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format-version: 1.2
date: 10:07:2024 09:36
[Term]
id: FPLX:5_hydroxytryptamine_receptors_G_protein_coupled
name: 5-hydroxytryptamine-receptors-G-protein-coupled
xref: HGNC_GROUP:170
is_a: FPLX:HTR
inverse_is_a: FPLX:HTR1
inverse_is_a: FPLX:HTR2
inverse_is_a: HGNC:HTR4
inverse_is_a: HGNC:HTR6
inverse_is_a: HGNC:HTR7
[Term]
id: FPLX:5_hydroxytryptamine_receptors_ionotropic
name: 5-hydroxytryptamine-receptors-ionotropic
def: "A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM." [mesh:D044406]
xref: HGNC_GROUP:172
xref: MESH:D044406
is_a: FPLX:HTR
is_a: FPLX:Ligand_gated_ion_channels
inverse_is_a: HGNC:HTR3A
inverse_is_a: HGNC:HTR3B
inverse_is_a: HGNC:HTR3C
inverse_is_a: HGNC:HTR3D
inverse_is_a: HGNC:HTR3E
[Term]
id: FPLX:9_1_1
name: 9-1-1
synonym: "(9-1-1) complex" EXACT []
synonym: "9-1-1 complex" EXACT []
synonym: "9-1-1" EXACT []
synonym: "h9-1-1 complex" EXACT []
xref: BEL:"9-1-1 Complex"
xref: SCOMP:C0001
is_a: FPLX:root
has_part: HGNC:HUS1
has_part: HGNC:RAD1
has_part: HGNC:RAD9A
[Term]
id: FPLX:A4GALT_family
name: A4GALT-family
is_a: FPLX:Glycosyltransferase
inverse_is_a: HGNC:A4GALT
inverse_is_a: HGNC:A4GNT
[Term]
id: FPLX:ABL_family
name: ABL-family
def: "Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia." [mesh:D016313]
synonym: "ABL family" EXACT []
synonym: "ABL" EXACT []
xref: IP:IPR015015
xref: MEDSCAN:urn:agi-aopfc:0000567
xref: MESH:D016313
xref: RE:R-HSA-376002
is_a: FPLX:root
inverse_is_a: HGNC:ABL1
inverse_is_a: HGNC:ABL2
[Term]
id: FPLX:ACAD
name: ACAD
def: "A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex with ELECTRON TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE." [mesh:D042964]
synonym: "ACAD" EXACT []
synonym: "acyl CoA dehydrogenase" EXACT []
synonym: "acyl-CoA dehydrogenase" EXACT []
xref: BEL:"ACAD Family"
xref: ECCODE:1.3.8.7
xref: MESH:D042964
xref: NEXTPROT-FAMILY:00093
xref: SFAM:F0002
is_a: FPLX:root
inverse_is_a: HGNC:ACAD8
inverse_is_a: HGNC:ACAD9
inverse_is_a: HGNC:ACADL
inverse_is_a: HGNC:ACADM
inverse_is_a: HGNC:ACADS
inverse_is_a: HGNC:ACADVL
inverse_is_a: HGNC:ACAD10
inverse_is_a: HGNC:ACAD11
inverse_is_a: HGNC:ACADSB
inverse_is_a: HGNC:GCDH
inverse_is_a: HGNC:IVD
[Term]
id: FPLX:ACC
name: ACC
def: "A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2." [mesh:D000103]
synonym: "ACC" EXACT []
synonym: "ACCs" EXACT []
synonym: "Acetyl Coenzyme A Carboxylase" EXACT []
synonym: "Acetyl-CoA carboxylase" EXACT []
synonym: "acetyl-CoA carboxylase" EXACT []
xref: BEL:"Acetyl CoA Carboxylase Complex"
xref: ECCODE:6.4.1.2
xref: IP:IPR013537
xref: MESH:D000103
xref: RE:R-HSA-200563
xref: SCOMP:C0005
is_a: FPLX:root
has_part: HGNC:ACACA
has_part: HGNC:ACACB
[Term]
id: FPLX:Acetyl_CoA_synthetase
name: Acetyl-CoA-synthetase
def: "An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1." [mesh:D000106]
synonym: "Acetate-CoA ligase" EXACT []
synonym: "acetyl CoA ligase" EXACT []
synonym: "acetyl CoA synthase" EXACT []
synonym: "Acetyl-CoA synthetase" EXACT []
synonym: "acetyl-CoA synthetase" EXACT []
synonym: "acetyl-coenzyme A synthase" EXACT []
synonym: "ACS" EXACT []
xref: BEL:"Acetyl-CoA Synthetase Family"
xref: MESH:D000106
xref: SFAM:F0003
is_a: FPLX:root
