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annotations.jsonl
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{"text": "Furthermore, Smad-phosphorylation was followed by upregulation of Id1 mRNA and Id1 protein, whereas Id2 and Id3 expression was not affected.", "spans": [{"text": "Smad", "start": 13, "token_start": 2, "token_end": 2, "end": 17, "type": "span", "label": "GGP"}, {"text": "Id1", "start": 66, "token_start": 10, "token_end": 10, "end": 69, "type": "span", "label": "GGP"}, {"text": "Id1", "start": 79, "token_start": 13, "token_end": 13, "end": 82, "type": "span", "label": "GGP"}, {"text": "Id2", "start": 100, "token_start": 17, "token_end": 17, "end": 103, "type": "span", "label": "GGP"}, {"text": "Id3", "start": 108, "token_start": 19, "token_end": 19, "end": 111, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1134658-00-TIAB.txt"}, "_input_hash": -13216227, "_task_hash": -1944660624, "tokens": [{"text": "Furthermore", "start": 0, "end": 11, "id": 0, "ws": false, "disabled": true}, {"text": ",", "start": 11, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "Smad", "start": 13, "end": 17, "id": 2, "ws": false, "disabled": false}, {"text": "-", "start": 17, "end": 18, "id": 3, "ws": false, "disabled": true}, {"text": "phosphorylation", "start": 18, "end": 33, "id": 4, "ws": true, "disabled": true}, {"text": "was", "start": 34, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "followed", "start": 38, "end": 46, "id": 6, "ws": true, "disabled": true}, {"text": "by", "start": 47, "end": 49, "id": 7, "ws": true, "disabled": true}, {"text": "upregulation", "start": 50, "end": 62, "id": 8, "ws": true, "disabled": true}, {"text": "of", "start": 63, "end": 65, "id": 9, "ws": true, "disabled": true}, {"text": "Id1", "start": 66, "end": 69, "id": 10, "ws": true, "disabled": false}, {"text": "mRNA", "start": 70, "end": 74, "id": 11, "ws": true, "disabled": true}, {"text": "and", "start": 75, "end": 78, "id": 12, "ws": true, "disabled": true}, {"text": "Id1", "start": 79, "end": 82, "id": 13, "ws": true, "disabled": false}, {"text": "protein", "start": 83, "end": 90, "id": 14, "ws": false, "disabled": true}, {"text": ",", "start": 90, "end": 91, "id": 15, "ws": true, "disabled": true}, {"text": "whereas", "start": 92, "end": 99, "id": 16, "ws": true, "disabled": true}, {"text": "Id2", "start": 100, "end": 103, "id": 17, "ws": true, "disabled": false}, {"text": "and", "start": 104, "end": 107, "id": 18, "ws": true, "disabled": true}, {"text": "Id3", "start": 108, "end": 111, "id": 19, "ws": true, "disabled": false}, {"text": "expression", "start": 112, "end": 122, "id": 20, "ws": true, "disabled": true}, {"text": "was", "start": 123, "end": 126, "id": 21, "ws": true, "disabled": true}, {"text": "not", "start": 127, "end": 130, "id": 22, "ws": true, "disabled": true}, {"text": "affected", "start": 131, "end": 139, "id": 23, "ws": false, "disabled": true}, {"text": ".", "start": 139, "end": 140, "id": 24, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 2, "child": 10, "head_span": {"start": 13, "end": 17, "token_start": 2, "token_end": 2, "label": "GGP"}, "child_span": {"start": 66, "end": 69, "token_start": 10, "token_end": 10, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 2, "child": 13, "head_span": {"start": 13, "end": 17, "token_start": 2, "token_end": 2, "label": "GGP"}, "child_span": {"start": 79, "end": 82, "token_start": 13, "token_end": 13, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 2, "child": 17, "head_span": {"start": 13, "end": 17, "token_start": 2, "token_end": 2, "label": "GGP"}, "child_span": {"start": 100, "end": 103, "token_start": 17, "token_end": 17, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}, {"head": 2, "child": 19, "head_span": {"start": 13, "end": 17, "token_start": 2, "token_end": 2, "label": "GGP"}, "child_span": {"start": 108, "end": 111, "token_start": 19, "token_end": 19, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).", "spans": [{"text": "BMP-6", "start": 0, "token_start": 0, "token_end": 0, "end": 5, "type": "span", "label": "GGP"}, {"text": "Act-RIA", "start": 62, "token_start": 11, "token_end": 13, "end": 69, "type": "span", "label": "GGP"}, {"text": "BMP-RIA", "start": 71, "token_start": 15, "token_end": 17, "end": 78, "type": "span", "label": "GGP"}, {"text": "BMP-RIB", "start": 84, "token_start": 20, "token_end": 22, "end": 91, "type": "span", "label": "GGP"}, {"text": "BMP-RII", "start": 118, "token_start": 28, "token_end": 30, "end": 125, "type": "span", "label": "GGP"}, {"text": "Act-RIIA", "start": 127, "token_start": 32, "token_end": 34, "end": 135, "type": "span", "label": "GGP"}, {"text": "Act-RIIB", "start": 140, "token_start": 36, "token_end": 38, "end": 148, "type": "span", "label": "GGP"}, {"text": "Smad-1", "start": 207, "token_start": 50, "token_end": 50, "end": 213, "type": "span", "label": "GGP"}, {"text": "Smad-5", "start": 215, "token_start": 52, "token_end": 52, "end": 221, "type": "span", "label": "GGP"}, {"text": "Smad-8", "start": 227, "token_start": 55, "token_end": 55, "end": 233, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1134658-01-Background.txt"}, "_input_hash": 727082570, "_task_hash": 212084727, "tokens": [{"text": "BMP-6", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": false}, {"text": "can", "start": 6, "end": 9, "id": 1, "ws": true, "disabled": true}, {"text": "signal", "start": 10, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "through", "start": 17, "end": 24, "id": 3, "ws": true, "disabled": true}, {"text": "the", "start": 25, "end": 28, "id": 4, "ws": true, "disabled": true}, {"text": "ligation", "start": 29, "end": 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{"text": "The up-regulation of Id1 mRNA was characteristic of an early inducible gene, with maximal upregulation two hours after the addition of BMP-6 and returned to baseline after 24 hours.", "spans": [{"text": "Id1", "start": 21, "token_start": 5, "token_end": 5, "end": 24, "type": "span", "label": "GGP"}, {"text": "BMP-6", "start": 135, "token_start": 24, "token_end": 24, "end": 140, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1134658-06-Results-05.txt"}, "_input_hash": -577520572, "_task_hash": -967715784, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "up", "start": 4, "end": 6, "id": 1, "ws": false, "disabled": true}, {"text": "-", "start": 6, "end": 7, "id": 2, "ws": false, "disabled": true}, {"text": "regulation", "start": 7, "end": 17, "id": 3, "ws": true, "disabled": true}, {"text": "of", "start": 18, "end": 20, "id": 4, "ws": true, "disabled": true}, {"text": "Id1", "start": 21, "end": 24, "id": 5, "ws": true, "disabled": false}, {"text": "mRNA", "start": 25, "end": 29, "id": 6, "ws": true, "disabled": true}, {"text": "was", "start": 30, "end": 33, "id": 7, "ws": true, "disabled": true}, {"text": "characteristic", "start": 34, "end": 48, "id": 8, "ws": true, "disabled": true}, {"text": "of", "start": 49, "end": 51, "id": 9, "ws": true, "disabled": true}, {"text": "an", "start": 52, "end": 54, "id": 10, "ws": true, "disabled": true}, {"text": "early", "start": 55, "end": 60, "id": 11, "ws": true, "disabled": true}, {"text": "inducible", "start": 61, "end": 70, "id": 12, "ws": true, "disabled": true}, {"text": "gene", "start": 71, "end": 75, "id": 13, "ws": false, "disabled": true}, {"text": ",", "start": 75, "end": 76, "id": 14, "ws": true, "disabled": true}, {"text": "with", "start": 77, "end": 81, "id": 15, "ws": true, "disabled": true}, {"text": "maximal", "start": 82, "end": 89, "id": 16, "ws": true, "disabled": true}, {"text": "upregulation", "start": 90, "end": 102, "id": 17, "ws": true, "disabled": true}, {"text": "two", "start": 103, "end": 106, "id": 18, "ws": true, "disabled": true}, {"text": "hours", "start": 107, "end": 112, "id": 19, "ws": true, "disabled": true}, {"text": "after", "start": 113, "end": 118, "id": 20, "ws": true, "disabled": true}, {"text": "the", "start": 119, "end": 122, "id": 21, "ws": true, "disabled": true}, {"text": "addition", "start": 123, "end": 131, "id": 22, "ws": true, "disabled": true}, {"text": "of", "start": 132, "end": 134, "id": 23, "ws": true, "disabled": true}, {"text": "BMP-6", "start": 135, "end": 140, "id": 24, "ws": true, "disabled": false}, {"text": "and", "start": 141, "end": 144, "id": 25, "ws": true, "disabled": true}, {"text": "returned", "start": 145, "end": 153, "id": 26, "ws": true, "disabled": true}, {"text": "to", "start": 154, "end": 156, "id": 27, "ws": true, "disabled": true}, {"text": "baseline", "start": 157, "end": 165, "id": 28, "ws": true, "disabled": true}, {"text": "after", "start": 166, "end": 171, "id": 29, "ws": true, "disabled": true}, {"text": "24", "start": 172, "end": 174, "id": 30, "ws": true, "disabled": true}, {"text": "hours", "start": 175, "end": 180, "id": 31, "ws": false, "disabled": true}, {"text": ".", "start": 180, "end": 181, "id": 32, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 24, "child": 5, "head_span": {"start": 135, "end": 140, "token_start": 24, "token_end": 24, "label": "GGP"}, "child_span": {"start": 21, "end": 24, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "This is in line with others, showing that Noggin can function as a BMP-6 antagonist [21,22].", "spans": [{"text": "Noggin", "start": 42, "token_start": 9, "token_end": 9, "end": 48, "type": "span", "label": "GGP"}, {"text": "BMP-6", "start": 67, "token_start": 14, "token_end": 14, "end": 72, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1134658-08-Discussion.txt"}, "_input_hash": 1372022403, "_task_hash": -2146109854, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "is", "start": 5, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "in", "start": 8, "end": 10, "id": 2, "ws": true, "disabled": true}, {"text": "line", "start": 11, "end": 15, "id": 3, "ws": true, "disabled": true}, {"text": "with", "start": 16, "end": 20, "id": 4, "ws": true, "disabled": true}, {"text": "others", "start": 21, "end": 27, "id": 5, "ws": false, "disabled": true}, {"text": ",", "start": 27, "end": 28, "id": 6, "ws": true, "disabled": true}, {"text": "showing", "start": 29, "end": 36, "id": 7, "ws": true, "disabled": true}, {"text": "that", "start": 37, "end": 41, "id": 8, "ws": true, "disabled": true}, {"text": "Noggin", "start": 42, "end": 48, "id": 9, "ws": true, "disabled": false}, {"text": "can", "start": 49, "end": 52, "id": 10, "ws": true, "disabled": true}, {"text": "function", "start": 53, "end": 61, "id": 11, "ws": true, "disabled": true}, {"text": "as", "start": 62, "end": 64, "id": 12, "ws": true, "disabled": true}, {"text": "a", "start": 65, "end": 66, "id": 13, "ws": true, "disabled": true}, {"text": "BMP-6", "start": 67, "end": 72, "id": 14, "ws": true, "disabled": false}, {"text": "antagonist", "start": 73, "end": 83, "id": 15, "ws": true, "disabled": true}, {"text": "[", "start": 84, "end": 85, "id": 16, "ws": false, "disabled": true}, {"text": "21,22", "start": 85, "end": 90, "id": 17, "ws": false, "disabled": true}, {"text": "]", "start": 90, "end": 91, "id": 18, "ws": false, "disabled": true}, {"text": ".", "start": 91, "end": 92, "id": 19, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 9, "child": 14, "head_span": {"start": 42, "end": 48, "token_start": 9, "token_end": 9, "label": "GGP"}, "child_span": {"start": 67, "end": 72, "token_start": 14, "token_end": 14, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "Furthermore, BMP-2 has been shown to induce activation of STAT3 in myeloma cells [9].", "spans": [{"text": "BMP-2", "start": 13, "token_start": 2, "token_end": 2, "end": 18, "type": "span", "label": "GGP"}, {"text": "STAT3", "start": 58, "token_start": 10, "token_end": 10, "end": 63, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1134658-08-Discussion.txt"}, "_input_hash": -1041954416, "_task_hash": 1574866598, "tokens": [{"text": "Furthermore", "start": 0, "end": 11, "id": 0, "ws": false, "disabled": true}, {"text": ",", "start": 11, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "BMP-2", "start": 13, "end": 18, "id": 2, "ws": true, "disabled": false}, {"text": "has", "start": 19, "end": 22, "id": 3, "ws": true, "disabled": true}, {"text": "been", "start": 23, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "shown", "start": 28, "end": 33, "id": 5, "ws": true, "disabled": true}, {"text": "to", "start": 34, "end": 36, "id": 6, "ws": true, "disabled": true}, {"text": "induce", "start": 37, "end": 43, "id": 7, "ws": true, "disabled": true}, {"text": "activation", "start": 44, "end": 54, "id": 8, "ws": true, "disabled": true}, {"text": "of", "start": 55, "end": 57, "id": 9, "ws": true, "disabled": true}, {"text": "STAT3", "start": 58, "end": 63, "id": 10, "ws": true, "disabled": false}, {"text": "in", "start": 64, "end": 66, "id": 11, "ws": true, "disabled": true}, {"text": "myeloma", "start": 67, "end": 74, "id": 12, "ws": true, "disabled": true}, {"text": "cells", "start": 75, "end": 80, "id": 13, "ws": true, "disabled": true}, {"text": "[", "start": 81, "end": 82, "id": 14, "ws": false, "disabled": true}, {"text": "9", "start": 82, "end": 83, "id": 15, "ws": false, "disabled": true}, {"text": "]", "start": 83, "end": 84, "id": 16, "ws": false, "disabled": true}, {"text": ".", "start": 84, "end": 85, "id": 17, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 2, "child": 10, "head_span": {"start": 13, "end": 18, "token_start": 2, "token_end": 2, "label": "GGP"}, "child_span": {"start": 58, "end": 63, "token_start": 10, "token_end": 10, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "In that respect, it is noteworthy that TGF-beta signalling in early and mature B cells induces both Id2 and Id3 expression [36,37], but not Id1 (data not shown).", "spans": [{"text": "TGF-beta", "start": 39, "token_start": 8, "token_end": 10, "end": 47, "type": "span", "label": "GGP"}, {"text": "Id2", "start": 100, "token_start": 20, "token_end": 20, "end": 103, "type": "span", "label": "GGP"}, {"text": "Id3", "start": 108, "token_start": 22, "token_end": 22, "end": 111, "type": "span", "label": "GGP"}, {"text": "Id1", "start": 140, "token_start": 30, "token_end": 30, "end": 143, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1134658-08-Discussion.txt"}, "_input_hash": 1843710425, "_task_hash": 1985132968, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "that", "start": 3, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "respect", "start": 8, "end": 15, "id": 2, "ws": false, "disabled": true}, {"text": ",", "start": 15, "end": 16, "id": 3, "ws": true, "disabled": true}, {"text": "it", "start": 17, "end": 19, "id": 4, "ws": true, "disabled": true}, {"text": "is", "start": 20, "end": 22, "id": 5, "ws": true, "disabled": true}, {"text": "noteworthy", "start": 23, "end": 33, "id": 6, "ws": true, "disabled": true}, {"text": "that", "start": 34, "end": 38, "id": 7, "ws": true, "disabled": true}, {"text": "TGF", "start": 39, "end": 42, "id": 8, "ws": false, "disabled": false}, {"text": "-", "start": 42, "end": 43, "id": 9, "ws": false, "disabled": false}, {"text": "beta", "start": 43, "end": 47, "id": 10, "ws": true, "disabled": false}, {"text": "signalling", "start": 48, "end": 58, "id": 11, "ws": true, "disabled": true}, {"text": "in", "start": 59, "end": 61, "id": 12, "ws": true, "disabled": true}, {"text": "early", "start": 62, "end": 67, "id": 13, "ws": true, "disabled": true}, {"text": "and", "start": 68, "end": 71, "id": 14, "ws": true, "disabled": true}, {"text": "mature", "start": 72, "end": 78, "id": 15, "ws": true, "disabled": true}, {"text": "B", "start": 79, "end": 80, "id": 16, "ws": true, "disabled": true}, {"text": "cells", "start": 81, "end": 86, "id": 17, "ws": true, "disabled": true}, {"text": "induces", "start": 87, "end": 94, "id": 18, "ws": true, "disabled": true}, {"text": "both", "start": 95, "end": 99, "id": 19, "ws": true, "disabled": true}, {"text": "Id2", "start": 100, "end": 103, "id": 20, "ws": true, "disabled": false}, {"text": "and", "start": 104, "end": 107, "id": 21, "ws": true, "disabled": true}, {"text": "Id3", "start": 108, "end": 111, "id": 22, "ws": true, "disabled": false}, {"text": "expression", "start": 112, "end": 122, "id": 23, "ws": true, "disabled": true}, {"text": "[", "start": 123, "end": 124, "id": 24, "ws": false, "disabled": true}, {"text": "36,37", "start": 124, "end": 129, "id": 25, "ws": false, "disabled": true}, {"text": "]", "start": 129, "end": 130, "id": 26, "ws": false, "disabled": true}, {"text": ",", "start": 130, "end": 131, "id": 27, "ws": true, "disabled": true}, {"text": "but", "start": 132, "end": 135, "id": 28, "ws": true, "disabled": true}, {"text": "not", "start": 136, "end": 139, "id": 29, "ws": true, "disabled": true}, {"text": "Id1", "start": 140, "end": 143, "id": 30, "ws": true, "disabled": false}, {"text": "(", "start": 144, "end": 145, "id": 31, "ws": false, "disabled": true}, {"text": "data", "start": 145, "end": 149, "id": 32, "ws": true, "disabled": true}, {"text": "not", "start": 150, "end": 153, "id": 33, "ws": true, "disabled": true}, {"text": "shown", "start": 154, "end": 159, "id": 34, "ws": false, "disabled": true}, {"text": ")", "start": 159, "end": 160, "id": 35, "ws": false, "disabled": true}, {"text": ".", "start": 160, "end": 161, "id": 36, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 10, "child": 20, "head_span": {"start": 39, "end": 47, "token_start": 8, "token_end": 10, "label": "GGP"}, "child_span": {"start": 100, "end": 103, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 10, "child": 22, "head_span": {"start": 39, "end": 47, "token_start": 8, "token_end": 10, "label": "GGP"}, "child_span": {"start": 108, "end": 111, "token_start": 22, "token_end": 22, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 10, "child": 30, "head_span": {"start": 39, "end": 47, "token_start": 8, "token_end": 10, "label": "GGP"}, "child_span": {"start": 140, "end": 143, "token_start": 30, "token_end": 30, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
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{"text": "Luciferase assays revealed a approximately20-fold increased transcriptional activity of the 1025 bp sequence as compared to the empty vector, indicating that we had identified an active A3G promoter sequence (Figure 3B).", "spans": [{"text": "Luciferase", "start": 0, "token_start": 0, "token_end": 0, "end": 10, "type": "span", "label": "GGP"}, {"text": "A3G", "start": 186, "token_start": 27, "token_end": 28, "end": 189, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-10-RESULTS-02.txt"}, "_input_hash": -1957661057, "_task_hash": -33135077, "tokens": [{"text": "Luciferase", "start": 0, "end": 10, "id": 0, "ws": true, "disabled": false}, {"text": "assays", "start": 11, "end": 17, "id": 1, "ws": true, "disabled": true}, {"text": "revealed", "start": 18, "end": 26, "id": 2, "ws": true, "disabled": true}, {"text": "a", "start": 27, "end": 28, "id": 3, "ws": true, "disabled": true}, {"text": "approximately20-fold", "start": 29, "end": 49, "id": 4, "ws": true, "disabled": true}, {"text": "increased", "start": 50, "end": 59, "id": 5, "ws": true, "disabled": true}, {"text": "transcriptional", "start": 60, "end": 75, "id": 6, "ws": true, "disabled": true}, {"text": "activity", "start": 76, "end": 84, "id": 7, "ws": true, "disabled": true}, {"text": "of", "start": 85, "end": 87, "id": 8, "ws": true, "disabled": true}, {"text": "the", "start": 88, "end": 91, "id": 9, "ws": true, "disabled": true}, {"text": "1025", "start": 92, "end": 96, "id": 10, "ws": true, "disabled": true}, {"text": "bp", "start": 97, "end": 99, "id": 11, "ws": true, "disabled": true}, {"text": "sequence", "start": 100, "end": 108, "id": 12, "ws": true, "disabled": true}, {"text": "as", "start": 109, "end": 111, "id": 13, "ws": true, "disabled": true}, {"text": "compared", "start": 112, "end": 120, "id": 14, "ws": true, "disabled": true}, {"text": "to", "start": 121, "end": 123, "id": 15, "ws": true, "disabled": true}, {"text": "the", "start": 124, "end": 127, "id": 16, "ws": true, "disabled": true}, {"text": "empty", "start": 128, "end": 133, "id": 17, "ws": true, "disabled": true}, {"text": "vector", "start": 134, "end": 140, "id": 18, "ws": false, "disabled": true}, {"text": ",", "start": 140, "end": 141, "id": 19, "ws": true, "disabled": true}, {"text": "indicating", "start": 142, "end": 152, "id": 20, "ws": true, "disabled": true}, {"text": "that", "start": 153, "end": 157, "id": 21, "ws": true, "disabled": true}, {"text": "we", "start": 158, "end": 160, "id": 22, "ws": true, "disabled": true}, {"text": "had", "start": 161, "end": 164, "id": 23, "ws": true, "disabled": true}, {"text": "identified", "start": 165, "end": 175, "id": 24, "ws": true, "disabled": true}, {"text": "an", "start": 176, "end": 178, "id": 25, "ws": true, "disabled": true}, {"text": "active", "start": 179, "end": 185, "id": 26, "ws": true, "disabled": true}, {"text": "A3", "start": 186, "end": 188, "id": 27, "ws": false, "disabled": false}, {"text": "G", "start": 188, "end": 189, "id": 28, "ws": true, "disabled": false}, {"text": "promoter", "start": 190, "end": 198, "id": 29, "ws": true, "disabled": true}, {"text": "sequence", "start": 199, "end": 207, "id": 30, "ws": true, "disabled": true}, {"text": "(", "start": 208, "end": 209, "id": 31, "ws": false, "disabled": true}, {"text": "Figure", "start": 209, "end": 215, "id": 32, "ws": true, "disabled": true}, {"text": "3B", "start": 216, "end": 218, "id": 33, "ws": false, "disabled": true}, {"text": ")", "start": 218, "end": 219, "id": 34, "ws": false, "disabled": true}, {"text": ".", "start": 219, "end": 220, "id": 35, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 28, "child": 0, "head_span": {"start": 186, "end": 189, "token_start": 27, "token_end": 28, "label": "GGP"}, "child_span": {"start": 0, "end": 10, "token_start": 0, "token_end": 0, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "The latter has evolved a mechanism to counteract A3G activity by expressing the regulatory protein Vif (4).", "spans": [{"text": "A3G", "start": 49, "token_start": 8, "token_end": 9, "end": 52, "type": "span", "label": "GGP"}, {"text": "Vif", "start": 99, "token_start": 16, "token_end": 16, "end": 102, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-11-RESULTS-03.txt"}, "_input_hash": 410753930, "_task_hash": -1089817132, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "latter", "start": 4, "end": 10, "id": 1, "ws": true, "disabled": true}, {"text": "has", "start": 11, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "evolved", "start": 15, "end": 22, "id": 3, "ws": true, "disabled": true}, {"text": "a", "start": 23, "end": 24, "id": 4, "ws": true, "disabled": true}, {"text": "mechanism", "start": 25, "end": 34, "id": 5, "ws": true, "disabled": true}, {"text": "to", "start": 35, "end": 37, "id": 6, "ws": true, "disabled": true}, {"text": "counteract", "start": 38, "end": 48, "id": 7, "ws": true, "disabled": true}, {"text": "A3", "start": 49, "end": 51, "id": 8, "ws": false, "disabled": false}, {"text": "G", "start": 51, "end": 52, "id": 9, "ws": true, "disabled": false}, {"text": "activity", "start": 53, "end": 61, "id": 10, "ws": true, "disabled": true}, {"text": "by", "start": 62, "end": 64, "id": 11, "ws": true, "disabled": true}, {"text": "expressing", "start": 65, "end": 75, "id": 12, "ws": true, "disabled": true}, {"text": "the", "start": 76, "end": 79, "id": 13, "ws": true, "disabled": true}, {"text": "regulatory", "start": 80, "end": 90, "id": 14, "ws": true, "disabled": true}, {"text": "protein", "start": 91, "end": 98, "id": 15, "ws": true, "disabled": true}, {"text": "Vif", "start": 99, "end": 102, "id": 16, "ws": true, "disabled": false}, {"text": "(", "start": 103, "end": 104, "id": 17, "ws": false, "disabled": true}, {"text": "4", "start": 104, "end": 105, "id": 18, "ws": false, "disabled": true}, {"text": ")", "start": 105, "end": 106, "id": 19, "ws": false, "disabled": true}, {"text": ".", "start": 106, "end": 107, "id": 20, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 16, "child": 9, "head_span": {"start": 99, "end": 102, "token_start": 16, "token_end": 16, "label": "GGP"}, "child_span": {"start": 49, "end": 52, "token_start": 8, "token_end": 9, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "Vif induces proteasomal degradation of A3G and additionally inhibits A3G activity by further mechanisms (8, 37-43).", "spans": [{"text": "Vif", "start": 0, "token_start": 0, "token_end": 0, "end": 3, "type": "span", "label": "GGP"}, {"text": "A3G", "start": 39, "token_start": 5, "token_end": 6, "end": 42, "type": "span", "label": "GGP"}, {"text": "A3G", "start": 69, "token_start": 10, "token_end": 11, "end": 72, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-11-RESULTS-03.txt"}, "_input_hash": 576771685, "_task_hash": -787645499, "tokens": [{"text": "Vif", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": false}, {"text": "induces", "start": 4, "end": 11, "id": 1, "ws": true, "disabled": true}, {"text": "proteasomal", "start": 12, "end": 23, "id": 2, "ws": true, "disabled": true}, {"text": "degradation", "start": 24, "end": 35, "id": 3, "ws": true, "disabled": true}, {"text": "of", "start": 36, "end": 38, "id": 4, "ws": true, "disabled": true}, {"text": "A3", "start": 39, "end": 41, "id": 5, "ws": false, "disabled": false}, {"text": "G", "start": 41, "end": 42, "id": 6, "ws": true, "disabled": false}, {"text": "and", "start": 43, "end": 46, "id": 7, "ws": true, "disabled": true}, {"text": "additionally", "start": 47, "end": 59, "id": 8, "ws": true, "disabled": true}, {"text": "inhibits", "start": 60, "end": 68, "id": 9, "ws": true, "disabled": true}, {"text": "A3", "start": 69, "end": 71, "id": 10, "ws": false, "disabled": false}, {"text": "G", "start": 71, "end": 72, "id": 11, "ws": true, "disabled": false}, {"text": "activity", "start": 73, "end": 81, "id": 12, "ws": true, "disabled": true}, {"text": "by", "start": 82, "end": 84, "id": 13, "ws": true, "disabled": true}, {"text": "further", "start": 85, "end": 92, "id": 14, "ws": true, "disabled": true}, {"text": "mechanisms", "start": 93, "end": 103, "id": 15, "ws": true, "disabled": true}, {"text": "(", "start": 104, "end": 105, "id": 16, "ws": false, "disabled": true}, {"text": "8", "start": 105, "end": 106, "id": 17, "ws": false, "disabled": true}, {"text": ",", "start": 106, "end": 107, "id": 18, "ws": true, "disabled": true}, {"text": "37", "start": 108, "end": 110, "id": 19, "ws": false, "disabled": true}, {"text": "-", "start": 110, "end": 111, "id": 20, "ws": false, "disabled": true}, {"text": "43", "start": 111, "end": 113, "id": 21, "ws": false, "disabled": true}, {"text": ")", "start": 113, "end": 114, "id": 22, "ws": false, "disabled": true}, {"text": ".", "start": 114, "end": 115, "id": 23, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 6, "head_span": {"start": 0, "end": 3, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 39, "end": 42, "token_start": 5, "token_end": 6, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 0, "child": 11, "head_span": {"start": 0, "end": 3, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 69, "end": 72, "token_start": 10, "token_end": 11, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "In addition, we observed that the A3G promoter was not inducible by IFN-alpha or IFN-gamma in A3.01 T cells, whereas in the hepatic cell line HepG2, a moderate induction was measured.", "spans": [{"text": "A3G", "start": 34, "token_start": 7, "token_end": 8, "end": 37, "type": "span", "label": "GGP"}, {"text": "IFN-alpha", "start": 68, "token_start": 14, "token_end": 16, "end": 77, "type": "span", "label": "GGP"}, {"text": "IFN-gamma", "start": 81, "token_start": 18, "token_end": 20, "end": 90, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-15-DISCUSSION.txt"}, "_input_hash": 404967644, "_task_hash": 495314081, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "addition", "start": 3, "end": 11, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 11, "end": 12, "id": 2, "ws": true, "disabled": true}, {"text": "we", "start": 13, "end": 15, "id": 3, "ws": true, "disabled": true}, {"text": "observed", "start": 16, "end": 24, "id": 4, "ws": true, "disabled": true}, {"text": "that", "start": 25, "end": 29, "id": 5, "ws": true, "disabled": true}, {"text": "the", "start": 30, "end": 33, "id": 6, "ws": true, "disabled": true}, {"text": "A3", "start": 34, "end": 36, "id": 7, "ws": false, "disabled": false}, {"text": "G", "start": 36, "end": 37, "id": 8, "ws": true, "disabled": false}, {"text": "promoter", "start": 38, "end": 46, "id": 9, "ws": true, "disabled": true}, {"text": "was", "start": 47, "end": 50, "id": 10, "ws": true, "disabled": true}, {"text": "not", "start": 51, "end": 54, "id": 11, "ws": true, "disabled": true}, {"text": "inducible", "start": 55, "end": 64, "id": 12, "ws": true, "disabled": true}, {"text": "by", "start": 65, "end": 67, "id": 13, "ws": true, "disabled": true}, {"text": "IFN", "start": 68, "end": 71, "id": 14, "ws": false, "disabled": false}, {"text": "-", "start": 71, "end": 72, "id": 15, "ws": false, "disabled": false}, {"text": "alpha", "start": 72, "end": 77, "id": 16, "ws": true, "disabled": false}, {"text": "or", "start": 78, "end": 80, "id": 17, "ws": true, "disabled": true}, {"text": "IFN", "start": 81, "end": 84, "id": 18, "ws": false, "disabled": false}, {"text": "-", "start": 84, "end": 85, "id": 19, "ws": false, "disabled": false}, {"text": "gamma", "start": 85, "end": 90, "id": 20, "ws": true, "disabled": false}, {"text": "in", "start": 91, "end": 93, "id": 21, "ws": true, "disabled": true}, {"text": "A3.01", "start": 94, "end": 99, "id": 22, "ws": true, "disabled": true}, {"text": "T", "start": 100, "end": 101, "id": 23, "ws": true, "disabled": true}, {"text": "cells", "start": 102, "end": 107, "id": 24, "ws": false, "disabled": true}, {"text": ",", "start": 107, "end": 108, "id": 25, "ws": true, "disabled": true}, {"text": "whereas", "start": 109, "end": 116, "id": 26, "ws": true, "disabled": true}, {"text": "in", "start": 117, "end": 119, "id": 27, "ws": true, "disabled": true}, {"text": "the", "start": 120, "end": 123, "id": 28, "ws": true, "disabled": true}, {"text": "hepatic", "start": 124, "end": 131, "id": 29, "ws": true, "disabled": true}, {"text": "cell", "start": 132, "end": 136, "id": 30, "ws": true, "disabled": true}, {"text": "line", "start": 137, "end": 141, "id": 31, "ws": true, "disabled": true}, {"text": "HepG2", "start": 142, "end": 147, "id": 32, "ws": false, "disabled": true}, {"text": ",", "start": 147, "end": 148, "id": 33, "ws": true, "disabled": true}, {"text": "a", "start": 149, "end": 150, "id": 34, "ws": true, "disabled": true}, {"text": "moderate", "start": 151, "end": 159, "id": 35, "ws": true, "disabled": true}, {"text": "induction", "start": 160, "end": 169, "id": 36, "ws": true, "disabled": true}, {"text": "was", "start": 170, "end": 173, "id": 37, "ws": true, "disabled": true}, {"text": "measured", "start": 174, "end": 182, "id": 38, "ws": false, "disabled": true}, {"text": ".", "start": 182, "end": 183, "id": 39, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 16, "child": 8, "head_span": {"start": 68, "end": 77, "token_start": 14, "token_end": 16, "label": "GGP"}, "child_span": {"start": 34, "end": 37, "token_start": 7, "token_end": 8, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}, {"head": 20, "child": 8, "head_span": {"start": 81, "end": 90, "token_start": 18, "token_end": 20, "label": "GGP"}, "child_span": {"start": 34, "end": 37, "token_start": 7, "token_end": 8, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "A recent study found no influence of IFN-alpha or IFN-gamma on A3G expression in resting primary blood lymphocytes (52).", "spans": [{"text": "IFN-alpha", "start": 37, "token_start": 7, "token_end": 9, "end": 46, "type": "span", "label": "GGP"}, {"text": "IFN-gamma", "start": 50, "token_start": 11, "token_end": 13, "end": 59, "type": "span", "label": "GGP"}, {"text": "A3G", "start": 63, "token_start": 15, "token_end": 16, "end": 66, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-15-DISCUSSION.txt"}, "_input_hash": 459339187, "_task_hash": -276949644, "tokens": [{"text": "A", "start": 0, "end": 1, "id": 0, "ws": true, "disabled": true}, {"text": "recent", "start": 2, "end": 8, "id": 1, "ws": true, "disabled": true}, {"text": "study", "start": 9, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "found", "start": 15, "end": 20, "id": 3, "ws": true, "disabled": true}, {"text": "no", "start": 21, "end": 23, "id": 4, "ws": true, "disabled": true}, {"text": "influence", "start": 24, "end": 33, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 34, "end": 36, "id": 6, "ws": true, "disabled": true}, {"text": "IFN", "start": 37, "end": 40, "id": 7, "ws": false, "disabled": false}, {"text": "-", "start": 40, "end": 41, "id": 8, "ws": false, "disabled": false}, {"text": "alpha", "start": 41, "end": 46, "id": 9, "ws": true, "disabled": false}, {"text": "or", "start": 47, "end": 49, "id": 10, "ws": true, "disabled": true}, {"text": "IFN", "start": 50, "end": 53, "id": 11, "ws": false, "disabled": false}, {"text": "-", "start": 53, "end": 54, "id": 12, "ws": false, "disabled": false}, {"text": "gamma", "start": 54, "end": 59, "id": 13, "ws": true, "disabled": false}, {"text": "on", "start": 60, "end": 62, "id": 14, "ws": true, "disabled": true}, {"text": "A3", "start": 63, "end": 65, "id": 15, "ws": false, "disabled": false}, {"text": "G", "start": 65, "end": 66, "id": 16, "ws": true, "disabled": false}, {"text": "expression", "start": 67, "end": 77, "id": 17, "ws": true, "disabled": true}, {"text": "in", "start": 78, "end": 80, "id": 18, "ws": true, "disabled": true}, {"text": "resting", "start": 81, "end": 88, "id": 19, "ws": true, "disabled": true}, {"text": "primary", "start": 89, "end": 96, "id": 20, "ws": true, "disabled": true}, {"text": "blood", "start": 97, "end": 102, "id": 21, "ws": true, "disabled": true}, {"text": "lymphocytes", "start": 103, "end": 114, "id": 22, "ws": true, "disabled": true}, {"text": "(", "start": 115, "end": 116, "id": 23, "ws": false, "disabled": true}, {"text": "52", "start": 116, "end": 118, "id": 24, "ws": false, "disabled": true}, {"text": ")", "start": 118, "end": 119, "id": 25, "ws": false, "disabled": true}, {"text": ".", "start": 119, "end": 120, "id": 26, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 9, "child": 16, "head_span": {"start": 37, "end": 46, "token_start": 7, "token_end": 9, "label": "GGP"}, "child_span": {"start": 63, "end": 66, "token_start": 15, "token_end": 16, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}, {"head": 13, "child": 16, "head_span": {"start": 50, "end": 59, "token_start": 11, "token_end": 13, "label": "GGP"}, "child_span": {"start": 63, "end": 66, "token_start": 15, "token_end": 16, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "Another publication describes an enhanced expression of A3G after IFN-alpha treatment in resting primary CD4 T cells, but not in activated T cells (53).", "spans": [{"text": "A3G", "start": 56, "token_start": 7, "token_end": 8, "end": 59, "type": "span", "label": "GGP"}, {"text": "IFN-alpha", "start": 66, "token_start": 10, "token_end": 12, "end": 75, "type": "span", "label": "GGP"}, {"text": "CD4", "start": 105, "token_start": 17, "token_end": 17, "end": 108, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-15-DISCUSSION.txt"}, "_input_hash": -959909238, "_task_hash": -1537197838, "tokens": [{"text": "Another", "start": 0, "end": 7, "id": 0, "ws": true, "disabled": true}, {"text": "publication", "start": 8, "end": 19, "id": 1, "ws": true, "disabled": true}, {"text": "describes", "start": 20, "end": 29, "id": 2, "ws": true, "disabled": true}, {"text": "an", "start": 30, "end": 32, "id": 3, "ws": true, "disabled": true}, {"text": "enhanced", "start": 33, "end": 41, "id": 4, "ws": true, "disabled": true}, {"text": "expression", "start": 42, "end": 52, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 53, "end": 55, "id": 6, "ws": true, "disabled": true}, {"text": "A3", "start": 56, "end": 58, "id": 7, "ws": false, "disabled": false}, {"text": "G", "start": 58, "end": 59, "id": 8, "ws": true, "disabled": false}, {"text": "after", "start": 60, "end": 65, "id": 9, "ws": true, "disabled": true}, {"text": "IFN", "start": 66, "end": 69, "id": 10, "ws": false, "disabled": false}, {"text": "-", "start": 69, "end": 70, "id": 11, "ws": false, "disabled": false}, {"text": "alpha", "start": 70, "end": 75, "id": 12, "ws": true, "disabled": false}, {"text": "treatment", "start": 76, "end": 85, "id": 13, "ws": true, "disabled": true}, {"text": "in", "start": 86, "end": 88, "id": 14, "ws": true, "disabled": true}, {"text": "resting", "start": 89, "end": 96, "id": 15, "ws": true, "disabled": true}, {"text": "primary", "start": 97, "end": 104, "id": 16, "ws": true, "disabled": true}, {"text": "CD4", "start": 105, "end": 108, "id": 17, "ws": true, "disabled": false}, {"text": "T", "start": 109, "end": 110, "id": 18, "ws": true, "disabled": true}, {"text": "cells", "start": 111, "end": 116, "id": 19, "ws": false, "disabled": true}, {"text": ",", "start": 116, "end": 117, "id": 20, "ws": true, "disabled": true}, {"text": "but", "start": 118, "end": 121, "id": 21, "ws": true, "disabled": true}, {"text": "not", "start": 122, "end": 125, "id": 22, "ws": true, "disabled": true}, {"text": "in", "start": 126, "end": 128, "id": 23, "ws": true, "disabled": true}, {"text": "activated", "start": 