diff --git a/lib/modules/manager/pip-compile/artifacts.spec.ts b/lib/modules/manager/pip-compile/artifacts.spec.ts
index a22f9aca75dd55..2bd1c0e1072166 100644
--- a/lib/modules/manager/pip-compile/artifacts.spec.ts
+++ b/lib/modules/manager/pip-compile/artifacts.spec.ts
@@ -9,7 +9,7 @@ import { logger } from '../../../logger';
 import * as docker from '../../../util/exec/docker';
 import type { StatusResult } from '../../../util/git/types';
 import * as _datasource from '../../datasource';
-import type { UpdateArtifactsConfig } from '../types';
+import type { UpdateArtifactsConfig, Upgrade } from '../types';
 import { constructPipCompileCmd } from './artifacts';
 import { updateArtifacts } from '.';
 
@@ -272,6 +272,33 @@ describe('modules/manager/pip-compile/artifacts', () => {
     ]);
   });
 
+  it('uses --upgrade-package only for isLockfileUpdate', async () => {
+    fs.readLocalFile.mockResolvedValueOnce(simpleHeader);
+    const execSnapshots = mockExecAll();
+    git.getRepoStatus.mockResolvedValue(
+      partial<StatusResult>({
+        modified: ['requirements.txt'],
+      }),
+    );
+    fs.readLocalFile.mockResolvedValueOnce('New requirements.txt');
+    expect(
+      await updateArtifacts({
+        packageFileName: 'requirements.in',
+        updatedDeps: [
+          { depName: 'foo', newVersion: '1.0.2', isLockfileUpdate: true },
+          { depName: 'bar', newVersion: '2.0.0' },
+        ] satisfies Upgrade[],
+        newPackageFileContent: '{}',
+        config: { ...lockMaintenanceConfig, lockFiles: ['requirements.txt'] },
+      }),
+    ).not.toBeNull();
+    expect(execSnapshots).toMatchObject([
+      {
+        cmd: 'pip-compile --no-emit-index-url requirements.in --upgrade-package=foo==1.0.2',
+      },
+    ]);
+  });
+
   it('uses pip-compile version from config', async () => {
     fs.readLocalFile.mockResolvedValueOnce(simpleHeader);
     GlobalConfig.set(dockerAdminConfig);
@@ -408,5 +435,23 @@ describe('modules/manager/pip-compile/artifacts', () => {
         ),
       ).toThrow(/custom/);
     });
+
+    it('add --upgrade-package to command if Upgrade[] passed', () => {
+      expect(
+        constructPipCompileCmd(
+          getCommandInHeader(
+            'pip-compile --output-file=requirements.txt requirements.in',
+          ),
+          'subdir/requirements.txt',
+          false,
+          [
+            { depName: 'foo', newVersion: '1.0.2' },
+            { depName: 'bar', newVersion: '2.0.0' },
+          ] satisfies Upgrade[],
+        ),
+      ).toBe(
+        'pip-compile --no-emit-index-url --output-file=requirements.txt requirements.in --upgrade-package=foo==1.0.2 --upgrade-package=bar==2.0.0',
+      );
+    });
   });
 });
diff --git a/lib/modules/manager/pip-compile/artifacts.ts b/lib/modules/manager/pip-compile/artifacts.ts
index 48172d6f601624..abbbc6ff929845 100644
--- a/lib/modules/manager/pip-compile/artifacts.ts
+++ b/lib/modules/manager/pip-compile/artifacts.ts
@@ -10,7 +10,7 @@ import {
 } from '../../../util/fs';
 import { getRepoStatus } from '../../../util/git';
 import * as pipRequirements from '../pip_requirements';
-import type { UpdateArtifact, UpdateArtifactsResult } from '../types';
+import type { UpdateArtifact, UpdateArtifactsResult, Upgrade } from '../types';
 import {
   extractHeaderCommand,
   getExecOptions,
@@ -21,6 +21,7 @@ export function constructPipCompileCmd(
   content: string,
   outputFileName: string,
   haveCredentials: boolean,
+  upgradePackages: Upgrade[] = [],
 ): string {
   const compileArgs = extractHeaderCommand(content, outputFileName);
   if (compileArgs.isCustomCommand) {
@@ -56,12 +57,18 @@ export function constructPipCompileCmd(
   ) {
     compileArgs.argv.splice(1, 0, '--no-emit-index-url');
   }
+  for (const dep of upgradePackages) {
+    compileArgs.argv.push(
+      `--upgrade-package=${quote(dep.depName + '==' + dep.newVersion)}`,
+    );
+  }
   return compileArgs.argv.map(quote).join(' ');
 }
 
 export async function updateArtifacts({
   packageFileName: inputFileName,
   newPackageFileContent: newInputContent,
+  updatedDeps,
   config,
 }: UpdateArtifact): Promise<UpdateArtifactsResult[] | null> {
   if (!config.lockFiles) {
@@ -89,12 +96,14 @@ export async function updateArtifacts({
       if (config.isLockFileMaintenance) {
         await deleteLocalFile(outputFileName);
       }
+      const upgradePackages = updatedDeps.filter((dep) => dep.isLockfileUpdate);
       const packageFile = pipRequirements.extractPackageFile(newInputContent);
       const registryUrlVars = getRegistryUrlVarsFromPackageFile(packageFile);
       const cmd = constructPipCompileCmd(
         existingOutput,
         outputFileName,
         registryUrlVars.haveCredentials,
+        upgradePackages,
       );
       const execOptions = await getExecOptions(
         config,