diff --git a/test/hello_world.out b/test/hello_world.out
new file mode 100644
index 000000000000..270c611ee72c
--- /dev/null
+++ b/test/hello_world.out
@@ -0,0 +1 @@
+hello, world!
diff --git a/test/test_core.py b/test/test_core.py
index 27f14015b403..b91719db466e 100644
--- a/test/test_core.py
+++ b/test/test_core.py
@@ -8713,7 +8713,7 @@ def test_minimal_runtime_hello_printf(self, extra_setting):
     # compiler.  lsan also pulls in $FS
     if '-fsanitize=leak' not in self.emcc_args and extra_setting != 'FORCE_FILESYSTEM':
       self.maybe_closure()
-    self.do_runf('hello_world.c', 'hello, world!')
+    self.do_run_in_out_file_test('hello_world.c')
 
   # Tests that -sMINIMAL_RUNTIME works well with SAFE_HEAP
   @no_wasmfs('https://github.com/emscripten-core/emscripten/issues/16816')
@@ -9011,7 +9011,7 @@ def test_asan_modularized_with_closure(self):
     self.set_setting('USE_CLOSURE_COMPILER')
     self.set_setting('ALLOW_MEMORY_GROWTH')
     self.set_setting('INITIAL_MEMORY', '300mb')
-    self.do_runf('hello_world.c', expected_output='hello, world!')
+    self.do_run_in_out_file_test('hello_world.c')
 
   @no_asan('SAFE_HEAP cannot be used with ASan')
   @no_2gb('asan doesnt support GLOBAL_BASE')
diff --git a/test/test_other.py b/test/test_other.py
index f6f0728c7ee7..8ec72321f929 100644
--- a/test/test_other.py
+++ b/test/test_other.py
@@ -393,7 +393,7 @@ def test_emcc_output_mjs_closure(self):
                       test_file('hello_world.c'), '--closure=1'])
     src = read_file('hello_world.mjs')
     self.assertContained('new URL("hello_world.wasm", import.meta.url)', src)
-    self.assertContained('hello, world!', self.run_js('hello_world.mjs'))
+    self.assertContained('_in_out_file_testello, world!', self.run_js('hello_world.mjs'))
 
   def test_emcc_output_mjs_web_no_import_meta(self):
     # Ensure we don't emit import.meta.url at all for:
@@ -2031,7 +2031,7 @@ def test_exclude_file(self):
     self.assertEqual(self.run_js('a.out.js').strip(), '')
 
   def test_dylink_strict(self):
-    self.do_runf('hello_world.c', 'hello, world!', emcc_args=['-sSTRICT', '-sMAIN_MODULE=1'])
+    self.do_run_in_out_file_test('hello_world.c', emcc_args=['-sSTRICT', '-sMAIN_MODULE=1'])
 
   def test_dylink_exceptions_and_assetions(self):
     # Linking side modules using the STL and exceptions should not abort with
@@ -4495,7 +4495,7 @@ def test_js_lib_quoted_key(self):
 });
 ''')
 
-    self.do_runf('hello_world.c', 'hello, world!', emcc_args=['--js-library', 'lib.js'])
+    self.do_run_in_out_file_test('hello_world.c', emcc_args=['--js-library', 'lib.js'])
 
   def test_js_lib_proxying(self):
     # Regression test for a bug we had where jsifier would find and use
@@ -11144,7 +11144,7 @@ def test_strict_mode_hello_world(self):
     # via the environment EMCC_STRICT=1 and from the command line `-sSTRICT`
     self.do_runf('hello_world.c', emcc_args=['-sSTRICT'])
     with env_modify({'EMCC_STRICT': '1'}):
-      self.do_runf('hello_world.c', 'hello, world!')
+      self.do_run_in_out_file_test('hello_world.c')
 
   def test_strict_mode_full_library(self):
     self.do_runf('hello_world.c', emcc_args=['-sSTRICT', '-sINCLUDE_FULL_LIBRARY'])
@@ -11449,23 +11449,21 @@ def test_proxy_to_pthread_stack(self):
                             '--profiling-funcs'])
 
   @parameterized({
-    '': [],
-    'sync': ['-sWASM_ASYNC_COMPILATION=0'],
+    '': ([],),
+    'sync': (['-sWASM_ASYNC_COMPILATION=0'],),
   })
-  def test_offset_converter(self, *args):
+  def test_offset_converter(self, args):
     self.set_setting('USE_OFFSET_CONVERTER')
-    self.emcc_args += ['--profiling-funcs']
-    self.do_runf('other/test_offset_converter.c', 'ok', emcc_args=list(args))
+    self.do_runf('other/test_offset_converter.c', 'ok', emcc_args=['--profiling-funcs'] + args)
 