129, "end": 138, "id": 24, "ws": true, "disabled": true}, {"text": "T", "start": 139, "end": 140, "id": 25, "ws": true, "disabled": true}, {"text": "cells", "start": 141, "end": 146, "id": 26, "ws": true, "disabled": true}, {"text": "(", "start": 147, "end": 148, "id": 27, "ws": false, "disabled": true}, {"text": "53", "start": 148, "end": 150, "id": 28, "ws": false, "disabled": true}, {"text": ")", "start": 150, "end": 151, "id": 29, "ws": false, "disabled": true}, {"text": ".", "start": 151, "end": 152, "id": 30, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 12, "child": 8, "head_span": {"start": 66, "end": 75, "token_start": 10, "token_end": 12, "label": "GGP"}, "child_span": {"start": 56, "end": 59, "token_start": 7, "token_end": 8, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Our analysis indicates that transcription from the A3G promoter is unaffected by Vif or other HIV-1 proteins.", "spans": [{"text": "A3G", "start": 51, "token_start": 7, "token_end": 8, "end": 54, "type": "span", "label": "GGP"}, {"text": "Vif", "start": 81, "token_start": 13, "token_end": 13, "end": 84, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-15-DISCUSSION.txt"}, "_input_hash": -34746414, "_task_hash": 399599564, "tokens": [{"text": "Our", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "analysis", "start": 4, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "indicates", "start": 13, "end": 22, "id": 2, "ws": true, "disabled": true}, {"text": "that", "start": 23, "end": 27, "id": 3, "ws": true, "disabled": true}, {"text": "transcription", "start": 28, "end": 41, "id": 4, "ws": true, "disabled": true}, {"text": "from", "start": 42, "end": 46, "id": 5, "ws": true, "disabled": true}, {"text": "the", "start": 47, "end": 50, "id": 6, "ws": true, "disabled": true}, {"text": "A3", "start": 51, "end": 53, "id": 7, "ws": false, "disabled": false}, {"text": "G", "start": 53, "end": 54, "id": 8, "ws": true, "disabled": false}, {"text": "promoter", "start": 55, "end": 63, "id": 9, "ws": true, "disabled": true}, {"text": "is", "start": 64, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "unaffected", "start": 67, "end": 77, "id": 11, "ws": true, "disabled": true}, {"text": "by", "start": 78, "end": 80, "id": 12, "ws": true, "disabled": true}, {"text": "Vif", "start": 81, "end": 84, "id": 13, "ws": true, "disabled": false}, {"text": "or", "start": 85, "end": 87, "id": 14, "ws": true, "disabled": true}, {"text": "other", "start": 88, "end": 93, "id": 15, "ws": true, "disabled": true}, {"text": "HIV-1", "start": 94, "end": 99, "id": 16, "ws": true, "disabled": true}, {"text": "proteins", "start": 100, "end": 108, "id": 17, "ws": false, "disabled": true}, {"text": ".", "start": 108, "end": 109, "id": 18, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 13, "child": 8, "head_span": {"start": 81, "end": 84, "token_start": 13, "token_end": 13, "label": "GGP"}, "child_span": {"start": 51, "end": 54, "token_start": 7, "token_end": 8, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "This observation is consistent with the results of the 5'-RACE, since Sp1 is known to play an important role for RNA polymerase II to bind to the transcription initiation site in TATA-boxless promoters and is associated with multiple transcription initiation sites (54-56).", "spans": [{"text": "Sp1", "start": 70, "token_start": 12, "token_end": 12, "end": 73, "type": "span", "label": "GGP"}, {"text": "RNA polymerase II", "start": 113, "token_start": 21, "token_end": 23, "end": 130, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-15-DISCUSSION.txt"}, "_input_hash": -1698713293, "_task_hash": -896916330, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "observation", "start": 5, "end": 16, "id": 1, "ws": true, "disabled": true}, {"text": "is", "start": 17, "end": 19, "id": 2, "ws": true, "disabled": true}, {"text": "consistent", "start": 20, "end": 30, "id": 3, "ws": true, 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{"text": "Luciferase activities of A3G promoter constructs in different cell lines.", "spans": [{"text": "Luciferase", "start": 0, "token_start": 0, "token_end": 0, "end": 10, "type": "span", "label": "GGP"}, {"text": "A3G", "start": 25, "token_start": 3, "token_end": 4, "end": 28, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-1920263-18-caption-03.txt"}, "_input_hash": 598330005, "_task_hash": -1766865530, "tokens": [{"text": "Luciferase", "start": 0, "end": 10, "id": 0, "ws": true, "disabled": false}, {"text": "activities", "start": 11, "end": 21, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 22, "end": 24, "id": 2, "ws": true, "disabled": true}, {"text": "A3", "start": 25, "end": 27, "id": 3, "ws": false, "disabled": false}, {"text": "G", "start": 27, "end": 28, "id": 4, "ws": true, "disabled": false}, {"text": "promoter", "start": 29, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "constructs", "start": 38, "end": 48, "id": 6, "ws": true, "disabled": true}, {"text": "in", "start": 49, "end": 51, "id": 7, "ws": true, "disabled": true}, {"text": "different", "start": 52, "end": 61, "id": 8, "ws": true, "disabled": true}, {"text": "cell", "start": 62, "end": 66, "id": 9, "ws": true, "disabled": true}, {"text": "lines", "start": 67, "end": 72, "id": 10, "ws": false, "disabled": true}, {"text": ".", "start": 72, "end": 73, "id": 11, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 4, "child": 0, "head_span": {"start": 25, "end": 28, "token_start": 3, "token_end": 4, "label": "GGP"}, "child_span": {"start": 0, "end": 10, "token_start": 0, "token_end": 0, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "We demonstrated that interleukin 4 (IL-4) present at the time of T cell priming inhibits FOXP3.", "spans": [{"text": "interleukin 4", "start": 21, "token_start": 3, "token_end": 4, "end": 34, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 36, "token_start": 6, "token_end": 6, "end": 40, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 89, "token_start": 17, "token_end": 17, "end": 94, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-00-TIAB.txt"}, "_input_hash": -242803465, "_task_hash": -1937482127, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "demonstrated", "start": 3, "end": 15, "id": 1, "ws": true, "disabled": true}, {"text": "that", "start": 16, "end": 20, "id": 2, "ws": true, "disabled": true}, {"text": "interleukin", "start": 21, "end": 32, "id": 3, "ws": true, "disabled": false}, {"text": "4", "start": 33, "end": 34, "id": 4, "ws": true, "disabled": false}, {"text": "(", "start": 35, "end": 36, "id": 5, "ws": false, "disabled": true}, {"text": "IL-4", "start": 36, "end": 40, "id": 6, "ws": false, "disabled": false}, {"text": ")", "start": 40, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "present", "start": 42, "end": 49, "id": 8, "ws": true, "disabled": true}, {"text": "at", "start": 50, "end": 52, "id": 9, "ws": true, "disabled": true}, {"text": "the", "start": 53, "end": 56, "id": 10, "ws": true, "disabled": true}, {"text": "time", "start": 57, "end": 61, "id": 11, "ws": true, "disabled": true}, {"text": "of", "start": 62, "end": 64, "id": 12, "ws": true, "disabled": true}, {"text": "T", "start": 65, "end": 66, "id": 13, "ws": true, "disabled": true}, {"text": "cell", "start": 67, "end": 71, "id": 14, "ws": true, "disabled": true}, {"text": "priming", "start": 72, "end": 79, "id": 15, "ws": true, "disabled": true}, {"text": "inhibits", "start": 80, "end": 88, "id": 16, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 89, "end": 94, "id": 17, "ws": false, "disabled": false}, {"text": ".", "start": 94, "end": 95, "id": 18, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 4, "child": 17, "head_span": {"start": 21, "end": 34, "token_start": 3, "token_end": 4, "label": "GGP"}, "child_span": {"start": 89, "end": 94, "token_start": 17, "token_end": 17, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 6, "child": 17, "head_span": {"start": 36, "end": 40, "token_start": 6, "token_end": 6, "label": "GGP"}, "child_span": {"start": 89, "end": 94, "token_start": 17, "token_end": 17, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "This inhibitory mechanism was also confirmed in Th2 cells and in T cells of transgenic mice overexpressing GATA-3 in T cells, which are shown to be deficient in transforming growth factor (TGF)-beta-mediated FOXP3 induction.", "spans": [{"text": "GATA-3", "start": 107, "token_start": 17, "token_end": 17, "end": 113, "type": "span", "label": "GGP"}, {"text": "transforming growth factor (TGF)-beta", "start": 161, "token_start": 29, "token_end": 33, "end": 198, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 208, "token_start": 36, "token_end": 36, "end": 213, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-00-TIAB.txt"}, "_input_hash": 410095735, "_task_hash": 1294399381, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "inhibitory", "start": 5, "end": 15, "id": 1, "ws": true, "disabled": true}, {"text": "mechanism", "start": 16, "end": 25, "id": 2, "ws": true, "disabled": true}, {"text": "was", "start": 26, "end": 29, "id": 3, "ws": true, "disabled": true}, {"text": "also", "start": 30, "end": 34, "id": 4, "ws": true, "disabled": true}, {"text": "confirmed", "start": 35, "end": 44, "id": 5, "ws": true, "disabled": true}, {"text": "in", "start": 45, "end": 47, "id": 6, "ws": true, "disabled": true}, {"text": "Th2", "start": 48, "end": 51, "id": 7, "ws": true, "disabled": true}, {"text": "cells", "start": 52, "end": 57, "id": 8, "ws": true, "disabled": true}, {"text": "and", "start": 58, "end": 61, "id": 9, "ws": true, "disabled": true}, {"text": "in", "start": 62, "end": 64, "id": 10, "ws": true, "disabled": true}, {"text": "T", "start": 65, "end": 66, "id": 11, "ws": true, "disabled": true}, {"text": "cells", "start": 67, "end": 72, "id": 12, "ws": true, "disabled": true}, {"text": "of", "start": 73, "end": 75, "id": 13, "ws": true, "disabled": true}, {"text": "transgenic", "start": 76, "end": 86, "id": 14, "ws": true, "disabled": true}, {"text": "mice", "start": 87, "end": 91, "id": 15, "ws": true, "disabled": true}, {"text": "overexpressing", "start": 92, "end": 106, "id": 16, "ws": true, "disabled": true}, {"text": "GATA-3", "start": 107, "end": 113, "id": 17, "ws": true, "disabled": false}, {"text": "in", "start": 114, "end": 116, "id": 18, "ws": true, "disabled": true}, {"text": "T", "start": 117, "end": 118, "id": 19, "ws": true, "disabled": true}, {"text": "cells", "start": 119, "end": 124, "id": 20, "ws": false, "disabled": true}, {"text": ",", "start": 124, "end": 125, "id": 21, "ws": true, "disabled": true}, {"text": "which", "start": 126, "end": 131, "id": 22, "ws": true, "disabled": true}, {"text": "are", "start": 132, "end": 135, "id": 23, "ws": true, "disabled": true}, {"text": "shown", "start": 136, "end": 141, "id": 24, "ws": true, "disabled": true}, {"text": "to", "start": 142, "end": 144, "id": 25, "ws": true, "disabled": true}, {"text": "be", "start": 145, "end": 147, "id": 26, "ws": true, "disabled": true}, {"text": "deficient", "start": 148, "end": 157, "id": 27, "ws": true, "disabled": true}, {"text": "in", "start": 158, "end": 160, "id": 28, "ws": true, "disabled": true}, {"text": "transforming", "start": 161, "end": 173, "id": 29, "ws": true, "disabled": false}, {"text": "growth", "start": 174, "end": 180, "id": 30, "ws": true, "disabled": false}, {"text": "factor", "start": 181, "end": 187, "id": 31, "ws": true, "disabled": false}, {"text": "(", "start": 188, "end": 189, "id": 32, "ws": false, "disabled": false}, {"text": "TGF)-beta", "start": 189, "end": 198, "id": 33, "ws": false, "disabled": false}, {"text": "-", "start": 198, "end": 199, "id": 34, "ws": false, "disabled": true}, {"text": "mediated", "start": 199, "end": 207, "id": 35, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 208, "end": 213, "id": 36, "ws": true, "disabled": false}, {"text": "induction", "start": 214, "end": 223, "id": 37, "ws": false, "disabled": true}, {"text": ".", "start": 223, "end": 224, "id": 38, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 33, "child": 36, "head_span": {"start": 161, "end": 198, "token_start": 29, "token_end": 33, "label": "GGP"}, "child_span": {"start": 208, "end": 213, "token_start": 36, "token_end": 36, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "This inhibition is mediated by direct binding of GATA3 to the FOXP3 promoter, which represses its transactivation process.", "spans": [{"text": "GATA3", "start": 49, "token_start": 8, "token_end": 8, "end": 54, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 62, "token_start": 11, "token_end": 11, "end": 67, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-00-TIAB.txt"}, "_input_hash": -1136967867, "_task_hash": 1256549649, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "inhibition", "start": 5, "end": 15, "id": 1, "ws": true, "disabled": true}, {"text": "is", "start": 16, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "mediated", "start": 19, "end": 27, "id": 3, "ws": true, "disabled": true}, {"text": "by", "start": 28, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "direct", "start": 31, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "binding", "start": 38, "end": 45, "id": 6, "ws": true, "disabled": true}, {"text": "of", "start": 46, "end": 48, "id": 7, "ws": true, "disabled": true}, {"text": "GATA3", "start": 49, "end": 54, "id": 8, "ws": true, "disabled": false}, {"text": "to", "start": 55, "end": 57, "id": 9, "ws": true, "disabled": true}, {"text": "the", "start": 58, "end": 61, "id": 10, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 62, "end": 67, "id": 11, "ws": true, "disabled": false}, {"text": "promoter", "start": 68, "end": 76, "id": 12, "ws": false, "disabled": true}, {"text": ",", "start": 76, "end": 77, "id": 13, "ws": true, "disabled": true}, {"text": "which", "start": 78, "end": 83, "id": 14, "ws": true, "disabled": true}, {"text": "represses", "start": 84, "end": 93, "id": 15, "ws": true, "disabled": true}, {"text": "its", "start": 94, "end": 97, "id": 16, "ws": true, "disabled": true}, {"text": "transactivation", "start": 98, "end": 113, "id": 17, "ws": true, "disabled": true}, {"text": "process", "start": 114, "end": 121, "id": 18, "ws": false, "disabled": true}, {"text": ".", "start": 121, "end": 122, "id": 19, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 11, "head_span": {"start": 49, "end": 54, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 62, "end": 67, "token_start": 11, "token_end": 11, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "We demonstrate that the Th2 cytokine IL-4 inhibits the induction of FOXP3 and thus inhibits the generation of inducible Treg cells.", "spans": [{"text": "IL-4", "start": 37, "token_start": 6, "token_end": 6, "end": 41, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 68, "token_start": 11, "token_end": 11, "end": 73, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-00-TIAB.txt"}, "_input_hash": -174036305, "_task_hash": 1129743996, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "demonstrate", "start": 3, "end": 14, "id": 1, "ws": true, "disabled": true}, {"text": "that", "start": 15, "end": 19, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 20, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "Th2", "start": 24, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "cytokine", "start": 28, "end": 36, "id": 5, "ws": true, "disabled": true}, {"text": "IL-4", "start": 37, "end": 41, "id": 6, "ws": true, "disabled": false}, {"text": "inhibits", "start": 42, "end": 50, "id": 7, "ws": true, "disabled": true}, {"text": "the", "start": 51, "end": 54, "id": 8, "ws": true, "disabled": true}, {"text": "induction", "start": 55, "end": 64, "id": 9, "ws": true, "disabled": true}, {"text": "of", "start": 65, "end": 67, "id": 10, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 68, "end": 73, "id": 11, "ws": true, "disabled": false}, {"text": "and", "start": 74, "end": 77, "id": 12, "ws": true, "disabled": true}, {"text": "thus", "start": 78, "end": 82, "id": 13, "ws": true, "disabled": true}, {"text": "inhibits", "start": 83, "end": 91, "id": 14, "ws": true, "disabled": true}, {"text": "the", "start": 92, "end": 95, "id": 15, "ws": true, "disabled": true}, {"text": "generation", "start": 96, "end": 106, "id": 16, "ws": true, "disabled": true}, {"text": "of", "start": 107, "end": 109, "id": 17, "ws": true, "disabled": true}, {"text": "inducible", "start": 110, "end": 119, "id": 18, "ws": true, "disabled": true}, {"text": "Treg", "start": 120, "end": 124, "id": 19, "ws": true, "disabled": true}, {"text": "cells", "start": 125, "end": 130, "id": 20, "ws": false, "disabled": true}, {"text": ".", "start": 130, "end": 131, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 6, "child": 11, "head_span": {"start": 37, "end": 41, "token_start": 6, "token_end": 6, "label": "GGP"}, "child_span": {"start": 68, "end": 73, "token_start": 11, "token_end": 11, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "This is mediated by IL-4 induction of GATA3, which binds directly to and represses the FOXP3 promoter.", "spans": [{"text": "IL-4", "start": 20, "token_start": 4, "token_end": 4, "end": 24, "type": "span", "label": "GGP"}, {"text": "GATA3", "start": 38, "token_start": 7, "token_end": 7, "end": 43, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 87, "token_start": 16, "token_end": 16, "end": 92, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-00-TIAB.txt"}, "_input_hash": -1074535365, "_task_hash": -1870034211, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "is", "start": 5, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "mediated", "start": 8, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "by", "start": 17, "end": 19, "id": 3, "ws": true, "disabled": true}, {"text": "IL-4", "start": 20, "end": 24, "id": 4, "ws": true, "disabled": false}, {"text": "induction", "start": 25, "end": 34, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 35, "end": 37, "id": 6, "ws": true, "disabled": true}, {"text": "GATA3", "start": 38, "end": 43, "id": 7, "ws": false, "disabled": false}, {"text": ",", "start": 43, "end": 44, "id": 8, "ws": true, "disabled": true}, {"text": "which", "start": 45, "end": 50, "id": 9, "ws": true, "disabled": true}, {"text": "binds", "start": 51, "end": 56, "id": 10, "ws": true, "disabled": true}, {"text": "directly", "start": 57, "end": 65, "id": 11, "ws": true, "disabled": true}, {"text": "to", "start": 66, "end": 68, "id": 12, "ws": true, "disabled": true}, {"text": "and", "start": 69, "end": 72, "id": 13, "ws": true, "disabled": true}, {"text": "represses", "start": 73, "end": 82, "id": 14, "ws": true, "disabled": true}, {"text": "the", "start": 83, "end": 86, "id": 15, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 87, "end": 92, "id": 16, "ws": true, "disabled": false}, {"text": "promoter", "start": 93, "end": 101, "id": 17, "ws": false, "disabled": true}, {"text": ".", "start": 101, "end": 102, "id": 18, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 4, "child": 7, "head_span": {"start": 20, "end": 24, "token_start": 4, "token_end": 4, "label": "GGP"}, "child_span": {"start": 38, "end": 43, "token_start": 7, "token_end": 7, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 7, "child": 16, "head_span": {"start": 38, "end": 43, "token_start": 7, "token_end": 7, "label": "GGP"}, "child_span": {"start": 87, "end": 92, "token_start": 16, "token_end": 16, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}, {"head": 7, "child": 16, "head_span": {"start": 38, "end": 43, "token_start": 7, "token_end": 7, "label": "GGP"}, "child_span": {"start": 87, "end": 92, "token_start": 16, "token_end": 16, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "GATA3 is sufficient to induce a Th2 phenotype [3] and acts not only through the induction of IL-4, IL-5 and IL-13, the Th2 cytokines, but also through the inhibition of Th1 cell-specific factors [3].", "spans": [{"text": "GATA3", "start": 0, "token_start": 0, "token_end": 0, "end": 5, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 93, "token_start": 19, "token_end": 19, "end": 97, "type": "span", "label": "GGP"}, {"text": "IL-5", "start": 99, "token_start": 21, "token_end": 21, "end": 103, "type": "span", "label": "GGP"}, {"text": "IL-13", "start": 108, "token_start": 23, "token_end": 23, "end": 113, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-01-Introduction.txt"}, "_input_hash": 494991592, "_task_hash": -647146049, "tokens": [{"text": "GATA3", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": false}, {"text": "is", "start": 6, "end": 8, "id": 1, "ws": true, "disabled": true}, {"text": "sufficient", 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{"text": "Repeated exposure to TGF-beta did not further increase the FOXP3 expression in the iTreg lineage but transiently induced FOXP3 expression in Th1 cells.", "spans": [{"text": "TGF-beta", "start": 21, "token_start": 3, "token_end": 5, "end": 29, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 59, "token_start": 11, "token_end": 11, "end": 64, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 121, "token_start": 20, "token_end": 20, "end": 126, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-02-Results-01.txt"}, "_input_hash": -635519014, "_task_hash": -573922397, "tokens": [{"text": "Repeated", "start": 0, "end": 8, "id": 0, "ws": true, "disabled": true}, {"text": "exposure", "start": 9, "end": 17, "id": 1, "ws": true, "disabled": true}, {"text": "to", "start": 18, "end": 20, "id": 2, "ws": true, "disabled": true}, {"text": "TGF", "start": 21, "end": 24, "id": 3, "ws": false, "disabled": false}, {"text": "-", "start": 24, "end": 25, "id": 4, "ws": false, "disabled": false}, {"text": "beta", "start": 25, "end": 29, "id": 5, "ws": true, "disabled": false}, {"text": "did", "start": 30, "end": 33, "id": 6, "ws": true, "disabled": true}, {"text": "not", "start": 34, "end": 37, "id": 7, "ws": true, "disabled": true}, {"text": "further", "start": 38, "end": 45, "id": 8, "ws": true, "disabled": true}, {"text": "increase", "start": 46, "end": 54, "id": 9, "ws": true, "disabled": true}, {"text": "the", "start": 55, "end": 58, "id": 10, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 59, "end": 64, "id": 11, "ws": true, "disabled": false}, {"text": "expression", "start": 65, "end": 75, "id": 12, "ws": true, "disabled": true}, {"text": "in", "start": 76, "end": 78, "id": 13, "ws": true, "disabled": true}, {"text": "the", "start": 79, "end": 82, "id": 14, "ws": true, "disabled": true}, {"text": "iTreg", "start": 83, "end": 88, "id": 15, "ws": true, "disabled": true}, {"text": "lineage", "start": 89, "end": 96, "id": 16, "ws": true, "disabled": true}, {"text": "but", "start": 97, "end": 100, "id": 17, "ws": true, "disabled": true}, {"text": "transiently", "start": 101, "end": 112, "id": 18, "ws": true, "disabled": true}, {"text": "induced", "start": 113, "end": 120, "id": 19, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 121, "end": 126, "id": 20, "ws": true, "disabled": false}, {"text": "expression", "start": 127, "end": 137, "id": 21, "ws": true, "disabled": true}, {"text": "in", "start": 138, "end": 140, "id": 22, "ws": true, "disabled": true}, {"text": "Th1", "start": 141, "end": 144, "id": 23, "ws": true, "disabled": true}, {"text": "cells", "start": 145, "end": 150, "id": 24, "ws": false, "disabled": true}, {"text": ".", "start": 150, "end": 151, "id": 25, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 5, "child": 11, "head_span": {"start": 21, "end": 29, "token_start": 3, "token_end": 5, "label": "GGP"}, "child_span": {"start": 59, "end": 64, "token_start": 11, "token_end": 11, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "Furthermore TGF-beta-mediated FOXP3 induction failed in these cells in contrast to the naive T cells (Figure 2B).", "spans": [{"text": "TGF-beta", "start": 12, "token_start": 1, "token_end": 3, "end": 20, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 30, "token_start": 6, "token_end": 6, "end": 35, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-02-Results-01.txt"}, "_input_hash": -165950534, "_task_hash": 319865694, "tokens": [{"text": "Furthermore", "start": 0, "end": 11, "id": 0, "ws": true, "disabled": true}, {"text": "TGF", "start": 12, "end": 15, "id": 1, "ws": false, "disabled": false}, {"text": "-", "start": 15, "end": 16, "id": 2, "ws": false, "disabled": false}, {"text": "beta", "start": 16, "end": 20, "id": 3, "ws": false, "disabled": false}, {"text": "-", "start": 20, "end": 21, "id": 4, "ws": false, "disabled": true}, {"text": "mediated", "start": 21, "end": 29, "id": 5, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 30, "end": 35, "id": 6, "ws": true, "disabled": false}, {"text": "induction", "start": 36, "end": 45, "id": 7, "ws": true, "disabled": true}, {"text": "failed", "start": 46, "end": 52, "id": 8, "ws": true, "disabled": true}, {"text": "in", "start": 53, "end": 55, "id": 9, "ws": true, "disabled": true}, {"text": "these", "start": 56, "end": 61, "id": 10, "ws": true, "disabled": true}, {"text": "cells", "start": 62, "end": 67, "id": 11, "ws": true, "disabled": true}, {"text": "in", "start": 68, "end": 70, "id": 12, "ws": true, "disabled": true}, {"text": "contrast", "start": 71, "end": 79, "id": 13, "ws": true, "disabled": true}, {"text": "to", "start": 80, "end": 82, "id": 14, "ws": true, "disabled": true}, {"text": "the", "start": 83, "end": 86, "id": 15, "ws": true, "disabled": true}, {"text": "naive", "start": 87, "end": 92, "id": 16, "ws": true, "disabled": true}, {"text": "T", "start": 93, "end": 94, "id": 17, "ws": true, "disabled": true}, {"text": "cells", "start": 95, "end": 100, "id": 18, "ws": true, "disabled": true}, {"text": "(", "start": 101, "end": 102, "id": 19, "ws": false, "disabled": true}, {"text": "Figure", "start": 102, "end": 108, "id": 20, "ws": true, "disabled": true}, {"text": "2B", "start": 109, "end": 111, "id": 21, "ws": false, "disabled": true}, {"text": ")", "start": 111, "end": 112, "id": 22, "ws": false, "disabled": true}, {"text": ".", "start": 112, "end": 113, "id": 23, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 6, "head_span": {"start": 12, "end": 20, "token_start": 1, "token_end": 3, "label": "GGP"}, "child_span": {"start": 30, "end": 35, "token_start": 6, "token_end": 6, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "We therefore asked whether IL-4 is able to inhibit TGF-beta induction of FOXP3 during the priming of naive T cells.", "spans": [{"text": "IL-4", "start": 27, "token_start": 4, "token_end": 4, "end": 31, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 51, "token_start": 9, "token_end": 11, "end": 59, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 73, "token_start": 14, "token_end": 14, "end": 78, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-04-Results-03.txt"}, "_input_hash": -1911453808, "_task_hash": -2026194566, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "therefore", "start": 3, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "asked", "start": 13, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "whether", "start": 19, "end": 26, "id": 3, "ws": true, "disabled": true}, {"text": "IL-4", "start": 27, "end": 31, "id": 4, "ws": true, "disabled": false}, {"text": "is", "start": 32, "end": 34, "id": 5, "ws": true, "disabled": true}, {"text": "able", "start": 35, "end": 39, "id": 6, "ws": true, "disabled": true}, {"text": "to", "start": 40, "end": 42, "id": 7, "ws": true, "disabled": true}, {"text": "inhibit", "start": 43, "end": 50, "id": 8, "ws": true, "disabled": true}, {"text": "TGF", "start": 51, "end": 54, "id": 9, "ws": false, "disabled": false}, {"text": "-", "start": 54, "end": 55, "id": 10, "ws": false, "disabled": false}, {"text": "beta", "start": 55, "end": 59, "id": 11, "ws": true, "disabled": false}, {"text": "induction", "start": 60, "end": 69, "id": 12, "ws": true, "disabled": true}, {"text": "of", "start": 70, "end": 72, "id": 13, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 73, "end": 78, "id": 14, "ws": true, "disabled": false}, {"text": "during", "start": 79, "end": 85, "id": 15, "ws": true, "disabled": true}, {"text": "the", "start": 86, "end": 89, "id": 16, "ws": true, "disabled": true}, {"text": "priming", "start": 90, "end": 97, "id": 17, "ws": true, "disabled": true}, {"text": "of", "start": 98, "end": 100, "id": 18, "ws": true, "disabled": true}, {"text": "naive", "start": 101, "end": 106, "id": 19, "ws": true, "disabled": true}, {"text": "T", "start": 107, "end": 108, "id": 20, "ws": true, "disabled": true}, {"text": "cells", "start": 109, "end": 114, "id": 21, "ws": false, "disabled": true}, {"text": ".", "start": 114, "end": 115, "id": 22, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 11, "child": 14, "head_span": {"start": 51, "end": 59, "token_start": 9, "token_end": 11, "label": "GGP"}, "child_span": {"start": 73, "end": 78, "token_start": 14, "token_end": 14, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "However, at low concentration, IL-4 was able to marginally induce FOXP3 expression.", "spans": [{"text": "IL-4", "start": 31, "token_start": 6, "token_end": 6, "end": 35, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 66, "token_start": 12, "token_end": 12, "end": 71, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-04-Results-03.txt"}, "_input_hash": 686314424, "_task_hash": -1982737449, "tokens": [{"text": "However", "start": 0, "end": 7, "id": 0, "ws": false, "disabled": true}, {"text": ",", "start": 7, "end": 8, "id": 1, "ws": true, "disabled": true}, {"text": "at", "start": 9, "end": 11, "id": 2, "ws": true, "disabled": true}, {"text": "low", "start": 12, "end": 15, "id": 3, "ws": true, "disabled": true}, {"text": "concentration", "start": 16, "end": 29, "id": 4, "ws": false, "disabled": true}, {"text": ",", "start": 29, "end": 30, "id": 5, "ws": true, "disabled": true}, {"text": "IL-4", "start": 31, "end": 35, "id": 6, "ws": true, "disabled": false}, {"text": "was", "start": 36, "end": 39, "id": 7, "ws": true, "disabled": true}, {"text": "able", "start": 40, "end": 44, "id": 8, "ws": true, "disabled": true}, {"text": "to", "start": 45, "end": 47, "id": 9, "ws": true, "disabled": true}, {"text": "marginally", "start": 48, "end": 58, "id": 10, "ws": true, "disabled": true}, {"text": "induce", "start": 59, "end": 65, "id": 11, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 66, "end": 71, "id": 12, "ws": true, "disabled": false}, {"text": "expression", "start": 72, "end": 82, "id": 13, "ws": false, "disabled": true}, {"text": ".", "start": 82, "end": 83, "id": 14, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 6, "child": 12, "head_span": {"start": 31, "end": 35, "token_start": 6, "token_end": 6, "label": "GGP"}, "child_span": {"start": 66, "end": 71, "token_start": 12, "token_end": 12, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Of note, GATA3 was also induced in the presence of TGF-beta at high IL-4 concentration (Figure 5A and 5B).", "spans": [{"text": "GATA3", "start": 9, "token_start": 3, "token_end": 3, "end": 14, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 51, "token_start": 11, "token_end": 13, "end": 59, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 68, "token_start": 16, "token_end": 16, "end": 72, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-04-Results-03.txt"}, "_input_hash": 1809089635, "_task_hash": -1601562709, "tokens": [{"text": "Of", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "note", "start": 3, "end": 7, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 7, "end": 8, "id": 2, "ws": true, "disabled": true}, {"text": "GATA3", "start": 9, "end": 14, "id": 3, "ws": true, "disabled": false}, {"text": "was", "start": 15, "end": 18, "id": 4, "ws": true, "disabled": true}, {"text": "also", "start": 19, "end": 23, "id": 5, "ws": true, "disabled": true}, {"text": "induced", "start": 24, "end": 31, "id": 6, "ws": true, "disabled": true}, {"text": "in", "start": 32, "end": 34, "id": 7, "ws": true, "disabled": true}, {"text": "the", "start": 35, "end": 38, "id": 8, "ws": true, "disabled": true}, {"text": "presence", "start": 39, "end": 47, "id": 9, "ws": true, "disabled": true}, {"text": "of", "start": 48, "end": 50, "id": 10, "ws": true, "disabled": true}, {"text": "TGF", "start": 51, "end": 54, "id": 11, "ws": false, "disabled": false}, {"text": "-", "start": 54, "end": 55, "id": 12, "ws": false, "disabled": false}, {"text": "beta", "start": 55, "end": 59, "id": 13, "ws": true, "disabled": false}, {"text": "at", "start": 60, "end": 62, "id": 14, "ws": true, "disabled": true}, {"text": "high", "start": 63, "end": 67, "id": 15, "ws": true, "disabled": true}, {"text": "IL-4", "start": 68, "end": 72, "id": 16, "ws": true, "disabled": false}, {"text": "concentration", "start": 73, "end": 86, "id": 17, "ws": true, "disabled": true}, {"text": "(", "start": 87, "end": 88, "id": 18, "ws": false, "disabled": true}, {"text": "Figure", "start": 88, "end": 94, "id": 19, "ws": true, "disabled": true}, {"text": "5A", "start": 95, "end": 97, "id": 20, "ws": true, "disabled": true}, {"text": "and", "start": 98, "end": 101, "id": 21, "ws": true, "disabled": true}, {"text": "5B", "start": 102, "end": 104, "id": 22, "ws": false, "disabled": true}, {"text": ")", "start": 104, "end": 105, "id": 23, "ws": false, "disabled": true}, {"text": ".", "start": 105, "end": 106, "id": 24, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 13, "child": 3, "head_span": {"start": 51, "end": 59, "token_start": 11, "token_end": 13, "label": "GGP"}, "child_span": {"start": 9, "end": 14, "token_start": 3, "token_end": 3, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 16, "child": 3, "head_span": {"start": 68, "end": 72, "token_start": 16, "token_end": 16, "label": "GGP"}, "child_span": {"start": 9, "end": 14, "token_start": 3, "token_end": 3, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Increasing amounts of IL-4 increase intracellular GATA3, whereas FOXP3 decreased, which is consistent with the mRNA analysis (Figure 5D).", "spans": [{"text": "IL-4", "start": 22, "token_start": 3, "token_end": 3, "end": 26, "type": "span", "label": "GGP"}, {"text": "GATA3", "start": 50, "token_start": 6, "token_end": 6, "end": 55, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 65, "token_start": 9, "token_end": 9, "end": 70, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-04-Results-03.txt"}, "_input_hash": -2114769687, "_task_hash": 711153368, "tokens": [{"text": "Increasing", "start": 0, "end": 10, "id": 0, "ws": true, "disabled": true}, {"text": "amounts", "start": 11, "end": 18, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 19, "end": 21, "id": 2, "ws": true, "disabled": true}, {"text": "IL-4", "start": 22, "end": 26, "id": 3, "ws": true, "disabled": false}, {"text": "increase", "start": 27, "end": 35, "id": 4, "ws": true, "disabled": true}, {"text": "intracellular", "start": 36, "end": 49, "id": 5, "ws": true, "disabled": true}, {"text": "GATA3", "start": 50, "end": 55, "id": 6, "ws": false, "disabled": false}, {"text": ",", "start": 55, "end": 56, "id": 7, "ws": true, "disabled": true}, {"text": "whereas", "start": 57, "end": 64, "id": 8, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 65, "end": 70, "id": 9, "ws": true, "disabled": false}, {"text": "decreased", "start": 71, "end": 80, "id": 10, "ws": false, "disabled": true}, {"text": ",", "start": 80, "end": 81, "id": 11, "ws": true, "disabled": true}, {"text": "which", "start": 82, "end": 87, "id": 12, "ws": true, "disabled": true}, {"text": "is", "start": 88, "end": 90, "id": 13, "ws": true, "disabled": true}, {"text": "consistent", "start": 91, "end": 101, "id": 14, "ws": true, "disabled": true}, {"text": "with", "start": 102, "end": 106, "id": 15, "ws": true, "disabled": true}, {"text": "the", "start": 107, "end": 110, "id": 16, "ws": true, "disabled": true}, {"text": "mRNA", "start": 111, "end": 115, "id": 17, "ws": true, "disabled": true}, {"text": "analysis", "start": 116, "end": 124, "id": 18, "ws": true, "disabled": true}, {"text": "(", "start": 125, "end": 126, "id": 19, "ws": false, "disabled": true}, {"text": "Figure", "start": 126, "end": 132, "id": 20, "ws": true, "disabled": true}, {"text": "5D", "start": 133, "end": 135, "id": 21, "ws": false, "disabled": true}, {"text": ")", "start": 135, "end": 136, "id": 22, "ws": false, "disabled": true}, {"text": ".", "start": 136, "end": 137, "id": 23, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 6, "head_span": {"start": 22, "end": 26, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 50, "end": 55, "token_start": 6, "token_end": 6, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 3, "child": 9, "head_span": {"start": 22, "end": 26, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 65, "end": 70, "token_start": 9, "token_end": 9, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "In already-existing Treg cells, IL-4 failed to inhibit FOXP3 expression (Figure S3A), and the suppressive capacity was not altered (Figure S3C).", "spans": [{"text": "IL-4", "start": 32, "token_start": 7, "token_end": 7, "end": 36, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 55, "token_start": 11, "token_end": 11, "end": 60, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-04-Results-03.txt"}, "_input_hash": 1391078972, "_task_hash": 1130549355, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "already", "start": 