inverse_is_a: HGNC:SLC27A2
inverse_is_a: FPLX:ACSL
[Term]
id: FPLX:ACOX
name: ACOX
def: "An enzyme that catalyzes the first and rate-determining steps of peroxisomal beta-oxidation of fatty acids. It acts on COENZYME A derivatives of fatty acids with chain lengths from 8 to 18, using FLAVIN-ADENINE DINUCLEOTIDE as a cofactor." [mesh:D042962]
synonym: "Acyl-CoA Oxidase" EXACT []
synonym: "acyl-CoA oxidases" EXACT []
xref: BEL:"ACOX Family"
xref: IP:IPR002655
xref: MESH:D042962
xref: XFAM:PF01756
xref: SFAM:F0004
is_a: FPLX:root
inverse_is_a: HGNC:ACOX1
inverse_is_a: HGNC:ACOX2
inverse_is_a: HGNC:ACOX3
inverse_is_a: HGNC:ACOXL
[Term]
id: FPLX:ACSL
name: ACSL
synonym: "Acsl" EXACT []
synonym: "long-chain acyl-CoA synthetase" EXACT []
xref: BEL:"ACSL Family"
xref: SFAM:F0005
is_a: FPLX:Acetyl_CoA_synthetase
inverse_is_a: HGNC:ACSL1
inverse_is_a: HGNC:ACSL3
inverse_is_a: HGNC:ACSL4
inverse_is_a: HGNC:ACSL5
inverse_is_a: HGNC:ACSL6
[Term]
id: FPLX:Actin
name: Actin
def: "Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle." [mesh:D000199]
synonym: "actin" EXACT []
synonym: "actins" EXACT []
xref: BEL:"ACT Family"
xref: GO:0005884
xref: IP:IPR004000
xref: MEDSCAN:urn:agi-protfc:actins
xref: MESH:D000199
xref: NCIT:C16258
xref: NEXTPROT-FAMILY:00078
xref: XFAM:PF00022
xref: SFAM:F0006
is_a: FPLX:root
inverse_is_a: FPLX:F_actin
inverse_is_a: FPLX:G_actin
[Term]
id: FPLX:Actin_related_proteins
name: Actin-related-proteins
synonym: "Arp" EXACT []
synonym: "actin-related protein" EXACT []
synonym: "actin-related proteins" EXACT []
synonym: "Actin-related protein" EXACT []
synonym: "Actin-related proteins" EXACT []
xref: HGNC_GROUP:1436
is_a: FPLX:root
inverse_is_a: HGNC:ACTL10
inverse_is_a: HGNC:ACTL6A
inverse_is_a: HGNC:ACTL6B
inverse_is_a: HGNC:ACTL7A
inverse_is_a: HGNC:ACTL7B
inverse_is_a: HGNC:ACTL8
inverse_is_a: HGNC:ACTL9
inverse_is_a: HGNC:ACTR10
inverse_is_a: HGNC:ACTR1A
inverse_is_a: HGNC:ACTR1B
inverse_is_a: HGNC:ACTR2
inverse_is_a: HGNC:ACTR3
inverse_is_a: HGNC:ACTR3B
inverse_is_a: HGNC:ACTR3C
inverse_is_a: HGNC:ACTR5
inverse_is_a: HGNC:ACTR6
inverse_is_a: HGNC:ACTR8
inverse_is_a: HGNC:ACTRT1
inverse_is_a: HGNC:ACTRT2
inverse_is_a: HGNC:ACTRT3
[Term]
id: FPLX:Activin
name: Activin
def: "Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS." [mesh:D028341]
synonym: "activin protein" EXACT []
synonym: "Activin" EXACT []
synonym: "activin" EXACT []
synonym: "activins" EXACT []
xref: GO:0048180
xref: MESH:D028341
xref: NCIT:C20456
xref: RE:R-HSA-2470478
xref: RE:R-HSA-2470491
xref: RE:R-HSA-2470494
is_a: FPLX:root
inverse_is_a: FPLX:Activin_A
inverse_is_a: FPLX:Activin_AB
inverse_is_a: FPLX:Activin_B
[Term]
id: FPLX:Activin_A
name: Activin-A
synonym: "Activin A protein" EXACT []
synonym: "Activin A" EXACT []
synonym: "activin A" EXACT []
synonym: "activin-A" EXACT []
synonym: "activinA" EXACT []
xref: GO:0043509
xref: IP:IPR000491
xref: MESH:C422405
xref: RE:R-HSA-206893
is_a: FPLX:Activin
has_part: HGNC:INHBA
[Term]
id: FPLX:Activin_AB
name: Activin-AB
synonym: "activin AB" EXACT []
xref: RE:R-HSA-1449698
xref: RE:R-HSA-2470478
xref: RE:R-HSA-2470491
xref: RE:R-HSA-2470494
is_a: FPLX:Activin
has_part: HGNC:INHBA
has_part: HGNC:INHBB
[Term]
id: FPLX:Activin_B