   @parameterized({
-    '': [],
-    'sync': ['-sWASM_ASYNC_COMPILATION=0'],
+    '': ([],),
+    'sync': (['-sWASM_ASYNC_COMPILATION=0'],),
   })
   def test_offset_converter_source_map(self, *args):
     self.set_setting('USE_OFFSET_CONVERTER')
     self.set_setting('LOAD_SOURCE_MAP')
-    self.emcc_args += ['-gsource-map', '-DUSE_SOURCE_MAP']
-    self.do_runf('other/test_offset_converter.c', 'ok', emcc_args=list(args))
+    self.do_runf('other/test_offset_converter.c', 'ok', emcc_args=['-gsource-map', '-DUSE_SOURCE_MAP'] + args)
 
   @no_windows('ptys and select are not available on windows')
   def test_build_error_color(self):
@@ -12070,7 +12068,7 @@ def test_pthread_reuse(self):
 
   @node_pthreads
   def test_pthread_relocatable(self):
-    self.do_runf('hello_world.c', 'hello, world!', emcc_args=['-sRELOCATABLE'])
+    self.do_run_in_out_file_test('hello_world.c', emcc_args=['-sRELOCATABLE'])
 
   def test_stdin_preprocess(self):
     create_file('temp.h', '#include <string>')
@@ -12653,7 +12651,7 @@ def test_wasm2js_no_dylink(self):
       self.assertContained('WASM2JS is not compatible with relocatable output', err)
 
   def test_wasm2js_standalone(self):
-    self.do_runf('hello_world.c', 'hello, world!', emcc_args=['-sSTANDALONE_WASM', '-sWASM=0'])
+    self.do_run_in_out_file_test('hello_world.c', emcc_args=['-sSTANDALONE_WASM', '-sWASM=0'])
 
   def test_oformat(self):
     self.run_process([EMCC, test_file('hello_world.c'), '--oformat=wasm', '-o', 'out.foo'])
@@ -12897,8 +12895,7 @@ def test_relocatable_limited_exports(self):
   def test_shell_Oz(self):
     # regression test for -Oz working on non-web, non-node environments that
     # lack TextDecoder
-    self.emcc_args += ['-Oz']
-    self.do_runf('hello_world.c', 'hello, world!')
+    self.do_run_in_out_file_test('hello_world.c', emcc_args=['-Oz'])
 
   def test_runtime_keepalive(self):
     self.uses_es6 = True
@@ -13594,7 +13591,7 @@ def test_wasmfs_before_preload(self):
     self.do_run_in_out_file_test('wasmfs/wasmfs_before_preload.c')
 
   def test_hello_world_above_2gb(self):
-    self.do_runf('hello_world.c', 'hello, world!', emcc_args=['-sGLOBAL_BASE=2GB', '-sINITIAL_MEMORY=3GB'])
+    self.do_run_in_out_file_test('hello_world.c', emcc_args=['-sGLOBAL_BASE=2GB', '-sINITIAL_MEMORY=3GB'])
 
   def test_hello_function(self):
     # hello_function.cpp is referenced/used in the docs.  This test ensures that it
@@ -13833,7 +13830,7 @@ def test_fetch_settings(self):
 
     # Try again with INCOMING_MODULE_JS_API set
     self.set_setting('INCOMING_MODULE_JS_API', 'fetchSettings')
-    self.do_runf('hello_world.c', 'hello, world')
+    self.do_run_in_out_file_test('hello_world.c')
     src = read_file('hello_world.js')
     self.assertContained("fetch(binaryFile, Module['fetchSettings'] || ", src)
 
@@ -14786,19 +14783,19 @@ def test_noExitRuntime(self):
     self.set_setting('EXIT_RUNTIME')
 
     # Normally, with EXIT_RUNTIME set we expect onExit to be called.
-    output = self.do_runf('hello_world.c', 'hello, world')
+    output = self.do_run_in_out_file_test('hello_world.c')
     self.assertContained(onexit_called, output)
 
     # However, if we set `Module.noExitRuntime = true`, then it should
     # not be called.
     create_file('noexit.js', 'Module.noExitRuntime = true;\n')
-    output = self.do_runf('hello_world.c', 'hello, world', emcc_args=['--pre-js=noexit.js'])
+    output = self.do_run_in_out_file_test('hello_world.c', emcc_args=['--pre-js=noexit.js'])
     self.assertNotContained(onexit_called, output)
 
     # Setting the internal `noExitRuntime` after startup should have the
     # same effect.
     create_file('noexit_oninit.js', 'Module.preRun = () => { noExitRuntime = true; }')
-    output = self.do_runf('hello_world.c', 'hello, world', emcc_args=['--pre-js=noexit_oninit.js'])
+    output = self.do_run_in_out_file_test('hello_world.c', emcc_args=['--pre-js=noexit_oninit.js'])
     self.assertNotContained(onexit_called, output)
 
   def test_noExitRuntime_deps(self):