3, "end": 10, "id": 1, "ws": false, "disabled": true}, {"text": "-", "start": 10, "end": 11, "id": 2, "ws": false, "disabled": true}, {"text": "existing", "start": 11, "end": 19, "id": 3, "ws": true, "disabled": true}, {"text": "Treg", "start": 20, "end": 24, "id": 4, "ws": true, "disabled": true}, {"text": "cells", "start": 25, "end": 30, "id": 5, "ws": false, "disabled": true}, {"text": ",", "start": 30, "end": 31, "id": 6, "ws": true, "disabled": true}, {"text": "IL-4", "start": 32, "end": 36, "id": 7, "ws": true, "disabled": false}, {"text": "failed", "start": 37, "end": 43, "id": 8, "ws": true, "disabled": true}, {"text": "to", "start": 44, "end": 46, "id": 9, "ws": true, "disabled": true}, {"text": "inhibit", "start": 47, "end": 54, "id": 10, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 55, "end": 60, "id": 11, "ws": true, "disabled": false}, {"text": "expression", "start": 61, "end": 71, "id": 12, "ws": true, "disabled": true}, {"text": "(", "start": 72, "end": 73, "id": 13, "ws": false, "disabled": true}, {"text": "Figure", "start": 73, "end": 79, "id": 14, "ws": true, "disabled": true}, {"text": "S3A", "start": 80, "end": 83, "id": 15, "ws": false, "disabled": true}, {"text": ")", "start": 83, "end": 84, "id": 16, "ws": false, "disabled": true}, {"text": ",", "start": 84, "end": 85, "id": 17, "ws": true, "disabled": true}, {"text": "and", "start": 86, "end": 89, "id": 18, "ws": true, "disabled": true}, {"text": "the", "start": 90, "end": 93, "id": 19, "ws": true, "disabled": true}, {"text": "suppressive", "start": 94, "end": 105, "id": 20, "ws": true, "disabled": true}, {"text": "capacity", "start": 106, "end": 114, "id": 21, "ws": true, "disabled": true}, {"text": "was", "start": 115, "end": 118, "id": 22, "ws": true, "disabled": true}, {"text": "not", "start": 119, "end": 122, "id": 23, "ws": true, "disabled": true}, {"text": "altered", "start": 123, "end": 130, "id": 24, "ws": true, "disabled": true}, {"text": "(", "start": 131, "end": 132, "id": 25, "ws": false, "disabled": true}, {"text": "Figure", "start": 132, "end": 138, "id": 26, "ws": true, "disabled": true}, {"text": "S3C", "start": 139, "end": 142, "id": 27, "ws": false, "disabled": true}, {"text": ")", "start": 142, "end": 143, "id": 28, "ws": false, "disabled": true}, {"text": ".", "start": 143, "end": 144, "id": 29, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 7, "child": 11, "head_span": {"start": 32, "end": 36, "token_start": 7, "token_end": 7, "label": "GGP"}, "child_span": {"start": 55, "end": 60, "token_start": 11, "token_end": 11, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "Although TGF-beta-reduced CD25, IL-4 expression, and CD25 expression (Figure 6B), IL-4 significantly inhibited TGF-beta-mediated induction of FOXP3 in naive T cells driven toward FOXP3+ T cells, as shown by FACS analysis (Figure 6A).", "spans": [{"text": "TGF-beta", "start": 9, "token_start": 1, "token_end": 3, "end": 17, "type": "span", "label": "GGP"}, {"text": "CD25", "start": 26, "token_start": 6, "token_end": 6, "end": 30, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 32, "token_start": 8, "token_end": 8, "end": 36, "type": "span", "label": "GGP"}, {"text": "CD25", "start": 53, "token_start": 12, "token_end": 12, "end": 57, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 82, "token_start": 19, "token_end": 19, "end": 86, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 111, "token_start": 22, "token_end": 24, "end": 119, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 142, "token_start": 29, "token_end": 29, "end": 147, 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{"text": "FOXP3 expression decreased once GATA3 expression is high; therefore, we hypothesized a potential role for GATA3 in repressing FOXP3.", "spans": [{"text": "FOXP3", "start": 0, "token_start": 0, "token_end": 0, "end": 5, "type": "span", "label": "GGP"}, {"text": "GATA3", "start": 32, "token_start": 4, "token_end": 4, "end": 37, "type": "span", "label": "GGP"}, {"text": "GATA3", "start": 106, "token_start": 17, "token_end": 17, "end": 111, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 126, "token_start": 20, "token_end": 20, "end": 131, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-06-Results-05.txt"}, "_input_hash": -1469965727, "_task_hash": -1028430478, "tokens": [{"text": "FOXP3", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": false}, {"text": "expression", "start": 6, "end": 16, "id": 1, "ws": true, "disabled": true}, {"text": "decreased", "start": 17, "end": 26, "id": 2, "ws": true, "disabled": true}, {"text": "once", "start": 27, "end": 31, "id": 3, "ws": true, "disabled": true}, {"text": "GATA3", "start": 32, "end": 37, "id": 4, "ws": true, "disabled": false}, {"text": "expression", "start": 38, "end": 48, "id": 5, "ws": true, "disabled": true}, {"text": "is", "start": 49, "end": 51, "id": 6, "ws": true, "disabled": true}, {"text": "high", "start": 52, "end": 56, "id": 7, "ws": false, "disabled": true}, {"text": ";", "start": 56, "end": 57, "id": 8, "ws": true, "disabled": true}, {"text": "therefore", "start": 58, "end": 67, "id": 9, "ws": false, "disabled": true}, {"text": ",", "start": 67, "end": 68, "id": 10, "ws": true, "disabled": true}, {"text": "we", "start": 69, "end": 71, "id": 11, "ws": true, "disabled": true}, {"text": "hypothesized", "start": 72, "end": 84, "id": 12, "ws": true, "disabled": true}, {"text": "a", "start": 85, "end": 86, "id": 13, "ws": true, "disabled": true}, {"text": "potential", "start": 87, "end": 96, "id": 14, "ws": true, "disabled": true}, {"text": "role", "start": 97, "end": 101, "id": 15, "ws": true, "disabled": true}, {"text": "for", "start": 102, "end": 105, "id": 16, "ws": true, "disabled": true}, {"text": "GATA3", "start": 106, "end": 111, "id": 17, "ws": true, "disabled": false}, {"text": "in", "start": 112, "end": 114, "id": 18, "ws": true, "disabled": true}, {"text": "repressing", "start": 115, "end": 125, "id": 19, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 126, "end": 131, "id": 20, "ws": false, "disabled": false}, {"text": ".", "start": 131, "end": 132, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 4, "child": 0, "head_span": {"start": 32, "end": 37, "token_start": 4, "token_end": 4, "label": "GGP"}, "child_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 17, "child": 20, "head_span": {"start": 106, "end": 111, "token_start": 17, "token_end": 17, "label": "GGP"}, "child_span": {"start": 126, "end": 131, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
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{"text": "As described for the human cells, TGF-beta dramatically up-regulated Foxp3 in the DO11.10 littermate control mice.", "spans": [{"text": "TGF-beta", "start": 34, "token_start": 7, "token_end": 9, "end": 42, "type": "span", "label": "GGP"}, {"text": "Foxp3", "start": 69, "token_start": 14, "token_end": 14, "end": 74, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-06-Results-05.txt"}, "_input_hash": -494470483, "_task_hash": 46450451, "tokens": [{"text": "As", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "described", "start": 3, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "for", "start": 13, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 17, "end": 20, "id": 3, "ws": true, "disabled": true}, {"text": "human", "start": 21, "end": 26, "id": 4, "ws": true, "disabled": true}, {"text": "cells", "start": 27, "end": 32, "id": 5, "ws": false, "disabled": true}, {"text": ",", "start": 32, "end": 33, "id": 6, "ws": true, "disabled": true}, {"text": "TGF", "start": 34, "end": 37, "id": 7, "ws": false, "disabled": false}, {"text": "-", "start": 37, "end": 38, "id": 8, "ws": false, "disabled": false}, {"text": "beta", "start": 38, "end": 42, "id": 9, "ws": true, "disabled": false}, {"text": "dramatically", "start": 43, "end": 55, "id": 10, "ws": true, "disabled": true}, {"text": "up", "start": 56, "end": 58, "id": 11, "ws": false, "disabled": true}, {"text": "-", "start": 58, "end": 59, "id": 12, "ws": false, "disabled": true}, {"text": "regulated", "start": 59, "end": 68, "id": 13, "ws": true, "disabled": true}, {"text": "Foxp3", "start": 69, "end": 74, "id": 14, "ws": true, "disabled": false}, {"text": "in", "start": 75, "end": 77, "id": 15, "ws": true, "disabled": true}, {"text": "the", "start": 78, "end": 81, "id": 16, "ws": true, "disabled": true}, {"text": "DO11.10", "start": 82, "end": 89, "id": 17, "ws": true, "disabled": true}, {"text": "littermate", "start": 90, "end": 100, "id": 18, "ws": true, "disabled": true}, {"text": "control", "start": 101, "end": 108, "id": 19, "ws": true, "disabled": true}, {"text": "mice", "start": 109, "end": 113, "id": 20, "ws": false, "disabled": true}, {"text": ".", "start": 113, "end": 114, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 9, "child": 14, "head_span": {"start": 34, "end": 42, "token_start": 7, "token_end": 9, "label": "GGP"}, "child_span": {"start": 69, "end": 74, "token_start": 14, "token_end": 14, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "The current study reveals that FOXP3 induction, an important step in iTreg commitment, is inhibited by GATA3, which is the key regulator for polarization toward Th2 cells.", "spans": [{"text": "FOXP3", "start": 31, "token_start": 5, "token_end": 5, "end": 36, "type": "span", "label": "GGP"}, {"text": "GATA3", "start": 103, "token_start": 18, "token_end": 18, "end": 108, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": 99361454, "_task_hash": 771352556, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "current", "start": 4, "end": 11, "id": 1, "ws": true, "disabled": true}, {"text": "study", "start": 12, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "reveals", "start": 18, "end": 25, "id": 3, "ws": true, "disabled": true}, {"text": "that", "start": 26, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 31, "end": 36, "id": 5, "ws": true, "disabled": false}, {"text": "induction", "start": 37, "end": 46, "id": 6, "ws": false, "disabled": true}, {"text": ",", "start": 46, "end": 47, "id": 7, "ws": true, "disabled": true}, {"text": "an", "start": 48, "end": 50, "id": 8, "ws": true, "disabled": true}, {"text": "important", "start": 51, "end": 60, "id": 9, "ws": true, "disabled": true}, {"text": "step", "start": 61, "end": 65, "id": 10, "ws": true, "disabled": true}, {"text": "in", "start": 66, "end": 68, "id": 11, "ws": true, "disabled": true}, {"text": "iTreg", "start": 69, "end": 74, "id": 12, "ws": true, "disabled": true}, {"text": "commitment", "start": 75, "end": 85, "id": 13, "ws": false, "disabled": true}, {"text": ",", "start": 85, "end": 86, "id": 14, "ws": true, "disabled": true}, {"text": "is", "start": 87, "end": 89, "id": 15, "ws": true, "disabled": true}, {"text": "inhibited", "start": 90, "end": 99, "id": 16, "ws": true, "disabled": true}, {"text": "by", "start": 100, "end": 102, "id": 17, "ws": true, "disabled": true}, {"text": "GATA3", "start": 103, "end": 108, "id": 18, "ws": false, "disabled": false}, {"text": ",", "start": 108, "end": 109, "id": 19, "ws": true, "disabled": true}, {"text": "which", "start": 110, "end": 115, "id": 20, "ws": true, "disabled": true}, {"text": "is", "start": 116, "end": 118, "id": 21, "ws": true, "disabled": true}, {"text": "the", "start": 119, "end": 122, "id": 22, "ws": true, "disabled": true}, {"text": "key", "start": 123, "end": 126, "id": 23, "ws": true, "disabled": true}, {"text": "regulator", "start": 127, "end": 136, "id": 24, "ws": true, "disabled": true}, {"text": "for", "start": 137, "end": 140, "id": 25, "ws": true, "disabled": true}, {"text": "polarization", "start": 141, "end": 153, "id": 26, "ws": true, "disabled": true}, {"text": "toward", "start": 154, "end": 160, "id": 27, "ws": true, "disabled": true}, {"text": "Th2", "start": 161, "end": 164, "id": 28, "ws": true, "disabled": true}, {"text": "cells", "start": 165, "end": 170, "id": 29, "ws": false, "disabled": true}, {"text": ".", "start": 170, "end": 171, "id": 30, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 18, "child": 5, "head_span": {"start": 103, "end": 108, "token_start": 18, "token_end": 18, "label": "GGP"}, "child_span": {"start": 31, "end": 36, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "In contrast, naive T cells could efficiently up-regulate FOXP3 when treated with TGF-beta to induce iTreg cells [10,28-34], suggesting that FOXP3 plays an important role in the early differentiation process and may act in a way similar to that known for the Th1/Th2 decision factors T-bet and GATA3.", "spans": [{"text": "FOXP3", "start": 57, "token_start": 11, "token_end": 11, "end": 62, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 81, "token_start": 15, "token_end": 17, "end": 89, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 140, "token_start": 30, "token_end": 30, "end": 145, "type": "span", "label": "GGP"}, {"text": "T-bet", "start": 283, "token_start": 57, "token_end": 59, "end": 288, "type": "span", "label": "GGP"}, {"text": "GATA3", "start": 293, "token_start": 61, "token_end": 61, "end": 298, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": -488378685, 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{"text": "The Th2 cytokine IL-4 but not IL-13 (unpublished data) was able to inhibit TGF-beta-mediated FOXP3 induction and therefore prevented conversion into the regulatory phenotype.", "spans": [{"text": "IL-4", "start": 17, "token_start": 3, "token_end": 3, "end": 21, "type": "span", "label": "GGP"}, {"text": "IL-13", "start": 30, "token_start": 6, "token_end": 6, "end": 35, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 75, "token_start": 15, "token_end": 17, "end": 83, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 93, "token_start": 20, "token_end": 20, "end": 98, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": -361239165, "_task_hash": 1540112012, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "Th2", "start": 4, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "cytokine", "start": 8, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "IL-4", "start": 17, "end": 21, "id": 3, "ws": true, "disabled": false}, {"text": "but", "start": 22, "end": 25, "id": 4, "ws": true, "disabled": true}, {"text": "not", "start": 26, "end": 29, "id": 5, "ws": true, "disabled": true}, {"text": "IL-13", "start": 30, "end": 35, "id": 6, "ws": true, "disabled": false}, {"text": "(", "start": 36, "end": 37, "id": 7, "ws": false, "disabled": true}, {"text": "unpublished", "start": 37, "end": 48, "id": 8, "ws": true, "disabled": true}, {"text": "data", "start": 49, "end": 53, "id": 9, "ws": false, "disabled": true}, {"text": ")", "start": 53, "end": 54, "id": 10, "ws": true, "disabled": true}, {"text": "was", "start": 55, "end": 58, "id": 11, "ws": true, "disabled": true}, {"text": "able", "start": 59, "end": 63, "id": 12, "ws": true, "disabled": true}, {"text": "to", "start": 64, "end": 66, "id": 13, "ws": true, "disabled": true}, {"text": "inhibit", "start": 67, "end": 74, "id": 14, "ws": true, "disabled": true}, {"text": "TGF", "start": 75, "end": 78, "id": 15, "ws": false, "disabled": false}, {"text": "-", "start": 78, "end": 79, "id": 16, "ws": false, "disabled": false}, {"text": "beta", "start": 79, "end": 83, "id": 17, "ws": false, "disabled": false}, {"text": "-", "start": 83, "end": 84, "id": 18, "ws": false, "disabled": true}, {"text": "mediated", "start": 84, "end": 92, "id": 19, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 93, "end": 98, "id": 20, "ws": true, "disabled": false}, {"text": "induction", "start": 99, "end": 108, "id": 21, "ws": true, "disabled": true}, {"text": "and", "start": 109, "end": 112, "id": 22, "ws": true, "disabled": true}, {"text": "therefore", "start": 113, "end": 122, "id": 23, "ws": true, "disabled": true}, {"text": "prevented", "start": 123, "end": 132, "id": 24, "ws": true, "disabled": true}, {"text": "conversion", "start": 133, "end": 143, "id": 25, "ws": true, "disabled": true}, {"text": "into", "start": 144, "end": 148, "id": 26, "ws": true, "disabled": true}, {"text": "the", "start": 149, "end": 152, "id": 27, "ws": true, "disabled": true}, {"text": "regulatory", "start": 153, "end": 163, "id": 28, "ws": true, "disabled": true}, {"text": "phenotype", "start": 164, "end": 173, "id": 29, "ws": false, "disabled": true}, {"text": ".", "start": 173, "end": 174, "id": 30, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 17, "child": 20, "head_span": {"start": 75, "end": 83, "token_start": 15, "token_end": 17, "label": "GGP"}, "child_span": {"start": 93, "end": 98, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 3, "child": 20, "head_span": {"start": 17, "end": 21, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 93, "end": 98, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 6, "child": 20, "head_span": {"start": 30, "end": 35, "token_start": 6, "token_end": 6, "label": "GGP"}, "child_span": {"start": 93, "end": 98, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "In those experiments, the concentrations of IL-4 used were low, and as we also observed, IL-4 at low concentration slightly enhanced FOXP3 expression.", "spans": [{"text": "IL-4", "start": 44, "token_start": 7, "token_end": 7, "end": 48, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 89, "token_start": 18, "token_end": 18, "end": 93, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 133, "token_start": 24, "token_end": 24, "end": 138, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": -1493050216, "_task_hash": 101893057, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "those", "start": 3, "end": 8, "id": 1, "ws": true, "disabled": true}, {"text": "experiments", "start": 9, "end": 20, "id": 2, "ws": false, "disabled": true}, {"text": ",", "start": 20, "end": 21, "id": 3, "ws": true, "disabled": true}, {"text": "the", "start": 22, "end": 25, "id": 4, "ws": true, "disabled": true}, {"text": "concentrations", "start": 26, "end": 40, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 41, "end": 43, "id": 6, "ws": true, "disabled": true}, {"text": "IL-4", "start": 44, "end": 48, "id": 7, "ws": true, "disabled": false}, {"text": "used", "start": 49, "end": 53, "id": 8, "ws": true, "disabled": true}, {"text": "were", "start": 54, "end": 58, "id": 9, "ws": true, "disabled": true}, {"text": "low", "start": 59, "end": 62, "id": 10, "ws": false, "disabled": true}, {"text": ",", "start": 62, "end": 63, "id": 11, "ws": true, "disabled": true}, {"text": "and", "start": 64, "end": 67, "id": 12, "ws": true, "disabled": true}, {"text": "as", "start": 68, "end": 70, "id": 13, "ws": true, "disabled": true}, {"text": "we", "start": 71, "end": 73, "id": 14, "ws": true, "disabled": true}, {"text": "also", "start": 74, "end": 78, "id": 15, "ws": true, "disabled": true}, {"text": "observed", "start": 79, "end": 87, "id": 16, "ws": false, "disabled": true}, {"text": ",", "start": 87, "end": 88, "id": 17, "ws": true, "disabled": true}, {"text": "IL-4", "start": 89, "end": 93, "id": 18, "ws": true, "disabled": false}, {"text": "at", "start": 94, "end": 96, "id": 19, "ws": true, "disabled": true}, {"text": "low", "start": 97, "end": 100, "id": 20, "ws": true, "disabled": true}, {"text": "concentration", "start": 101, "end": 114, "id": 21, "ws": true, "disabled": true}, {"text": "slightly", "start": 115, "end": 123, "id": 22, "ws": true, "disabled": true}, {"text": "enhanced", "start": 124, "end": 132, "id": 23, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 133, "end": 138, "id": 24, "ws": true, "disabled": false}, {"text": "expression", "start": 139, "end": 149, "id": 25, "ws": false, "disabled": true}, {"text": ".", "start": 149, "end": 150, "id": 26, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 18, "child": 24, "head_span": {"start": 89, "end": 93, "token_start": 18, "token_end": 18, "label": "GGP"}, "child_span": {"start": 133, "end": 138, "token_start": 24, "token_end": 24, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Protein transduction of GATA3 into naive T cells inhibited FOXP3 induction in human, differentiating, naive T cells.", "spans": [{"text": "GATA3", "start": 24, "token_start": 3, "token_end": 3, "end": 29, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 59, "token_start": 9, "token_end": 9, "end": 64, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": -257138622, "_task_hash": 1765015100, "tokens": [{"text": "Protein", "start": 0, "end": 7, "id": 0, "ws": true, "disabled": true}, {"text": "transduction", "start": 8, "end": 20, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 21, "end": 23, "id": 2, "ws": true, "disabled": true}, {"text": "GATA3", "start": 24, "end": 29, "id": 3, "ws": true, "disabled": false}, {"text": "into", "start": 30, "end": 34, "id": 4, "ws": true, "disabled": true}, {"text": "naive", "start": 35, "end": 40, "id": 5, "ws": true, "disabled": true}, {"text": "T", "start": 41, "end": 42, "id": 6, "ws": true, "disabled": true}, {"text": "cells", "start": 43, "end": 48, "id": 7, "ws": true, "disabled": true}, {"text": "inhibited", "start": 49, "end": 58, "id": 8, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 59, "end": 64, "id": 9, "ws": true, "disabled": false}, {"text": "induction", "start": 65, "end": 74, "id": 10, "ws": true, "disabled": true}, {"text": "in", "start": 75, "end": 77, "id": 11, "ws": true, "disabled": true}, {"text": "human", "start": 78, "end": 83, "id": 12, "ws": false, "disabled": true}, {"text": ",", "start": 83, "end": 84, "id": 13, "ws": true, "disabled": true}, {"text": "differentiating", "start": 85, "end": 100, "id": 14, "ws": false, "disabled": true}, {"text": ",", "start": 100, "end": 101, "id": 15, "ws": true, "disabled": true}, {"text": "naive", "start": 102, "end": 107, "id": 16, "ws": true, "disabled": true}, {"text": "T", "start": 108, "end": 109, "id": 17, "ws": true, "disabled": true}, {"text": "cells", "start": 110, "end": 115, "id": 18, "ws": false, "disabled": true}, {"text": ".", "start": 115, "end": 116, "id": 19, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 9, "head_span": {"start": 24, "end": 29, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 59, "end": 64, "token_start": 9, "token_end": 9, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "Our study demonstrates that GATA3 repressed FOXP3 expression directly by binding to the FOXP3 promoter region.", "spans": [{"text": "GATA3", "start": 28, "token_start": 4, "token_end": 4, "end": 33, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 44, "token_start": 6, "token_end": 6, "end": 49, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 88, "token_start": 13, "token_end": 13, "end": 93, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": 1085973992, "_task_hash": 1250616712, "tokens": [{"text": "Our", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "study", "start": 4, "end": 9, "id": 1, "ws": true, "disabled": true}, {"text": "demonstrates", "start": 10, "end": 22, "id": 2, "ws": true, "disabled": true}, {"text": "that", "start": 23, "end": 27, "id": 3, "ws": true, "disabled": true}, {"text": "GATA3", "start": 28, "end": 33, "id": 4, "ws": true, "disabled": false}, {"text": "repressed", "start": 34, "end": 43, "id": 5, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 44, "end": 49, "id": 6, "ws": true, "disabled": false}, {"text": "expression", "start": 50, "end": 60, "id": 7, "ws": true, "disabled": true}, {"text": "directly", "start": 61, "end": 69, "id": 8, "ws": true, "disabled": true}, {"text": "by", "start": 70, "end": 72, "id": 9, "ws": true, "disabled": true}, {"text": "binding", "start": 73, "end": 80, "id": 10, "ws": true, "disabled": true}, {"text": "to", "start": 81, "end": 83, "id": 11, "ws": true, "disabled": true}, {"text": "the", "start": 84, "end": 87, "id": 12, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 88, "end": 93, "id": 13, "ws": true, "disabled": false}, {"text": "promoter", "start": 94, "end": 102, "id": 14, "ws": true, "disabled": true}, {"text": "region", "start": 103, "end": 109, "id": 15, "ws": false, "disabled": true}, {"text": ".", "start": 109, "end": 110, "id": 16, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 4, "child": 6, "head_span": {"start": 28, "end": 33, "token_start": 4, "token_end": 4, "label": "GGP"}, "child_span": {"start": 44, "end": 49, "token_start": 6, "token_end": 6, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 4, "child": 13, "head_span": {"start": 28, "end": 33, "token_start": 4, "token_end": 4, "label": "GGP"}, "child_span": {"start": 88, "end": 93, "token_start": 13, "token_end": 13, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "In summary, we demonstrated that FOXP3 is negatively regulated by cytokines such as IL-4.", "spans": [{"text": "FOXP3", "start": 33, "token_start": 6, "token_end": 6, "end": 38, "type": "span", "label": "GGP"}, {"text": "IL-4", "start": 84, "token_start": 14, "token_end": 14, "end": 88, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": 1566036395, "_task_hash": -1580592283, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "summary", "start": 3, "end": 10, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 10, "end": 11, "id": 2, "ws": true, "disabled": true}, {"text": "we", "start": 12, "end": 14, "id": 3, "ws": true, "disabled": true}, {"text": "demonstrated", "start": 15, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "that", "start": 28, "end": 32, "id": 5, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 33, "end": 38, "id": 6, "ws": true, "disabled": false}, {"text": "is", "start": 39, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "negatively", "start": 42, "end": 52, "id": 8, "ws": true, "disabled": true}, {"text": "regulated", "start": 53, "end": 62, "id": 9, "ws": true, "disabled": true}, {"text": "by", "start": 63, "end": 65, "id": 10, "ws": true, "disabled": true}, {"text": "cytokines", "start": 66, "end": 75, "id": 11, "ws": true, "disabled": true}, {"text": "such", "start": 76, "end": 80, "id": 12, "ws": true, "disabled": true}, {"text": "as", "start": 81, "end": 83, "id": 13, "ws": true, "disabled": true}, {"text": "IL-4", "start": 84, "end": 88, "id": 14, "ws": false, "disabled": false}, {"text": ".", "start": 88, "end": 89, "id": 15, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 14, "child": 6, "head_span": {"start": 84, "end": 88, "token_start": 14, "token_end": 14, "label": "GGP"}, "child_span": {"start": 33, "end": 38, "token_start": 6, "token_end": 6, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "GATA3 acts as an inhibitor of FOXP3 expression in early T cell differentiation, as well as in differentiated Th2 cells by directly binding and repressing the FOXP3 promoter.", "spans": [{"text": "GATA3", "start": 0, "token_start": 0, "token_end": 0, "end": 5, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 30, "token_start": 6, "token_end": 6, "end": 35, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 158, "token_start": 27, "token_end": 27, "end": 163, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": -540089401, "_task_hash": 1707421419, "tokens": [{"text": "GATA3", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": false}, {"text": "acts", "start": 6, "end": 10, "id": 1, "ws": true, "disabled": true}, {"text": "as", "start": 11, "end": 13, "id": 2, "ws": true, "disabled": true}, {"text": "an", "start": 14, "end": 16, "id": 3, "ws": true, "disabled": true}, {"text": "inhibitor", "start": 17, "end": 26, "id": 4, "ws": true, "disabled": true}, {"text": "of", "start": 27, "end": 29, "id": 5, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 30, "end": 35, "id": 6, "ws": true, "disabled": false}, {"text": "expression", "start": 36, "end": 46, "id": 7, "ws": true, "disabled": true}, {"text": "in", "start": 47, "end": 49, "id": 8, "ws": true, "disabled": true}, {"text": "early", "start": 50, "end": 55, "id": 9, "ws": true, "disabled": true}, {"text": "T", "start": 56, "end": 57, "id": 10, "ws": true, "disabled": true}, {"text": "cell", "start": 58, "end": 62, "id": 11, "ws": true, "disabled": true}, {"text": "differentiation", "start": 63, "end": 78, "id": 12, "ws": false, "disabled": true}, {"text": ",", "start": 78, "end": 79, "id": 13, "ws": true, "disabled": true}, {"text": "as", "start": 80, "end": 82, "id": 14, "ws": true, "disabled": true}, {"text": "well", "start": 83, "end": 87, "id": 15, "ws": true, "disabled": true}, {"text": "as", "start": 88, "end": 90, "id": 16, "ws": true, "disabled": true}, {"text": "in", "start": 91, "end": 93, "id": 17, "ws": true, "disabled": true}, {"text": "differentiated", "start": 94, "end": 108, "id": 18, "ws": true, "disabled": true}, {"text": "Th2", "start": 109, "end": 112, "id": 19, "ws": true, "disabled": true}, {"text": "cells", "start": 113, "end": 118, "id": 20, "ws": true, "disabled": true}, {"text": "by", "start": 119, "end": 121, "id": 21, "ws": true, "disabled": true}, {"text": "directly", "start": 122, "end": 130, "id": 22, "ws": true, "disabled": true}, {"text": "binding", "start": 131, "end": 138, "id": 23, "ws": true, "disabled": true}, {"text": "and", "start": 139, "end": 142, "id": 24, "ws": true, "disabled": true}, {"text": "repressing", "start": 143, "end": 153, "id": 25, "ws": true, "disabled": true}, {"text": "the", "start": 154, "end": 157, "id": 26, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 158, "end": 163, "id": 27, "ws": true, "disabled": false}, {"text": "promoter", "start": 164, "end": 172, "id": 28, "ws": false, "disabled": true}, {"text": ".", "start": 172, "end": 173, "id": 29, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 6, "head_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 30, "end": 35, "token_start": 6, "token_end": 6, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 0, "child": 27, "head_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 158, "end": 163, "token_start": 27, "token_end": 27, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}, {"head": 0, "child": 27, "head_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 158, "end": 163, "token_start": 27, "token_end": 27, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 0, "child": 27, "head_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 158, "end": 163, "token_start": 27, "token_end": 27, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "We therefore describe a new mechanism of how Il-4 avoids tolerance induction by repressing FOXP3 expression.", "spans": [{"text": "Il-4", "start": 45, "token_start": 8, "token_end": 8, "end": 49, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 91, "token_start": 14, "token_end": 14, "end": 96, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2222968-08-Discussion.txt"}, "_input_hash": 420729106, "_task_hash": 1253557606, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "therefore", "start": 3, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "describe", "start": 13, "end": 21, "id": 2, "ws": true, "disabled": true}, {"text": "a", "start": 22, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "new", "start": 24, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "mechanism", "start": 28, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 38, "end": 40, "id": 6, "ws": true, "disabled": true}, {"text": "how", "start": 41, "end": 44, "id": 7, "ws": true, "disabled": true}, {"text": "Il-4", "start": 45, "end": 49, "id": 8, "ws": true, "disabled": false}, {"text": "avoids", "start": 50, "end": 56, "id": 9, "ws": true, "disabled": true}, {"text": "tolerance", "start": 57, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "induction", "start": 67, "end": 76, "id": 11, "ws": true, "disabled": true}, {"text": "by", "start": 77, "end": 79, "id": 12, "ws": true, "disabled": true}, {"text": "repressing", "start": 80, "end": 90, "id": 13, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 91, "end": 96, "id": 14, "ws": true, "disabled": false}, {"text": "expression", "start": 97, "end": 107, "id": 15, "ws": false, "disabled": true}, {"text": ".", "start": 107, "end": 108, "id": 16, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 14, "head_span": {"start": 45, "end": 49, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 91, "end": 96, "token_start": 14, "token_end": 14, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "In this study, we show that the transforming growth factor-beta (TGF-beta) induces the expression of the Runt-related transcription factors RUNX1 and RUNX3 in CD4+ T cells.", "spans": [{"text": "transforming growth factor-beta", "start": 32, "token_start": 8, "token_end": 12, "end": 63, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 65, "token_start": 14, "token_end": 16, "end": 73, "type": "span", "label": "GGP"}, {"text": "RUNX1", "start": 140, "token_start": 28, "token_end": 28, "end": 145, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 150, "token_start": 30, "token_end": 30, "end": 155, "type": "span", "label": "GGP"}, {"text": "CD4", "start": 159, "token_start": 32, "token_end": 32, "end": 162, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-00-TIAB.txt"}, "_input_hash": -1115117401, "_task_hash": -915176554, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": 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{"text": "This induction seems to be a prerequisite for the binding of RUNX1 and RUNX3 to three putative RUNX binding sites in the FOXP3 promoter.", "spans": [{"text": "RUNX1", "start": 61, "token_start": 11, "token_end": 11, "end": 66, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 71, "token_start": 13, "token_end": 13, "end": 76, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 121, "token_start": 22, "token_end": 22, "end": 126, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-00-TIAB.txt"}, "_input_hash": -1349545922, "_task_hash": -2038534605, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "induction", "start": 5, "end": 14, "id": 1, "ws": true, "disabled": true}, {"text": "seems", "start": 15, "end": 20, "id": 2, "ws": true, "disabled": true}, {"text": "to", "start": 21, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "be", "start": 24, "end": 26, "id": 4, "ws": true, "disabled": true}, {"text": "a", "start": 27, "end": 28, "id": 5, "ws": true, "disabled": true}, {"text": "prerequisite", "start": 29, "end": 41, "id": 6, "ws": true, "disabled": true}, {"text": "for", "start": 42, "end": 45, "id": 7, "ws": true, "disabled": true}, {"text": "the", "start": 46, "end": 49, "id": 8, "ws": true, "disabled": true}, {"text": "binding", "start": 50, "end": 57, "id": 9, "ws": true, "disabled": true}, {"text": "of", "start": 58, "end": 60, "id": 10, "ws": true, "disabled": true}, {"text": "RUNX1", "start": 61, "end": 66, "id": 11, "ws": true, "disabled": false}, {"text": "and", "start": 67, "end": 70, "id": 12, "ws": true, "disabled": true}, {"text": "RUNX3", "start": 71, "end": 76, "id": 13, "ws": true, "disabled": false}, {"text": "to", "start": 77, "end": 79, "id": 14, "ws": true, "disabled": true}, {"text": "three", "start": 80, "end": 85, "id": 15, "ws": true, "disabled": true}, {"text": "putative", "start": 86, "end": 94, "id": 16, "ws": true, "disabled": true}, {"text": "RUNX", "start": 95, "end": 99, "id": 17, "ws": true, "disabled": true}, {"text": "binding", "start": 100, "end": 107, "id": 18, "ws": true, "disabled": true}, {"text": "sites", "start": 108, "end": 113, "id": 19, "ws": true, "disabled": true}, {"text": "in", "start": 114, "end": 116, "id": 20, "ws": true, "disabled": true}, {"text": "the", "start": 117, "end": 120, "id": 21, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 121, "end": 126, "id": 22, "ws": true, "disabled": false}, {"text": "promoter", "start": 127, "end": 135, "id": 23, "ws": false, "disabled": true}, {"text": ".", "start": 135, "end": 136, "id": 24, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 11, "child": 22, "head_span": {"start": 61, "end": 66, "token_start": 11, "token_end": 11, "label": "GGP"}, "child_span": {"start": 121, "end": 126, "token_start": 22, "token_end": 22, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}, {"head": 13, "child": 22, "head_span": {"start": 71, "end": 76, "token_start": 13, "token_end": 13, "label": "GGP"}, "child_span": {"start": 121, "end": 126, "token_start": 22, "token_end": 22, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "The Th2 cytokine IL-4 inhibits FOXP3 expression during T cell priming.", "spans": [{"text": "IL-4", "start": 17, "token_start": 3, "token_end": 3, "end": 21, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 31, "token_start": 5, "token_end": 5, "end": 36, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-01-INTRODUCTION.txt"}, "_input_hash": -978207198, "_task_hash": -2128861634, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "Th2", "start": 4, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "cytokine", "start": 8, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "IL-4", "start": 17, "end": 21, "id": 3, "ws": true, "disabled": false}, {"text": "inhibits", "start": 22, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 31, "end": 36, "id": 5, "ws": true, "disabled": false}, {"text": "expression", "start": 37, "end": 47, "id": 6, "ws": true, "disabled": true}, {"text": "during", "start": 48, "end": 54, "id": 7, "ws": true, "disabled": true}, {"text": "T", "start": 55, "end": 56, "id": 8, "ws": true, "disabled": true}, {"text": "cell", "start": 57, "end": 61, "id": 