name: Activin-B
synonym: "activin-B" EXACT []
xref: IP:IPR000381
xref: RE:R-HSA-1449672
is_a: FPLX:Activin
has_part: HGNC:INHBB
[Term]
id: FPLX:ACTN
name: ACTN
def: "A protein factor that regulates the length of R-actin. It is chemically similar, but immunochemically distinguishable from actin." [mesh:D000185]
synonym: "actinin" EXACT []
xref: BEL:"ACTN Family"
xref: MESH:D000185
xref: RE:R-HSA-451402
xref: SFAM:F0007
is_a: FPLX:root
inverse_is_a: HGNC:ACTN1
inverse_is_a: HGNC:ACTN2
inverse_is_a: HGNC:ACTN3
inverse_is_a: HGNC:ACTN4
[Term]
id: FPLX:ADA
name: ADA
xref: HGNC_GROUP:1303
is_a: FPLX:Adenosine_deaminase_family
inverse_is_a: HGNC:ADAD1
inverse_is_a: HGNC:ADAD2
inverse_is_a: HGNC:ADAR
inverse_is_a: HGNC:ADARB1
inverse_is_a: HGNC:ADARB2
inverse_is_a: HGNC:ADAT1
inverse_is_a: HGNC:ADAT2
inverse_is_a: HGNC:ADAT3
[Term]
id: FPLX:Adaptor_protein
name: Adaptor-protein
def: "A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found." [mesh:D033942]
synonym: "clathrin associated protein" EXACT []
xref: HGNC_GROUP:1670
xref: MESH:D033942
is_a: FPLX:root
inverse_is_a: FPLX:Adaptor_protein_I
inverse_is_a: FPLX:Adaptor_protein_II
inverse_is_a: FPLX:Adaptor_protein_III
inverse_is_a: FPLX:Adaptor_protein_IV
inverse_is_a: FPLX:Adaptor_protein_V
[Term]
id: FPLX:Adaptor_protein_I
name: Adaptor-protein-I
def: "A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK." [mesh:D033961]
xref: HGNC_GROUP:1671
xref: MESH:D033961
xref: SIGNOR:SIGNOR-C248
is_a: FPLX:Adaptor_protein
has_part: HGNC:AP1B1
has_part: HGNC:AP1G1
has_part: HGNC:AP1M1
has_part: HGNC:AP1M2
has_part: HGNC:AP1S1
has_part: HGNC:AP1S2
has_part: HGNC:AP1S3
[Term]
id: FPLX:Adaptor_protein_II
name: Adaptor-protein-II
def: "An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE." [mesh:D033962]
synonym: "Adaptor Protein 2 complex" EXACT []
synonym: "adaptor protein complex 2" EXACT []
synonym: "AP-2 adaptor complex" EXACT []
synonym: "AP-2 complex" EXACT []
synonym: "AP-2" EXACT []
synonym: "AP2 adaptor complex" EXACT []
synonym: "AP2 clathrin adaptor complex" EXACT []
synonym: "AP2 complex" EXACT []
synonym: "AP2" EXACT []
xref: BEL:"Adaptor Protein II Complex"
xref: GO:0030122
xref: HGNC_GROUP:1672
xref: MESH:D033962
xref: SIGNOR:SIGNOR-C245
xref: SCOMP:C0008
is_a: FPLX:Adaptor_protein
has_part: HGNC:AP2B1
has_part: HGNC:AP2M1
has_part: HGNC:AP2S1
has_part: FPLX:AP2A
[Term]
id: FPLX:Adaptor_protein_III
name: Adaptor-protein-III
def: "An adaptor protein complex found primarily on perinuclear compartments." [mesh:D033963]
synonym: "adaptor protein complex 3" EXACT []
synonym: "AP-3" EXACT []
synonym: "AP3" EXACT []
xref: BEL:"Adaptor Protein III Complex"
xref: HGNC_GROUP:1673
xref: MESH:D033963
xref: SIGNOR:SIGNOR-C247
xref: SCOMP:C0009
is_a: FPLX:Adaptor_protein
has_part: HGNC:AP3B1
has_part: HGNC:AP3D1
has_part: HGNC:AP3S1
has_part: HGNC:AP3S2
[Term]
id: FPLX:Adaptor_protein_IV
name: Adaptor-protein-IV
def: "An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system." [mesh:D033964]
xref: HGNC_GROUP:1674
xref: MESH:D033964
is_a: FPLX:Adaptor_protein
has_part: HGNC:AP4B1
has_part: HGNC:AP4E1
has_part: HGNC:AP4M1
has_part: HGNC:AP4S1
[Term]
id: FPLX:Adaptor_protein_V
name: Adaptor-protein-V
xref: HGNC_GROUP:1675
