diff --git a/lib/modules/platform/github/index.spec.ts b/lib/modules/platform/github/index.spec.ts
index eb133f6ecae99b..9eaf850b78dce7 100644
--- a/lib/modules/platform/github/index.spec.ts
+++ b/lib/modules/platform/github/index.spec.ts
@@ -1531,6 +1531,57 @@ describe('modules/platform/github/index', () => {
     });
   });
 
+  describe('getIssue()', () => {
+    it('returns null if issues disabled', async () => {
+      const scope = httpMock.scope(githubApiHost);
+      initRepoMock(scope, 'some/repo', { hasIssuesEnabled: false });
+      await github.initRepo({ repository: 'some/repo' });
+      const res = await github.getIssue(1);
+      expect(res).toBeNull();
+    });
+
+    it('returns issue', async () => {
+      const scope = httpMock.scope(githubApiHost);
+      initRepoMock(scope, 'some/repo');
+      const issue = {
+        number: 1,
+        state: 'open',
+        title: 'title-1',
+        body: 'body-1',
+      };
+      scope
+        .get('/repos/some/repo/issues/1')
+        .reply(200, { ...issue, updated_at: '2022-01-01T00:00:00Z' });
+      await github.initRepo({ repository: 'some/repo' });
+      const res = await github.getIssue(1);
+      expect(res).toMatchObject({
+        ...issue,
+        lastModified: '2022-01-01T00:00:00Z',
+      });
+    });
+
+    it('returns null if issue not found', async () => {
+      const scope = httpMock.scope(githubApiHost);
+      initRepoMock(scope, 'some/repo');
+      scope.get('/repos/some/repo/issues/1').reply(404);
+      await github.initRepo({ repository: 'some/repo' });
+      const res = await github.getIssue(1);
+      expect(res).toBeNull();
+    });
+
+    it('logs debug message if issue deleted', async () => {
+      const scope = httpMock.scope(githubApiHost);
+      initRepoMock(scope, 'some/repo');
+      scope.get('/repos/some/repo/issues/1').reply(410);
+      await github.initRepo({ repository: 'some/repo' });
+      const res = await github.getIssue(1);
+      expect(res).toBeNull();
+      expect(logger.logger.debug).toHaveBeenCalledWith(
+        'Issue #1 has been deleted',
+      );
+    });
+  });
+
   describe('findIssue()', () => {
     it('returns null if no issue', async () => {
       httpMock
diff --git a/lib/modules/platform/github/index.ts b/lib/modules/platform/github/index.ts
index 93488565ba630a..8551653ce0dac3 100644
--- a/lib/modules/platform/github/index.ts
+++ b/lib/modules/platform/github/index.ts
@@ -1231,7 +1231,6 @@ export async function getIssueList(): Promise<Issue[]> {
 }
 
 export async function getIssue(number: number): Promise<Issue | null> {
-  // istanbul ignore if
   if (config.hasIssuesEnabled === false) {
     return null;
   }
@@ -1246,8 +1245,12 @@ export async function getIssue(number: number): Promise<Issue | null> {
     );
     GithubIssueCache.updateIssue(issue);
     return issue;
-  } catch (err) /* istanbul ignore next */ {
+  } catch (err) {
     logger.debug({ err, number }, 'Error getting issue');
+    if (err.response?.statusCode === 410) {
+      logger.debug(`Issue #${number} has been deleted`);
+      GithubIssueCache.deleteIssue(number);
+    }
     return null;
   }
 }
diff --git a/lib/modules/platform/github/issue.spec.ts b/lib/modules/platform/github/issue.spec.ts
index 749364ddf5ad4e..8a9e9bd1cb82a4 100644
--- a/lib/modules/platform/github/issue.spec.ts
+++ b/lib/modules/platform/github/issue.spec.ts
@@ -159,6 +159,32 @@ describe('modules/platform/github/issue', () => {
       });
     });
 
+    it('removes particular issue from the cache', () => {
+      cache.platform = {
+        github: {
+          issuesCache: {
+            '1': {
+              number: 1,
+              body: 'body-1',
+              state: 'open',
+              title: 'title-1',
+              lastModified: '2020-01-01T00:00:00.000Z',
+            },
+          },
+        },
+      };
+
+      GithubIssueCache.deleteIssue(1);
+
+      expect(cache).toEqual({
+        platform: {
+          github: {
+            issuesCache: {},
+          },
+        },
+      });
+    });
+
     it('reconciles cache', () => {
       cache.platform = {
         github: {
diff --git a/lib/modules/platform/github/issue.ts b/lib/modules/platform/github/issue.ts
index 1cc85151777233..11a5d050dceceb 100644
--- a/lib/modules/platform/github/issue.ts
+++ b/lib/modules/platform/github/issue.ts
@@ -85,6 +85,13 @@ export class GithubIssueCache {
     }
   }
 
+  static deleteIssue(number: number): void {
+    const cacheData = this.data;
+    if (cacheData) {
+      delete cacheData[number];
+    }
+  }
+
   /**
    * At the moment of repo initialization, repository cache is not available.
    * What we can do is to store issues for later reconciliation.