diff --git a/scrapy_poet/_request_fingerprinter.py b/scrapy_poet/_request_fingerprinter.py
index f6593a16..7073754f 100644
--- a/scrapy_poet/_request_fingerprinter.py
+++ b/scrapy_poet/_request_fingerprinter.py
@@ -13,6 +13,7 @@
     from typing import Callable, Dict, List, Optional, get_args, get_origin
     from weakref import WeakKeyDictionary
 
+    from andi import CustomBuilder
     from scrapy import Request
     from scrapy.crawler import Crawler
     from scrapy.settings.default_settings import REQUEST_FINGERPRINTER_CLASS
@@ -34,6 +35,8 @@
     logger = getLogger(__name__)
 
     def _serialize_dep(cls):
+        if isinstance(cls, CustomBuilder):
+            cls = cls.result_class_or_fn
         try:
             from typing import Annotated
         except ImportError:
diff --git a/scrapy_poet/utils/testing.py b/scrapy_poet/utils/testing.py
index b334c8cb..6d7ad28c 100644
--- a/scrapy_poet/utils/testing.py
+++ b/scrapy_poet/utils/testing.py
@@ -15,6 +15,7 @@
 from twisted.web.resource import Resource
 from twisted.web.server import NOT_DONE_YET
 
+from scrapy_poet import ScrapyPoetRequestFingerprinter
 from scrapy_poet.utils.mockserver import MockServer
 
 
@@ -231,6 +232,7 @@ def create_scrapy_settings(request):
             InjectedDependenciesCollectorMiddleware: 542,
             "scrapy_poet.InjectionMiddleware": 543,
         },
+        REQUEST_FINGERPRINTER_CLASS=ScrapyPoetRequestFingerprinter,
     )
     return Settings(s)
 
diff --git a/tests/test_request_fingerprinter.py b/tests/test_request_fingerprinter.py
index b329590d..a860225b 100644
--- a/tests/test_request_fingerprinter.py
+++ b/tests/test_request_fingerprinter.py
@@ -512,3 +512,35 @@ async def parse_page(self, response, page: WebPage):
         fingerprinter.fingerprint(request)
         fingerprinter.fingerprint(request)
         mock.assert_called_once_with(request)
+
+
+def test_item(settings):
+    """Test that fingerprinting works even for items."""
+    from scrapy import Request, Spider
+    from web_poet import ItemPage, RulesRegistry
+
+    registry = RulesRegistry()
+
+    class MyItem:
+        pass
+
+    @registry.handle_urls("example.com")
+    class MyPage(ItemPage[MyItem]):
+        pass
+
+    class TestSpider(Spider):
+        name = "test"
+
+        def __init__(self, *args, **kwargs):
+            self.request = Request("https://example.com", callback=self.parse_page)
+
+        async def parse_page(self, response, a: MyItem):
+            pass
+
+    settings["SCRAPY_POET_RULES"] = registry.get_rules()
+    crawler = get_crawler(spider_cls=TestSpider, settings=settings)
+    fingerprinter = crawler.request_fingerprinter
+
+    fingerprint = fingerprinter.fingerprint(crawler.spider.request)
+    assert fingerprint
+    assert isinstance(fingerprint, bytes)