is_a: FPLX:Adaptor_protein
has_part: HGNC:AP5Z1
has_part: HGNC:AP5B1
has_part: HGNC:AP5M1
has_part: HGNC:AP5S1
[Term]
id: FPLX:ADCY
name: ADCY
def: "Enzymes of the lyase class that catalyze the formation of CYCLIC AMP and pyrophosphate from ATP." [mesh:D000262]
synonym: "adenylate cyclase" EXACT []
synonym: "adenylyl cyclase" EXACT []
xref: BEL:"ADCY Family"
xref: MESH:D000262
xref: NCIT:C16264
xref: RE:R-HSA-5610577
xref: RE:R-HSA-5610578
xref: SIGNOR:SIGNOR-PF92
xref: SFAM:F0008
is_a: FPLX:root
inverse_is_a: HGNC:ADCY1
inverse_is_a: HGNC:ADCY2
inverse_is_a: HGNC:ADCY3
inverse_is_a: HGNC:ADCY4
inverse_is_a: HGNC:ADCY5
inverse_is_a: HGNC:ADCY6
inverse_is_a: HGNC:ADCY7
inverse_is_a: HGNC:ADCY8
inverse_is_a: HGNC:ADCY9
inverse_is_a: HGNC:ADCY10
[Term]
id: FPLX:Adenosine_deaminase_family
name: Adenosine-deaminase-family
synonym: "adenosine deaminase" EXACT []
xref: HGNC_GROUP:1302
is_a: FPLX:root
inverse_is_a: HGNC:ADA
inverse_is_a: FPLX:ADA
inverse_is_a: HGNC:ADA2
inverse_is_a: HGNC:ADAL
inverse_is_a: HGNC:AMPD1
inverse_is_a: HGNC:AMPD2
inverse_is_a: HGNC:AMPD3
[Term]
id: FPLX:ADH
name: ADH
def: "A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen." [mesh:D000426]
synonym: "alcohol dehydrogenase" EXACT []
xref: BEL:"ADH Family"
xref: ECCODE:1.1.1.1
xref: MESH:D000426
xref: NCIT:C16272
xref: XFAM:PF00465
xref: SFAM:F0009
is_a: FPLX:root
inverse_is_a: HGNC:ADH1A
inverse_is_a: HGNC:ADH1B
inverse_is_a: HGNC:ADH1C
inverse_is_a: HGNC:ADH4
inverse_is_a: HGNC:ADH5
inverse_is_a: HGNC:ADH6
inverse_is_a: HGNC:ADH7
inverse_is_a: HGNC:ADHFE1
[Term]
id: FPLX:ADORA
name: ADORA
is_a: FPLX:Purinergic_receptors
inverse_is_a: HGNC:ADORA1
inverse_is_a: HGNC:ADORA2A
inverse_is_a: HGNC:ADORA2B
inverse_is_a: HGNC:ADORA3
[Term]
id: FPLX:ADRA
name: ADRA
def: "Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction." [mesh:D011941]
synonym: "a-adrenoreceptor" EXACT []
synonym: "alpha adrenoceptor" EXACT []
synonym: "alpha-adrenergic receptor" EXACT []
synonym: "alpha-adrenoreceptor" EXACT []
synonym: "alpha-adrenoreceptors" EXACT []
synonym: "alpha1 adrenoceptor" EXACT []
synonym: "α-adrenergic receptor" EXACT []
synonym: "α-adrenoreceptor" EXACT []
synonym: "α-adrenoreceptors" EXACT []
xref: BEL:"ADRA Family"
xref: GO:0004936
xref: GO:0004937
xref: MESH:D011941
xref: SFAM:F0010
is_a: FPLX:root
inverse_is_a: HGNC:ADRA1A
inverse_is_a: HGNC:ADRA1B
inverse_is_a: HGNC:ADRA1D
inverse_is_a: HGNC:ADRA2A
inverse_is_a: HGNC:ADRA2B
inverse_is_a: HGNC:ADRA2C
[Term]
id: FPLX:ADRA2
name: ADRA2
synonym: "alpha(2)-adrenoceptors" EXACT []
synonym: "alpha(2)-ARs" EXACT []
synonym: "alpha2 adrenoceptor" EXACT []
synonym: "alpha2-AR" EXACT []
synonym: "ofalpha(2)-adrenoceptor" EXACT []
synonym: "ofα(2)-adrenoceptor" EXACT []
synonym: "α(2)-adrenoceptors" EXACT []
synonym: "α(2)-ARs" EXACT []
synonym: "α2-AR" EXACT []
xref: BEL:"ADRA2 Family"
xref: GO:0004938
xref: RE:R-HSA-390664
xref: RE:R-HSA-390700
xref: SFAM:F0011
is_a: FPLX:root
inverse_is_a: HGNC:ADRA2A
inverse_is_a: HGNC:ADRA2B
inverse_is_a: HGNC:ADRA2C
[Term]
id: FPLX:ADRB
name: ADRB
def: "One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS." [mesh:D011943]
synonym: "b-adrenergic receptor" EXACT []
synonym: "b-receptors" EXACT []