9, "ws": true, "disabled": true}, {"text": "priming", "start": 62, "end": 69, "id": 10, "ws": false, "disabled": true}, {"text": ".", "start": 69, "end": 70, "id": 11, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 5, "head_span": {"start": 17, "end": 21, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 31, "end": 36, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "GATA3 binds to the FOXP3 promoter and can repress the FOXP3 trans-activation process directly in Th2 cells (Mantel et al., 2007).", "spans": [{"text": "GATA3", "start": 0, "token_start": 0, "token_end": 0, "end": 5, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 19, "token_start": 4, "token_end": 4, "end": 24, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 54, "token_start": 10, "token_end": 10, "end": 59, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-01-INTRODUCTION.txt"}, "_input_hash": -408236703, "_task_hash": -444594139, "tokens": [{"text": "GATA3", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": false}, {"text": "binds", "start": 6, "end": 11, "id": 1, "ws": true, "disabled": true}, {"text": "to", "start": 12, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 15, "end": 18, "id": 3, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 19, "end": 24, "id": 4, "ws": true, "disabled": false}, {"text": "promoter", "start": 25, "end": 33, "id": 5, "ws": true, "disabled": true}, {"text": "and", "start": 34, "end": 37, "id": 6, "ws": true, "disabled": true}, {"text": "can", "start": 38, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "repress", "start": 42, "end": 49, "id": 8, "ws": true, "disabled": true}, {"text": "the", "start": 50, "end": 53, "id": 9, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 54, "end": 59, "id": 10, "ws": true, "disabled": false}, {"text": "trans", "start": 60, "end": 65, "id": 11, "ws": false, "disabled": true}, {"text": "-", "start": 65, "end": 66, "id": 12, "ws": false, "disabled": true}, {"text": "activation", "start": 66, "end": 76, "id": 13, "ws": true, "disabled": true}, {"text": "process", "start": 77, "end": 84, "id": 14, "ws": true, "disabled": true}, {"text": "directly", "start": 85, "end": 93, "id": 15, "ws": true, "disabled": true}, {"text": "in", "start": 94, "end": 96, "id": 16, "ws": true, "disabled": true}, {"text": "Th2", "start": 97, "end": 100, "id": 17, "ws": true, "disabled": true}, {"text": "cells", "start": 101, "end": 106, "id": 18, "ws": true, "disabled": true}, {"text": "(", "start": 107, "end": 108, "id": 19, "ws": false, "disabled": true}, {"text": "Mantel", "start": 108, "end": 114, "id": 20, "ws": true, "disabled": true}, {"text": "et", "start": 115, "end": 117, "id": 21, "ws": true, "disabled": true}, {"text": "al", "start": 118, "end": 120, "id": 22, "ws": false, "disabled": true}, {"text": ".", "start": 120, "end": 121, "id": 23, "ws": false, "disabled": true}, {"text": ",", "start": 121, "end": 122, "id": 24, "ws": true, "disabled": true}, {"text": "2007", "start": 123, "end": 127, "id": 25, "ws": false, "disabled": true}, {"text": ")", "start": 127, "end": 128, "id": 26, "ws": false, "disabled": true}, {"text": ".", "start": 128, "end": 129, "id": 27, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 4, "head_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 19, "end": 24, "token_start": 4, "token_end": 4, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}, {"head": 0, "child": 10, "head_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 54, "end": 59, "token_start": 10, "token_end": 10, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "Because of the involvement of RUNX mutations in different autoimmune diseases and the known interaction with TGF-beta, we investigated the impact of RUNX1 and RUNX3 on the expression of FOXP3 and subsequently on the development and function of iT reg cells.", "spans": [{"text": "RUNX", "start": 30, "token_start": 5, "token_end": 5, "end": 34, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 109, "token_start": 16, "token_end": 18, "end": 117, "type": "span", "label": "GGP"}, {"text": "RUNX1", "start": 149, "token_start": 25, "token_end": 25, "end": 154, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 159, "token_start": 27, "token_end": 27, "end": 164, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 186, "token_start": 32, "token_end": 32, "end": 191, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-01-INTRODUCTION.txt"}, "_input_hash": 1778792108, "_task_hash": 1727658293, "tokens": 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{"text": "We observed no change in GATA3 expression in Th2 cells, T-bet expression in Th1 cells, or RORC2 mRNA expression in Th17 cells in which RUNX1 and RUNX3 were knocked down compared with control cells.", "spans": [{"text": "GATA3", "start": 25, "token_start": 5, "token_end": 5, "end": 30, "type": "span", "label": "GGP"}, {"text": "T-bet", "start": 56, "token_start": 11, "token_end": 13, "end": 61, "type": "span", "label": "GGP"}, {"text": "RORC2", "start": 90, "token_start": 20, "token_end": 20, "end": 95, "type": "span", "label": "GGP"}, {"text": "RUNX1", "start": 135, "token_start": 28, "token_end": 28, "end": 140, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 145, "token_start": 30, "token_end": 30, "end": 150, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-02-RESULTS-01.txt"}, "_input_hash": -1093688972, "_task_hash": 1902821798, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": 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{"text": "The most striking FOXP3 reduction was observed when RUNX1 and RUNX3 were silenced together (Fig.", "spans": [{"text": "FOXP3", "start": 18, "token_start": 3, "token_end": 3, "end": 23, "type": "span", "label": "GGP"}, {"text": "RUNX1", "start": 52, "token_start": 8, "token_end": 8, "end": 57, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 62, "token_start": 10, "token_end": 10, "end": 67, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-02-RESULTS-01.txt"}, "_input_hash": 637731734, "_task_hash": -285452515, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "most", "start": 4, "end": 8, "id": 1, "ws": true, "disabled": true}, {"text": "striking", "start": 9, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 18, "end": 23, "id": 3, "ws": true, "disabled": false}, {"text": "reduction", "start": 24, "end": 33, "id": 4, "ws": true, "disabled": true}, {"text": "was", "start": 34, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "observed", "start": 38, "end": 46, "id": 6, "ws": true, "disabled": true}, {"text": "when", "start": 47, "end": 51, "id": 7, "ws": true, "disabled": true}, {"text": "RUNX1", "start": 52, "end": 57, "id": 8, "ws": true, "disabled": false}, {"text": "and", "start": 58, "end": 61, "id": 9, "ws": true, "disabled": true}, {"text": "RUNX3", "start": 62, "end": 67, "id": 10, "ws": true, "disabled": false}, {"text": "were", "start": 68, "end": 72, "id": 11, "ws": true, "disabled": true}, {"text": "silenced", "start": 73, "end": 81, "id": 12, "ws": true, "disabled": true}, {"text": "together", "start": 82, "end": 90, "id": 13, "ws": true, "disabled": true}, {"text": "(", "start": 91, "end": 92, "id": 14, "ws": false, "disabled": true}, {"text": "Fig", "start": 92, "end": 95, "id": 15, "ws": false, "disabled": true}, {"text": ".", "start": 95, "end": 96, "id": 16, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 3, "head_span": {"start": 52, "end": 57, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 18, "end": 23, "token_start": 3, "token_end": 3, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 10, "child": 3, "head_span": {"start": 62, "end": 67, "token_start": 10, "token_end": 10, "label": "GGP"}, "child_span": {"start": 18, "end": 23, "token_start": 3, "token_end": 3, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "The increased impact of combined RUNX1 and RUNX3 knockdown implies that RUNX1 and RUNX3 might have redundant functions in the induction of FOXP3.", "spans": [{"text": "RUNX1", "start": 33, "token_start": 5, "token_end": 5, "end": 38, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 43, "token_start": 7, "token_end": 7, "end": 48, "type": "span", "label": "GGP"}, {"text": "RUNX1", "start": 72, "token_start": 11, "token_end": 11, "end": 77, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 82, "token_start": 13, "token_end": 13, "end": 87, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 139, "token_start": 22, "token_end": 22, "end": 144, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-02-RESULTS-01.txt"}, "_input_hash": 338997544, "_task_hash": 1024740399, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "increased", "start": 4, "end": 13, "id": 1, "ws": true, "disabled": true}, {"text": "impact", "start": 14, "end": 20, "id": 2, "ws": true, "disabled": true}, {"text": "of", "start": 21, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "combined", "start": 24, "end": 32, "id": 4, "ws": true, "disabled": true}, {"text": "RUNX1", "start": 33, "end": 38, "id": 5, "ws": true, "disabled": false}, {"text": "and", "start": 39, "end": 42, "id": 6, "ws": true, "disabled": true}, {"text": "RUNX3", "start": 43, "end": 48, "id": 7, "ws": true, "disabled": false}, {"text": "knockdown", "start": 49, "end": 58, "id": 8, "ws": true, "disabled": true}, {"text": "implies", "start": 59, "end": 66, "id": 9, "ws": true, "disabled": true}, {"text": "that", "start": 67, "end": 71, "id": 10, "ws": true, "disabled": true}, {"text": "RUNX1", "start": 72, "end": 77, "id": 11, "ws": true, "disabled": false}, {"text": "and", "start": 78, "end": 81, "id": 12, "ws": true, "disabled": true}, {"text": "RUNX3", "start": 82, "end": 87, "id": 13, "ws": true, "disabled": false}, {"text": "might", "start": 88, "end": 93, "id": 14, "ws": true, "disabled": true}, {"text": "have", "start": 94, "end": 98, "id": 15, "ws": true, "disabled": true}, {"text": "redundant", "start": 99, "end": 108, "id": 16, "ws": true, "disabled": true}, {"text": "functions", "start": 109, "end": 118, "id": 17, "ws": true, "disabled": true}, {"text": "in", "start": 119, "end": 121, "id": 18, "ws": true, "disabled": true}, {"text": "the", "start": 122, "end": 125, "id": 19, "ws": true, "disabled": true}, {"text": "induction", "start": 126, "end": 135, "id": 20, "ws": true, "disabled": true}, {"text": "of", "start": 136, "end": 138, "id": 21, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 139, "end": 144, "id": 22, "ws": false, "disabled": false}, {"text": ".", "start": 144, "end": 145, "id": 23, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 11, "child": 22, "head_span": {"start": 72, "end": 77, "token_start": 11, "token_end": 11, "label": "GGP"}, "child_span": {"start": 139, "end": 144, "token_start": 22, "token_end": 22, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 13, "child": 22, "head_span": {"start": 82, "end": 87, "token_start": 13, "token_end": 13, "label": "GGP"}, "child_span": {"start": 139, "end": 144, "token_start": 22, "token_end": 22, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
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{"text": "Supporting these findings, the overexpression of RUNX1 in human primary CD4+ T cells resulted in significantly elevated levels of FOXP3 protein measured by flow cytometry after 48 h. 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{"text": "These results demonstrate the important role of RUNX1 and RUNX3 not only for the induction of FOXP3, but also for the suppressive capacity of iT reg cells both in humans and in mice.", "spans": [{"text": "RUNX1", "start": 48, "token_start": 7, "token_end": 7, "end": 53, "type": "span", "label": "GGP"}, {"text": "RUNX3", "start": 58, "token_start": 9, "token_end": 9, "end": 63, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 94, "token_start": 16, "token_end": 16, "end": 99, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-06-RESULTS-05.txt"}, "_input_hash": 176899724, "_task_hash": 1598256456, "tokens": [{"text": "These", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": true}, {"text": "results", "start": 6, "end": 13, "id": 1, "ws": true, "disabled": true}, {"text": "demonstrate", "start": 14, "end": 25, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 26, "end": 29, "id": 3, "ws": true, "disabled": true}, {"text": "important", "start": 30, "end": 39, "id": 4, "ws": true, "disabled": true}, {"text": "role", "start": 40, "end": 44, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 45, "end": 47, "id": 6, "ws": true, "disabled": true}, {"text": "RUNX1", "start": 48, "end": 53, "id": 7, "ws": true, "disabled": false}, {"text": "and", "start": 54, "end": 57, "id": 8, "ws": true, "disabled": true}, {"text": "RUNX3", "start": 58, "end": 63, "id": 9, "ws": true, "disabled": false}, {"text": "not", "start": 64, "end": 67, "id": 10, "ws": true, "disabled": true}, {"text": "only", "start": 68, "end": 72, "id": 11, "ws": true, "disabled": true}, {"text": "for", "start": 73, "end": 76, "id": 12, "ws": true, "disabled": true}, {"text": "the", "start": 77, "end": 80, "id": 13, "ws": true, "disabled": true}, {"text": "induction", "start": 81, "end": 90, "id": 14, "ws": true, "disabled": true}, {"text": "of", "start": 91, "end": 93, "id": 15, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 94, "end": 99, "id": 16, "ws": false, "disabled": false}, {"text": ",", "start": 99, "end": 100, "id": 17, "ws": true, "disabled": true}, {"text": "but", "start": 101, "end": 104, "id": 18, "ws": true, "disabled": true}, {"text": "also", "start": 105, "end": 109, "id": 19, "ws": true, "disabled": true}, {"text": "for", "start": 110, "end": 113, "id": 20, "ws": true, "disabled": true}, {"text": "the", "start": 114, "end": 117, "id": 21, "ws": true, "disabled": true}, {"text": "suppressive", "start": 118, "end": 129, "id": 22, "ws": true, "disabled": true}, {"text": "capacity", "start": 130, "end": 138, "id": 23, "ws": true, "disabled": true}, {"text": "of", "start": 139, "end": 141, "id": 24, "ws": true, "disabled": true}, {"text": "iT", "start": 142, "end": 144, "id": 25, "ws": true, "disabled": true}, {"text": "reg", "start": 145, "end": 148, "id": 26, "ws": true, "disabled": true}, {"text": "cells", "start": 149, "end": 154, "id": 27, "ws": true, "disabled": true}, {"text": "both", "start": 155, "end": 159, "id": 28, "ws": true, "disabled": true}, {"text": "in", "start": 160, "end": 162, "id": 29, "ws": true, "disabled": true}, {"text": "humans", "start": 163, "end": 169, "id": 30, "ws": true, "disabled": true}, {"text": "and", "start": 170, "end": 173, "id": 31, "ws": true, "disabled": true}, {"text": "in", "start": 174, "end": 176, "id": 32, "ws": true, "disabled": true}, {"text": "mice", "start": 177, "end": 181, "id": 33, "ws": false, "disabled": true}, {"text": ".", "start": 181, "end": 182, "id": 34, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 7, "child": 16, "head_span": {"start": 48, "end": 53, "token_start": 7, "token_end": 7, "label": "GGP"}, "child_span": {"start": 94, "end": 99, "token_start": 16, "token_end": 16, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 9, "child": 16, "head_span": {"start": 58, "end": 63, "token_start": 9, "token_end": 9, "label": "GGP"}, "child_span": {"start": 94, "end": 99, "token_start": 16, "token_end": 16, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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{"text": "The RUNX protein that actually induces the expression of FOXP3 might therefore be dependent on the availability of the specific RUNX family member at certain stages of T cell development.", "spans": [{"text": "RUNX", "start": 4, "token_start": 1, "token_end": 1, "end": 8, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 57, "token_start": 9, "token_end": 9, "end": 62, "type": "span", "label": "GGP"}, {"text": "RUNX", "start": 128, "token_start": 20, "token_end": 20, "end": 132, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-07-DISCUSSION.txt"}, "_input_hash": -1185576669, "_task_hash": 1392196470, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "RUNX", "start": 4, "end": 8, "id": 1, "ws": true, "disabled": false}, {"text": "protein", "start": 9, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "that", "start": 17, "end": 21, "id": 3, "ws": true, "disabled": true}, {"text": "actually", "start": 22, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "induces", "start": 31, "end": 38, "id": 5, "ws": true, "disabled": true}, {"text": "the", "start": 39, "end": 42, "id": 6, "ws": true, "disabled": true}, {"text": "expression", "start": 43, "end": 53, "id": 7, "ws": true, "disabled": true}, {"text": "of", "start": 54, "end": 56, "id": 8, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 57, "end": 62, "id": 9, "ws": true, "disabled": false}, {"text": "might", "start": 63, "end": 68, "id": 10, "ws": true, "disabled": true}, {"text": "therefore", "start": 69, "end": 78, "id": 11, "ws": true, "disabled": true}, {"text": "be", "start": 79, "end": 81, "id": 12, "ws": true, "disabled": true}, {"text": "dependent", "start": 82, "end": 91, "id": 13, "ws": true, "disabled": true}, {"text": "on", "start": 92, "end": 94, "id": 14, "ws": true, "disabled": true}, {"text": "the", "start": 95, "end": 98, "id": 15, "ws": true, "disabled": true}, {"text": "availability", "start": 99, "end": 111, "id": 16, "ws": true, "disabled": true}, {"text": "of", "start": 112, "end": 114, "id": 17, "ws": true, "disabled": true}, {"text": "the", "start": 115, "end": 118, "id": 18, "ws": true, "disabled": true}, {"text": "specific", "start": 119, "end": 127, "id": 19, "ws": true, "disabled": true}, {"text": "RUNX", "start": 128, "end": 132, "id": 20, "ws": true, "disabled": false}, {"text": "family", "start": 133, "end": 139, "id": 21, "ws": true, "disabled": true}, {"text": "member", "start": 140, "end": 146, "id": 22, "ws": true, "disabled": true}, {"text": "at", "start": 147, "end": 149, "id": 23, "ws": true, "disabled": true}, {"text": "certain", "start": 150, "end": 157, "id": 24, "ws": true, "disabled": true}, {"text": "stages", "start": 158, "end": 164, "id": 25, "ws": true, "disabled": true}, {"text": "of", "start": 165, "end": 167, "id": 26, "ws": true, "disabled": true}, {"text": "T", "start": 168, "end": 169, "id": 27, "ws": true, "disabled": true}, {"text": "cell", "start": 170, "end": 174, "id": 28, "ws": true, "disabled": true}, {"text": "development", "start": 175, "end": 186, "id": 29, "ws": false, "disabled": true}, {"text": ".", "start": 186, "end": 187, "id": 30, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 1, "child": 9, "head_span": {"start": 4, "end": 8, "token_start": 1, "token_end": 1, "label": "GGP"}, "child_span": {"start": 57, "end": 62, "token_start": 9, "token_end": 9, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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{"text": "These data in mice confirm the human data that RUNX proteins play an important role for TGF-beta-dependent FOXP3 induction, as well as in the suppressive capacity of iT reg cells.", "spans": [{"text": "RUNX", "start": 47, "token_start": 9, "token_end": 9, "end": 51, "type": "span", "label": "GGP"}, {"text": "TGF-beta", "start": 88, "token_start": 16, "token_end": 18, "end": 96, "type": "span", "label": "GGP"}, {"text": "FOXP3", "start": 107, "token_start": 21, "token_end": 21, "end": 112, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMC-2806624-07-DISCUSSION.txt"}, "_input_hash": -369310212, "_task_hash": 2102316924, "tokens": [{"text": "These", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": true}, {"text": "data", "start": 6, "end": 10, "id": 1, "ws": true, "disabled": true}, {"text": "in", "start": 11, "end": 13, "id": 2, "ws": true, "disabled": true}, {"text": "mice", "start": 14, "end": 18, "id": 3, "ws": true, "disabled": true}, {"text": "confirm", "start": 19, "end": 26, "id": 4, "ws": true, "disabled": true}, {"text": "the", "start": 27, "end": 30, "id": 5, "ws": true, "disabled": true}, {"text": "human", "start": 31, "end": 36, "id": 6, "ws": true, "disabled": true}, {"text": "data", "start": 37, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "that", "start": 42, "end": 46, "id": 8, "ws": true, "disabled": true}, {"text": "RUNX", "start": 47, "end": 51, "id": 9, "ws": true, "disabled": false}, {"text": "proteins", "start": 52, "end": 60, "id": 10, "ws": true, "disabled": true}, {"text": "play", "start": 61, "end": 65, "id": 11, "ws": true, "disabled": true}, {"text": "an", "start": 66, "end": 68, "id": 12, "ws": true, "disabled": true}, {"text": "important", "start": 69, "end": 78, "id": 13, "ws": true, "disabled": true}, {"text": "role", "start": 79, "end": 83, "id": 14, "ws": true, "disabled": true}, {"text": "for", "start": 84, "end": 87, "id": 15, "ws": true, "disabled": true}, {"text": "TGF", "start": 88, "end": 91, "id": 16, "ws": false, "disabled": false}, {"text": "-", "start": 91, "end": 92, "id": 17, "ws": false, "disabled": false}, {"text": "beta", "start": 92, "end": 96, "id": 18, "ws": false, "disabled": false}, {"text": "-", "start": 96, "end": 97, "id": 19, "ws": false, "disabled": true}, {"text": "dependent", "start": 97, "end": 106, "id": 20, "ws": true, "disabled": true}, {"text": "FOXP3", "start": 107, "end": 112, "id": 21, "ws": true, "disabled": false}, {"text": "induction", "start": 113, "end": 122, "id": 22, "ws": false, "disabled": true}, {"text": ",", "start": 122, "end": 123, "id": 23, "ws": true, "disabled": true}, {"text": "as", "start": 124, "end": 126, "id": 24, "ws": true, "disabled": true}, {"text": "well", "start": 127, "end": 131, "id": 25, "ws": true, "disabled": true}, {"text": "as", "start": 132, "end": 134, "id": 26, "ws": true, "disabled": true}, {"text": "in", "start": 135, "end": 137, "id": 27, "ws": true, "disabled": true}, {"text": "the", "start": 138, "end": 141, "id": 28, "ws": true, "disabled": true}, {"text": "suppressive", "start": 142, "end": 153, "id": 29, "ws": true, "disabled": true}, {"text": "capacity", "start": 154, "end": 162, "id": 30, "ws": true, "disabled": true}, {"text": "of", "start": 163, "end": 165, "id": 31, "ws": true, "disabled": true}, {"text": "iT", "start": 166, "end": 168, "id": 32, "ws": true, "disabled": true}, {"text": "reg", "start": 169, "end": 172, "id": 33, "ws": true, "disabled": true}, {"text": "cells", "start": 173, "end": 178, "id": 34, "ws": false, "disabled": true}, {"text": ".", "start": 178, "end": 179, "id": 35, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 18, "child": 21, "head_span": {"start": 88, "end": 96, "token_start": 16, "token_end": 18, "label": "GGP"}, "child_span": {"start": 107, "end": 112, "token_start": 21, "token_end": 21, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 9, "child": 21, "head_span": {"start": 47, "end": 51, "token_start": 9, "token_end": 9, "label": "GGP"}, "child_span": {"start": 107, "end": 112, "token_start": 21, "token_end": 21, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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{"text": "Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise.", "spans": [{"text": "Fas", "start": 0, "token_start": 0, "token_end": 0, "end": 3, "type": "span", "label": "GGP"}, {"text": "FasL", "start": 4, "token_start": 2, "token_end": 2, "end": 8, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-10229231.txt"}, "_input_hash": 1888446882, "_task_hash": 1861739059, "tokens": [{"text": "Fas", "start": 0, "end": 3, "id": 0, "ws": false, "disabled": false}, {"text": "/", "start": 3, "end": 4, "id": 1, "ws": false, "disabled": true}, {"text": "FasL", "start": 4, "end": 8, "id": 2, "ws": true, "disabled": false}, {"text": "interaction", "start": 9, "end": 20, "id": 3, "ws": true, "disabled": true}, {"text": "initiates", "start": 21, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "cell", "start": 31, "end": 35, "id": 5, "ws": true, "disabled": true}, {"text": "death", "start": 36, "end": 41, "id": 6, "ws": true, "disabled": true}, {"text": "in", "start": 42, "end": 44, "id": 7, "ws": true, "disabled": true}, {"text": "many", "start": 45, "end": 49, "id": 8, "ws": true, "disabled": true}, {"text": "other", "start": 50, "end": 55, "id": 9, "ws": true, "disabled": true}, {"text": "systems", "start": 56, "end": 63, "id": 10, "ws": false, "disabled": true}, {"text": ",", "start": 63, "end": 64, "id": 11, "ws": true, "disabled": true}, {"text": "and", "start": 65, "end": 68, "id": 12, "ws": true, "disabled": true}, {"text": "its", "start": 69, "end": 72, "id": 13, "ws": true, "disabled": true}, {"text": "dysregulation", "start": 73, "end": 86, "id": 14, "ws": true, "disabled": true}, {"text": "is", "start": 87, "end": 89, "id": 15, "ws": true, "disabled": true}, {"text": "a", "start": 90, "end": 91, "id": 16, "ws": true, "disabled": true}, {"text": "mechanism", "start": 92, "end": 101, "id": 17, "ws": true, "disabled": true}, {"text": "by", "start": 102, "end": 104, "id": 18, "ws": true, "disabled": true}, {"text": "which", "start": 105, "end": 110, "id": 19, "ws": true, "disabled": true}, {"text": "several", "start": 111, "end": 118, "id": 20, "ws": true, "disabled": true}, {"text": "pathologic", "start": 119, "end": 129, "id": 21, "ws": true, "disabled": true}, {"text": "conditions", "start": 130, "end": 140, "id": 22, "ws": true, "disabled": true}, {"text": "arise", "start": 141, "end": 146, "id": 23, "ws": false, "disabled": true}, {"text": ".", "start": 146, "end": 147, "id": 24, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 2, "head_span": {"start": 0, "end": 3, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 4, "end": 8, "token_start": 2, "token_end": 2, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "It is interesting that IL-11 did not affect BAL fluid content of the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-inducible neutrophil chemoattractant (CINC); the presence of IL-11 did not affect these chemokines.", "spans": [{"text": "IL-11", "start": 23, "token_start": 4, "token_end": 4, "end": 28, "type": "span", "label": "GGP"}, {"text": "macrophage inflammatory protein-2", "start": 85, "token_start": 16, "token_end": 18, "end": 118, "type": "span", "label": "GGP"}, {"text": "MIP-2", "start": 120, "token_start": 20, "token_end": 20, "end": 125, "type": "span", "label": "GGP"}, {"text": "IL-11", "start": 201, "token_start": 35, "token_end": 35, "end": 206, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-10411003.txt"}, "_input_hash": -50555870, "_task_hash": -40470410, "tokens": [{"text": "It", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "is", "start": 3, "end": 5, "id": 1, "ws": 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{"text": "NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.", "spans": [{"text": "NIK", "start": 0, "token_start": 0, "token_end": 0, "end": 3, "type": "span", "label": "GGP"}, {"text": "IkappaB-alpha", "start": 25, "token_start": 4, "token_end": 6, "end": 38, "type": "span", "label": "GGP"}, {"text": "NIK", "start": 120, "token_start": 21, "token_end": 21, "end": 123, "type": "span", "label": "GGP"}, {"text": "IKK-alpha", "start": 212, "token_start": 34, "token_end": 36, "end": 221, "type": "span", "label": "GGP"}, {"text": "-beta", "start": 225, "token_start": 38, "token_end": 38, "end": 230, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-10455128.txt"}, "_input_hash": 1810852739, "_task_hash": -655668981, "tokens": [{"text": "NIK", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": false}, {"text": "can", "start": 4, "end": 7, "id": 1, "ws": false, "disabled": true}, {"text": "not", "start": 7, "end": 10, "id": 2, "ws": true, "disabled": true}, {"text": "phosphorylate", "start": 11, "end": 24, "id": 3, "ws": true, "disabled": true}, {"text": "IkappaB", "start": 25, "end": 32, "id": 4, "ws": false, "disabled": false}, {"text": "-", "start": 32, "end": 33, "id": 5, "ws": false, "disabled": false}, {"text": "alpha", "start": 33, "end": 38, "id": 6, "ws": true, "disabled": false}, {"text": "directly", "start": 39, "end": 47, "id": 7, "ws": false, "disabled": true}, {"text": ",", "start": 47, "end": 48, "id": 8, "ws": true, "disabled": true}, {"text": "but", "start": 49, "end": 52, "id": 9, "ws": true, "disabled": true}, {"text": "it", "start": 53, "end": 55, "id": 10, "ws": true, "disabled": true}, {"text": "appears", "start": 56, "end": 63, "id": 11, "ws": true, "disabled": true}, {"text": "to", "start": 64, "end": 66, "id": 12, "ws": true, "disabled": true}, {"text": "be", "start": 67, "end": 69, "id": 13, "ws": true, "disabled": true}, {"text": "a", "start": 70, "end": 71, "id": 14, "ws": true, "disabled": true}, {"text": "functionally", "start": 72, "end": 84, "id": 15, "ws": true, "disabled": true}, {"text": "important", "start": 85, "end": 94, "id": 16, "ws": true, "disabled": true}, {"text": "subunit", "start": 95, "end": 102, "id": 17, "ws": false, "disabled": true}, {"text": ",", "start": 102, "end": 103, "id": 18, "ws": true, "disabled": true}, {"text": "because", "start": 104, "end": 111, "id": 19, "ws": true, "disabled": true}, {"text": "mutated", "start": 112, "end": 119, "id": 20, "ws": true, "disabled": true}, {"text": "NIK", "start": 120, "end": 123, "id": 21, "ws": true, "disabled": false}, {"text": "inhibited", "start": 124, "end": 133, "id": 22, "ws": true, "disabled": true}, {"text": "stimulus", "start": 134, "end": 142, "id": 23, "ws": false, "disabled": true}, {"text": "-", "start": 142, "end": 143, "id": 24, "ws": false, "disabled": true}, {"text": "induced", "start": 143, "end": 150, "id": 25, "ws": true, "disabled": true}, {"text": "kappaB", "start": 151, "end": 157, "id": 26, "ws": false, "disabled": true}, {"text": "-", "start": 157, "end": 158, "id": 27, "ws": false, "disabled": true}, {"text": "dependent", "start": 158, "end": 167, "id": 28, "ws": true, "disabled": true}, {"text": "transcription", "start": 168, "end": 181, "id": 29, "ws": true, "disabled": true}, {"text": "more", "start": 182, "end": 186, "id": 30, "ws": true, "disabled": true}, {"text": "effectively", "start": 187, "end": 198, "id": 31, "ws": true, "disabled": true}, {"text": "than", "start": 199, "end": 203, "id": 32, "ws": true, "disabled": true}, {"text": "mutated", "start": 204, "end": 211, "id": 33, "ws": true, "disabled": true}, {"text": "IKK", "start": 212, "end": 215, "id": 34, "ws": false, "disabled": false}, {"text": "-", "start": 215, "end": 216, "id": 35, "ws": false, "disabled": false}, {"text": "alpha", "start": 216, "end": 221, "id": 36, "ws": true, "disabled": false}, {"text": "or", "start": 222, "end": 224, "id": 37, "ws": true, "disabled": true}, {"text": "-beta", "start": 225, "end": 230, "id": 38, "ws": false, "disabled": false}, {"text": ".", "start": 230, "end": 231, "id": 39, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 6, "head_span": {"start": 0, "end": 3, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 25, "end": 38, "token_start": 4, "token_end": 6, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
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{"text": "This erbA-binding site confers thyroid hormone responsiveness to a heterologous promoter in transient expression experiments and is a target for efficient down-regulation of CAII transcription by the v-erbA oncoprotein.", "spans": [{"text": "CAII", "start": 174, "token_start": 27, "token_end": 27, "end": 178, "type": "span", "label": "GGP"}, {"text": "v-erbA", "start": 200, "token_start": 31, "token_end": 33, "end": 206, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-1682217.txt"}, "_input_hash": 855041915, "_task_hash": -904318920, "tokens": [{"text": "This", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": true}, {"text": "erbA", "start": 5, "end": 9, "id": 1, "ws": false, "disabled": true}, {"text": "-", "start": 9, "end": 10, "id": 2, "ws": false, "disabled": true}, {"text": "binding", "start": 10, "end": 17, "id": 3, "ws": true, "disabled": true}, {"text": "site", "start": 18, "end": 22, "id": 4, "ws": true, "disabled": true}, {"text": "confers", "start": 23, "end": 30, "id": 5, "ws": true, "disabled": true}, {"text": "thyroid", "start": 31, "end": 38, "id": 6, "ws": true, "disabled": true}, {"text": "hormone", "start": 39, "end": 46, "id": 7, "ws": true, "disabled": true}, {"text": "responsiveness", "start": 47, "end": 61, "id": 8, "ws": true, "disabled": true}, {"text": "to", "start": 62, "end": 64, "id": 9, "ws": true, "disabled": true}, {"text": "a", "start": 65, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "heterologous", "start": 67, "end": 79, "id": 11, "ws": true, "disabled": true}, {"text": "promoter", "start": 80, "end": 88, "id": 12, "ws": true, "disabled": true}, {"text": "in", "start": 89, "end": 91, "id": 13, "ws": true, "disabled": true}, {"text": "transient", "start": 92, "end": 101, "id": 14, "ws": true, "disabled": true}, {"text": "expression", "start": 102, "end": 112, "id": 15, "ws": true, "disabled": true}, {"text": "experiments", "start": 113, "end": 124, "id": 16, "ws": true, "disabled": true}, {"text": "and", "start": 125, "end": 128, "id": 17, "ws": true, "disabled": true}, {"text": "is", "start": 129, "end": 131, "id": 18, "ws": true, "disabled": true}, {"text": "a", "start": 132, "end": 133, "id": 19, "ws": true, "disabled": true}, {"text": "target", "start": 134, "end": 140, "id": 20, "ws": true, "disabled": true}, {"text": "for", "start": 141, "end": 144, "id": 21, "ws": true, "disabled": true}, {"text": "efficient", "start": 145, "end": 154, "id": 22, "ws": true, "disabled": true}, {"text": "down", "start": 155, "end": 159, "id": 23, "ws": false, "disabled": true}, {"text": "-", "start": 159, "end": 160, "id": 24, "ws": false, "disabled": true}, {"text": "regulation", "start": 160, "end": 170, "id": 25, "ws": true, "disabled": true}, {"text": "of", "start": 171, "end": 173, "id": 26, "ws": true, "disabled": true}, {"text": "CAII", "start": 174, "end": 178, "id": 27, "ws": true, "disabled": false}, {"text": "transcription", "start": 179, "end": 192, "id": 28, "ws": true, "disabled": true}, {"text": "by", "start": 193, "end": 195, "id": 29, "ws": true, "disabled": true}, {"text": "the", "start": 196, "end": 199, "id": 30, "ws": true, "disabled": true}, {"text": "v", "start": 200, "end": 201, "id": 31, "ws": false, "disabled": false}, {"text": "-", "start": 201, "end": 202, "id": 32, "ws": false, "disabled": false}, {"text": "erbA", "start": 202, "end": 206, "id": 33, "ws": true, "disabled": false}, {"text": "oncoprotein", "start": 207, "end": 218, "id": 34, "ws": false, "disabled": true}, {"text": ".", "start": 218, "end": 219, "id": 35, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 33, "child": 27, "head_span": {"start": 200, "end": 206, "token_start": 31, "token_end": 33, "label": "GGP"}, "child_span": {"start": 174, "end": 178, "token_start": 27, "token_end": 27, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
