diff --git a/.github/workflows/ci_macos.yml b/.github/workflows/ci_macos.yml
index 65f446f1..53d3d2f0 100644
--- a/.github/workflows/ci_macos.yml
+++ b/.github/workflows/ci_macos.yml
@@ -9,6 +9,8 @@ on:
     branches:
       - 'main'
   pull_request:
+    types:
+      - unlabeled
   workflow_dispatch:
 
 concurrency:
@@ -25,49 +27,39 @@ defaults:
 
 jobs:
   build:
-    name: test
+    name: ${{ matrix.compiler }}
     runs-on: macos-12
     if: github.repository_owner == 'seqan' || github.event_name == 'workflow_dispatch' || github.event.label.name == 'lint'
+    strategy:
+      fail-fast: false
+      matrix:
+        compiler: ["clang-18", "clang-17", "gcc-14", "gcc-13", "gcc-12", "gcc-11"]
+        include:
+          - cxx_flags: "-std=c++23 -Wno-interference-size"
+          - compiler: "clang-18"
+            cxx_flags: "-std=c++23"
+          - compiler: "clang-17"
+            cxx_flags: "-std=c++20"
     steps:
       - name: Checkout
         uses: actions/checkout@v4
 
-      - name: Setup Homebrew
-        uses: Homebrew/actions/setup-homebrew@master
-
-      - name: Configure Homebrew
-        run: |
-          echo "HOMEBREW_NO_INSTALL_CLEANUP=1" >> "$GITHUB_ENV"
-          echo "HOMEBREW_NO_INSTALLED_DEPENDENTS_CHECK=1" >> "$GITHUB_ENV"
+      - name: Setup toolchain
+        uses: seqan/actions/setup-toolchain@main
+        with:
+          compiler: ${{ matrix.compiler }}
+          ccache_size: 75M
 
       - name: Install CMake
         uses: seqan/actions/setup-cmake@main
         with:
           cmake: 3.28.5
 
-      - name: install ccache
-        run: |
-          echo "version"
-          brew list --versions ccache
-          echo $?
-          brew list --versions gcc
-          echo $?
-          if [[ -z $(brew list --versions ccache) ]]; then
-              echo "install"
-              brew install --force-bottle ccache || true
-          else
-              # Unlink the package. brew unlink does not take a version.
-              echo "unlink"
-              brew unlink ccache || true
-              echo "upgrade"
-              brew upgrade --force-bottle ccache
-          fi
-
       - name: Configure tests
         run: |
           mkdir build
           cd build
-          cmake ../test/unit -DCMAKE_BUILD_TYPE=Release -DCMAKE_CXX_FLAGS="-std=c++23"
+          cmake ../test/unit -DCMAKE_BUILD_TYPE=Release -DCMAKE_CXX_FLAGS="${{ matrix.cxx_flags }}"
           make -j gtest_main
 
       - name: Build tests