synonym: "beta-adrenergic receptor" EXACT []
synonym: "beta-adrenoreceptor" EXACT []
synonym: "betaAR" EXACT []
synonym: "β-adrenergic receptor" EXACT []
synonym: "β-adrenoreceptor" EXACT []
synonym: "βAR" EXACT []
xref: BEL:"ADRB Family"
xref: MESH:D011943
xref: NCIT:C17062
xref: RE:R-HSA-390643
xref: RE:R-HSA-390670
xref: SFAM:F0012
is_a: FPLX:root
inverse_is_a: HGNC:ADRB1
inverse_is_a: HGNC:ADRB2
inverse_is_a: HGNC:ADRB3
[Term]
id: FPLX:ADRBK
name: ADRBK
def: "G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitization of BETA-ADRENERGIC RECEPTORS." [mesh:D051552]
synonym: "BARK" EXACT []
synonym: "beta adrenergic receptor kinase" EXACT []
synonym: "betaARK" EXACT []
synonym: "β adrenergic receptor kinase" EXACT []
synonym: "βARK" EXACT []
xref: BEL:"ADRBK Family"
xref: MESH:D051552
xref: RE:R-HSA-8866229
xref: SFAM:F0013
is_a: FPLX:GRK
inverse_is_a: HGNC:GRK2
inverse_is_a: HGNC:GRK3
[Term]
id: FPLX:AGTR
name: AGTR
def: "An angiotensin receptor subtype that is expressed at high levels in fetal tissues. Many effects of the angiotensin type 2 receptor such as VASODILATION and sodium loss are the opposite of that of the ANGIOTENSIN TYPE 1 RECEPTOR." [mesh:D044139]
synonym: "angiotensin receptor" EXACT []
synonym: "angiotensin receptors" EXACT []
synonym: "angiotensin-receptor" EXACT []
synonym: "Angiotensin receptor" EXACT []
synonym: "Angiotensin receptors" EXACT []
xref: HGNC_GROUP:221
xref: MESH:D044139
is_a: FPLX:root
inverse_is_a: HGNC:AGTR1
inverse_is_a: HGNC:AGTR2
[Term]
id: FPLX:AKT
name: AKT
def: "Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells." [mesh:D051057]
synonym: "AKT family" EXACT []
synonym: "AKT" EXACT []
synonym: "Akt" EXACT []
synonym: "PKB" EXACT []
synonym: "PKB-Akt" EXACT []
synonym: "PKB/Akt" EXACT []
xref: BEL:"AKT Family"
xref: MEDSCAN:urn:agi-aopfc:0000439
xref: MESH:D051057
xref: NCIT:C41625
xref: RE:R-HSA-202052
xref: RE:R-HSA-202072
xref: RE:R-HSA-202074
xref: RE:R-HSA-202088
xref: RE:R-HSA-2317310
xref: RE:R-HSA-2317317
xref: RE:R-HSA-2317329
xref: RE:R-HSA-2400006
xref: RE:R-HSA-2400013
xref: SIGNOR:SIGNOR-PF24
xref: SFAM:F0014
is_a: FPLX:root
inverse_is_a: HGNC:AKT1
inverse_is_a: HGNC:AKT2
inverse_is_a: HGNC:AKT3
[Term]
id: FPLX:ALDH
name: ALDH
def: "An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70." [mesh:D000444]
synonym: "aldehyde dehydrogenase (NAD+)" EXACT []
synonym: "Aldehyde dehydrogenase" EXACT []
synonym: "aldehyde dehydrogenase" EXACT []
synonym: "ALDH" EXACT []
xref: BEL:"ALDH Family"
xref: ECCODE:1.2.1.3
xref: MESH:D000444
xref: NCIT:C118481
xref: SFAM:F0015
is_a: FPLX:root
inverse_is_a: HGNC:ALDH1A1
inverse_is_a: HGNC:ALDH1A2
inverse_is_a: HGNC:ALDH1A3
inverse_is_a: HGNC:ALDH2
inverse_is_a: HGNC:ALDH3A1
inverse_is_a: HGNC:ALDH3A2
inverse_is_a: HGNC:ALDH3B1
inverse_is_a: HGNC:ALDH5A1
inverse_is_a: HGNC:ALDH7A1
inverse_is_a: HGNC:ALDH9A1
[Term]
id: FPLX:ALDO
name: ALDO
def: "An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. The enzyme also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. (Enzyme Nomenclature, 1992) E.C. 4.1.2.13." [mesh:D005634]
synonym: "ALDO" EXACT []
synonym: "fructose-bisphosphate aldolase" EXACT []
xref: BEL:"ALDO Family"
xref: ECCODE:4.1.2.13
xref: IP:IPR000741