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{"text": "Exogenous ETS1, but not ELF1, can transactivate GM-CSF, through the GM5 site, in a PMA/ionomycin dependent manner.", "spans": [{"text": "ETS1", "start": 10, "token_start": 1, "token_end": 1, "end": 14, "type": "span", "label": "GGP"}, {"text": "ELF1", "start": 24, "token_start": 5, "token_end": 5, "end": 28, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 48, "token_start": 9, "token_end": 11, "end": 54, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7478534.txt"}, "_input_hash": -693279501, "_task_hash": 1488700070, "tokens": [{"text": "Exogenous", "start": 0, "end": 9, "id": 0, "ws": true, "disabled": true}, {"text": "ETS1", "start": 10, "end": 14, "id": 1, "ws": false, "disabled": false}, {"text": ",", "start": 14, "end": 15, "id": 2, "ws": true, "disabled": true}, {"text": "but", "start": 16, "end": 19, "id": 3, "ws": true, "disabled": true}, {"text": "not", "start": 20, "end": 23, "id": 4, "ws": true, "disabled": true}, {"text": "ELF1", "start": 24, "end": 28, "id": 5, "ws": false, "disabled": false}, {"text": ",", "start": 28, "end": 29, "id": 6, "ws": true, "disabled": true}, {"text": "can", "start": 30, "end": 33, "id": 7, "ws": true, "disabled": true}, {"text": "transactivate", "start": 34, "end": 47, "id": 8, "ws": true, "disabled": true}, {"text": "GM", "start": 48, "end": 50, "id": 9, "ws": false, "disabled": false}, {"text": "-", "start": 50, "end": 51, "id": 10, "ws": false, "disabled": false}, {"text": "CSF", "start": 51, "end": 54, "id": 11, "ws": false, "disabled": false}, {"text": ",", "start": 54, "end": 55, "id": 12, "ws": true, "disabled": true}, {"text": "through", "start": 56, "end": 63, "id": 13, "ws": true, "disabled": true}, {"text": "the", "start": 64, "end": 67, "id": 14, "ws": true, "disabled": true}, {"text": "GM5", "start": 68, "end": 71, "id": 15, "ws": true, "disabled": true}, {"text": "site", "start": 72, "end": 76, "id": 16, "ws": false, "disabled": true}, {"text": ",", "start": 76, "end": 77, "id": 17, "ws": true, "disabled": true}, {"text": "in", "start": 78, "end": 80, "id": 18, "ws": true, "disabled": true}, {"text": "a", "start": 81, "end": 82, "id": 19, "ws": true, "disabled": true}, {"text": "PMA", "start": 83, "end": 86, "id": 20, "ws": false, "disabled": true}, {"text": "/", "start": 86, "end": 87, "id": 21, "ws": false, "disabled": true}, {"text": "ionomycin", "start": 87, "end": 96, "id": 22, "ws": true, "disabled": true}, {"text": "dependent", "start": 97, "end": 106, "id": 23, "ws": true, "disabled": true}, {"text": "manner", "start": 107, "end": 113, "id": 24, "ws": false, "disabled": true}, {"text": ".", "start": 113, "end": 114, "id": 25, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 1, "child": 11, "head_span": {"start": 10, "end": 14, "token_start": 1, "token_end": 1, "label": "GGP"}, "child_span": {"start": 48, "end": 54, "token_start": 9, "token_end": 11, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 5, "child": 11, "head_span": {"start": 24, "end": 28, "token_start": 5, "token_end": 5, "label": "GGP"}, "child_span": {"start": 48, "end": 54, "token_start": 9, "token_end": 11, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.", "spans": [{"text": "GM-CSF", "start": 4, "token_start": 1, "token_end": 3, "end": 10, "type": "span", "label": "GGP"}, {"text": "ETS1", "start": 48, "token_start": 12, "token_end": 12, "end": 52, "type": "span", "label": "GGP"}, {"text": "ETS1", "start": 126, "token_start": 27, "token_end": 27, "end": 130, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7478534.txt"}, "_input_hash": 2010941256, "_task_hash": -466919743, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "GM", "start": 4, "end": 6, "id": 1, "ws": false, "disabled": false}, {"text": "-", "start": 6, "end": 7, "id": 2, "ws": false, "disabled": false}, {"text": "CSF", "start": 7, "end": 10, "id": 3, "ws": true, "disabled": false}, {"text": "promoter", "start": 11, "end": 19, "id": 4, "ws": false, "disabled": true}, {"text": ",", "start": 19, "end": 20, "id": 5, "ws": true, "disabled": true}, {"text": "modified", "start": 21, "end": 29, "id": 6, "ws": true, "disabled": true}, {"text": "in", "start": 30, "end": 32, "id": 7, "ws": true, "disabled": true}, {"text": "this", "start": 33, "end": 37, "id": 8, "ws": true, "disabled": true}, {"text": "way", "start": 38, "end": 41, "id": 9, "ws": true, "disabled": true}, {"text": "to", "start": 42, "end": 44, "id": 10, "ws": true, "disabled": true}, {"text": "be", "start": 45, "end": 47, "id": 11, "ws": true, "disabled": true}, {"text": "ETS1", "start": 48, "end": 52, "id": 12, "ws": true, "disabled": false}, {"text": "specific", "start": 53, "end": 61, "id": 13, "ws": false, "disabled": true}, {"text": ",", "start": 61, "end": 62, "id": 14, "ws": true, "disabled": true}, {"text": "is", "start": 63, "end": 65, "id": 15, "ws": true, "disabled": true}, {"text": "fully", "start": 66, "end": 71, "id": 16, "ws": true, "disabled": true}, {"text": "responsive", "start": 72, "end": 82, "id": 17, "ws": true, "disabled": true}, {"text": "to", "start": 83, "end": 85, "id": 18, "ws": true, "disabled": true}, {"text": "PMA", "start": 86, "end": 89, "id": 19, "ws": false, "disabled": true}, {"text": "/", "start": 89, "end": 90, "id": 20, "ws": false, "disabled": true}, {"text": "ionomycin", "start": 90, "end": 99, "id": 21, "ws": true, "disabled": true}, {"text": "induction", "start": 100, "end": 109, "id": 22, "ws": false, "disabled": true}, {"text": ",", "start": 109, "end": 110, "id": 23, "ws": true, "disabled": true}, {"text": "in", "start": 111, "end": 113, "id": 24, "ws": true, "disabled": true}, {"text": "addition", "start": 114, "end": 122, "id": 25, "ws": true, "disabled": true}, {"text": "to", "start": 123, "end": 125, "id": 26, "ws": true, "disabled": true}, {"text": "ETS1", "start": 126, "end": 130, "id": 27, "ws": true, "disabled": false}, {"text": "transactivation", "start": 131, "end": 146, "id": 28, "ws": true, "disabled": true}, {"text": "in", "start": 147, "end": 149, "id": 29, "ws": true, "disabled": true}, {"text": "the", "start": 150, "end": 153, "id": 30, "ws": true, "disabled": true}, {"text": "presence", "start": 154, "end": 162, "id": 31, "ws": true, "disabled": true}, {"text": "of", "start": 163, "end": 165, "id": 32, "ws": true, "disabled": true}, {"text": "PMA", "start": 166, "end": 169, "id": 33, "ws": true, "disabled": true}, {"text": "and", "start": 170, "end": 173, "id": 34, "ws": true, "disabled": true}, {"text": "ionomycin", "start": 174, "end": 183, "id": 35, "ws": false, "disabled": true}, {"text": ".", "start": 183, "end": 184, "id": 36, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 12, "head_span": {"start": 4, "end": 10, "token_start": 1, "token_end": 3, "label": "GGP"}, "child_span": {"start": 48, "end": 52, "token_start": 12, "token_end": 12, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "Together these data suggest that ETS1 may be involved in mediating the increased GM-CSF production associated with T cell activation.", "spans": [{"text": "ETS1", "start": 33, "token_start": 5, "token_end": 5, "end": 37, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 81, "token_start": 13, "token_end": 15, "end": 87, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7478534.txt"}, "_input_hash": -1585594265, "_task_hash": 1859293559, "tokens": [{"text": "Together", "start": 0, "end": 8, "id": 0, "ws": true, "disabled": true}, {"text": "these", "start": 9, "end": 14, "id": 1, "ws": true, "disabled": true}, {"text": "data", "start": 15, "end": 19, "id": 2, "ws": true, "disabled": true}, {"text": "suggest", "start": 20, "end": 27, "id": 3, "ws": true, "disabled": true}, {"text": "that", "start": 28, "end": 32, "id": 4, "ws": true, "disabled": true}, {"text": "ETS1", "start": 33, "end": 37, "id": 5, "ws": true, "disabled": false}, {"text": "may", "start": 38, "end": 41, "id": 6, "ws": true, "disabled": true}, {"text": "be", "start": 42, "end": 44, "id": 7, "ws": true, "disabled": true}, {"text": "involved", "start": 45, "end": 53, "id": 8, "ws": true, "disabled": true}, {"text": "in", "start": 54, "end": 56, "id": 9, "ws": true, "disabled": true}, {"text": "mediating", "start": 57, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "the", "start": 67, "end": 70, "id": 11, "ws": true, "disabled": true}, {"text": "increased", "start": 71, "end": 80, "id": 12, "ws": true, "disabled": true}, {"text": "GM", "start": 81, "end": 83, "id": 13, "ws": false, "disabled": false}, {"text": "-", "start": 83, "end": 84, "id": 14, "ws": false, "disabled": false}, {"text": "CSF", "start": 84, "end": 87, "id": 15, "ws": true, "disabled": false}, {"text": "production", "start": 88, "end": 98, "id": 16, "ws": true, "disabled": true}, {"text": "associated", "start": 99, "end": 109, "id": 17, "ws": true, "disabled": true}, {"text": "with", "start": 110, "end": 114, "id": 18, "ws": true, "disabled": true}, {"text": "T", "start": 115, "end": 116, "id": 19, "ws": true, "disabled": true}, {"text": "cell", "start": 117, "end": 121, "id": 20, "ws": true, "disabled": true}, {"text": "activation", "start": 122, "end": 132, "id": 21, "ws": false, "disabled": true}, {"text": ".", "start": 132, "end": 133, "id": 22, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 5, "child": 15, "head_span": {"start": 33, "end": 37, "token_start": 5, "token_end": 5, "label": "GGP"}, "child_span": {"start": 81, "end": 87, "token_start": 13, "token_end": 15, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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{"text": "We examined alpha A1 (an alpha A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers) for their effects on the GM-CSF promoter.", "spans": [{"text": "alpha A1", "start": 12, "token_start": 2, "token_end": 3, "end": 20, "type": "span", "label": "GGP"}, {"text": "alpha B1", "start": 51, "token_start": 13, "token_end": 14, "end": 59, "type": "span", "label": "GGP"}, {"text": "alpha B2", "start": 64, "token_start": 16, "token_end": 17, "end": 72, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 128, "token_start": 31, "token_end": 33, "end": 134, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7605990.txt"}, "_input_hash": 1808014701, "_task_hash": 1101889525, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "examined", "start": 3, "end": 11, "id": 1, "ws": true, "disabled": true}, {"text": "alpha", "start": 12, "end": 17, "id": 2, "ws": true, "disabled": false}, {"text": "A1", "start": 18, "end": 20, "id": 3, "ws": true, "disabled": false}, {"text": "(", "start": 21, "end": 22, "id": 4, "ws": false, "disabled": true}, {"text": "an", "start": 22, "end": 24, "id": 5, "ws": true, "disabled": true}, {"text": "alpha", "start": 25, "end": 30, "id": 6, "ws": true, "disabled": true}, {"text": "A", "start": 31, "end": 32, "id": 7, "ws": false, "disabled": true}, {"text": "-", "start": 32, "end": 33, "id": 8, "ws": false, "disabled": true}, {"text": "gene", "start": 33, "end": 37, "id": 9, "ws": true, "disabled": true}, {"text": "product", "start": 38, "end": 45, "id": 10, "ws": false, "disabled": true}, {"text": ")", "start": 45, "end": 46, "id": 11, "ws": true, "disabled": true}, {"text": "and", "start": 47, "end": 50, "id": 12, "ws": true, "disabled": true}, {"text": "alpha", "start": 51, "end": 56, "id": 13, "ws": true, "disabled": false}, {"text": "B1", "start": 57, "end": 59, "id": 14, "ws": true, "disabled": false}, {"text": "and", "start": 60, "end": 63, "id": 15, "ws": true, "disabled": true}, {"text": "alpha", "start": 64, "end": 69, "id": 16, "ws": true, "disabled": false}, {"text": "B2", "start": 70, "end": 72, "id": 17, "ws": true, "disabled": false}, {"text": "(", "start": 73, "end": 74, "id": 18, "ws": false, "disabled": true}, {"text": "two", "start": 74, "end": 77, "id": 19, "ws": true, "disabled": true}, {"text": "alpha", "start": 78, "end": 83, "id": 20, "ws": true, "disabled": true}, {"text": "B", "start": 84, "end": 85, "id": 21, "ws": false, "disabled": true}, {"text": "-", "start": 85, "end": 86, "id": 22, "ws": false, "disabled": true}, {"text": "encoded", "start": 86, "end": 93, "id": 23, "ws": true, "disabled": true}, {"text": "isomers", "start": 94, "end": 101, "id": 24, "ws": false, "disabled": true}, {"text": ")", "start": 101, "end": 102, "id": 25, "ws": true, "disabled": true}, {"text": "for", "start": 103, "end": 106, "id": 26, "ws": true, "disabled": true}, {"text": "their", "start": 107, "end": 112, "id": 27, "ws": true, "disabled": true}, {"text": "effects", "start": 113, "end": 120, "id": 28, "ws": true, "disabled": true}, {"text": "on", "start": 121, "end": 123, "id": 29, "ws": true, "disabled": true}, {"text": "the", "start": 124, "end": 127, "id": 30, "ws": true, "disabled": true}, {"text": "GM", "start": 128, "end": 130, "id": 31, "ws": false, "disabled": false}, {"text": "-", "start": 130, "end": 131, "id": 32, "ws": false, "disabled": false}, {"text": "CSF", "start": 131, "end": 134, "id": 33, "ws": true, "disabled": false}, {"text": "promoter", "start": 135, "end": 143, "id": 34, "ws": false, "disabled": true}, {"text": ".", "start": 143, "end": 144, "id": 35, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 33, "head_span": {"start": 12, "end": 20, "token_start": 2, "token_end": 3, "label": "GGP"}, "child_span": {"start": 128, "end": 134, "token_start": 31, "token_end": 33, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 14, "child": 33, "head_span": {"start": 51, "end": 59, "token_start": 13, "token_end": 14, "label": "GGP"}, "child_span": {"start": 128, "end": 134, "token_start": 31, "token_end": 33, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 17, "child": 33, "head_span": {"start": 64, "end": 72, "token_start": 16, "token_end": 17, "label": "GGP"}, "child_span": {"start": 128, "end": 134, "token_start": 31, "token_end": 33, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
{"text": "Our results suggest that SP1 phosphorylation induced by OKA, a selective inhibitor of the serine-threonine phosphatase PP2A, facilitates the formation of a transcription complex involving general transcription factors, HIV Tat, and Sp1 proteins.", "spans": [{"text": "SP1", "start": 25, "token_start": 4, "token_end": 4, "end": 28, "type": "span", "label": "GGP"}, {"text": "PP2A", "start": 119, "token_start": 19, "token_end": 19, "end": 123, "type": "span", "label": "GGP"}, {"text": "Tat", "start": 223, "token_start": 34, "token_end": 34, "end": 226, "type": "span", "label": "GGP"}, {"text": "Sp1", "start": 232, "token_start": 37, "token_end": 37, "end": 235, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7747447.txt"}, "_input_hash": 1938892680, "_task_hash": -283606129, "tokens": [{"text": "Our", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "results", "start": 4, "end": 11, "id": 1, "ws": true, "disabled": 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{"text": "The transactivation of multiple cis elements, especially S and X2, of the DR alpha proximal promoter in group II CID cells is CIITA dependent.", "spans": [{"text": "DR alpha", "start": 74, "token_start": 14, "token_end": 15, "end": 82, "type": "span", "label": "GGP"}, {"text": "CIITA", "start": 126, "token_start": 24, "token_end": 24, "end": 131, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7749985.txt"}, "_input_hash": -1816761932, "_task_hash": 1829752658, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "transactivation", "start": 4, "end": 19, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 20, "end": 22, "id": 2, "ws": true, "disabled": true}, {"text": "multiple", "start": 23, "end": 31, "id": 3, "ws": true, "disabled": true}, {"text": "cis", "start": 32, "end": 35, "id": 4, "ws": true, "disabled": true}, {"text": "elements", "start": 36, "end": 44, "id": 5, "ws": false, "disabled": true}, {"text": ",", "start": 44, "end": 45, "id": 6, "ws": true, "disabled": true}, {"text": "especially", "start": 46, "end": 56, "id": 7, "ws": true, "disabled": true}, {"text": "S", "start": 57, "end": 58, "id": 8, "ws": true, "disabled": true}, {"text": "and", "start": 59, "end": 62, "id": 9, "ws": true, "disabled": true}, {"text": "X2", "start": 63, "end": 65, "id": 10, "ws": false, "disabled": true}, {"text": ",", "start": 65, "end": 66, "id": 11, "ws": true, "disabled": true}, {"text": "of", "start": 67, "end": 69, "id": 12, "ws": true, "disabled": true}, {"text": "the", "start": 70, "end": 73, "id": 13, "ws": true, "disabled": true}, {"text": "DR", "start": 74, "end": 76, "id": 14, "ws": true, "disabled": false}, {"text": "alpha", "start": 77, "end": 82, "id": 15, "ws": true, "disabled": false}, {"text": "proximal", "start": 83, "end": 91, "id": 16, "ws": true, "disabled": true}, {"text": "promoter", "start": 92, "end": 100, "id": 17, "ws": true, "disabled": true}, {"text": "in", "start": 101, "end": 103, "id": 18, "ws": true, "disabled": true}, {"text": "group", "start": 104, "end": 109, "id": 19, "ws": true, "disabled": true}, {"text": "II", "start": 110, "end": 112, "id": 20, "ws": true, "disabled": true}, {"text": "CID", "start": 113, "end": 116, "id": 21, "ws": true, "disabled": true}, {"text": "cells", "start": 117, "end": 122, "id": 22, "ws": true, "disabled": true}, {"text": "is", "start": 123, "end": 125, "id": 23, "ws": true, "disabled": true}, {"text": "CIITA", "start": 126, "end": 131, "id": 24, "ws": true, "disabled": false}, {"text": "dependent", "start": 132, "end": 141, "id": 25, "ws": false, "disabled": true}, {"text": ".", "start": 141, "end": 142, "id": 26, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 24, "child": 15, "head_span": {"start": 126, "end": 131, "token_start": 24, "token_end": 24, "label": "GGP"}, "child_span": {"start": 74, "end": 82, "token_start": 14, "token_end": 15, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
{"text": "Costimulatory signals, such as activation of the CD28 cell surface molecule on T cells, lead to activation through a distinct region of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter.", "spans": [{"text": "CD28", "start": 49, "token_start": 8, "token_end": 8, "end": 53, "type": "span", "label": "GGP"}, {"text": "granulocyte-macrophage colony-stimulating factor", "start": 140, "token_start": 25, "token_end": 31, "end": 188, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 190, "token_start": 33, "token_end": 35, "end": 196, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7759956.txt"}, "_input_hash": -347876067, "_task_hash": -526277308, "tokens": [{"text": "Costimulatory", "start": 0, "end": 13, "id": 0, "ws": true, "disabled": true}, {"text": "signals", "start": 14, "end": 21, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 21, "end": 22, "id": 2, "ws": true, "disabled": true}, {"text": "such", "start": 23, "end": 27, "id": 3, "ws": true, "disabled": true}, {"text": "as", "start": 28, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "activation", "start": 31, "end": 41, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 42, "end": 44, "id": 6, "ws": true, "disabled": true}, {"text": "the", "start": 45, "end": 48, "id": 7, "ws": true, "disabled": true}, {"text": "CD28", "start": 49, "end": 53, "id": 8, "ws": true, "disabled": false}, {"text": "cell", "start": 54, "end": 58, "id": 9, "ws": true, "disabled": true}, {"text": "surface", "start": 59, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "molecule", "start": 67, "end": 75, "id": 11, "ws": true, "disabled": true}, {"text": "on", "start": 76, "end": 78, "id": 12, "ws": true, "disabled": true}, {"text": "T", "start": 79, "end": 80, "id": 13, "ws": true, "disabled": true}, {"text": "cells", "start": 81, "end": 86, "id": 14, "ws": false, "disabled": true}, {"text": ",", "start": 86, "end": 87, "id": 15, "ws": true, "disabled": true}, {"text": "lead", "start": 88, "end": 92, "id": 16, "ws": true, "disabled": true}, {"text": "to", "start": 93, "end": 95, "id": 17, "ws": true, "disabled": true}, {"text": "activation", "start": 96, "end": 106, "id": 18, "ws": true, "disabled": true}, {"text": "through", "start": 107, "end": 114, "id": 19, "ws": true, "disabled": true}, {"text": "a", "start": 115, "end": 116, "id": 20, "ws": true, "disabled": true}, {"text": "distinct", "start": 117, "end": 125, "id": 21, "ws": true, "disabled": true}, {"text": "region", "start": 126, "end": 132, "id": 22, "ws": true, "disabled": true}, {"text": "of", "start": 133, "end": 135, "id": 23, "ws": true, "disabled": true}, {"text": "the", "start": 136, "end": 139, "id": 24, "ws": true, "disabled": true}, {"text": "granulocyte", "start": 140, "end": 151, "id": 25, "ws": false, "disabled": false}, {"text": "-", "start": 151, "end": 152, "id": 26, "ws": false, "disabled": false}, {"text": "macrophage", "start": 152, "end": 162, "id": 27, "ws": true, "disabled": false}, {"text": "colony", "start": 163, "end": 169, "id": 28, "ws": false, "disabled": false}, {"text": "-", "start": 169, "end": 170, "id": 29, "ws": false, "disabled": false}, {"text": "stimulating", "start": 170, "end": 181, "id": 30, "ws": true, "disabled": false}, {"text": "factor", "start": 182, "end": 188, "id": 31, "ws": true, "disabled": false}, {"text": "(", "start": 189, "end": 190, "id": 32, "ws": false, "disabled": true}, {"text": "GM", "start": 190, "end": 192, "id": 33, "ws": false, "disabled": false}, {"text": "-", "start": 192, "end": 193, "id": 34, "ws": false, "disabled": false}, {"text": "CSF", "start": 193, "end": 196, "id": 35, "ws": false, "disabled": false}, {"text": ")", "start": 196, "end": 197, "id": 36, "ws": true, "disabled": true}, {"text": "promoter", "start": 198, "end": 206, "id": 37, "ws": false, "disabled": true}, {"text": ".", "start": 206, "end": 207, "id": 38, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 31, "head_span": {"start": 49, "end": 53, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 140, "end": 188, "token_start": 25, "token_end": 31, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 8, "child": 35, "head_span": {"start": 49, "end": 53, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 190, "end": 196, "token_start": 33, "token_end": 35, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "We have found that the HTLV-1 transactivator protein, tax, acts as a costimulatory signal for GM-CSF and IL-2 gene transcription, in that it can cooperate with TCR signals to mediate high level gene expression.", "spans": [{"text": "tax", "start": 54, "token_start": 9, "token_end": 9, "end": 57, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 94, "token_start": 17, "token_end": 19, "end": 100, "type": "span", "label": "GGP"}, {"text": "IL-2", "start": 105, "token_start": 21, "token_end": 21, "end": 109, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7759956.txt"}, "_input_hash": -199350331, "_task_hash": -1946053732, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "have", "start": 3, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "found", "start": 8, "end": 13, "id": 2, "ws": true, "disabled": true}, {"text": "that", "start": 14, "end": 18, "id": 3, "ws": true, "disabled": true}, {"text": "the", "start": 19, "end": 22, "id": 4, "ws": true, "disabled": true}, {"text": "HTLV-1", "start": 23, "end": 29, "id": 5, "ws": true, "disabled": true}, {"text": "transactivator", "start": 30, "end": 44, "id": 6, "ws": true, "disabled": true}, {"text": "protein", "start": 45, "end": 52, "id": 7, "ws": false, "disabled": true}, {"text": ",", "start": 52, "end": 53, "id": 8, "ws": true, "disabled": true}, {"text": "tax", "start": 54, "end": 57, "id": 9, "ws": false, "disabled": false}, {"text": ",", "start": 57, "end": 58, "id": 10, "ws": true, "disabled": true}, {"text": "acts", "start": 59, "end": 63, "id": 11, "ws": true, "disabled": true}, {"text": "as", "start": 64, "end": 66, "id": 12, "ws": true, "disabled": true}, {"text": "a", "start": 67, "end": 68, "id": 13, "ws": true, "disabled": true}, {"text": "costimulatory", "start": 69, "end": 82, "id": 14, "ws": true, "disabled": true}, {"text": "signal", "start": 83, "end": 89, "id": 15, "ws": true, "disabled": true}, {"text": "for", "start": 90, "end": 93, "id": 16, "ws": true, "disabled": true}, {"text": "GM", "start": 94, "end": 96, "id": 17, "ws": false, "disabled": false}, {"text": "-", "start": 96, "end": 97, "id": 18, "ws": false, "disabled": false}, {"text": "CSF", "start": 97, "end": 100, "id": 19, "ws": true, "disabled": false}, {"text": "and", "start": 101, "end": 104, "id": 20, "ws": true, "disabled": true}, {"text": "IL-2", "start": 105, "end": 109, "id": 21, "ws": true, "disabled": false}, {"text": "gene", "start": 110, "end": 114, "id": 22, "ws": true, "disabled": true}, {"text": "transcription", "start": 115, "end": 128, "id": 23, "ws": false, "disabled": true}, {"text": ",", "start": 128, "end": 129, "id": 24, "ws": true, "disabled": true}, {"text": "in", "start": 130, "end": 132, "id": 25, "ws": true, "disabled": true}, {"text": "that", "start": 133, "end": 137, "id": 26, "ws": true, "disabled": true}, {"text": "it", "start": 138, "end": 140, "id": 27, "ws": true, "disabled": true}, {"text": "can", "start": 141, "end": 144, "id": 28, "ws": true, "disabled": true}, {"text": "cooperate", "start": 145, "end": 154, "id": 29, "ws": true, "disabled": true}, {"text": "with", "start": 155, "end": 159, "id": 30, "ws": true, "disabled": true}, {"text": "TCR", "start": 160, "end": 163, "id": 31, "ws": true, "disabled": true}, {"text": "signals", "start": 164, "end": 171, "id": 32, "ws": true, "disabled": true}, {"text": "to", "start": 172, "end": 174, "id": 33, "ws": true, "disabled": true}, {"text": "mediate", "start": 175, "end": 182, "id": 34, "ws": true, "disabled": true}, {"text": "high", "start": 183, "end": 187, "id": 35, "ws": true, "disabled": true}, {"text": "level", "start": 188, "end": 193, "id": 36, "ws": true, "disabled": true}, {"text": "gene", "start": 194, "end": 198, "id": 37, "ws": true, "disabled": true}, {"text": "expression", "start": 199, "end": 209, "id": 38, "ws": false, "disabled": true}, {"text": ".", "start": 209, "end": 210, "id": 39, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 9, "child": 19, "head_span": {"start": 54, "end": 57, "token_start": 9, "token_end": 9, "label": "GGP"}, "child_span": {"start": 94, "end": 100, "token_start": 17, "token_end": 19, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 9, "child": 21, "head_span": {"start": 54, "end": 57, "token_start": 9, "token_end": 9, "label": "GGP"}, "child_span": {"start": 105, "end": 109, "token_start": 21, "token_end": 21, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Tax activates the GM-CSF promoter through the CK-1/CD28RE region and also activates nuclear factor-kappa B binding to this region.", "spans": [{"text": "Tax", "start": 0, "token_start": 0, "token_end": 0, "end": 3, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 18, "token_start": 3, "token_end": 5, "end": 24, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7759956.txt"}, "_input_hash": -2025939742, "_task_hash": 914985464, "tokens": [{"text": "Tax", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": false}, {"text": "activates", "start": 4, "end": 13, "id": 1, "ws": true, "disabled": true}, {"text": "the", "start": 14, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "GM", "start": 18, "end": 20, "id": 3, "ws": false, "disabled": false}, {"text": "-", "start": 20, "end": 21, "id": 4, "ws": false, "disabled": false}, {"text": "CSF", "start": 21, "end": 24, "id": 5, "ws": true, "disabled": false}, {"text": "promoter", "start": 25, "end": 33, "id": 6, "ws": true, "disabled": true}, {"text": "through", "start": 34, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "the", "start": 42, "end": 45, "id": 8, "ws": true, "disabled": true}, {"text": "CK-1", "start": 46, "end": 50, "id": 9, "ws": false, "disabled": true}, {"text": "/", "start": 50, "end": 51, "id": 10, "ws": false, "disabled": true}, {"text": "CD28RE", "start": 51, "end": 57, "id": 11, "ws": true, "disabled": true}, {"text": "region", "start": 58, "end": 64, "id": 12, "ws": true, "disabled": true}, {"text": "and", "start": 65, "end": 68, "id": 13, "ws": true, "disabled": true}, {"text": "also", "start": 69, "end": 73, "id": 14, "ws": true, "disabled": true}, {"text": "activates", "start": 74, "end": 83, "id": 15, "ws": true, "disabled": true}, {"text": "nuclear", "start": 84, "end": 91, "id": 16, "ws": true, "disabled": true}, {"text": "factor", "start": 92, "end": 98, "id": 17, "ws": false, "disabled": true}, {"text": "-", "start": 98, "end": 99, "id": 18, "ws": false, "disabled": true}, {"text": "kappa", "start": 99, "end": 104, "id": 19, "ws": true, "disabled": true}, {"text": "B", "start": 105, "end": 106, "id": 20, "ws": true, "disabled": true}, {"text": "binding", "start": 107, "end": 114, "id": 21, "ws": true, "disabled": true}, {"text": "to", "start": 115, "end": 117, "id": 22, "ws": true, "disabled": true}, {"text": "this", "start": 118, "end": 122, "id": 23, "ws": true, "disabled": true}, {"text": "region", "start": 123, "end": 129, "id": 24, "ws": false, "disabled": true}, {"text": ".", "start": 129, "end": 130, "id": 25, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 5, "head_span": {"start": 0, "end": 3, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 18, "end": 24, "token_start": 3, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "In coimmunoprecipitation experiments using transfected COS cells, GATA-1 and ER associate in a ligand-dependent manner.", "spans": [{"text": "GATA-1", "start": 66, "token_start": 8, "token_end": 8, "end": 72, "type": "span", "label": "GGP"}, {"text": "ER", "start": 77, "token_start": 10, "token_end": 10, "end": 79, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7760810.txt"}, "_input_hash": -354104448, "_task_hash": 1737848379, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "coimmunoprecipitation", "start": 3, "end": 24, "id": 1, "ws": true, "disabled": true}, {"text": "experiments", "start": 25, "end": 36, "id": 2, "ws": true, "disabled": true}, {"text": "using", "start": 37, "end": 42, "id": 3, "ws": true, "disabled": true}, {"text": "transfected", "start": 43, "end": 54, "id": 4, "ws": true, "disabled": true}, {"text": "COS", "start": 55, "end": 58, "id": 5, "ws": true, "disabled": true}, {"text": "cells", "start": 59, "end": 64, "id": 6, "ws": false, "disabled": true}, {"text": ",", "start": 64, "end": 65, "id": 7, "ws": true, "disabled": true}, {"text": "GATA-1", "start": 66, "end": 72, "id": 8, "ws": true, "disabled": false}, {"text": "and", "start": 73, "end": 76, "id": 9, "ws": true, "disabled": true}, {"text": "ER", "start": 77, "end": 79, "id": 10, "ws": true, "disabled": false}, {"text": "associate", "start": 80, "end": 89, "id": 11, "ws": true, "disabled": true}, {"text": "in", "start": 90, "end": 92, "id": 12, "ws": true, "disabled": true}, {"text": "a", "start": 93, "end": 94, "id": 13, "ws": true, "disabled": true}, {"text": "ligand", "start": 95, "end": 101, "id": 14, "ws": false, "disabled": true}, {"text": "-", "start": 101, "end": 102, "id": 15, "ws": false, "disabled": true}, {"text": "dependent", "start": 102, "end": 111, "id": 16, "ws": true, "disabled": true}, {"text": "manner", "start": 112, "end": 118, "id": 17, "ws": false, "disabled": true}, {"text": ".", "start": 118, "end": 119, "id": 18, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 10, "head_span": {"start": 66, "end": 72, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 77, "end": 79, "token_start": 10, "token_end": 10, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "We speculate that estrogens exert effects on erythropoiesis by modulating GATA-1 activity through protein-protein interaction with the ER.", "spans": [{"text": "GATA-1", "start": 74, "token_start": 10, "token_end": 10, "end": 80, "type": "span", "label": "GGP"}, {"text": "ER", "start": 135, "token_start": 19, "token_end": 19, "end": 137, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7760810.txt"}, "_input_hash": -1846922421, "_task_hash": -1674134279, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "speculate", "start": 3, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "that", "start": 13, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "estrogens", "start": 18, "end": 27, "id": 3, "ws": true, "disabled": true}, {"text": "exert", "start": 28, "end": 33, "id": 4, "ws": true, "disabled": true}, {"text": "effects", "start": 34, "end": 41, "id": 5, "ws": true, "disabled": true}, {"text": "on", "start": 42, "end": 44, "id": 6, "ws": true, "disabled": true}, {"text": "erythropoiesis", "start": 45, "end": 59, "id": 7, "ws": true, "disabled": true}, {"text": "by", "start": 60, "end": 62, "id": 8, "ws": true, "disabled": true}, {"text": "modulating", "start": 63, "end": 73, "id": 9, "ws": true, "disabled": true}, {"text": "GATA-1", "start": 74, "end": 80, "id": 10, "ws": true, "disabled": false}, {"text": "activity", "start": 81, "end": 89, "id": 11, "ws": true, "disabled": true}, {"text": "through", "start": 90, "end": 97, "id": 12, "ws": true, "disabled": true}, {"text": "protein", "start": 98, "end": 105, "id": 13, "ws": false, "disabled": true}, {"text": "-", "start": 105, "end": 106, "id": 14, "ws": false, "disabled": true}, {"text": "protein", "start": 106, "end": 113, "id": 15, "ws": true, "disabled": true}, {"text": "interaction", "start": 114, "end": 125, "id": 16, "ws": true, "disabled": true}, {"text": "with", "start": 126, "end": 130, "id": 17, "ws": true, "disabled": true}, {"text": "the", "start": 131, "end": 134, "id": 18, "ws": true, "disabled": true}, {"text": "ER", "start": 135, "end": 137, "id": 19, "ws": false, "disabled": false}, {"text": ".", "start": 137, "end": 138, "id": 20, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 10, "child": 19, "head_span": {"start": 74, "end": 80, "token_start": 10, "token_end": 10, "label": "GGP"}, "child_span": {"start": 135, "end": 137, "token_start": 19, "token_end": 19, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter.", "spans": [{"text": "EGR-1", "start": 0, "token_start": 0, "token_end": 0, "end": 5, "type": "span", "label": "GGP"}, {"text": "EGR-1", "start": 71, "token_start": 14, "token_end": 14, "end": 76, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-7769834.txt"}, "_input_hash": 1839276277, "_task_hash": -1821117571, "tokens": [{"text": "EGR-1", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": false}, {"text": "transcription", "start": 6, "end": 19, "id": 1, "ws": true, "disabled": true}, {"text": "is", "start": 20, "end": 22, "id": 2, "ws": true, "disabled": true}, {"text": "conferred", "start": 23, "end": 32, "id": 3, "ws": true, "disabled": true}, {"text": "by", "start": 33, "end": 35, "id": 4, "ws": true, "disabled": true}, {"text": "the", "start": 36, "end": 39, "id": 5, "ws": true, "disabled": true}, {"text": "CArG", "start": 40, "end": 44, "id": 6, "ws": true, "disabled": true}, {"text": "motif", "start": 45, "end": 50, "id": 7, "ws": true, "disabled": true}, {"text": "(", "start": 51, "end": 52, "id": 8, "ws": false, "disabled": true}, {"text": "C", "start": 52, "end": 53, "id": 9, "ws": true, "disabled": true}, {"text": "C[AT]6GG", "start": 54, "end": 62, "id": 10, "ws": false, "disabled": true}, {"text": ")", "start": 62, "end": 63, "id": 11, "ws": true, "disabled": true}, {"text": "in", "start": 64, "end": 66, "id": 12, "ws": true, "disabled": true}, {"text": "the", "start": 67, "end": 70, "id": 13, "ws": true, "disabled": true}, {"text": "EGR-1", "start": 71, "end": 76, "id": 14, "ws": true, "disabled": false}, {"text": "promoter", "start": 77, "end": 85, "id": 15, "ws": false, "disabled": true}, {"text": ".", "start": 85, "end": 86, "id": 16, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 14, "child": 0, "head_span": {"start": 71, "end": 76, "token_start": 14, "token_end": 14, "label": "GGP"}, "child_span": {"start": 0, "end": 5, "token_start": 0, "token_end": 0, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Interferon regulatory factor 2 (IRF-2) is a transcriptional regulatory protein that terminates interferon beta expression initiated by interferon regulatory factor 1.", "spans": [{"text": "Interferon regulatory factor 2", "start": 0, "token_start": 0, "token_end": 3, "end": 30, "type": "span", "label": "GGP"}, {"text": "IRF-2", "start": 32, "token_start": 5, "token_end": 5, "end": 37, "type": "span", "label": "GGP"}, {"text": "interferon beta", "start": 95, "token_start": 14, "token_end": 15, "end": 110, "type": "span", "label": "GGP"}, {"text": "interferon regulatory factor 1", "start": 135, "token_start": 19, "token_end": 22, "end": 165, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8106512.txt"}, "_input_hash": -1212190103, "_task_hash": -2043876316, "tokens": [{"text": "Interferon", "start": 0, "end": 10, "id": 0, "ws": true, "disabled": false}, {"text": "regulatory", "start": 11, "end": 21, "id": 1, "ws": true, "disabled": false}, {"text": "factor", "start": 22, "end": 28, "id": 2, "ws": true, "disabled": false}, {"text": "2", "start": 29, "end": 30, "id": 3, "ws": true, "disabled": false}, {"text": "(", "start": 31, "end": 32, "id": 4, "ws": false, "disabled": true}, {"text": "IRF-2", "start": 32, "end": 37, "id": 5, "ws": false, "disabled": false}, {"text": ")", "start": 37, "end": 38, "id": 6, "ws": true, "disabled": true}, {"text": "is", "start": 39, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "a", "start": 42, "end": 43, "id": 8, "ws": true, "disabled": true}, {"text": "transcriptional", "start": 44, "end": 59, "id": 9, "ws": true, "disabled": true}, {"text": "regulatory", "start": 60, "end": 70, "id": 10, "ws": true, "disabled": true}, {"text": "protein", "start": 71, "end": 78, "id": 11, "ws": true, "disabled": true}, {"text": "that", "start": 79, "end": 83, "id": 12, "ws": true, "disabled": true}, {"text": "terminates", "start": 84, "end": 94, "id": 13, "ws": true, "disabled": true}, {"text": "interferon", "start": 95, "end": 105, "id": 14, "ws": true, "disabled": false}, {"text": "beta", "start": 106, "end": 110, "id": 15, "ws": true, "disabled": false}, {"text": "expression", "start": 111, "end": 121, "id": 16, "ws": true, "disabled": true}, {"text": "initiated", "start": 122, "end": 131, "id": 17, "ws": true, "disabled": true}, {"text": "by", "start": 132, "end": 134, "id": 18, "ws": true, "disabled": true}, {"text": "interferon", "start": 135, "end": 145, "id": 19, "ws": true, "disabled": false}, {"text": "regulatory", "start": 146, "end": 156, "id": 20, "ws": true, "disabled": false}, {"text": "factor", "start": 157, "end": 163, "id": 21, "ws": true, "disabled": false}, {"text": "1", "start": 164, "end": 165, "id": 22, "ws": false, "disabled": false}, {"text": ".", "start": 165, "end": 166, "id": 23, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 15, "head_span": {"start": 0, "end": 30, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 95, "end": 110, "token_start": 14, "token_end": 15, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 5, "child": 15, "head_span": {"start": 32, "end": 37, "token_start": 5, "token_end": 5, "label": "GGP"}, "child_span": {"start": 95, "end": 110, "token_start": 14, "token_end": 15, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 22, "child": 15, "head_span": {"start": 135, "end": 165, "token_start": 19, "token_end": 22, "label": "GGP"}, "child_span": {"start": 95, "end": 110, "token_start": 14, "token_end": 15, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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{"text": "The Tax protein of HTLV-I, a positive transcriptional activator of HTLV-I gene expression, is a viral oncogene that also increases transcription of cellular genes including GM-CSF, IL-2R alpha and IL-2.", "spans": [{"text": "Tax", "start": 4, "token_start": 1, "token_end": 1, "end": 7, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 173, "token_start": 31, "token_end": 33, "end": 179, "type": "span", "label": "GGP"}, {"text": "IL-2R alpha", "start": 181, "token_start": 35, "token_end": 36, "end": 192, "type": "span", "label": "GGP"}, {"text": "IL-2", "start": 