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KP.3.1.1 + S:D88E (16 Seqs , 3 places) #2076

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FedeGueli opened this issue Sep 23, 2024 · 0 comments
Open

KP.3.1.1 + S:D88E (16 Seqs , 3 places) #2076

FedeGueli opened this issue Sep 23, 2024 · 0 comments
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KP.3.1.1 New mutations Lineage with an unusual/new/interesting mutation S:88

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@FedeGueli
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S:D88E has been sampled less than 1K in the course of the pandemic mainly during the VOCs era.
Now it popped up on Kp.3.1.1 backbone, as usual KP.3.1.1 sublineages don't show any advantage over parental baseline.

Still interesting to keep it tracked for a while. S:P85X has been under selective pressure since S:S31del is widespread.

KP.3.1.1 > Orf1a:K141R (A687G) > A24820G (= S:K1086K silent) > S:D88E (T21826A)
Query: A687G,T21826A
Samples: 17
First collected on 2024-06-23 (UK)
Places : 3 Uk, Us, Can

Tree:
Interestingly the main two branches are defined by two Orf3a mutations: the upper branch by Orf3a:S60F. (convergent with JN.1.48.3) and the bottom branch by Orf3a:K16N 8 convergent with #2068

Screenshot 2024-09-23 alle 02 08 40 https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_5d138_fc5250.json?c=userOrOld&label=id:node_7028939
@FedeGueli FedeGueli added New mutations Lineage with an unusual/new/interesting mutation KP.3.1.1 S:88 labels Sep 23, 2024
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