xref: IP:IPR029768
xref: MESH:D005634
xref: RE:R-HSA-179508
xref: SIGNOR:SIGNOR-PF75
xref: SFAM:F0016
is_a: FPLX:root
inverse_is_a: HGNC:ALDOA
inverse_is_a: HGNC:ALDOB
inverse_is_a: HGNC:ALDOC
[Term]
id: FPLX:ALG10
name: ALG10
synonym: "ALG10" EXACT []
synonym: "Alpha-1,2-glucosyltransferase" EXACT []
synonym: "Alpha-1,2-glucosyltransferases" EXACT []
synonym: "alpha-1,2-glucosyltransferase" EXACT []
synonym: "alpha-1,2-glucosyltransferases" EXACT []
is_a: FPLX:Glycosyltransferase
inverse_is_a: HGNC:ALG10
inverse_is_a: HGNC:ALG10B
[Term]
id: FPLX:ALG13_family
name: ALG13-family
is_a: FPLX:Glycosyltransferase
inverse_is_a: HGNC:ALG13
inverse_is_a: HGNC:ALG14
[Term]
id: FPLX:ALG1_family
name: ALG1-family
is_a: FPLX:Glycosyltransferase
inverse_is_a: HGNC:ALG1
inverse_is_a: HGNC:ALG1L1P
inverse_is_a: HGNC:ALG1L2
inverse_is_a: HGNC:ALG2
inverse_is_a: HGNC:ALG11
inverse_is_a: HGNC:GLT1D1
inverse_is_a: HGNC:GTDC1
inverse_is_a: HGNC:GYS1
inverse_is_a: HGNC:GYS2
inverse_is_a: HGNC:PIGA
[Term]
id: FPLX:ALG3_family
name: ALG3-family
is_a: FPLX:Glycosyltransferase
inverse_is_a: HGNC:ALG3
inverse_is_a: HGNC:ALG9
inverse_is_a: HGNC:ALG12
inverse_is_a: HGNC:PIGB
inverse_is_a: HGNC:PIGM
inverse_is_a: HGNC:PIGV
inverse_is_a: HGNC:PIGZ
inverse_is_a: HGNC:POMT1
inverse_is_a: HGNC:POMT2
[Term]
id: FPLX:ALG6_family
name: ALG6-family
synonym: "Alpha-1,3-glucosyltransferase" EXACT []
synonym: "Alpha-1,3-glucosyltransferases" EXACT []
synonym: "alpha-1,3-glucosyltransferase" EXACT []
synonym: "alpha-1,3-glucosyltransferases" EXACT []
synonym: "Alpha-1,4-glucosyltransferase" EXACT []
synonym: "Alpha-1,4-glucosyltransferases" EXACT []
synonym: "alpha-1,4-glucosyltransferase" EXACT []
synonym: "alpha-1,4-glucosyltransferases" EXACT []
xref: MESH:C036655
is_a: FPLX:Glycosyltransferase
inverse_is_a: HGNC:ALG6
inverse_is_a: HGNC:ALG8
[Term]
id: FPLX:AMPK
name: AMPK
def: "Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP." [mesh:D055372]
synonym: "AMPK" EXACT []
synonym: "AMP-activated" EXACT []
xref: BEL:"AMP Activated Protein Kinase Complex"
xref: ECCODE:2.7.11.31
xref: MEDSCAN:urn:agi-protfc:AMPK
xref: MESH:D055372
xref: NCIT:C94701
xref: NEXTPROT-FAMILY:03071
xref: RE:R-HSA-380931
xref: RE:R-HSA-380934
xref: RE:R-HSA-380961
xref: RE:R-HSA-6805467
xref: SIGNOR:SIGNOR-C15
xref: SCOMP:C0002
is_a: FPLX:root
inverse_is_a: FPLX:AMPK_A1B1G1
inverse_is_a: FPLX:AMPK_A1B1G2
inverse_is_a: FPLX:AMPK_A1B1G3
inverse_is_a: FPLX:AMPK_A1B2G1
inverse_is_a: FPLX:AMPK_A1B2G2
inverse_is_a: FPLX:AMPK_A1B2G3
inverse_is_a: FPLX:AMPK_A2B1G1
inverse_is_a: FPLX:AMPK_A2B1G2
inverse_is_a: FPLX:AMPK_A2B1G3
inverse_is_a: FPLX:AMPK_A2B2G1
inverse_is_a: FPLX:AMPK_A2B2G2
inverse_is_a: FPLX:AMPK_A2B2G3
has_part: FPLX:AMPK_alpha
has_part: FPLX:AMPK_beta
has_part: FPLX:AMPK_gamma
[Term]
id: FPLX:AMPK_A1B1G1
name: AMPK-A1B1G1
synonym: "AMPK (alpha 1, beta 1, gamma 1)" EXACT []
synonym: "AMPK (α 1, β 1, γ 1)" EXACT []
synonym: "alpha1beta1gamma1" EXACT []
synonym: "AMPK (A1/B1/G1)" EXACT []
synonym: "AMPK a1b1g1" EXACT []
synonym: "AMPK alpha1beta1gamma1" EXACT []
synonym: "AMPK α1β1γ1" EXACT []
synonym: "α1β1γ1" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA1
has_part: HGNC:PRKAB1
has_part: HGNC:PRKAG1
[Term]