197, "token_start": 38, "token_end": 38, "end": 201, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8108127.txt"}, "_input_hash": 1417035987, "_task_hash": -624281003, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "Tax", "start": 4, "end": 7, "id": 1, "ws": true, "disabled": false}, {"text": "protein", "start": 8, "end": 15, "id": 2, "ws": true, "disabled": true}, {"text": "of", "start": 16, "end": 18, "id": 3, "ws": true, "disabled": true}, {"text": "HTLV", "start": 19, "end": 23, "id": 4, "ws": false, "disabled": true}, {"text": "-", "start": 23, "end": 24, "id": 5, "ws": false, "disabled": true}, {"text": "I", "start": 24, "end": 25, "id": 6, "ws": false, "disabled": true}, {"text": ",", "start": 25, "end": 26, "id": 7, "ws": true, "disabled": true}, {"text": "a", "start": 27, "end": 28, "id": 8, "ws": true, "disabled": true}, {"text": "positive", "start": 29, "end": 37, "id": 9, "ws": true, "disabled": true}, {"text": "transcriptional", "start": 38, "end": 53, "id": 10, "ws": true, "disabled": true}, {"text": "activator", "start": 54, "end": 63, "id": 11, "ws": true, "disabled": true}, {"text": "of", "start": 64, "end": 66, "id": 12, "ws": true, "disabled": true}, {"text": "HTLV", "start": 67, "end": 71, "id": 13, "ws": false, "disabled": true}, {"text": "-", "start": 71, "end": 72, "id": 14, "ws": false, "disabled": true}, {"text": "I", "start": 72, "end": 73, "id": 15, "ws": true, "disabled": true}, {"text": "gene", "start": 74, "end": 78, "id": 16, "ws": true, "disabled": true}, {"text": "expression", "start": 79, "end": 89, "id": 17, "ws": false, "disabled": true}, {"text": ",", "start": 89, "end": 90, "id": 18, "ws": true, "disabled": true}, {"text": "is", "start": 91, "end": 93, "id": 19, "ws": true, "disabled": true}, {"text": "a", "start": 94, "end": 95, "id": 20, "ws": true, "disabled": true}, {"text": "viral", "start": 96, "end": 101, "id": 21, "ws": true, "disabled": true}, {"text": "oncogene", "start": 102, "end": 110, "id": 22, "ws": true, "disabled": true}, {"text": "that", "start": 111, "end": 115, "id": 23, "ws": true, "disabled": true}, {"text": "also", "start": 116, "end": 120, "id": 24, "ws": true, "disabled": true}, {"text": "increases", "start": 121, "end": 130, "id": 25, "ws": true, "disabled": true}, {"text": "transcription", "start": 131, "end": 144, "id": 26, "ws": true, "disabled": true}, {"text": "of", "start": 145, "end": 147, "id": 27, "ws": true, "disabled": true}, {"text": "cellular", "start": 148, "end": 156, "id": 28, "ws": true, "disabled": true}, {"text": "genes", "start": 157, "end": 162, "id": 29, "ws": true, "disabled": true}, {"text": "including", "start": 163, "end": 172, "id": 30, "ws": true, "disabled": true}, {"text": "GM", "start": 173, "end": 175, "id": 31, "ws": false, "disabled": false}, {"text": "-", "start": 175, "end": 176, "id": 32, "ws": false, "disabled": false}, {"text": "CSF", "start": 176, "end": 179, "id": 33, "ws": false, "disabled": false}, {"text": ",", "start": 179, "end": 180, "id": 34, "ws": true, "disabled": true}, {"text": "IL-2R", "start": 181, "end": 186, "id": 35, "ws": true, "disabled": false}, {"text": "alpha", "start": 187, "end": 192, "id": 36, "ws": true, "disabled": false}, {"text": "and", "start": 193, "end": 196, "id": 37, "ws": true, "disabled": true}, {"text": "IL-2", "start": 197, "end": 201, "id": 38, "ws": false, "disabled": false}, {"text": ".", "start": 201, "end": 202, "id": 39, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 1, "child": 33, "head_span": {"start": 4, "end": 7, "token_start": 1, "token_end": 1, "label": "GGP"}, "child_span": {"start": 173, "end": 179, "token_start": 31, "token_end": 33, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 1, "child": 36, "head_span": {"start": 4, "end": 7, "token_start": 1, "token_end": 1, "label": "GGP"}, "child_span": {"start": 181, "end": 192, "token_start": 35, "token_end": 36, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 1, "child": 38, "head_span": {"start": 4, "end": 7, "token_start": 1, "token_end": 1, "label": "GGP"}, "child_span": {"start": 197, "end": 201, "token_start": 38, "token_end": 38, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "B. The present study demonstrates that tumor necrosis factor alpha-induced degradation of I kappa B alpha in human T cells is preceded by its rapid phosphorylation in vivo.", "spans": [{"text": "tumor necrosis factor alpha", "start": 39, "token_start": 6, "token_end": 9, "end": 66, "type": "span", "label": "GGP"}, {"text": "I kappa B alpha", "start": 90, "token_start": 14, "token_end": 17, "end": 105, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8108414.txt"}, "_input_hash": 1682960049, "_task_hash": -156641676, "tokens": [{"text": "B.", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "The", "start": 3, "end": 6, "id": 1, "ws": true, "disabled": true}, {"text": "present", "start": 7, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "study", "start": 15, "end": 20, "id": 3, "ws": true, "disabled": true}, {"text": "demonstrates", "start": 21, "end": 33, "id": 4, "ws": true, "disabled": true}, {"text": "that", "start": 34, "end": 38, "id": 5, "ws": true, "disabled": true}, {"text": "tumor", "start": 39, "end": 44, "id": 6, "ws": true, "disabled": false}, {"text": "necrosis", "start": 45, "end": 53, "id": 7, "ws": true, "disabled": false}, {"text": "factor", "start": 54, "end": 60, "id": 8, "ws": true, "disabled": false}, {"text": "alpha", "start": 61, "end": 66, "id": 9, "ws": false, "disabled": false}, {"text": "-", "start": 66, "end": 67, "id": 10, "ws": false, "disabled": true}, {"text": "induced", "start": 67, "end": 74, "id": 11, "ws": true, "disabled": true}, {"text": "degradation", "start": 75, "end": 86, "id": 12, "ws": true, "disabled": true}, {"text": "of", "start": 87, "end": 89, "id": 13, "ws": true, "disabled": true}, {"text": "I", "start": 90, "end": 91, "id": 14, "ws": true, "disabled": false}, {"text": "kappa", "start": 92, "end": 97, "id": 15, "ws": true, "disabled": false}, {"text": "B", "start": 98, "end": 99, "id": 16, "ws": true, "disabled": false}, {"text": "alpha", "start": 100, "end": 105, "id": 17, "ws": true, "disabled": false}, {"text": "in", "start": 106, "end": 108, "id": 18, "ws": true, "disabled": true}, {"text": "human", "start": 109, "end": 114, "id": 19, "ws": true, "disabled": true}, {"text": "T", "start": 115, "end": 116, "id": 20, "ws": true, "disabled": true}, {"text": "cells", "start": 117, "end": 122, "id": 21, "ws": true, "disabled": true}, {"text": "is", "start": 123, "end": 125, "id": 22, "ws": true, "disabled": true}, {"text": "preceded", "start": 126, "end": 134, "id": 23, "ws": true, "disabled": true}, {"text": "by", "start": 135, "end": 137, "id": 24, "ws": true, "disabled": true}, {"text": "its", "start": 138, "end": 141, "id": 25, "ws": true, "disabled": true}, {"text": "rapid", "start": 142, "end": 147, "id": 26, "ws": true, "disabled": true}, {"text": "phosphorylation", "start": 148, "end": 163, "id": 27, "ws": true, "disabled": true}, {"text": "in", "start": 164, "end": 166, "id": 28, "ws": true, "disabled": true}, {"text": "vivo", "start": 167, "end": 171, "id": 29, "ws": false, "disabled": true}, {"text": ".", "start": 171, "end": 172, "id": 30, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 9, "child": 17, "head_span": {"start": 39, "end": 66, "token_start": 6, "token_end": 9, "label": "GGP"}, "child_span": {"start": 90, "end": 105, "token_start": 14, "token_end": 17, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "The presence of c-fos had a negative influence on GR function and correlated with the cell-specific synergistic or antagonistic activity of Jun with respect to GR; high basal expression of c-fos as well as AP-1 DNA binding and transcriptional activity were observed in HeLa cells, but not in T cells.", "spans": [{"text": "c-fos", "start": 16, "token_start": 3, "token_end": 5, "end": 21, "type": "span", "label": "GGP"}, {"text": "GR", "start": 50, "token_start": 11, "token_end": 11, "end": 52, "type": "span", "label": "GGP"}, {"text": "GR", "start": 160, "token_start": 29, "token_end": 29, "end": 162, "type": "span", "label": "GGP"}, {"text": "c-fos", "start": 189, "token_start": 35, "token_end": 37, "end": 194, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8388998.txt"}, "_input_hash": -1967573668, "_task_hash": -2079724512, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "presence", 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{"text": "These data suggest the potential utility of agents that disrupt calcineurin-mediated signal transduction pathways by blocking formation of the catalytically active dimer of calcineurin A and B subunits.", "spans": [{"text": "calcineurin A", "start": 173, "token_start": 25, "token_end": 26, "end": 186, "type": "span", "label": "GGP"}, {"text": "B subunits", "start": 191, "token_start": 28, "token_end": 29, "end": 201, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8561779.txt"}, "_input_hash": 1610616028, "_task_hash": 1635437832, "tokens": [{"text": "These", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": true}, {"text": "data", "start": 6, "end": 10, "id": 1, "ws": true, "disabled": true}, {"text": "suggest", "start": 11, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 19, "end": 22, "id": 3, "ws": true, "disabled": true}, {"text": "potential", "start": 23, "end": 32, "id": 4, "ws": true, "disabled": true}, {"text": "utility", "start": 33, "end": 40, "id": 5, "ws": true, "disabled": true}, {"text": "of", "start": 41, "end": 43, "id": 6, "ws": true, "disabled": true}, {"text": "agents", "start": 44, "end": 50, "id": 7, "ws": true, "disabled": true}, {"text": "that", "start": 51, "end": 55, "id": 8, "ws": true, "disabled": true}, {"text": "disrupt", "start": 56, "end": 63, "id": 9, "ws": true, "disabled": true}, {"text": "calcineurin", "start": 64, "end": 75, "id": 10, "ws": false, "disabled": true}, {"text": "-", "start": 75, "end": 76, "id": 11, "ws": false, "disabled": true}, {"text": "mediated", "start": 76, "end": 84, "id": 12, "ws": true, "disabled": true}, {"text": "signal", "start": 85, "end": 91, "id": 13, "ws": true, "disabled": true}, {"text": "transduction", "start": 92, "end": 104, "id": 14, "ws": true, "disabled": true}, {"text": "pathways", "start": 105, "end": 113, "id": 15, "ws": true, "disabled": true}, {"text": "by", "start": 114, "end": 116, "id": 16, "ws": true, "disabled": true}, {"text": "blocking", "start": 117, "end": 125, "id": 17, "ws": true, "disabled": true}, {"text": "formation", "start": 126, "end": 135, "id": 18, "ws": true, "disabled": true}, {"text": "of", "start": 136, "end": 138, "id": 19, "ws": true, "disabled": true}, {"text": "the", "start": 139, "end": 142, "id": 20, "ws": true, "disabled": true}, {"text": "catalytically", "start": 143, "end": 156, "id": 21, "ws": true, "disabled": true}, {"text": "active", "start": 157, "end": 163, "id": 22, "ws": true, "disabled": true}, {"text": "dimer", "start": 164, "end": 169, "id": 23, "ws": true, "disabled": true}, {"text": "of", "start": 170, "end": 172, "id": 24, "ws": true, "disabled": true}, {"text": "calcineurin", "start": 173, "end": 184, "id": 25, "ws": true, "disabled": false}, {"text": "A", "start": 185, "end": 186, "id": 26, "ws": true, "disabled": false}, {"text": "and", "start": 187, "end": 190, "id": 27, "ws": true, "disabled": true}, {"text": "B", "start": 191, "end": 192, "id": 28, "ws": true, "disabled": false}, {"text": "subunits", "start": 193, "end": 201, "id": 29, "ws": false, "disabled": false}, {"text": ".", "start": 201, "end": 202, "id": 30, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 26, "child": 29, "head_span": {"start": 173, "end": 186, "token_start": 25, "token_end": 26, "label": "GGP"}, "child_span": {"start": 191, "end": 201, "token_start": 28, "token_end": 29, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "To investigate the inhibitory mechanisms, we constructed a secreted-type placental alkaline phosphatase (PLAP) reporter gene whose transcription is controlled by a 1.4-kb human TNF-alpha promoter.", "spans": [{"text": "placental alkaline phosphatase", "start": 73, "token_start": 12, "token_end": 14, "end": 103, "type": "span", "label": "GGP"}, {"text": "PLAP", "start": 105, "token_start": 16, "token_end": 16, "end": 109, "type": "span", "label": "GGP"}, {"text": "TNF-alpha", "start": 177, "token_start": 28, "token_end": 30, "end": 186, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8622636.txt"}, "_input_hash": 264871246, "_task_hash": -1366950675, "tokens": [{"text": "To", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "investigate", "start": 3, "end": 14, "id": 1, "ws": true, "disabled": true}, {"text": "the", "start": 15, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "inhibitory", "start": 19, "end": 29, "id": 3, "ws": true, "disabled": true}, {"text": "mechanisms", "start": 30, "end": 40, "id": 4, "ws": false, "disabled": true}, {"text": ",", "start": 40, "end": 41, "id": 5, "ws": true, "disabled": true}, {"text": "we", "start": 42, "end": 44, "id": 6, "ws": true, "disabled": true}, {"text": "constructed", "start": 45, "end": 56, "id": 7, "ws": true, "disabled": true}, {"text": "a", "start": 57, "end": 58, "id": 8, "ws": true, "disabled": true}, {"text": "secreted", "start": 59, "end": 67, "id": 9, "ws": false, "disabled": true}, {"text": "-", "start": 67, "end": 68, "id": 10, "ws": false, "disabled": true}, {"text": "type", "start": 68, "end": 72, "id": 11, "ws": true, "disabled": true}, {"text": "placental", "start": 73, "end": 82, "id": 12, "ws": true, "disabled": false}, {"text": "alkaline", "start": 83, "end": 91, "id": 13, "ws": true, "disabled": false}, {"text": "phosphatase", "start": 92, "end": 103, "id": 14, "ws": true, "disabled": false}, {"text": "(", "start": 104, "end": 105, "id": 15, "ws": false, "disabled": true}, {"text": "PLAP", "start": 105, "end": 109, "id": 16, "ws": false, "disabled": false}, {"text": ")", "start": 109, "end": 110, "id": 17, "ws": true, "disabled": true}, {"text": "reporter", "start": 111, "end": 119, "id": 18, "ws": true, "disabled": true}, {"text": "gene", "start": 120, "end": 124, "id": 19, "ws": true, "disabled": true}, {"text": "whose", "start": 125, "end": 130, "id": 20, "ws": true, "disabled": true}, {"text": "transcription", "start": 131, "end": 144, "id": 21, "ws": true, "disabled": true}, {"text": "is", "start": 145, "end": 147, "id": 22, "ws": true, "disabled": true}, {"text": "controlled", "start": 148, "end": 158, "id": 23, "ws": true, "disabled": true}, {"text": "by", "start": 159, "end": 161, "id": 24, "ws": true, "disabled": true}, {"text": "a", "start": 162, "end": 163, "id": 25, "ws": true, "disabled": true}, {"text": "1.4-kb", "start": 164, "end": 170, "id": 26, "ws": true, "disabled": true}, {"text": "human", "start": 171, "end": 176, "id": 27, "ws": true, "disabled": true}, {"text": "TNF", "start": 177, "end": 180, "id": 28, "ws": false, "disabled": false}, {"text": "-", "start": 180, "end": 181, "id": 29, "ws": false, "disabled": false}, {"text": "alpha", "start": 181, "end": 186, "id": 30, "ws": true, "disabled": false}, {"text": "promoter", "start": 187, "end": 195, "id": 31, "ws": false, "disabled": true}, {"text": ".", "start": 195, "end": 196, "id": 32, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 30, "child": 16, "head_span": {"start": 177, "end": 186, "token_start": 28, "token_end": 30, "label": "GGP"}, "child_span": {"start": 105, "end": 109, "token_start": 16, "token_end": 16, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 30, "child": 14, "head_span": {"start": 177, "end": 186, "token_start": 28, "token_end": 30, "label": "GGP"}, "child_span": {"start": 73, "end": 103, "token_start": 12, "token_end": 14, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
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{"text": "Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase, paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter.", "spans": [{"text": "p16", "start": 73, "token_start": 11, "token_end": 11, "end": 76, "type": "span", "label": "GGP"}, {"text": "thymidine kinase", "start": 116, "token_start": 17, "token_end": 18, "end": 132, "type": "span", "label": "GGP"}, {"text": "retinoblastoma protein", "start": 195, "token_start": 29, "token_end": 30, "end": 217, "type": "span", "label": "GGP"}, {"text": "thymidine kinase", "start": 269, "token_start": 42, "token_end": 43, "end": 285, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8622883.txt"}, "_input_hash": 1590253210, "_task_hash": -1064921713, "tokens": [{"text": "Nevertheless", "start": 0, "end": 12, "id": 0, 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{"text": "We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein.", "spans": [{"text": "p16", "start": 28, "token_start": 5, "token_end": 5, "end": 31, "type": "span", "label": "GGP"}, {"text": "retinoblastoma protein", "start": 136, "token_start": 22, "token_end": 23, "end": 158, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8622883.txt"}, "_input_hash": 537640159, "_task_hash": -356317123, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "demonstrate", "start": 3, "end": 14, "id": 1, "ws": true, "disabled": true}, {"text": "that", "start": 15, "end": 19, "id": 2, "ws": true, "disabled": true}, {"text": "loss", "start": 20, "end": 24, "id": 3, "ws": true, "disabled": true}, {"text": "of", "start": 25, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "p16", "start": 28, "end": 31, "id": 5, "ws": true, "disabled": false}, {"text": "causes", "start": 32, "end": 38, "id": 6, "ws": true, "disabled": true}, {"text": "upregulation", "start": 39, "end": 51, "id": 7, "ws": true, "disabled": true}, {"text": "of", "start": 52, "end": 54, "id": 8, "ws": true, "disabled": true}, {"text": "this", "start": 55, "end": 59, "id": 9, "ws": true, "disabled": true}, {"text": "DNA", "start": 60, "end": 63, "id": 10, "ws": true, "disabled": true}, {"text": "precursor", "start": 64, "end": 73, "id": 11, "ws": true, "disabled": true}, {"text": "pathway", "start": 74, "end": 81, "id": 12, "ws": true, "disabled": true}, {"text": "enzyme", "start": 82, "end": 88, "id": 13, "ws": true, "disabled": true}, {"text": "via", "start": 89, "end": 92, "id": 14, "ws": true, "disabled": true}, {"text": "activation", "start": 93, "end": 103, "id": 15, "ws": true, "disabled": true}, {"text": "of", "start": 104, "end": 106, "id": 16, "ws": true, "disabled": true}, {"text": "E2F", "start": 107, "end": 110, "id": 17, "ws": true, "disabled": true}, {"text": "by", "start": 111, "end": 113, "id": 18, "ws": true, "disabled": true}, {"text": "a", "start": 114, "end": 115, "id": 19, "ws": true, "disabled": true}, {"text": "mechanism", "start": 116, "end": 125, "id": 20, "ws": true, "disabled": true}, {"text": "involving", "start": 126, "end": 135, "id": 21, "ws": true, "disabled": true}, {"text": "retinoblastoma", "start": 136, "end": 150, "id": 22, "ws": true, "disabled": false}, {"text": "protein", "start": 151, "end": 158, "id": 23, "ws": false, "disabled": false}, {"text": ".", "start": 158, "end": 159, "id": 24, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 5, "child": 23, "head_span": {"start": 28, "end": 31, "token_start": 5, "token_end": 5, "label": "GGP"}, "child_span": {"start": 136, "end": 158, "token_start": 22, "token_end": 23, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "These findings establish that Rel can function as an activator or repressor of gene expression and is required by T lymphocytes for production of IL-3 and GM-CSF.", "spans": [{"text": "Rel", "start": 30, "token_start": 4, "token_end": 4, "end": 33, "type": "span", "label": "GGP"}, {"text": "IL-3", "start": 146, "token_start": 24, "token_end": 24, "end": 150, "type": "span", "label": "GGP"}, {"text": "GM-CSF", "start": 155, "token_start": 26, "token_end": 28, "end": 161, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8622948.txt"}, "_input_hash": -565976017, "_task_hash": -1400929236, "tokens": [{"text": "These", "start": 0, "end": 5, "id": 0, "ws": true, "disabled": true}, {"text": "findings", "start": 6, "end": 14, "id": 1, "ws": true, "disabled": true}, {"text": "establish", "start": 15, "end": 24, "id": 2, "ws": true, "disabled": true}, {"text": "that", "start": 25, "end": 29, "id": 3, "ws": true, "disabled": true}, {"text": "Rel", "start": 30, "end": 33, "id": 4, "ws": true, "disabled": false}, {"text": "can", "start": 34, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "function", "start": 38, "end": 46, "id": 6, "ws": true, "disabled": true}, {"text": "as", "start": 47, "end": 49, "id": 7, "ws": true, "disabled": true}, {"text": "an", "start": 50, "end": 52, "id": 8, "ws": true, "disabled": true}, {"text": "activator", "start": 53, "end": 62, "id": 9, "ws": true, "disabled": true}, {"text": "or", "start": 63, "end": 65, "id": 10, "ws": true, "disabled": true}, {"text": "repressor", "start": 66, "end": 75, "id": 11, "ws": true, "disabled": true}, {"text": "of", "start": 76, "end": 78, "id": 12, "ws": true, "disabled": true}, {"text": "gene", "start": 79, "end": 83, "id": 13, "ws": true, "disabled": true}, {"text": "expression", "start": 84, "end": 94, "id": 14, "ws": true, "disabled": true}, {"text": "and", "start": 95, "end": 98, "id": 15, "ws": true, "disabled": true}, {"text": "is", "start": 99, "end": 101, "id": 16, "ws": true, "disabled": true}, {"text": "required", "start": 102, "end": 110, "id": 17, "ws": true, "disabled": true}, {"text": "by", "start": 111, "end": 113, "id": 18, "ws": true, "disabled": true}, {"text": "T", "start": 114, "end": 115, "id": 19, "ws": true, "disabled": true}, {"text": "lymphocytes", "start": 116, "end": 127, "id": 20, "ws": true, "disabled": true}, {"text": "for", "start": 128, "end": 131, "id": 21, "ws": true, "disabled": true}, {"text": "production", "start": 132, "end": 142, "id": 22, "ws": true, "disabled": true}, {"text": "of", "start": 143, "end": 145, "id": 23, "ws": true, "disabled": true}, {"text": "IL-3", "start": 146, "end": 150, "id": 24, "ws": true, "disabled": false}, {"text": "and", "start": 151, "end": 154, "id": 25, "ws": true, "disabled": true}, {"text": "GM", "start": 155, "end": 157, "id": 26, "ws": false, "disabled": false}, {"text": "-", "start": 157, "end": 158, "id": 27, "ws": false, "disabled": false}, {"text": "CSF", "start": 158, "end": 161, "id": 28, "ws": false, "disabled": false}, {"text": ".", "start": 161, "end": 162, "id": 29, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 4, "child": 24, "head_span": {"start": 30, "end": 33, "token_start": 4, "token_end": 4, "label": "GGP"}, "child_span": {"start": 146, "end": 150, "token_start": 24, "token_end": 24, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 4, "child": 28, "head_span": {"start": 30, "end": 33, "token_start": 4, "token_end": 4, "label": "GGP"}, "child_span": {"start": 155, "end": 161, "token_start": 26, "token_end": 28, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "In co-transfection experiments, the galectin-3 promoter was significantly up-regulated by expression vectors encoding the 40-kd Tax protein, a potent transactivator in HTLV-I. 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{"text": "Transfection of human promonocytic U-937 cells with an HTLV-I Tax expression vector induced galectin-3 expression in this cell line.", "spans": [{"text": "Tax", "start": 62, "token_start": 11, "token_end": 11, "end": 65, "type": "span", "label": "GGP"}, {"text": "galectin-3", "start": 92, "token_start": 15, "token_end": 15, "end": 102, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8623933.txt"}, "_input_hash": 1205944502, "_task_hash": -1313161507, "tokens": [{"text": "Transfection", "start": 0, "end": 12, "id": 0, "ws": true, "disabled": true}, {"text": "of", "start": 13, "end": 15, "id": 1, "ws": true, "disabled": true}, {"text": "human", "start": 16, "end": 21, "id": 2, "ws": true, "disabled": true}, {"text": "promonocytic", "start": 22, "end": 34, "id": 3, "ws": true, "disabled": true}, {"text": "U-937", "start": 35, "end": 40, "id": 4, "ws": true, "disabled": true}, {"text": "cells", "start": 41, "end": 46, "id": 5, "ws": true, "disabled": true}, {"text": "with", "start": 47, "end": 51, "id": 6, "ws": true, "disabled": true}, {"text": "an", "start": 52, "end": 54, "id": 7, "ws": true, "disabled": true}, {"text": "HTLV", "start": 55, "end": 59, "id": 8, "ws": false, "disabled": true}, {"text": "-", "start": 59, "end": 60, "id": 9, "ws": false, "disabled": true}, {"text": "I", "start": 60, "end": 61, "id": 10, "ws": true, "disabled": true}, {"text": "Tax", "start": 62, "end": 65, "id": 11, "ws": true, "disabled": false}, {"text": "expression", "start": 66, "end": 76, "id": 12, "ws": true, "disabled": true}, {"text": "vector", "start": 77, "end": 83, "id": 13, "ws": true, "disabled": true}, {"text": "induced", "start": 84, "end": 91, "id": 14, "ws": true, "disabled": true}, {"text": "galectin-3", "start": 92, "end": 102, "id": 15, "ws": true, "disabled": false}, {"text": "expression", "start": 103, "end": 113, "id": 16, "ws": true, "disabled": true}, {"text": "in", "start": 114, "end": 116, "id": 17, "ws": true, "disabled": true}, {"text": "this", "start": 117, "end": 121, "id": 18, "ws": true, "disabled": true}, {"text": "cell", "start": 122, "end": 126, "id": 19, "ws": true, "disabled": true}, {"text": "line", "start": 127, "end": 131, "id": 20, "ws": false, "disabled": true}, {"text": ".", "start": 131, "end": 132, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 11, "child": 15, "head_span": {"start": 62, "end": 65, "token_start": 11, "token_end": 11, "label": "GGP"}, "child_span": {"start": 92, "end": 102, "token_start": 15, "token_end": 15, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Functionally, galectin-3 was shown to activate interleukin-2 production in Jurkat T cells.", "spans": [{"text": "galectin-3", "start": 14, "token_start": 2, "token_end": 2, "end": 24, "type": "span", "label": "GGP"}, {"text": "interleukin-2", "start": 47, "token_start": 7, "token_end": 7, "end": 60, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8623933.txt"}, "_input_hash": 882885840, "_task_hash": 627639265, "tokens": [{"text": "Functionally", "start": 0, "end": 12, "id": 0, "ws": false, "disabled": true}, {"text": ",", "start": 12, "end": 13, "id": 1, "ws": true, "disabled": true}, {"text": "galectin-3", "start": 14, "end": 24, "id": 2, "ws": true, "disabled": false}, {"text": "was", "start": 25, "end": 28, "id": 3, "ws": true, "disabled": true}, {"text": "shown", "start": 29, "end": 34, "id": 4, "ws": true, "disabled": true}, {"text": "to", "start": 35, "end": 37, "id": 5, "ws": true, "disabled": true}, {"text": "activate", "start": 38, "end": 46, "id": 6, "ws": true, "disabled": true}, {"text": "interleukin-2", "start": 47, "end": 60, "id": 7, "ws": true, "disabled": false}, {"text": "production", "start": 61, "end": 71, "id": 8, "ws": true, "disabled": true}, {"text": "in", "start": 72, "end": 74, "id": 9, "ws": true, "disabled": true}, {"text": "Jurkat", "start": 75, "end": 81, "id": 10, "ws": true, "disabled": true}, {"text": "T", "start": 82, "end": 83, "id": 11, "ws": true, "disabled": true}, {"text": "cells", "start": 84, "end": 89, "id": 12, "ws": false, "disabled": true}, {"text": ".", "start": 89, "end": 90, "id": 13, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 2, "child": 7, "head_span": {"start": 14, "end": 24, "token_start": 2, "token_end": 2, "label": "GGP"}, "child_span": {"start": 47, "end": 60, "token_start": 7, "token_end": 7, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Together, these findings raise the possibility that HTLV-I Tax production induces the transcription and subsequent synthesis and secretion of galectin-3, which in turn may further activate these T cells and contribute to the altered properties of cell growth found in adult T cell leukemia induced by HTLV-I.", "spans": [{"text": "Tax", "start": 59, "token_start": 11, "token_end": 11, "end": 62, "type": "span", "label": "GGP"}, {"text": "galectin-3", "start": 142, "token_start": 22, "token_end": 22, "end": 152, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8623933.txt"}, "_input_hash": -903097970, "_task_hash": -1862838014, "tokens": [{"text": "Together", "start": 0, "end": 8, "id": 0, "ws": false, "disabled": true}, {"text": ",", "start": 8, "end": 9, "id": 1, "ws": true, "disabled": true}, {"text": "these", "start": 10, "end": 15, "id": 2, "ws": true, "disabled": true}, {"text": "findings", "start": 16, "end": 24, "id": 3, "ws": 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{"text": "In this study the effect of IL-10 on the expression of the protooncogene c-fos was investigated, because Fos plays a potential role in the regulation of B cell proliferation and differentiation.", "spans": [{"text": "IL-10", "start": 28, "token_start": 6, "token_end": 6, "end": 33, "type": "span", "label": "GGP"}, {"text": "c-fos", "start": 73, "token_start": 13, "token_end": 15, "end": 78, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8675228.txt"}, "_input_hash": -342983969, "_task_hash": 503814891, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "this", "start": 3, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "study", "start": 8, "end": 13, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 14, "end": 17, "id": 3, "ws": true, "disabled": true}, {"text": "effect", "start": 18, "end": 24, "id": 4, "ws": true, "disabled": true}, {"text": "of", "start": 25, "end": 27, "id": 5, "ws": true, "disabled": true}, {"text": "IL-10", "start": 28, "end": 33, "id": 6, "ws": true, "disabled": false}, {"text": "on", "start": 34, "end": 36, "id": 7, "ws": true, "disabled": true}, {"text": "the", "start": 37, "end": 40, "id": 8, "ws": true, "disabled": true}, {"text": "expression", "start": 41, "end": 51, "id": 9, "ws": true, "disabled": true}, {"text": "of", "start": 52, "end": 54, "id": 10, "ws": true, "disabled": true}, {"text": "the", "start": 55, "end": 58, "id": 11, "ws": true, "disabled": true}, {"text": "protooncogene", "start": 59, "end": 72, "id": 12, "ws": true, "disabled": true}, {"text": "c", "start": 73, "end": 74, "id": 13, "ws": false, "disabled": false}, {"text": "-", "start": 74, "end": 75, "id": 14, "ws": false, "disabled": false}, {"text": "fos", "start": 75, "end": 78, "id": 15, "ws": true, "disabled": false}, {"text": "was", "start": 79, "end": 82, "id": 16, "ws": true, "disabled": true}, {"text": "investigated", "start": 83, "end": 95, "id": 17, "ws": false, "disabled": true}, {"text": ",", "start": 95, "end": 96, "id": 18, "ws": true, "disabled": true}, {"text": "because", "start": 97, "end": 104, "id": 19, "ws": true, "disabled": true}, {"text": "Fos", "start": 105, "end": 108, "id": 20, "ws": true, "disabled": true}, {"text": "plays", "start": 109, "end": 114, "id": 21, "ws": true, "disabled": true}, {"text": "a", "start": 115, "end": 116, "id": 22, "ws": true, "disabled": true}, {"text": "potential", "start": 117, "end": 126, "id": 23, "ws": true, "disabled": true}, {"text": "role", "start": 127, "end": 131, "id": 24, "ws": true, "disabled": true}, {"text": "in", "start": 132, "end": 134, "id": 25, "ws": true, "disabled": true}, {"text": "the", "start": 135, "end": 138, "id": 26, "ws": true, "disabled": true}, {"text": "regulation", "start": 139, "end": 149, "id": 27, "ws": true, "disabled": true}, {"text": "of", "start": 150, "end": 152, "id": 28, "ws": true, "disabled": true}, {"text": "B", "start": 153, "end": 154, "id": 29, "ws": true, "disabled": true}, {"text": "cell", "start": 155, "end": 159, "id": 30, "ws": true, "disabled": true}, {"text": "proliferation", "start": 160, "end": 173, "id": 31, "ws": true, "disabled": true}, {"text": "and", "start": 174, "end": 177, "id": 32, "ws": true, "disabled": true}, {"text": "differentiation", "start": 178, "end": 193, "id": 33, "ws": false, "disabled": true}, {"text": ".", "start": 193, "end": 194, "id": 34, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 6, "child": 15, "head_span": {"start": 28, "end": 33, "token_start": 6, "token_end": 6, "label": "GGP"}, "child_span": {"start": 73, "end": 78, "token_start": 13, "token_end": 15, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
