b/test/accuracy_test.py
index 441e5c28..7ecf0506 100644
--- a/test/accuracy_test.py
+++ b/test/accuracy_test.py
@@ -24,7 +24,6 @@
 except ImportError:
     from urllib.request import urlretrieve # Python 3
 import gzip
-from nose.plugins.attrib import attr
 
 class AccuracyTest(unittest.TestCase):
     def _get_index(self, dataset):
diff --git a/test/hamming_index_test.py b/test/hamming_index_test.py
index 74de10a9..fade8a5a 100644
--- a/test/hamming_index_test.py
+++ b/test/hamming_index_test.py
@@ -12,11 +12,11 @@
 # License for the specific language governing permissions and limitations under
 # the License.
 
+import unittest
 import numpy
 import random
 from common import TestCase
 from annoy import AnnoyIndex
-from nose.plugins.skip import SkipTest
 
 
 class HammingIndexTest(TestCase):
@@ -85,7 +85,7 @@ def test_many_vectors(self):
         avg_dist = 1.0 * sum(dists) / len(dists)
         self.assertLessEqual(avg_dist, 0.42)
 
-    @SkipTest  # will fix later
+    @unittest.skip('will fix later')
     def test_zero_vectors(self):
         # Mentioned on the annoy-user list
         bitstrings = [
diff --git a/tox.ini b/tox.ini
index 5a2e5cae..00d229a0 100644
--- a/tox.ini
+++ b/tox.ini
@@ -7,7 +7,7 @@ setenv =
 commands =
   pip install numpy h5py
   pip install .
-  python setup.py nosetests --verbosity=3
+  python -m unittest -v
 
 [testenv:go]
 setenv =