id: FPLX:AMPK_A1B1G2
name: AMPK-A1B1G2
synonym: "AMPK (alpha 1, beta 1, gamma 2)" EXACT []
synonym: "AMPK (α 1, β 1, γ 2)" EXACT []
synonym: "alpha1beta1gamma2" EXACT []
synonym: "AMPK (A1/B1/G2)" EXACT []
synonym: "AMPK a1b1g2" EXACT []
synonym: "AMPK alpha1beta1gamma2" EXACT []
synonym: "AMPK α1β1γ2" EXACT []
synonym: "α1β1γ2" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA1
has_part: HGNC:PRKAB1
has_part: HGNC:PRKAG2
[Term]
id: FPLX:AMPK_A1B1G3
name: AMPK-A1B1G3
synonym: "AMPK (alpha 1, beta 1, gamma 3)" EXACT []
synonym: "AMPK (α 1, β 1, γ 3)" EXACT []
synonym: "alpha1beta1gamma3" EXACT []
synonym: "AMPK (A1/B1/G3)" EXACT []
synonym: "AMPK a1b1g3" EXACT []
synonym: "AMPK alpha1beta1gamma3" EXACT []
synonym: "AMPK α1β1γ3" EXACT []
synonym: "α1β1γ3" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA1
has_part: HGNC:PRKAB1
has_part: HGNC:PRKAG3
[Term]
id: FPLX:AMPK_A1B2G1
name: AMPK-A1B2G1
synonym: "AMPK (alpha 1, beta 2, gamma 1)" EXACT []
synonym: "AMPK (α 1, β 2, γ 1)" EXACT []
synonym: "alpha1beta2gamma1" EXACT []
synonym: "AMPK (A1/B2/G1)" EXACT []
synonym: "AMPK a1b2g1" EXACT []
synonym: "AMPK alpha1beta2gamma1" EXACT []
synonym: "AMPK α1β2γ1" EXACT []
synonym: "α1β2γ1" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA1
has_part: HGNC:PRKAB2
has_part: HGNC:PRKAG1
[Term]
id: FPLX:AMPK_A1B2G2
name: AMPK-A1B2G2
synonym: "AMPK (alpha 1, beta 2, gamma 2)" EXACT []
synonym: "AMPK (α 1, β 2, γ 2)" EXACT []
synonym: "alpha1beta2gamma2" EXACT []
synonym: "AMPK (A1/B2/G2)" EXACT []
synonym: "AMPK a1b2g2" EXACT []
synonym: "AMPK alpha1beta2gamma2" EXACT []
synonym: "AMPK α1β2γ2" EXACT []
synonym: "α1β2γ2" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA1
has_part: HGNC:PRKAB2
has_part: HGNC:PRKAG2
[Term]
id: FPLX:AMPK_A1B2G3
name: AMPK-A1B2G3
synonym: "AMPK (alpha 1, beta 2, gamma 3)" EXACT []
synonym: "AMPK (α 1, β 2, γ 3)" EXACT []
synonym: "AMPK (A1/B2/G3)" EXACT []
synonym: "AMPK alpha1beta2gamma3" EXACT []
synonym: "AMPK α1β2γ3" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA1
has_part: HGNC:PRKAB2
has_part: HGNC:PRKAG3
[Term]
id: FPLX:AMPK_A2B1G1
name: AMPK-A2B1G1
synonym: "AMPK (alpha 2, beta 1, gamma 1)" EXACT []
synonym: "AMPK (α 2, β 1, γ 1)" EXACT []
synonym: "alpha2beta1gamma1" EXACT []
synonym: "AMPK (A2/B1/G1)" EXACT []
synonym: "AMPK a2b1g1" EXACT []
synonym: "AMPK alpha2beta1gamma1" EXACT []
synonym: "AMPK α2β1γ1" EXACT []
synonym: "α2β1γ1" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA2
has_part: HGNC:PRKAB1
has_part: HGNC:PRKAG1
[Term]
id: FPLX:AMPK_A2B1G2
name: AMPK-A2B1G2
synonym: "AMPK (alpha 2, beta 1, gamma 2)" EXACT []
synonym: "AMPK (α 2, β 1, γ 2)" EXACT []
synonym: "AMPK (A2/B1/G2)" EXACT []
synonym: "AMPK alpha2beta1gamma2" EXACT []
synonym: "AMPK α2β1γ2" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA2
has_part: HGNC:PRKAB1
has_part: HGNC:PRKAG2
[Term]
id: FPLX:AMPK_A2B1G3
name: AMPK-A2B1G3
synonym: "AMPK (alpha 2, beta 1, gamma 3)" EXACT []
synonym: "AMPK (α 2, β 1, γ 3)" EXACT []
synonym: "AMPK (A2/B1/G3)" EXACT []
synonym: "AMPK alpha2beta1gamma3" EXACT []
synonym: "AMPK α2β1γ3" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA2
has_part: HGNC:PRKAB1
has_part: HGNC:PRKAG3
[Term]
id: FPLX:AMPK_A2B2G1