{"text": "The IL-10 effect on c-fos expression was not blocked by polymyxin B. Using the tyrosine kinase inhibitor genistein (10 microM) a complete inhibition of IL-10 induced c-fos expression was observed.", "spans": [{"text": "IL-10", "start": 4, "token_start": 1, "token_end": 1, "end": 9, "type": "span", "label": "GGP"}, {"text": "c-fos", "start": 20, "token_start": 4, "token_end": 6, "end": 25, "type": "span", "label": "GGP"}, {"text": "IL-10", "start": 152, "token_start": 28, "token_end": 28, "end": 157, "type": "span", "label": "GGP"}, {"text": "c-fos", "start": 166, "token_start": 30, "token_end": 32, "end": 171, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8675228.txt"}, "_input_hash": -1525220622, "_task_hash": -1208441966, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "IL-10", "start": 4, "end": 9, "id": 1, "ws": true, "disabled": false}, {"text": "effect", "start": 10, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "on", "start": 17, "end": 19, "id": 3, "ws": true, "disabled": true}, {"text": "c", "start": 20, "end": 21, "id": 4, "ws": false, "disabled": false}, {"text": "-", "start": 21, "end": 22, "id": 5, "ws": false, "disabled": false}, {"text": "fos", "start": 22, "end": 25, "id": 6, "ws": true, "disabled": false}, {"text": "expression", "start": 26, "end": 36, "id": 7, "ws": true, "disabled": true}, {"text": "was", "start": 37, "end": 40, "id": 8, "ws": true, "disabled": true}, {"text": "not", "start": 41, "end": 44, "id": 9, "ws": true, "disabled": true}, {"text": "blocked", "start": 45, "end": 52, "id": 10, "ws": true, "disabled": true}, {"text": "by", "start": 53, "end": 55, "id": 11, "ws": true, "disabled": true}, {"text": "polymyxin", "start": 56, "end": 65, "id": 12, "ws": true, "disabled": true}, {"text": "B.", "start": 66, "end": 68, "id": 13, "ws": true, "disabled": true}, {"text": "Using", "start": 69, "end": 74, "id": 14, "ws": true, "disabled": true}, {"text": "the", "start": 75, "end": 78, "id": 15, "ws": true, "disabled": true}, {"text": "tyrosine", "start": 79, "end": 87, "id": 16, "ws": true, "disabled": true}, {"text": "kinase", "start": 88, "end": 94, "id": 17, "ws": true, "disabled": true}, {"text": "inhibitor", "start": 95, "end": 104, "id": 18, "ws": true, "disabled": true}, {"text": "genistein", "start": 105, "end": 114, "id": 19, "ws": true, "disabled": true}, {"text": "(", "start": 115, "end": 116, "id": 20, "ws": false, "disabled": true}, {"text": "10", "start": 116, "end": 118, "id": 21, "ws": true, "disabled": true}, {"text": "microM", "start": 119, "end": 125, "id": 22, "ws": false, "disabled": true}, {"text": ")", "start": 125, "end": 126, "id": 23, "ws": true, "disabled": true}, {"text": "a", "start": 127, "end": 128, "id": 24, "ws": true, "disabled": true}, {"text": "complete", "start": 129, "end": 137, "id": 25, "ws": true, "disabled": true}, {"text": "inhibition", "start": 138, "end": 148, "id": 26, "ws": true, "disabled": true}, {"text": "of", "start": 149, "end": 151, "id": 27, "ws": true, "disabled": true}, {"text": "IL-10", "start": 152, "end": 157, "id": 28, "ws": true, "disabled": false}, {"text": "induced", "start": 158, "end": 165, "id": 29, "ws": true, "disabled": true}, {"text": "c", "start": 166, "end": 167, "id": 30, "ws": false, "disabled": false}, {"text": "-", "start": 167, "end": 168, "id": 31, "ws": false, "disabled": false}, {"text": "fos", "start": 168, "end": 171, "id": 32, "ws": true, "disabled": false}, {"text": "expression", "start": 172, "end": 182, "id": 33, "ws": true, "disabled": true}, {"text": "was", "start": 183, "end": 186, "id": 34, "ws": true, "disabled": true}, {"text": "observed", "start": 187, "end": 195, "id": 35, "ws": false, "disabled": true}, {"text": ".", "start": 195, "end": 196, "id": 36, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 1, "child": 6, "head_span": {"start": 4, "end": 9, "token_start": 1, "token_end": 1, "label": "GGP"}, "child_span": {"start": 20, "end": 25, "token_start": 4, "token_end": 6, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 28, "child": 32, "head_span": {"start": 152, "end": 157, "token_start": 28, "token_end": 28, "label": "GGP"}, "child_span": {"start": 166, "end": 171, "token_start": 30, "token_end": 32, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "In addition, H-7 (10 microM), a specific inhibitor of serine/threonine kinases, significantly blocked IL-10 mediated c-fos expression (p < 0.05).", "spans": [{"text": "IL-10", "start": 102, "token_start": 20, "token_end": 20, "end": 107, "type": "span", "label": "GGP"}, {"text": "c-fos", "start": 117, "token_start": 22, "token_end": 24, "end": 122, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8675228.txt"}, "_input_hash": 426537378, "_task_hash": -824446731, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "addition", "start": 3, "end": 11, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 11, "end": 12, "id": 2, "ws": true, "disabled": true}, {"text": "H-7", "start": 13, "end": 16, "id": 3, "ws": true, "disabled": true}, {"text": "(", "start": 17, "end": 18, "id": 4, "ws": false, "disabled": true}, {"text": "10", "start": 18, "end": 20, "id": 5, "ws": true, "disabled": true}, {"text": "microM", "start": 21, "end": 27, "id": 6, "ws": false, "disabled": true}, {"text": ")", "start": 27, "end": 28, "id": 7, "ws": false, "disabled": true}, {"text": ",", "start": 28, "end": 29, "id": 8, "ws": true, "disabled": true}, {"text": "a", "start": 30, "end": 31, "id": 9, "ws": true, "disabled": true}, {"text": "specific", "start": 32, "end": 40, "id": 10, "ws": true, "disabled": true}, {"text": "inhibitor", "start": 41, "end": 50, "id": 11, "ws": true, "disabled": true}, {"text": "of", "start": 51, "end": 53, "id": 12, "ws": true, "disabled": true}, {"text": "serine", "start": 54, "end": 60, "id": 13, "ws": false, "disabled": true}, {"text": "/", "start": 60, "end": 61, "id": 14, "ws": false, "disabled": true}, {"text": "threonine", "start": 61, "end": 70, "id": 15, "ws": true, "disabled": true}, {"text": "kinases", "start": 71, "end": 78, "id": 16, "ws": false, "disabled": true}, {"text": ",", "start": 78, "end": 79, "id": 17, "ws": true, "disabled": true}, {"text": "significantly", "start": 80, "end": 93, "id": 18, "ws": true, "disabled": true}, {"text": "blocked", "start": 94, "end": 101, "id": 19, "ws": true, "disabled": true}, {"text": "IL-10", "start": 102, "end": 107, "id": 20, "ws": true, "disabled": false}, {"text": "mediated", "start": 108, "end": 116, "id": 21, "ws": true, "disabled": true}, {"text": "c", "start": 117, "end": 118, "id": 22, "ws": false, "disabled": false}, {"text": "-", "start": 118, "end": 119, "id": 23, "ws": false, "disabled": false}, {"text": "fos", "start": 119, "end": 122, "id": 24, "ws": true, "disabled": false}, {"text": "expression", "start": 123, "end": 133, "id": 25, "ws": true, "disabled": true}, {"text": "(", "start": 134, "end": 135, "id": 26, "ws": false, "disabled": true}, {"text": "p", "start": 135, "end": 136, "id": 27, "ws": true, "disabled": true}, {"text": "<", "start": 137, "end": 138, "id": 28, "ws": true, "disabled": true}, {"text": "0.05", "start": 139, "end": 143, "id": 29, "ws": false, "disabled": true}, {"text": ")", "start": 143, "end": 144, "id": 30, "ws": false, "disabled": true}, {"text": ".", "start": 144, "end": 145, "id": 31, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 20, "child": 24, "head_span": {"start": 102, "end": 107, "token_start": 20, "token_end": 20, "label": "GGP"}, "child_span": {"start": 117, "end": 122, "token_start": 22, "token_end": 24, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "In conclusion, these data show that IL-10 induces c-fos expression in human B-cells by activation of tyrosine and serine/threonine kinases.", "spans": [{"text": "IL-10", "start": 36, "token_start": 7, "token_end": 7, "end": 41, "type": "span", "label": "GGP"}, {"text": "c-fos", "start": 50, "token_start": 9, "token_end": 11, "end": 55, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8675228.txt"}, "_input_hash": 1746721288, "_task_hash": -430577039, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "conclusion", "start": 3, "end": 13, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 13, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "these", "start": 15, "end": 20, "id": 3, "ws": true, "disabled": true}, {"text": "data", "start": 21, "end": 25, "id": 4, "ws": true, "disabled": true}, {"text": "show", "start": 26, "end": 30, "id": 5, "ws": true, "disabled": true}, {"text": "that", "start": 31, "end": 35, "id": 6, "ws": true, "disabled": true}, {"text": "IL-10", "start": 36, "end": 41, "id": 7, "ws": true, "disabled": false}, {"text": "induces", "start": 42, "end": 49, "id": 8, "ws": true, "disabled": true}, {"text": "c", "start": 50, "end": 51, "id": 9, "ws": false, "disabled": false}, {"text": "-", "start": 51, "end": 52, "id": 10, "ws": false, "disabled": false}, {"text": "fos", "start": 52, "end": 55, "id": 11, "ws": true, "disabled": false}, {"text": "expression", "start": 56, "end": 66, "id": 12, "ws": true, "disabled": true}, {"text": "in", "start": 67, "end": 69, "id": 13, "ws": true, "disabled": true}, {"text": "human", "start": 70, "end": 75, "id": 14, "ws": true, "disabled": true}, {"text": "B", "start": 76, "end": 77, "id": 15, "ws": false, "disabled": true}, {"text": "-", "start": 77, "end": 78, "id": 16, "ws": false, "disabled": true}, {"text": "cells", "start": 78, "end": 83, "id": 17, "ws": true, "disabled": true}, {"text": "by", "start": 84, "end": 86, "id": 18, "ws": true, "disabled": true}, {"text": "activation", "start": 87, "end": 97, "id": 19, "ws": true, "disabled": true}, {"text": "of", "start": 98, "end": 100, "id": 20, "ws": true, "disabled": true}, {"text": "tyrosine", "start": 101, "end": 109, "id": 21, "ws": true, "disabled": true}, {"text": "and", "start": 110, "end": 113, "id": 22, "ws": true, "disabled": true}, {"text": "serine", "start": 114, "end": 120, "id": 23, "ws": false, "disabled": true}, {"text": "/", "start": 120, "end": 121, "id": 24, "ws": false, "disabled": true}, {"text": "threonine", "start": 121, "end": 130, "id": 25, "ws": true, "disabled": true}, {"text": "kinases", "start": 131, "end": 138, "id": 26, "ws": false, "disabled": true}, {"text": ".", "start": 138, "end": 139, "id": 27, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 7, "child": 11, "head_span": {"start": 36, "end": 41, "token_start": 7, "token_end": 7, "label": "GGP"}, "child_span": {"start": 50, "end": 55, "token_start": 9, "token_end": 11, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Restimulation of T cell blasts up-regulates Fas and Fas ligand expression, with subsequent interaction leading to cell death.", "spans": [{"text": "Fas", "start": 44, "token_start": 8, "token_end": 8, "end": 47, "type": "span", "label": "GGP"}, {"text": "Fas ligand", "start": 52, "token_start": 10, "token_end": 11, "end": 62, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8892614.txt"}, "_input_hash": -1397801478, "_task_hash": 146814347, "tokens": [{"text": "Restimulation", "start": 0, "end": 13, "id": 0, "ws": true, "disabled": true}, {"text": "of", "start": 14, "end": 16, "id": 1, "ws": true, "disabled": true}, {"text": "T", "start": 17, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "cell", "start": 19, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "blasts", "start": 24, "end": 30, "id": 4, "ws": true, "disabled": true}, {"text": "up", "start": 31, "end": 33, "id": 5, "ws": false, "disabled": true}, {"text": "-", "start": 33, "end": 34, "id": 6, "ws": false, "disabled": true}, {"text": "regulates", "start": 34, "end": 43, "id": 7, "ws": true, "disabled": true}, {"text": "Fas", "start": 44, "end": 47, "id": 8, "ws": true, "disabled": false}, {"text": "and", "start": 48, "end": 51, "id": 9, "ws": true, "disabled": true}, {"text": "Fas", "start": 52, "end": 55, "id": 10, "ws": true, "disabled": false}, {"text": "ligand", "start": 56, "end": 62, "id": 11, "ws": true, "disabled": false}, {"text": "expression", "start": 63, "end": 73, "id": 12, "ws": false, "disabled": true}, {"text": ",", "start": 73, "end": 74, "id": 13, "ws": true, "disabled": true}, {"text": "with", "start": 75, "end": 79, "id": 14, "ws": true, "disabled": true}, {"text": "subsequent", "start": 80, "end": 90, "id": 15, "ws": true, "disabled": true}, {"text": "interaction", "start": 91, "end": 102, "id": 16, "ws": true, "disabled": true}, {"text": "leading", "start": 103, "end": 110, "id": 17, "ws": true, "disabled": true}, {"text": "to", "start": 111, "end": 113, "id": 18, "ws": true, "disabled": true}, {"text": "cell", "start": 114, "end": 118, "id": 19, "ws": true, "disabled": true}, {"text": "death", "start": 119, "end": 124, "id": 20, "ws": false, "disabled": true}, {"text": ".", "start": 124, "end": 125, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 11, "head_span": {"start": 44, "end": 47, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 52, "end": 62, "token_start": 10, "token_end": 11, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "Expression of the human interleukin-2 (IL-2) receptor alpha chain gene is potently upregulated by its own ligand, IL-2.", "spans": [{"text": "interleukin-2 (IL-2) receptor alpha chain", "start": 24, "token_start": 4, "token_end": 10, "end": 65, "type": "span", "label": "GGP"}, {"text": "IL-2", "start": 114, "token_start": 20, "token_end": 20, "end": 118, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8896456.txt"}, "_input_hash": 798853650, "_task_hash": -86621929, "tokens": [{"text": "Expression", "start": 0, "end": 10, "id": 0, "ws": true, "disabled": true}, {"text": "of", "start": 11, "end": 13, "id": 1, "ws": true, "disabled": true}, {"text": "the", "start": 14, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "human", "start": 18, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "interleukin-2", "start": 24, "end": 37, "id": 4, "ws": true, "disabled": false}, {"text": "(", "start": 38, "end": 39, "id": 5, "ws": false, "disabled": false}, {"text": "IL-2", "start": 39, "end": 43, "id": 6, "ws": false, "disabled": false}, {"text": ")", "start": 43, "end": 44, "id": 7, "ws": true, "disabled": false}, {"text": "receptor", "start": 45, "end": 53, "id": 8, "ws": true, "disabled": false}, {"text": "alpha", "start": 54, "end": 59, "id": 9, "ws": true, "disabled": false}, {"text": "chain", "start": 60, "end": 65, "id": 10, "ws": true, "disabled": false}, {"text": "gene", "start": 66, "end": 70, "id": 11, "ws": true, "disabled": true}, {"text": "is", "start": 71, "end": 73, "id": 12, "ws": true, "disabled": true}, {"text": "potently", "start": 74, "end": 82, "id": 13, "ws": true, "disabled": true}, {"text": "upregulated", "start": 83, "end": 94, "id": 14, "ws": true, "disabled": true}, {"text": "by", "start": 95, "end": 97, "id": 15, "ws": true, "disabled": true}, {"text": "its", "start": 98, "end": 101, "id": 16, "ws": true, "disabled": true}, {"text": "own", "start": 102, "end": 105, "id": 17, "ws": true, "disabled": true}, {"text": "ligand", "start": 106, "end": 112, "id": 18, "ws": false, "disabled": true}, {"text": ",", "start": 112, "end": 113, "id": 19, "ws": true, "disabled": true}, {"text": "IL-2", "start": 114, "end": 118, "id": 20, "ws": false, "disabled": false}, {"text": ".", "start": 118, "end": 119, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 20, "child": 10, "head_span": {"start": 114, "end": 118, "token_start": 20, "token_end": 20, "label": "GGP"}, "child_span": {"start": 24, "end": 65, "token_start": 4, "token_end": 10, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Previously we and others showed by targeted gene disruption that the zinc finger gene, erythroid Kruppel-like factor (EKLF), is required for expression of the beta-globin gene in mice, presumably through interaction with a high-affinity binding site in the proximal promoter.", "spans": [{"text": "erythroid Kruppel-like factor", "start": 87, "token_start": 15, "token_end": 19, "end": 116, "type": "span", "label": "GGP"}, {"text": "EKLF", "start": 118, "token_start": 21, "token_end": 21, "end": 122, "type": "span", "label": "GGP"}, {"text": "beta-globin", "start": 159, "token_start": 30, "token_end": 32, "end": 170, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8901569.txt"}, "_input_hash": -1917389083, "_task_hash": 211145933, "tokens": [{"text": "Previously", "start": 0, "end": 10, "id": 0, "ws": true, "disabled": true}, {"text": "we", "start": 11, "end": 13, "id": 1, "ws": true, "disabled": true}, {"text": "and", "start": 14, 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{"text": "Impaired silencing of gamma-globin expression identifies EKLF as the first transcription factor participating quantitatively in the gamma-globin to beta-globin switch.", "spans": [{"text": "gamma-globin", "start": 22, "token_start": 3, "token_end": 5, "end": 34, "type": "span", "label": "GGP"}, {"text": "EKLF", "start": 57, "token_start": 8, "token_end": 8, "end": 61, "type": "span", "label": "GGP"}, {"text": "gamma-globin", "start": 132, "token_start": 18, "token_end": 20, "end": 144, "type": "span", "label": "GGP"}, {"text": "beta-globin", "start": 148, "token_start": 22, "token_end": 24, "end": 159, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-8901569.txt"}, "_input_hash": 1600100775, "_task_hash": 773617245, "tokens": [{"text": "Impaired", "start": 0, "end": 8, "id": 0, "ws": true, "disabled": true}, {"text": "silencing", "start": 9, "end": 18, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 19, "end": 21, "id": 2, "ws": true, "disabled": true}, {"text": "gamma", "start": 22, "end": 27, "id": 3, "ws": false, "disabled": false}, {"text": "-", "start": 27, "end": 28, "id": 4, "ws": false, "disabled": false}, {"text": "globin", "start": 28, "end": 34, "id": 5, "ws": true, "disabled": false}, {"text": "expression", "start": 35, "end": 45, "id": 6, "ws": true, "disabled": true}, {"text": "identifies", "start": 46, "end": 56, "id": 7, "ws": true, "disabled": true}, {"text": "EKLF", "start": 57, "end": 61, "id": 8, "ws": true, "disabled": false}, {"text": "as", "start": 62, "end": 64, "id": 9, "ws": true, "disabled": true}, {"text": "the", "start": 65, "end": 68, "id": 10, "ws": true, "disabled": true}, {"text": "first", "start": 69, "end": 74, "id": 11, "ws": true, "disabled": true}, {"text": "transcription", "start": 75, "end": 88, "id": 12, "ws": true, "disabled": true}, {"text": "factor", "start": 89, "end": 95, "id": 13, "ws": true, "disabled": true}, {"text": "participating", "start": 96, "end": 109, "id": 14, "ws": true, "disabled": true}, {"text": "quantitatively", "start": 110, "end": 124, "id": 15, "ws": true, "disabled": true}, {"text": "in", "start": 125, "end": 127, "id": 16, "ws": true, "disabled": true}, {"text": "the", "start": 128, "end": 131, "id": 17, "ws": true, "disabled": true}, {"text": "gamma", "start": 132, "end": 137, "id": 18, "ws": false, "disabled": false}, {"text": "-", "start": 137, "end": 138, "id": 19, "ws": false, "disabled": false}, {"text": "globin", "start": 138, "end": 144, "id": 20, "ws": true, "disabled": false}, {"text": "to", "start": 145, "end": 147, "id": 21, "ws": true, "disabled": true}, {"text": "beta", "start": 148, "end": 152, "id": 22, "ws": false, "disabled": false}, {"text": "-", "start": 152, "end": 153, "id": 23, "ws": false, "disabled": false}, {"text": "globin", "start": 153, "end": 159, "id": 24, "ws": true, "disabled": false}, {"text": "switch", "start": 160, "end": 166, "id": 25, "ws": false, "disabled": true}, {"text": ".", "start": 166, "end": 167, "id": 26, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 20, "head_span": {"start": 57, "end": 61, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 132, "end": 144, "token_start": 18, "token_end": 20, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 8, "child": 24, "head_span": {"start": 57, "end": 61, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 148, "end": 159, "token_start": 22, "token_end": 24, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
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{"text": "The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.", "spans": [{"text": "IL-6", "start": 16, "token_start": 3, "token_end": 3, "end": 20, "type": "span", "label": "GGP"}, {"text": "IL-6", "start": 112, "token_start": 20, "token_end": 20, "end": 116, "type": "span", "label": "GGP"}, {"text": "TNF alpha", "start": 146, "token_start": 26, "token_end": 27, "end": 155, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9154298.txt"}, "_input_hash": -611140026, "_task_hash": -1890121307, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "increase", "start": 4, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "in", "start": 13, "end": 15, "id": 2, "ws": true, "disabled": true}, {"text": "IL-6", "start": 16, "end": 20, "id": 3, "ws": true, "disabled": false}, {"text": "luciferase", "start": 21, "end": 31, "id": 4, "ws": true, "disabled": true}, {"text": "activity", "start": 32, "end": 40, "id": 5, "ws": true, "disabled": true}, {"text": "occurs", "start": 41, "end": 47, "id": 6, "ws": true, "disabled": true}, {"text": "in", "start": 48, "end": 50, "id": 7, "ws": true, "disabled": true}, {"text": "the", "start": 51, "end": 54, "id": 8, "ws": true, "disabled": true}, {"text": "absence", "start": 55, "end": 62, "id": 9, "ws": true, "disabled": true}, {"text": "of", "start": 63, "end": 65, "id": 10, "ws": true, "disabled": true}, {"text": "the", "start": 66, "end": 69, "id": 11, "ws": true, "disabled": true}, {"text": "multiple", "start": 70, "end": 78, "id": 12, "ws": true, "disabled": true}, {"text": "response", "start": 79, "end": 87, "id": 13, "ws": true, "disabled": true}, {"text": "region", "start": 88, "end": 94, "id": 14, "ws": false, "disabled": true}, {"text": ",", "start": 94, "end": 95, "id": 15, "ws": true, "disabled": true}, {"text": "the", "start": 96, "end": 99, "id": 16, "ws": true, "disabled": true}, {"text": "area", "start": 100, "end": 104, "id": 17, "ws": true, "disabled": true}, {"text": "of", "start": 105, "end": 107, "id": 18, "ws": true, "disabled": true}, {"text": "the", "start": 108, "end": 111, "id": 19, "ws": true, "disabled": true}, {"text": "IL-6", "start": 112, "end": 116, "id": 20, "ws": true, "disabled": false}, {"text": "promoter", "start": 117, "end": 125, "id": 21, "ws": true, "disabled": true}, {"text": "responsive", "start": 126, "end": 136, "id": 22, "ws": true, "disabled": true}, {"text": "to", "start": 137, "end": 139, "id": 23, "ws": true, "disabled": true}, {"text": "IL-1", "start": 140, "end": 144, "id": 24, "ws": false, "disabled": true}, {"text": ",", "start": 144, "end": 145, "id": 25, "ws": true, "disabled": true}, {"text": "TNF", "start": 146, "end": 149, "id": 26, "ws": true, "disabled": false}, {"text": "alpha", "start": 150, "end": 155, "id": 27, "ws": false, "disabled": false}, {"text": ",", "start": 155, "end": 156, "id": 28, "ws": true, "disabled": true}, {"text": "cyclic", "start": 157, "end": 163, "id": 29, "ws": true, "disabled": true}, {"text": "amp", "start": 164, "end": 167, "id": 30, "ws": false, "disabled": true}, {"text": ",", "start": 167, "end": 168, "id": 31, "ws": true, "disabled": true}, {"text": "and", "start": 169, "end": 172, "id": 32, "ws": true, "disabled": true}, {"text": "phorbol", "start": 173, "end": 180, "id": 33, "ws": true, "disabled": true}, {"text": "12-myristate", "start": 181, "end": 193, "id": 34, "ws": true, "disabled": true}, {"text": "13-acetate", "start": 194, "end": 204, "id": 35, "ws": false, "disabled": true}, {"text": ".", "start": 204, "end": 205, "id": 36, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 27, "child": 20, "head_span": {"start": 146, "end": 155, "token_start": 26, "token_end": 27, "label": "GGP"}, "child_span": {"start": 112, "end": 116, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
{"text": "Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32.", "spans": [{"text": "CIITA", "start": 64, "token_start": 9, "token_end": 9, "end": 69, "type": "span", "label": "GGP"}, {"text": "TAFII32", "start": 123, "token_start": 18, "token_end": 18, "end": 130, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9171108.txt"}, "_input_hash": 809240104, "_task_hash": -726740973, "tokens": [{"text": "Decreased", "start": 0, "end": 9, "id": 0, "ws": true, "disabled": true}, {"text": "transcriptional", "start": 10, "end": 25, "id": 1, "ws": true, "disabled": true}, {"text": "activation", "start": 26, "end": 36, "id": 2, "ws": true, "disabled": true}, {"text": "by", "start": 37, "end": 39, "id": 3, "ws": true, "disabled": true}, {"text": "N", "start": 40, "end": 41, "id": 4, "ws": false, "disabled": true}, {"text": "-", "start": 41, "end": 42, "id": 5, "ws": false, "disabled": true}, {"text": "terminal", "start": 42, "end": 50, "id": 6, "ws": true, "disabled": true}, {"text": "deletions", "start": 51, "end": 60, "id": 7, "ws": true, "disabled": true}, {"text": "of", "start": 61, "end": 63, "id": 8, "ws": true, "disabled": true}, {"text": "CIITA", "start": 64, "end": 69, "id": 9, "ws": true, "disabled": false}, {"text": "is", "start": 70, "end": 72, "id": 10, "ws": true, "disabled": true}, {"text": "correlated", "start": 73, "end": 83, "id": 11, "ws": true, "disabled": true}, {"text": "directly", "start": 84, "end": 92, "id": 12, "ws": true, "disabled": true}, {"text": "with", "start": 93, "end": 97, "id": 13, "ws": true, "disabled": true}, {"text": "their", "start": 98, "end": 103, "id": 14, "ws": true, "disabled": true}, {"text": "reduced", "start": 104, "end": 111, "id": 15, "ws": true, "disabled": true}, {"text": "binding", "start": 112, "end": 119, "id": 16, "ws": true, "disabled": true}, {"text": "to", "start": 120, "end": 122, "id": 17, "ws": true, "disabled": true}, {"text": "TAFII32", "start": 123, "end": 130, "id": 18, "ws": false, "disabled": false}, {"text": ".", "start": 130, "end": 131, "id": 19, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 9, "child": 18, "head_span": {"start": 64, "end": 69, "token_start": 9, "token_end": 9, "label": "GGP"}, "child_span": {"start": 123, "end": 130, "token_start": 18, "token_end": 18, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "Previous reports have suggested the CD28 stimulation contributes to the activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including AP-1 and nuclear factor-kappaB (NF-kappaB)/Rel family members as well as an uncharacterized transcription factor called CD28 response complex.", "spans": [{"text": "CD28", "start": 36, "token_start": 5, "token_end": 5, "end": 40, "type": "span", "label": "GGP"}, {"text": "IL-2", "start": 90, "token_start": 13, "token_end": 13, "end": 94, "type": "span", "label": "GGP"}, {"text": "CD28", "start": 298, "token_start": 47, "token_end": 47, "end": 302, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9233628.txt"}, "_input_hash": -420131871, "_task_hash": -1320072507, "tokens": [{"text": "Previous", "start": 0, "end": 8, "id": 0, "ws": true, "disabled": true}, {"text": "reports", "start": 9, "end": 16, "id": 1, "ws": true, "disabled": true}, {"text": "have", 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{"text": "ZEB blocks the activity of c-Myb and Ets individually, but together the factors synergize to resist this repression.", "spans": [{"text": "ZEB", "start": 0, "token_start": 0, "token_end": 0, "end": 3, "type": "span", "label": "GGP"}, {"text": "c-Myb", "start": 27, "token_start": 5, "token_end": 7, "end": 32, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9233802.txt"}, "_input_hash": -1462806254, "_task_hash": 1975289620, "tokens": [{"text": "ZEB", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": false}, {"text": "blocks", "start": 4, "end": 10, "id": 1, "ws": true, "disabled": true}, {"text": "the", "start": 11, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "activity", "start": 15, "end": 23, "id": 3, "ws": true, "disabled": true}, {"text": "of", "start": 24, "end": 26, "id": 4, "ws": true, "disabled": true}, {"text": "c", "start": 27, "end": 28, "id": 5, "ws": false, "disabled": false}, {"text": "-", "start": 28, "end": 29, "id": 6, "ws": false, "disabled": false}, {"text": "Myb", "start": 29, "end": 32, "id": 7, "ws": true, "disabled": false}, {"text": "and", "start": 33, "end": 36, "id": 8, "ws": true, "disabled": true}, {"text": "Ets", "start": 37, "end": 40, "id": 9, "ws": true, "disabled": true}, {"text": "individually", "start": 41, "end": 53, "id": 10, "ws": false, "disabled": true}, {"text": ",", "start": 53, "end": 54, "id": 11, "ws": true, "disabled": true}, {"text": "but", "start": 55, "end": 58, "id": 12, "ws": true, "disabled": true}, {"text": "together", "start": 59, "end": 67, "id": 13, "ws": true, "disabled": true}, {"text": "the", "start": 68, "end": 71, "id": 14, "ws": true, "disabled": true}, {"text": "factors", "start": 72, "end": 79, "id": 15, "ws": true, "disabled": true}, {"text": "synergize", "start": 80, "end": 89, "id": 16, "ws": true, "disabled": true}, {"text": "to", "start": 90, "end": 92, "id": 17, "ws": true, "disabled": true}, {"text": "resist", "start": 93, "end": 99, "id": 18, "ws": true, "disabled": true}, {"text": "this", "start": 100, "end": 104, "id": 19, "ws": true, "disabled": true}, {"text": "repression", "start": 105, "end": 115, "id": 20, "ws": false, "disabled": true}, {"text": ".", "start": 115, "end": 116, "id": 21, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 7, "head_span": {"start": 0, "end": 3, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 27, "end": 32, "token_start": 5, "token_end": 7, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "We show here that c-Raf, which is at the helm of the classic MAP-Erk cascade, contributes to IL-2 induction through a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene.", "spans": [{"text": "c-Raf", "start": 18, "token_start": 4, "token_end": 6, "end": 23, "type": "span", "label": "GGP"}, {"text": "IL-2", "start": 93, "token_start": 23, "token_end": 23, "end": 97, "type": "span", "label": "GGP"}, {"text": "IL-2", "start": 245, "token_start": 47, "token_end": 47, "end": 249, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9234696.txt"}, "_input_hash": -1755871994, "_task_hash": -1456369426, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "show", "start": 3, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "here", "start": 8, "end": 12, "id": 2, "ws": true, "disabled": true}, {"text": "that", 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{"text": "During CD30 signal transduction, we found that binding of TRAF2 to the cytoplasmic domain of CD30 results in the rapid depletion of TRAF2 and the associated protein TRAF1 by proteolysis.", "spans": [{"text": "CD30", "start": 7, "token_start": 1, "token_end": 1, "end": 11, "type": "span", "label": "GGP"}, {"text": "TRAF2", "start": 58, "token_start": 10, "token_end": 10, "end": 63, "type": "span", "label": "GGP"}, {"text": "CD30", "start": 93, "token_start": 16, "token_end": 16, "end": 97, "type": "span", "label": "GGP"}, {"text": "TRAF2", "start": 132, "token_start": 23, "token_end": 23, "end": 137, "type": "span", "label": "GGP"}, {"text": "TRAF1", "start": 165, "token_start": 28, "token_end": 28, "end": 170, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9353251.txt"}, "_input_hash": -1776574105, "_task_hash": 326014866, "tokens": [{"text": "During", "start": 0, "end": 6, "id": 0, "ws": true, "disabled": true}, {"text": "CD30", "start": 7, "end": 11, "id": 1, "ws": true, "disabled": false}, {"text": "signal", "start": 12, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "transduction", "start": 19, "end": 31, "id": 3, "ws": false, "disabled": true}, {"text": ",", "start": 31, "end": 32, "id": 4, "ws": true, "disabled": true}, {"text": "we", "start": 33, "end": 35, "id": 5, "ws": true, "disabled": true}, {"text": "found", "start": 36, "end": 41, "id": 6, "ws": true, "disabled": true}, {"text": "that", "start": 42, "end": 46, "id": 7, "ws": true, "disabled": true}, {"text": "binding", "start": 47, "end": 54, "id": 8, "ws": true, "disabled": true}, {"text": "of", "start": 55, "end": 57, "id": 9, "ws": true, "disabled": true}, {"text": "TRAF2", "start": 58, "end": 63, "id": 10, "ws": true, "disabled": false}, {"text": "to", "start": 64, "end": 66, "id": 11, "ws": true, "disabled": true}, {"text": "the", "start": 67, "end": 70, "id": 12, "ws": true, "disabled": true}, {"text": "cytoplasmic", "start": 71, "end": 82, "id": 13, "ws": true, "disabled": true}, {"text": "domain", "start": 83, "end": 89, "id": 14, "ws": true, "disabled": true}, {"text": "of", "start": 90, "end": 92, "id": 15, "ws": true, "disabled": true}, {"text": "CD30", "start": 93, "end": 97, "id": 16, "ws": true, "disabled": false}, {"text": "results", "start": 98, "end": 105, "id": 17, "ws": true, "disabled": true}, {"text": "in", "start": 106, "end": 108, "id": 18, "ws": true, "disabled": true}, {"text": "the", "start": 109, "end": 112, "id": 19, "ws": true, "disabled": true}, {"text": "rapid", "start": 113, "end": 118, "id": 20, "ws": true, "disabled": true}, {"text": "depletion", "start": 119, "end": 128, "id": 21, "ws": true, "disabled": true}, {"text": "of", "start": 129, "end": 131, "id": 22, "ws": true, "disabled": true}, {"text": "TRAF2", "start": 132, "end": 137, "id": 23, "ws": true, "disabled": false}, {"text": "and", "start": 138, "end": 141, "id": 24, "ws": true, "disabled": true}, {"text": "the", "start": 142, "end": 145, "id": 25, "ws": true, "disabled": true}, {"text": "associated", "start": 146, "end": 156, "id": 26, "ws": true, "disabled": true}, {"text": "protein", "start": 157, "end": 164, "id": 27, "ws": true, "disabled": true}, {"text": "TRAF1", "start": 165, "end": 170, "id": 28, "ws": true, "disabled": false}, {"text": "by", "start": 171, "end": 173, "id": 29, "ws": true, "disabled": true}, {"text": "proteolysis", "start": 174, "end": 185, "id": 30, "ws": false, "disabled": true}, {"text": ".", "start": 185, "end": 186, "id": 31, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 10, "child": 16, "head_span": {"start": 58, "end": 63, "token_start": 10, "token_end": 10, "label": "GGP"}, "child_span": {"start": 93, "end": 97, "token_start": 16, "token_end": 16, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 10, "child": 23, "head_span": {"start": 58, "end": 63, "token_start": 10, "token_end": 10, "label": "GGP"}, "child_span": {"start": 132, "end": 137, "token_start": 23, "token_end": 23, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}, {"head": 10, "child": 28, "head_span": {"start": 58, "end": 63, "token_start": 10, "token_end": 10, "label": "GGP"}, "child_span": {"start": 165, "end": 170, "token_start": 28, "token_end": 28, "label": "GGP"}, "color": "#d9fbad", "label": "Neg-Reg"}], "answer": "accept"}
{"text": "Ctx combined with TNFalpha or IL-1beta to produce a synergistic increase in p24 antigen production in U1 promonocytic cells.", "spans": [{"text": "TNFalpha", "start": 18, "token_start": 3, "token_end": 3, "end": 26, "type": "span", "label": "GGP"}, {"text": "IL-1beta", "start": 30, "token_start": 5, "token_end": 5, "end": 38, "type": "span", "label": "GGP"}, {"text": "p24 antigen", "start": 76, "token_start": 12, "token_end": 13, "end": 87, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9356353.txt"}, "_input_hash": 1157974101, "_task_hash": 1079092450, "tokens": [{"text": "Ctx", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "combined", "start": 4, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "with", "start": 13, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "TNFalpha", "start": 18, "end": 26, "id": 3, "ws": true, "disabled": false}, {"text": "or", "start": 27, "end": 29, "id": 4, "ws": true, "disabled": true}, {"text": "IL-1beta", "start": 30, "end": 38, "id": 5, "ws": true, "disabled": false}, {"text": "to", "start": 39, "end": 41, "id": 6, "ws": true, "disabled": true}, {"text": "produce", "start": 42, "end": 49, "id": 7, "ws": true, "disabled": true}, {"text": "a", "start": 50, "end": 51, "id": 8, "ws": true, "disabled": true}, {"text": "synergistic", "start": 52, "end": 63, "id": 9, "ws": true, "disabled": true}, {"text": "increase", "start": 64, "end": 72, "id": 10, "ws": true, "disabled": true}, {"text": "in", "start": 73, "end": 75, "id": 11, "ws": true, "disabled": true}, {"text": "p24", "start": 76, "end": 79, "id": 12, "ws": true, "disabled": false}, {"text": "antigen", "start": 80, "end": 87, "id": 13, "ws": true, "disabled": false}, {"text": "production", "start": 88, "end": 98, "id": 14, "ws": true, "disabled": true}, {"text": "in", "start": 99, "end": 101, "id": 15, "ws": true, "disabled": true}, {"text": "U1", "start": 102, "end": 104, "id": 16, "ws": true, "disabled": true}, {"text": "promonocytic", "start": 105, "end": 117, "id": 17, "ws": true, "disabled": true}, {"text": "cells", "start": 118, "end": 123, "id": 18, "ws": false, "disabled": true}, {"text": ".", "start": 123, "end": 124, "id": 19, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 13, "head_span": {"start": 18, "end": 26, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 76, "end": 87, "token_start": 12, "token_end": 13, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 5, "child": 13, "head_span": {"start": 30, "end": 38, "token_start": 5, "token_end": 5, "label": "GGP"}, "child_span": {"start": 76, "end": 87, "token_start": 12, "token_end": 13, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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{"text": "The purpose of the present study was to investigate the importance of NF-kappaB induction in the up-regulation of the B cell activation markers ICAM-1 and CD71 by LMP1.", "spans": [{"text": "ICAM-1", "start": 144, "token_start": 27, "token_end": 27, "end": 150, "type": "span", "label": "GGP"}, {"text": "CD71", "start": 155, "token_start": 29, "token_end": 29, "end": 159, "type": "span", "label": "GGP"}, {"text": "LMP1", "start": 163, "token_start": 31, "token_end": 31, "end": 167, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9747720.txt"}, "_input_hash": -1898682261, "_task_hash": -1197313632, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "purpose", "start": 4, "end": 11, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 12, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 15, "end": 18, "id": 3, "ws": true, "disabled": true}, {"text": "present", "start": 19, "end": 26, "id": 4, "ws": true, "disabled": true}, {"text": "study", "start": 27, "end": 32, "id": 5, "ws": true, "disabled": true}, {"text": "was", "start": 33, "end": 36, "id": 6, "ws": true, "disabled": true}, {"text": "to", "start": 37, "end": 39, "id": 7, "ws": true, "disabled": true}, {"text": "investigate", "start": 40, "end": 51, "id": 8, "ws": true, "disabled": true}, {"text": "the", "start": 52, "end": 55, "id": 9, "ws": true, "disabled": true}, {"text": "importance", "start": 56, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "of", "start": 67, "end": 69, "id": 11, "ws": true, "disabled": true}, {"text": "NF", "start": 70, "end": 72, "id": 12, "ws": false, "disabled": true}, {"text": "-", "start": 72, "end": 73, "id": 13, "ws": false, "disabled": true}, {"text": "kappaB", "start": 73, "end": 79, "id": 14, "ws": true, "disabled": true}, {"text": "induction", "start": 80, "end": 89, "id": 15, "ws": true, "disabled": true}, {"text": "in", "start": 90, "end": 92, "id": 16, "ws": true, "disabled": true}, {"text": "the", "start": 93, "end": 96, "id": 17, "ws": true, "disabled": true}, {"text": "up", "start": 97, "end": 99, "id": 18, "ws": false, "disabled": true}, {"text": "-", "start": 99, "end": 100, "id": 19, "ws": false, "disabled": true}, {"text": "regulation", "start": 100, "end": 110, "id": 20, "ws": true, "disabled": true}, {"text": "of", "start": 111, "end": 113, "id": 21, "ws": true, "disabled": true}, {"text": "the", "start": 114, "end": 117, "id": 22, "ws": true, "disabled": true}, {"text": "B", "start": 118, "end": 119, "id": 23, "ws": true, "disabled": true}, {"text": "cell", "start": 120, "end": 124, "id": 24, "ws": true, "disabled": true}, {"text": "activation", "start": 125, "end": 135, "id": 25, "ws": true, "disabled": true}, {"text": "markers", "start": 136, "end": 143, "id": 26, "ws": true, "disabled": true}, {"text": "ICAM-1", "start": 144, "end": 150, "id": 27, "ws": true, "disabled": false}, {"text": "and", "start": 151, "end": 154, "id": 28, "ws": true, "disabled": true}, {"text": "CD71", "start": 155, "end": 159, "id": 29, "ws": true, "disabled": false}, {"text": "by", "start": 160, "end": 162, "id": 30, "ws": true, "disabled": true}, {"text": "LMP1", "start": 163, "end": 167, "id": 31, "ws": false, "disabled": false}, {"text": ".", "start": 167, "end": 168, "id": 32, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 31, "child": 29, "head_span": {"start": 163, "end": 167, "token_start": 31, "token_end": 31, "label": "GGP"}, "child_span": {"start": 155, "end": 159, "token_start": 29, "token_end": 29, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 31, "child": 27, "head_span": {"start": 163, "end": 167, "token_start": 31, "token_end": 31, "label": "GGP"}, "child_span": {"start": 144, "end": 150, "token_start": 27, "token_end": 27, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "We have examined changes in HS1 phosphorylation after differential stimulation of CD3, CD2, and CD28 to elucidate its role in T cells and to further delineate the signaling pathways recruited by these receptors.", "spans": [{"text": "HS1", "start": 28, "token_start": 5, "token_end": 5, "end": 31, "type": "span", "label": "GGP"}, {"text": "CD2", "start": 87, "token_start": 13, "token_end": 13, "end": 90, "type": "span", "label": "GGP"}, {"text": "CD28", "start": 96, "token_start": 16, "token_end": 16, "end": 100, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9794375.txt"}, "_input_hash": 816090938, "_task_hash": -314711161, "tokens": [{"text": "We", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "have", "start": 3, "end": 7, "id": 1, "ws": true, "disabled": true}, {"text": "examined", "start": 8, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "changes", "start": 17, "end": 24, "id": 3, "ws": true, "disabled": true}, {"text": "in", "start": 25, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "HS1", "start": 28, "end": 31, "id": 5, "ws": true, "disabled": false}, {"text": "phosphorylation", "start": 32, "end": 47, "id": 6, "ws": true, "disabled": true}, {"text": "after", "start": 48, "end": 53, "id": 7, "ws": true, "disabled": true}, {"text": "differential", "start": 54, "end": 66, "id": 8, "ws": true, "disabled": true}, {"text": "stimulation", "start": 67, "end": 78, "id": 9, "ws": true, "disabled": true}, {"text": "of", "start": 79, "end": 81, "id": 10, "ws": true, "disabled": true}, {"text": "CD3", "start": 82, "end": 85, "id": 11, "ws": false, "disabled": true}, {"text": ",", "start": 85, "end": 86, "id": 12, "ws": true, "disabled": true}, {"text": "CD2", "start": 87, "end": 90, "id": 13, "ws": false, "disabled": false}, {"text": ",", "start": 90, "end": 91, "id": 14, "ws": true, "disabled": true}, {"text": "and", "start": 92, "end": 95, "id": 15, "ws": true, "disabled": true}, {"text": "CD28", "start": 96, "end": 100, "id": 16, "ws": true, "disabled": false}, {"text": "to", "start": 101, "end": 103, "id": 17, "ws": true, "disabled": true}, {"text": "elucidate", "start": 104, "end": 113, "id": 18, "ws": true, "disabled": true}, {"text": "its", "start": 114, "end": 117, "id": 19, "ws": true, "disabled": true}, {"text": "role", "start": 118, "end": 122, "id": 20, "ws": true, "disabled": true}, {"text": "in", "start": 123, "end": 125, "id": 21, "ws": true, "disabled": true}, {"text": "T", "start": 126, "end": 127, "id": 22, "ws": true, "disabled": true}, {"text": "cells", "start": 128, "end": 133, "id": 23, "ws": true, "disabled": true}, {"text": "and", "start": 134, "end": 137, "id": 24, "ws": true, "disabled": true}, {"text": "to", "start": 138, "end": 140, "id": 25, "ws": true, "disabled": true}, {"text": "further", "start": 141, "end": 148, "id": 26, "ws": true, "disabled": true}, {"text": "delineate", "start": 149, "end": 158, "id": 27, "ws": true, "disabled": true}, {"text": "the", "start": 159, "end": 162, "id": 28, "ws": true, "disabled": true}, {"text": "signaling", "start": 163, "end": 172, "id": 29, "ws": true, "disabled": true}, {"text": "pathways", "start": 173, "end": 181, "id": 30, "ws": true, "disabled": true}, {"text": "recruited", "start": 182, "end": 191, "id": 31, "ws": true, "disabled": true}, {"text": "by", "start": 192, "end": 194, "id": 32, "ws": true, "disabled": true}, {"text": "these", "start": 195, "end": 200, "id": 33, "ws": true, "disabled": true}, {"text": "receptors", "start": 201, "end": 210, "id": 34, "ws": false, "disabled": true}, {"text": ".", "start": 210, "end": 211, "id": 35, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 13, "child": 5, "head_span": {"start": 87, "end": 90, "token_start": 13, "token_end": 13, "label": "GGP"}, "child_span": {"start": 28, "end": 31, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 16, "child": 5, "head_span": {"start": 96, "end": 100, "token_start": 16, "token_end": 16, "label": "GGP"}, "child_span": {"start": 28, "end": 31, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
{"text": "Unlike ligation of CD3, stimulation with anti-CD28 mAb or CHO cells expressing the CD28 ligands CD80 or CD86 did not lead to tyrosine phosphorylation of HS1 in Jurkat T cells.", "spans": [{"text": "CD28", "start": 46, "token_start": 9, "token_end": 9, "end": 50, "type": "span", "label": "GGP"}, {"text": "CD28", "start": 83, "token_start": 16, "token_end": 16, "end": 87, "type": "span", "label": "GGP"}, {"text": "CD80", "start": 96, "token_start": 18, "token_end": 18, "end": 100, "type": "span", "label": "GGP"}, {"text": "CD86", "start": 104, "token_start": 20, "token_end": 20, "end": 108, "type": "span", "label": "GGP"}, {"text": "HS1", "start": 153, "token_start": 28, "token_end": 28, "end": 156, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9794375.txt"}, "_input_hash": -2085888072, "_task_hash": -2242279, "tokens": [{"text": "Unlike", "start": 0, "end": 6, "id": 0, "ws": true, "disabled": true}, {"text": "ligation", "start": 7, "end": 15, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 16, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "CD3", "start": 19, "end": 22, "id": 3, "ws": false, "disabled": true}, {"text": ",", "start": 22, "end": 23, "id": 4, "ws": true, "disabled": true}, {"text": "stimulation", "start": 24, "end": 35, "id": 5, "ws": true, "disabled": true}, {"text": "with", "start": 36, "end": 40, "id": 6, "ws": true, "disabled": true}, {"text": "anti", "start": 41, "end": 45, "id": 7, "ws": false, "disabled": true}, {"text": "-", "start": 45, "end": 46, "id": 8, "ws": false, "disabled": true}, {"text": "CD28", "start": 46, "end": 50, "id": 9, "ws": true, "disabled": false}, {"text": "mAb", "start": 51, "end": 54, "id": 10, "ws": true, "disabled": true}, {"text": "or", "start": 55, "end": 57, "id": 11, "ws": true, "disabled": true}, {"text": "CHO", "start": 58, "end": 61, "id": 12, "ws": true, "disabled": true}, {"text": "cells", "start": 62, "end": 67, "id": 13, "ws": true, "disabled": true}, {"text": "expressing", "start": 68, "end": 78, "id": 14, "ws": true, "disabled": true}, {"text": "the", "start": 79, "end": 82, "id": 15, "ws": true, "disabled": true}, {"text": "CD28", "start": 83, "end": 87, "id": 16, "ws": true, "disabled": false}, {"text": "ligands", "start": 88, "end": 95, "id": 17, "ws": true, "disabled": true}, {"text": "CD80", "start": 96, "end": 100, "id": 18, "ws": true, "disabled": false}, {"text": "or", "start": 101, "end": 103, "id": 19, "ws": true, "disabled": true}, {"text": "CD86", "start": 104, "end": 108, "id": 20, "ws": true, "disabled": false}, {"text": "did", "start": 109, "end": 112, "id": 21, "ws": true, "disabled": true}, {"text": "not", "start": 113, "end": 116, "id": 22, "ws": true, "disabled": true}, {"text": "lead", "start": 117, "end": 121, "id": 23, "ws": true, "disabled": true}, {"text": "to", "start": 122, "end": 124, "id": 24, "ws": true, "disabled": true}, {"text": "tyrosine", "start": 125, "end": 133, "id": 25, "ws": true, "disabled": true}, {"text": "phosphorylation", "start": 134, "end": 149, "id": 26, "ws": true, "disabled": true}, {"text": "of", "start": 150, "end": 152, "id": 27, "ws": true, "disabled": true}, {"text": "HS1", "start": 153, "end": 156, "id": 28, "ws": true, "disabled": false}, {"text": "in", "start": 157, "end": 159, "id": 29, "ws": true, "disabled": true}, {"text": "Jurkat", "start": 160, "end": 166, "id": 30, "ws": true, "disabled": true}, {"text": "T", "start": 167, "end": 168, "id": 31, "ws": true, "disabled": true}, {"text": "cells", "start": 169, "end": 174, "id": 32, "ws": false, "disabled": true}, {"text": ".", "start": 174, "end": 175, "id": 33, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 16, "child": 18, "head_span": {"start": 83, "end": 87, "token_start": 16, "token_end": 16, "label": "GGP"}, "child_span": {"start": 96, "end": 100, "token_start": 18, "token_end": 18, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}, {"head": 16, "child": 20, "head_span": {"start": 83, "end": 87, "token_start": 16, "token_end": 16, "label": "GGP"}, "child_span": {"start": 104, "end": 108, "token_start": 20, "token_end": 20, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "In vivo studies indicated that CD3-induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD45, did not require MEK1 kinase activity, and was regulated by protein kinase C activation.", "spans": [{"text": "HSI", "start": 43, "token_start": 6, "token_end": 6, "end": 46, "type": "span", "label": "GGP"}, {"text": "Src", "start": 91, "token_start": 13, "token_end": 13, "end": 94, "type": "span", "label": "GGP"}, {"text": "Lck", "start": 118, "token_start": 17, "token_end": 17, "end": 121, "type": "span", "label": "GGP"}, {"text": "CD45", "start": 151, "token_start": 22, "token_end": 22, "end": 155, "type": "span", "label": "GGP"}, {"text": "MEK1", "start": 173, "token_start": 27, "token_end": 27, "end": 177, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9794375.txt"}, "_input_hash": -491870785, "_task_hash": -641166345, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, 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{"text": "Thus, although CD3, CD28, and CD2 activate many of the same signaling molecules, they differed in their capacity to induce the tyrosine phosphorylation of HSI.", "spans": [{"text": "CD28", "start": 20, "token_start": 5, "token_end": 5, "end": 24, "type": "span", "label": "GGP"}, {"text": "CD2", "start": 30, "token_start": 8, "token_end": 8, "end": 33, "type": "span", "label": "GGP"}, {"text": "HSI", "start": 155, "token_start": 28, "token_end": 28, "end": 158, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9794375.txt"}, "_input_hash": 2001426833, "_task_hash": 134293175, "tokens": [{"text": "Thus", "start": 0, "end": 4, "id": 0, "ws": false, "disabled": true}, {"text": ",", "start": 4, "end": 5, "id": 1, "ws": true, "disabled": true}, {"text": "although", "start": 6, "end": 14, "id": 2, "ws": true, "disabled": true}, {"text": "CD3", "start": 15, "end": 18, "id": 3, "ws": false, "disabled": true}, {"text": ",", "start": 18, "end": 19, "id": 4, "ws": true, "disabled": true}, {"text": "CD28", "start": 20, "end": 24, "id": 5, "ws": false, "disabled": false}, {"text": ",", "start": 24, "end": 25, "id": 6, "ws": true, "disabled": true}, {"text": "and", "start": 26, "end": 29, "id": 7, "ws": true, "disabled": true}, {"text": "CD2", "start": 30, "end": 33, "id": 8, "ws": true, "disabled": false}, {"text": "activate", "start": 34, "end": 42, "id": 9, "ws": true, "disabled": true}, {"text": "many", "start": 43, "end": 47, "id": 10, "ws": true, "disabled": true}, {"text": "of", "start": 48, "end": 50, "id": 11, "ws": true, "disabled": true}, {"text": "the", "start": 51, "end": 54, "id": 12, "ws": true, "disabled": true}, {"text": "same", "start": 55, "end": 59, "id": 13, "ws": true, "disabled": true}, {"text": "signaling", "start": 60, "end": 69, "id": 14, "ws": true, "disabled": true}, {"text": "molecules", "start": 70, "end": 79, "id": 15, "ws": false, "disabled": true}, {"text": ",", "start": 79, "end": 80, "id": 16, "ws": true, "disabled": true}, {"text": "they", "start": 81, "end": 85, "id": 17, "ws": true, "disabled": true}, {"text": "differed", "start": 86, "end": 94, "id": 18, "ws": true, "disabled": true}, {"text": "in", "start": 95, "end": 97, "id": 19, "ws": true, "disabled": true}, {"text": "their", "start": 98, "end": 103, "id": 20, "ws": true, "disabled": true}, {"text": "capacity", "start": 104, "end": 112, "id": 21, "ws": true, "disabled": true}, {"text": "to", "start": 113, "end": 115, "id": 22, "ws": true, "disabled": true}, {"text": "induce", "start": 116, "end": 122, "id": 23, "ws": true, "disabled": true}, {"text": "the", "start": 123, "end": 126, "id": 24, "ws": true, "disabled": true}, {"text": "tyrosine", "start": 127, "end": 135, "id": 25, "ws": true, "disabled": true}, {"text": "phosphorylation", "start": 136, "end": 151, "id": 26, "ws": true, "disabled": true}, {"text": "of", "start": 152, "end": 154, "id": 27, "ws": true, "disabled": true}, {"text": "HSI", "start": 155, "end": 158, "id": 28, "ws": false, "disabled": false}, {"text": ".", "start": 158, "end": 159, "id": 29, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 5, "child": 28, "head_span": {"start": 20, "end": 24, "token_start": 5, "token_end": 5, "label": "GGP"}, "child_span": {"start": 155, "end": 158, "token_start": 28, "token_end": 28, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 8, "child": 28, "head_span": {"start": 30, "end": 33, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 155, "end": 158, "token_start": 28, "token_end": 28, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity.", "spans": [{"text": "IL-7", "start": 0, "token_start": 0, "token_end": 0, "end": 4, "type": "span", "label": "GGP"}, {"text": "c-Myc", "start": 49, "token_start": 9, "token_end": 11, "end": 54, "type": "span", "label": "GGP"}, {"text": "Bcl-2", "start": 56, "token_start": 13, "token_end": 13, "end": 61, "type": "span", "label": "GGP"}, {"text": "Bcl-xL", "start": 67, "token_start": 16, "token_end": 18, "end": 73, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9794389.txt"}, "_input_hash": -860085078, "_task_hash": -316880999, "tokens": [{"text": "IL-7", "start": 0, "end": 4, "id": 0, "ws": true, "disabled": false}, {"text": "also", "start": 5, "end": 9, "id": 1, "ws": true, "disabled": true}, {"text": "delayed", "start": 10, "end": 17, "id": 2, "ws": true, "disabled": true}, {"text": "the", "start": 18, "end": 21, "id": 3, "ws": true, "disabled": true}, {"text": "decreases", "start": 22, "end": 31, "id": 4, "ws": true, "disabled": true}, {"text": "in", "start": 32, "end": 34, "id": 5, "ws": true, "disabled": true}, {"text": "the", "start": 35, "end": 38, "id": 6, "ws": true, "disabled": true}, {"text": "levels", "start": 39, "end": 45, "id": 7, "ws": true, "disabled": true}, {"text": "of", "start": 46, "end": 48, "id": 8, "ws": true, "disabled": true}, {"text": "c", "start": 49, "end": 50, "id": 9, "ws": false, "disabled": false}, {"text": "-", "start": 50, "end": 51, "id": 10, "ws": false, "disabled": false}, {"text": "Myc", "start": 51, "end": 54, "id": 11, "ws": false, "disabled": false}, {"text": ",", "start": 54, "end": 55, "id": 12, "ws": true, "disabled": true}, {"text": "Bcl-2", "start": 56, "end": 61, "id": 13, "ws": false, "disabled": false}, {"text": ",", "start": 61, "end": 62, "id": 14, "ws": true, "disabled": true}, {"text": "and", "start": 63, "end": 66, "id": 15, "ws": true, "disabled": true}, {"text": "Bcl", "start": 67, "end": 70, "id": 16, "ws": false, "disabled": false}, {"text": "-", "start": 70, "end": 71, "id": 17, "ws": false, "disabled": false}, {"text": "xL", "start": 71, "end": 73, "id": 18, "ws": true, "disabled": false}, {"text": "that", "start": 74, "end": 78, "id": 19, "ws": true, "disabled": true}, {"text": "occur", "start": 79, "end": 84, "id": 20, "ws": true, "disabled": true}, {"text": "upon", "start": 85, "end": 89, "id": 21, "ws": true, "disabled": true}, {"text": "loss", "start": 90, "end": 94, "id": 22, "ws": true, "disabled": true}, {"text": "of", "start": 95, "end": 97, "id": 23, "ws": true, "disabled": true}, {"text": "v", "start": 98, "end": 99, "id": 24, "ws": false, "disabled": true}, {"text": "-", "start": 99, "end": 100, "id": 25, "ws": false, "disabled": true}, {"text": "Abl", "start": 100, "end": 103, "id": 26, "ws": true, "disabled": true}, {"text": "kinase", "start": 104, "end": 110, "id": 27, "ws": true, "disabled": true}, {"text": "activity", "start": 111, "end": 119, "id": 28, "ws": false, "disabled": true}, {"text": ".", "start": 119, "end": 120, "id": 29, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 0, "child": 11, "head_span": {"start": 0, "end": 4, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 49, "end": 54, "token_start": 9, "token_end": 11, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 0, "child": 13, "head_span": {"start": 0, "end": 4, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 56, "end": 61, "token_start": 13, "token_end": 13, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}, {"head": 0, "child": 18, "head_span": {"start": 0, "end": 4, "token_start": 0, "token_end": 0, "label": "GGP"}, "child_span": {"start": 67, "end": 73, "token_start": 16, "token_end": 18, "label": "GGP"}, "color": "#c5bdf4", "label": "Reg"}], "answer": "accept"}
{"text": "In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR.", "spans": [{"text": "p21ras", "start": 13, "token_start": 3, "token_end": 3, "end": 19, "type": "span", "label": "GGP"}, {"text": "Akt", "start": 49, "token_start": 9, "token_end": 9, "end": 52, "type": "span", "label": "GGP"}, {"text": "PKB", "start": 53, "token_start": 11, "token_end": 11, "end": 56, "type": "span", "label": "GGP"}, {"text": "Akt", "start": 109, "token_start": 22, "token_end": 22, "end": 112, "type": "span", "label": "GGP"}, {"text": "PKB", "start": 113, "token_start": 24, "token_end": 24, "end": 116, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9796702.txt"}, "_input_hash": 1450383283, "_task_hash": 1419389420, "tokens": [{"text": "In", "start": 0, "end": 2, "id": 0, "ws": true, "disabled": true}, {"text": "contrast", "start": 3, "end": 11, "id": 1, "ws": false, "disabled": true}, {"text": ",", "start": 11, "end": 12, "id": 2, "ws": true, "disabled": true}, {"text": "p21ras", "start": 13, "end": 19, "id": 3, "ws": true, "disabled": false}, {"text": "signals", "start": 20, "end": 27, "id": 4, "ws": true, "disabled": true}, {"text": "are", "start": 28, "end": 31, "id": 5, "ws": true, "disabled": true}, {"text": "unable", "start": 32, "end": 38, "id": 6, "ws": true, "disabled": true}, {"text": "to", "start": 39, "end": 41, "id": 7, "ws": true, "disabled": true}, {"text": "induce", "start": 42, "end": 48, "id": 8, "ws": true, "disabled": true}, {"text": "Akt", "start": 49, "end": 52, "id": 9, "ws": false, "disabled": false}, {"text": "/", "start": 52, "end": 53, "id": 10, "ws": false, "disabled": true}, {"text": "PKB", "start": 53, "end": 56, "id": 11, "ws": true, "disabled": false}, {"text": "activity", "start": 57, "end": 65, "id": 12, "ws": true, "disabled": true}, {"text": "in", "start": 66, "end": 68, "id": 13, "ws": true, "disabled": true}, {"text": "T", "start": 69, "end": 70, "id": 14, "ws": true, "disabled": true}, {"text": "cell", "start": 71, "end": 75, "id": 15, "ws": true, "disabled": true}, {"text": "nor", "start": 76, "end": 79, "id": 16, "ws": true, "disabled": true}, {"text": "is", "start": 80, "end": 82, "id": 17, "ws": true, "disabled": true}, {"text": "Ras", "start": 83, "end": 86, "id": 18, "ws": true, "disabled": true}, {"text": "function", "start": 87, "end": 95, "id": 19, "ws": true, "disabled": true}, {"text": "required", "start": 96, "end": 104, "id": 20, "ws": true, "disabled": true}, {"text": "for", "start": 105, "end": 108, "id": 21, "ws": true, "disabled": true}, {"text": "Akt", "start": 109, "end": 112, "id": 22, "ws": false, "disabled": false}, {"text": "/", "start": 112, "end": 113, "id": 23, "ws": false, "disabled": true}, {"text": "PKB", "start": 113, "end": 116, "id": 24, "ws": true, "disabled": false}, {"text": "activation", "start": 117, "end": 127, "id": 25, "ws": true, "disabled": true}, {"text": "in", "start": 128, "end": 130, "id": 26, "ws": true, "disabled": true}, {"text": "response", "start": 131, "end": 139, "id": 27, "ws": true, "disabled": true}, {"text": "to", "start": 140, "end": 142, "id": 28, "ws": true, "disabled": true}, {"text": "the", "start": 143, "end": 146, "id": 29, "ws": true, "disabled": true}, {"text": "TCR", "start": 147, "end": 150, "id": 30, "ws": false, "disabled": true}, {"text": ".", "start": 150, "end": 151, "id": 31, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 3, "child": 9, "head_span": {"start": 13, "end": 19, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 49, "end": 52, "token_start": 9, "token_end": 9, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}, {"head": 3, "child": 11, "head_span": {"start": 13, "end": 19, "token_start": 3, "token_end": 3, "label": "GGP"}, "child_span": {"start": 53, "end": 56, "token_start": 11, "token_end": 11, "label": "GGP"}, "color": "#ffdaf9", "label": "No-rel"}], "answer": "accept"}
{"text": "Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2. \nHuman lysosomal acid lipase (LAL) is a hydrolase required for the cleavage of cholesteryl esters and triglycerides derived from plasma lipoproteins.", "spans": [{"text": "lysosomal acid lipase", "start": 30, "token_start": 3, "token_end": 5, "end": 51, "type": "span", "label": "GGP"}, {"text": "Sp1", "start": 118, "token_start": 14, "token_end": 14, "end": 121, "type": "span", "label": "GGP"}, {"text": "lysosomal acid lipase", "start": 139, "token_start": 20, "token_end": 22, "end": 160, "type": "span", "label": "GGP"}, {"text": "LAL", "start": 162, "token_start": 24, "token_end": 24, "end": 165, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9799798.txt"}, "_input_hash": 250115739, "_task_hash": -1296976990, "tokens": [{"text": "Transcriptional", "start": 0, "end": 15, "id": 0, "ws": true, "disabled": true}, {"text": "regulation", "start": 16, "end": 26, "id": 1, "ws": true, "disabled": true}, {"text": "of", "start": 27, "end": 29, "id": 2, "ws": true, "disabled": true}, {"text": "lysosomal", "start": 30, "end": 39, "id": 3, "ws": true, "disabled": false}, {"text": "acid", "start": 40, "end": 44, "id": 4, "ws": true, "disabled": false}, {"text": "lipase", "start": 45, "end": 51, "id": 5, "ws": true, "disabled": false}, {"text": "in", "start": 52, "end": 54, "id": 6, "ws": true, "disabled": true}, {"text": "differentiating", "start": 55, "end": 70, "id": 7, "ws": true, "disabled": true}, {"text": "monocytes", "start": 71, "end": 80, "id": 8, "ws": true, "disabled": true}, {"text": "is", "start": 81, "end": 83, "id": 9, "ws": true, "disabled": true}, {"text": "mediated", "start": 84, "end": 92, "id": 10, "ws": true, "disabled": true}, {"text": "by", "start": 93, "end": 95, "id": 11, "ws": true, "disabled": true}, {"text": "transcription", "start": 96, "end": 109, "id": 12, "ws": true, "disabled": true}, {"text": "factors", "start": 110, "end": 117, "id": 13, "ws": true, "disabled": true}, {"text": "Sp1", "start": 118, "end": 121, "id": 14, "ws": true, "disabled": false}, {"text": "and", "start": 122, "end": 125, "id": 15, "ws": true, "disabled": true}, {"text": "AP-2", "start": 126, "end": 130, "id": 16, "ws": false, "disabled": true}, {"text": ".", "start": 130, "end": 131, "id": 17, "ws": true, "disabled": true}, {"text": "\n", "start": 132, "end": 133, "id": 18, "ws": false, "disabled": true}, {"text": "Human", "start": 133, "end": 138, "id": 19, "ws": true, "disabled": true}, {"text": "lysosomal", "start": 139, "end": 148, "id": 20, "ws": true, "disabled": false}, {"text": "acid", "start": 149, "end": 153, "id": 21, "ws": true, "disabled": false}, {"text": "lipase", "start": 154, "end": 160, "id": 22, "ws": true, "disabled": false}, {"text": "(", "start": 161, "end": 162, "id": 23, "ws": false, "disabled": true}, {"text": "LAL", "start": 162, "end": 165, "id": 24, "ws": false, "disabled": false}, {"text": ")", "start": 165, "end": 166, "id": 25, "ws": true, "disabled": true}, {"text": "is", "start": 167, "end": 169, "id": 26, "ws": true, "disabled": true}, {"text": "a", "start": 170, "end": 171, "id": 27, "ws": true, "disabled": true}, {"text": "hydrolase", "start": 172, "end": 181, "id": 28, "ws": true, "disabled": true}, {"text": "required", "start": 182, "end": 190, "id": 29, "ws": true, "disabled": true}, {"text": "for", "start": 191, "end": 194, "id": 30, "ws": true, "disabled": true}, {"text": "the", "start": 195, "end": 198, "id": 31, "ws": true, "disabled": true}, {"text": "cleavage", "start": 199, "end": 207, "id": 32, "ws": true, "disabled": true}, {"text": "of", "start": 208, "end": 210, "id": 33, "ws": true, "disabled": true}, {"text": "cholesteryl", "start": 211, "end": 222, "id": 34, "ws": true, "disabled": true}, {"text": "esters", "start": 223, "end": 229, "id": 35, "ws": true, "disabled": true}, {"text": "and", "start": 230, "end": 233, "id": 36, "ws": true, "disabled": true}, {"text": "triglycerides", "start": 234, "end": 247, "id": 37, "ws": true, "disabled": true}, {"text": "derived", "start": 248, "end": 255, "id": 38, "ws": true, "disabled": true}, {"text": "from", "start": 256, "end": 260, "id": 39, "ws": true, "disabled": true}, {"text": "plasma", "start": 261, "end": 267, "id": 40, "ws": true, "disabled": true}, {"text": "lipoproteins", "start": 268, "end": 280, "id": 41, "ws": false, "disabled": true}, {"text": ".", "start": 280, "end": 281, "id": 42, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 14, "child": 5, "head_span": {"start": 118, "end": 121, "token_start": 14, "token_end": 14, "label": "GGP"}, "child_span": {"start": 30, "end": 51, "token_start": 3, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "Gel mobility shift assays demonstrated that binding of Sp1 and AP-2 to the LAL promoter is increased by PMA in THP-1 cells.", "spans": [{"text": "Sp1", "start": 55, "token_start": 8, "token_end": 8, "end": 58, "type": "span", "label": "GGP"}, {"text": "LAL", "start": 75, "token_start": 13, "token_end": 13, "end": 78, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9799798.txt"}, "_input_hash": -1474737253, "_task_hash": -387496458, "tokens": [{"text": "Gel", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "mobility", "start": 4, "end": 12, "id": 1, "ws": true, "disabled": true}, {"text": "shift", "start": 13, "end": 18, "id": 2, "ws": true, "disabled": true}, {"text": "assays", "start": 19, "end": 25, "id": 3, "ws": true, "disabled": true}, {"text": "demonstrated", "start": 26, "end": 38, "id": 4, "ws": true, "disabled": true}, {"text": "that", "start": 39, "end": 43, "id": 5, "ws": true, "disabled": true}, {"text": "binding", "start": 44, "end": 51, "id": 6, "ws": true, "disabled": true}, {"text": "of", "start": 52, "end": 54, "id": 7, "ws": true, "disabled": true}, {"text": "Sp1", "start": 55, "end": 58, "id": 8, "ws": true, "disabled": false}, {"text": "and", "start": 59, "end": 62, "id": 9, "ws": true, "disabled": true}, {"text": "AP-2", "start": 63, "end": 67, "id": 10, "ws": true, "disabled": true}, {"text": "to", "start": 68, "end": 70, "id": 11, "ws": true, "disabled": true}, {"text": "the", "start": 71, "end": 74, "id": 12, "ws": true, "disabled": true}, {"text": "LAL", "start": 75, "end": 78, "id": 13, "ws": true, "disabled": false}, {"text": "promoter", "start": 79, "end": 87, "id": 14, "ws": true, "disabled": true}, {"text": "is", "start": 88, "end": 90, "id": 15, "ws": true, "disabled": true}, {"text": "increased", "start": 91, "end": 100, "id": 16, "ws": true, "disabled": true}, {"text": "by", "start": 101, "end": 103, "id": 17, "ws": true, "disabled": true}, {"text": "PMA", "start": 104, "end": 107, "id": 18, "ws": true, "disabled": true}, {"text": "in", "start": 108, "end": 110, "id": 19, "ws": true, "disabled": true}, {"text": "THP-1", "start": 111, "end": 116, "id": 20, "ws": true, "disabled": true}, {"text": "cells", "start": 117, "end": 122, "id": 21, "ws": false, "disabled": true}, {"text": ".", "start": 122, "end": 123, "id": 22, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 8, "child": 13, "head_span": {"start": 55, "end": 58, "token_start": 8, "token_end": 8, "label": "GGP"}, "child_span": {"start": 75, "end": 78, "token_start": 13, "token_end": 13, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "Co-transfections with expression plasmids for Sp1 and AP-2 further emphasized the important role of these transcription factors in both basal and PMA-enhanced LAL expression.", "spans": [{"text": "Sp1", "start": 46, "token_start": 7, "token_end": 7, "end": 49, "type": "span", "label": "GGP"}, {"text": "LAL", "start": 159, "token_start": 26, "token_end": 26, "end": 162, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9799798.txt"}, "_input_hash": -1704257861, "_task_hash": -2088541619, "tokens": [{"text": "Co", "start": 0, "end": 2, "id": 0, "ws": false, "disabled": true}, {"text": "-", "start": 2, "end": 3, "id": 1, "ws": false, "disabled": true}, {"text": "transfections", "start": 3, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "with", "start": 17, "end": 21, "id": 3, "ws": true, "disabled": true}, {"text": "expression", "start": 22, "end": 32, "id": 4, "ws": true, "disabled": true}, {"text": "plasmids", "start": 33, "end": 41, "id": 5, "ws": true, "disabled": true}, {"text": "for", "start": 42, "end": 45, "id": 6, "ws": true, "disabled": true}, {"text": "Sp1", "start": 46, "end": 49, "id": 7, "ws": true, "disabled": false}, {"text": "and", "start": 50, "end": 53, "id": 8, "ws": true, "disabled": true}, {"text": "AP-2", "start": 54, "end": 58, "id": 9, "ws": true, "disabled": true}, {"text": "further", "start": 59, "end": 66, "id": 10, "ws": true, "disabled": true}, {"text": "emphasized", "start": 67, "end": 77, "id": 11, "ws": true, "disabled": true}, {"text": "the", "start": 78, "end": 81, "id": 12, "ws": true, "disabled": true}, {"text": "important", "start": 82, "end": 91, "id": 13, "ws": true, "disabled": true}, {"text": "role", "start": 92, "end": 96, "id": 14, "ws": true, "disabled": true}, {"text": "of", "start": 97, "end": 99, "id": 15, "ws": true, "disabled": true}, {"text": "these", "start": 100, "end": 105, "id": 16, "ws": true, "disabled": true}, {"text": "transcription", "start": 106, "end": 119, "id": 17, "ws": true, "disabled": true}, {"text": "factors", "start": 120, "end": 127, "id": 18, "ws": true, "disabled": true}, {"text": "in", "start": 128, "end": 130, "id": 19, "ws": true, "disabled": true}, {"text": "both", "start": 131, "end": 135, "id": 20, "ws": true, "disabled": true}, {"text": "basal", "start": 136, "end": 141, "id": 21, "ws": true, "disabled": true}, {"text": "and", "start": 142, "end": 145, "id": 22, "ws": true, "disabled": true}, {"text": "PMA", "start": 146, "end": 149, "id": 23, "ws": false, "disabled": true}, {"text": "-", "start": 149, "end": 150, "id": 24, "ws": false, "disabled": true}, {"text": "enhanced", "start": 150, "end": 158, "id": 25, "ws": true, "disabled": true}, {"text": "LAL", "start": 159, "end": 162, "id": 26, "ws": true, "disabled": false}, {"text": "expression", "start": 163, "end": 173, "id": 27, "ws": false, "disabled": true}, {"text": ".", "start": 173, "end": 174, "id": 28, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 7, "child": 26, "head_span": {"start": 46, "end": 49, "token_start": 7, "token_end": 7, "label": "GGP"}, "child_span": {"start": 159, "end": 162, "token_start": 26, "token_end": 26, "label": "GGP"}, "color": "#c2f2f6", "label": "Binds"}], "answer": "accept"}
{"text": "Our data suggest that differentiation dependent increase of lysosomal acid lipase (LAL) expression in THP-1 cells is mediated by a concerted action of Sp1 and AP-2.", "spans": [{"text": "lysosomal acid lipase", "start": 60, "token_start": 8, "token_end": 10, "end": 81, "type": "span", "label": "GGP"}, {"text": "LAL", "start": 83, "token_start": 12, "token_end": 12, "end": 86, "type": "span", "label": "GGP"}, {"text": "Sp1", "start": 151, "token_start": 25, "token_end": 25, "end": 154, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9799798.txt"}, "_input_hash": 1323922834, "_task_hash": 1793028552, "tokens": [{"text": "Our", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "data", "start": 4, "end": 8, "id": 1, "ws": true, "disabled": true}, {"text": "suggest", "start": 9, "end": 16, "id": 2, "ws": true, "disabled": true}, {"text": "that", "start": 17, "end": 21, "id": 3, "ws": true, "disabled": true}, {"text": "differentiation", "start": 22, "end": 37, "id": 4, "ws": true, "disabled": true}, {"text": "dependent", "start": 38, "end": 47, "id": 5, "ws": true, "disabled": true}, {"text": "increase", "start": 48, "end": 56, "id": 6, "ws": true, "disabled": true}, {"text": "of", "start": 57, "end": 59, "id": 7, "ws": true, "disabled": true}, {"text": "lysosomal", "start": 60, "end": 69, "id": 8, "ws": true, "disabled": false}, {"text": "acid", "start": 70, "end": 74, "id": 9, "ws": true, "disabled": false}, {"text": "lipase", "start": 75, "end": 81, "id": 10, "ws": true, "disabled": false}, {"text": "(", "start": 82, "end": 83, "id": 11, "ws": false, "disabled": true}, {"text": "LAL", "start": 83, "end": 86, "id": 12, "ws": false, "disabled": false}, {"text": ")", "start": 86, "end": 87, "id": 13, "ws": true, "disabled": true}, {"text": "expression", "start": 88, "end": 98, "id": 14, "ws": true, "disabled": true}, {"text": "in", "start": 99, "end": 101, "id": 15, "ws": true, "disabled": true}, {"text": "THP-1", "start": 102, "end": 107, "id": 16, "ws": true, "disabled": true}, {"text": "cells", "start": 108, "end": 113, "id": 17, "ws": true, "disabled": true}, {"text": "is", "start": 114, "end": 116, "id": 18, "ws": true, "disabled": true}, {"text": "mediated", "start": 117, "end": 125, "id": 19, "ws": true, "disabled": true}, {"text": "by", "start": 126, "end": 128, "id": 20, "ws": true, "disabled": true}, {"text": "a", "start": 129, "end": 130, "id": 21, "ws": true, "disabled": true}, {"text": "concerted", "start": 131, "end": 140, "id": 22, "ws": true, "disabled": true}, {"text": "action", "start": 141, "end": 147, "id": 23, "ws": true, "disabled": true}, {"text": "of", "start": 148, "end": 150, "id": 24, "ws": true, "disabled": true}, {"text": "Sp1", "start": 151, "end": 154, "id": 25, "ws": true, "disabled": false}, {"text": "and", "start": 155, "end": 158, "id": 26, "ws": true, "disabled": true}, {"text": "AP-2", "start": 159, "end": 163, "id": 27, "ws": false, "disabled": true}, {"text": ".", "start": 163, "end": 164, "id": 28, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 25, "child": 10, "head_span": {"start": 151, "end": 154, "token_start": 25, "token_end": 25, "label": "GGP"}, "child_span": {"start": 60, "end": 81, "token_start": 8, "token_end": 10, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 25, "child": 12, "head_span": {"start": 151, "end": 154, "token_start": 25, "token_end": 25, "label": "GGP"}, "child_span": {"start": 83, "end": 86, "token_start": 12, "token_end": 12, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
{"text": "The up-regulation of IL-1beta message could be mediated by the latent membrane protein-1, EBV nuclear proteins 2, 3, 4, and 6 genes.", "spans": [{"text": "IL-1beta", "start": 21, "token_start": 5, "token_end": 5, "end": 29, "type": "span", "label": "GGP"}, {"text": "latent membrane protein-1", "start": 63, "token_start": 12, "token_end": 14, "end": 88, "type": "span", "label": "GGP"}, {"text": "EBV nuclear proteins 2", "start": 90, "token_start": 16, "token_end": 19, "end": 112, "type": "span", "label": "GGP"}, {"text": "3", "start": 114, "token_start": 21, "token_end": 21, "end": 115, "type": "span", "label": "GGP"}, {"text": "4", "start": 117, "token_start": 23, "token_end": 23, "end": 118, "type": "span", "label": "GGP"}, {"text": "6 genes", "start": 124, "token_start": 26, "token_end": 27, "end": 131, "type": "span", "label": "GGP"}], "meta": {"source": "BioNLP 2011 Genia Shared Task, PMID-9878621.txt"}, "_input_hash": -400334998, "_task_hash": 1861007191, "tokens": [{"text": "The", "start": 0, "end": 3, "id": 0, "ws": true, "disabled": true}, {"text": "up", "start": 4, "end": 6, "id": 1, "ws": false, "disabled": true}, {"text": "-", "start": 6, "end": 7, "id": 2, "ws": false, "disabled": true}, {"text": "regulation", "start": 7, "end": 17, "id": 3, "ws": true, "disabled": true}, {"text": "of", "start": 18, "end": 20, "id": 4, "ws": true, "disabled": true}, {"text": "IL-1beta", "start": 21, "end": 29, "id": 5, "ws": true, "disabled": false}, {"text": "message", "start": 30, "end": 37, "id": 6, "ws": true, "disabled": true}, {"text": "could", "start": 38, "end": 43, "id": 7, "ws": true, "disabled": true}, {"text": "be", "start": 44, "end": 46, "id": 8, "ws": true, "disabled": true}, {"text": "mediated", "start": 47, "end": 55, "id": 9, "ws": true, "disabled": true}, {"text": "by", "start": 56, "end": 58, "id": 10, "ws": true, "disabled": true}, {"text": "the", "start": 59, "end": 62, "id": 11, "ws": true, "disabled": true}, {"text": "latent", "start": 63, "end": 69, "id": 12, "ws": true, "disabled": false}, {"text": "membrane", "start": 70, "end": 78, "id": 13, "ws": true, "disabled": false}, {"text": "protein-1", "start": 79, "end": 88, "id": 14, "ws": false, "disabled": false}, {"text": ",", "start": 88, "end": 89, "id": 15, "ws": true, "disabled": true}, {"text": "EBV", "start": 90, "end": 93, "id": 16, "ws": true, "disabled": false}, {"text": "nuclear", "start": 94, "end": 101, "id": 17, "ws": true, "disabled": false}, {"text": "proteins", "start": 102, "end": 110, "id": 18, "ws": true, "disabled": false}, {"text": "2", "start": 111, "end": 112, "id": 19, "ws": false, "disabled": false}, {"text": ",", "start": 112, "end": 113, "id": 20, "ws": true, "disabled": true}, {"text": "3", "start": 114, "end": 115, "id": 21, "ws": false, "disabled": false}, {"text": ",", "start": 115, "end": 116, "id": 22, "ws": true, "disabled": true}, {"text": "4", "start": 117, "end": 118, "id": 23, "ws": false, "disabled": false}, {"text": ",", "start": 118, "end": 119, "id": 24, "ws": true, "disabled": true}, {"text": "and", "start": 120, "end": 123, "id": 25, "ws": true, "disabled": true}, {"text": "6", "start": 124, "end": 125, "id": 26, "ws": true, "disabled": false}, {"text": "genes", "start": 126, "end": 131, "id": 27, "ws": false, "disabled": false}, {"text": ".", "start": 131, "end": 132, "id": 28, "ws": false, "disabled": true}], "_session_id": null, "_view_id": "relations", "relations": [{"head": 14, "child": 5, "head_span": {"start": 63, "end": 88, "token_start": 12, "token_end": 14, "label": "GGP"}, "child_span": {"start": 21, "end": 29, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 19, "child": 5, "head_span": {"start": 90, "end": 112, "token_start": 16, "token_end": 19, "label": "GGP"}, "child_span": {"start": 21, "end": 29, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 21, "child": 5, "head_span": {"start": 114, "end": 115, "token_start": 21, "token_end": 21, "label": "GGP"}, "child_span": {"start": 21, "end": 29, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 23, "child": 5, "head_span": {"start": 117, "end": 118, "token_start": 23, "token_end": 23, "label": "GGP"}, "child_span": {"start": 21, "end": 29, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}, {"head": 27, "child": 5, "head_span": {"start": 124, "end": 131, "token_start": 26, "token_end": 27, "label": "GGP"}, "child_span": {"start": 21, "end": 29, "token_start": 5, "token_end": 5, "label": "GGP"}, "color": "#ffd882", "label": "Pos-Reg"}], "answer": "accept"}
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