name: AMPK-A2B2G1
synonym: "AMPK (alpha 2, beta 2, gamma 1)" EXACT []
synonym: "AMPK (α 2, β 2, γ 1)" EXACT []
synonym: "alpha2beta2gamma1" EXACT []
synonym: "AMPK (A2/B2/G1)" EXACT []
synonym: "AMPK a2b2g1" EXACT []
synonym: "AMPK alpha2beta2gamma1" EXACT []
synonym: "AMPK α2β2γ1" EXACT []
synonym: "α2β2γ1" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA2
has_part: HGNC:PRKAB2
has_part: HGNC:PRKAG1
[Term]
id: FPLX:AMPK_A2B2G2
name: AMPK-A2B2G2
synonym: "AMPK (alpha 2, beta 2, gamma 2)" EXACT []
synonym: "AMPK (α 2, β 2, γ 2)" EXACT []
synonym: "alpha2beta2gamma2" EXACT []
synonym: "AMPK (A2/B2/G2)" EXACT []
synonym: "AMPK a2b2g2" EXACT []
synonym: "AMPK alpha2beta2gamma2" EXACT []
synonym: "AMPK α2β2γ2" EXACT []
synonym: "α2β2γ2" EXACT []
xref: RE:R-HSA-163679
xref: RE:R-HSA-163736
xref: RE:R-HSA-163747
xref: RE:R-HSA-200408
is_a: FPLX:AMPK
has_part: HGNC:PRKAA2
has_part: HGNC:PRKAB2
has_part: HGNC:PRKAG2
[Term]
id: FPLX:AMPK_A2B2G3
name: AMPK-A2B2G3
synonym: "AMPK (alpha 2, beta 2, gamma 3)" EXACT []
synonym: "AMPK (α 2, β 2, γ 3)" EXACT []
synonym: "alpha2beta2gamma3" EXACT []
synonym: "AMPK (A2/B2/G3)" EXACT []
synonym: "AMPK a2b2g3" EXACT []
synonym: "AMPK alpha2beta2gamma3" EXACT []
synonym: "AMPK α2β2γ3" EXACT []
synonym: "α2β2γ3" EXACT []
is_a: FPLX:AMPK
has_part: HGNC:PRKAA2
has_part: HGNC:PRKAB2
has_part: HGNC:PRKAG3
[Term]
id: FPLX:AMPK_alpha
name: AMPK-alpha
synonym: "AMPKalpha" EXACT []
synonym: "AMPKα" EXACT []
synonym: "PRKAA" EXACT []
xref: BEL:"PRKAA Family"
xref: IP:IPR032270
xref: NCIT:C116019
xref: RE:R-HSA-2151213
xref: RE:R-HSA-381844
xref: RE:R-HSA-381845
xref: SIGNOR:SIGNOR-PF6
xref: SFAM:F0194
part_of: FPLX:AMPK
inverse_is_a: HGNC:PRKAA1
inverse_is_a: HGNC:PRKAA2
[Term]
id: FPLX:AMPK_beta
name: AMPK-beta
synonym: "PRKAB" EXACT []
xref: BEL:"PRKAB Family"
xref: IP:IPR006828
xref: IP:IPR032640
xref: RE:R-HSA-2151208
xref: RE:R-HSA-381854
xref: SFAM:F0195
part_of: FPLX:AMPK
inverse_is_a: HGNC:PRKAB1
inverse_is_a: HGNC:PRKAB2
[Term]
id: FPLX:AMPK_gamma
name: AMPK-gamma
synonym: "PRKAG" EXACT []
xref: BEL:"PRKAG Family"
xref: RE:R-HSA-2151212
xref: RE:R-HSA-2316451
xref: RE:R-HSA-381851
xref: SFAM:F0196
part_of: FPLX:AMPK
inverse_is_a: HGNC:PRKAG1
inverse_is_a: HGNC:PRKAG2
inverse_is_a: HGNC:PRKAG3
[Term]
id: FPLX:Annexin_II_heterotetramer
name: Annexin-II-heterotetramer
synonym: "A2t" EXACT []
synonym: "annexin A2 heterotetramer" EXACT []
synonym: "annexin II heterotetramer" EXACT []
synonym: "ANXA2 heterotetramer" EXACT []
xref: BEL:"Annexin II Heterotetramer Complex"
xref: RE:R-HSA-5336141
xref: SCOMP:C0011
is_a: FPLX:root
has_part: HGNC:ANXA2
has_part: HGNC:S100A10
[Term]
id: FPLX:ANO
name: ANO
def: "A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding." [mesh:D000075368]
xref: HGNC_GROUP:865
xref: MESH:D000075368
is_a: FPLX:Chloride_calcium_activated_channels
inverse_is_a: HGNC:ANO1
inverse_is_a: HGNC:ANO10
inverse_is_a: HGNC:ANO2
inverse_is_a: HGNC:ANO3
inverse_is_a: HGNC:ANO4
inverse_is_a: HGNC:ANO5
inverse_is_a: HGNC:ANO6
inverse_is_a: HGNC:ANO7
inverse_is_a: HGNC:ANO8
inverse_is_a: HGNC:ANO9
[Term]
id: FPLX:AP1
name: AP1
def: "A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes." [mesh:D018808]
synonym: "AP-1" EXACT []